Gene Symbol: Plekha5
Description: pleckstrin homology domain containing, family A member 5
Alias: 2810431N21Rik, AI428202, AK129423, AMH-Cre, Ayu21-9, Gt(pU21)9Imeg, Pepp2, Tg(AMH-cre)1Flor, pleckstrin homology domain-containing family A member 5, Gt(Ayu21)9Imeg, phosphoinositol 3-phosphate-binding protein-2
Species: mouse
Products:     Plekha5

Top Publications

  1. Chang C, Chen Y, Yeh S, Xu Q, Wang R, Guillou F, et al. Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells. Proc Natl Acad Sci U S A. 2004;101:6876-81 pubmed
    ..Together, our Sertoli cell-specific AR knockout mice provide in vivo evidence of the need for functional AR in Sertoli cells to maintain normal spermatogenesis and testosterone production, and ensure normal male fertility. ..
  2. Lecureuil C, Fontaine I, Crepieux P, Guillou F. Sertoli and granulosa cell-specific Cre recombinase activity in transgenic mice. Genesis. 2002;33:114-8 pubmed
  3. Zhang C, Yeh S, Chen Y, Wu C, Chuang K, Lin H, et al. Oligozoospermia with normal fertility in male mice lacking the androgen receptor in testis peritubular myoid cells. Proc Natl Acad Sci U S A. 2006;103:17718-23 pubmed
  4. Tsai M, Yeh S, Wang R, Yeh S, Zhang C, Lin H, et al. Differential effects of spermatogenesis and fertility in mice lacking androgen receptor in individual testis cells. Proc Natl Acad Sci U S A. 2006;103:18975-80 pubmed
    ..These contrasting data with G-AR(-/y) mice suggest AR might have different roles in the various cells within testis to contribute to normal spermatogenesis and male fertility in mice. ..
  5. Tan K, De Gendt K, Atanassova N, Walker M, Sharpe R, Saunders P, et al. The role of androgens in sertoli cell proliferation and functional maturation: studies in mice with total or Sertoli cell-selective ablation of the androgen receptor. Endocrinology. 2005;146:2674-83 pubmed
  6. De Gendt K, Atanassova N, Tan K, de França L, Parreira G, McKinnell C, et al. Development and function of the adult generation of Leydig cells in mice with Sertoli cell-selective or total ablation of the androgen receptor. Endocrinology. 2005;146:4117-26 pubmed
    ..These results show that loss of androgen action on SC has major consequences for LC development, and this could be mediated indirectly via platelet-derived growth factor-A and/or estrogens/EST. ..
  7. Abel M, Baker P, Charlton H, Monteiro A, Verhoeven G, De Gendt K, et al. Spermatogenesis and sertoli cell activity in mice lacking sertoli cell receptors for follicle-stimulating hormone and androgen. Endocrinology. 2008;149:3279-85 pubmed publisher
    ..In addition, the Sertoli cell retains a significant capacity for activity, which is independent of direct hormonal regulation. ..
  8. Sridharan S, Simon L, Meling D, Cyr D, Gutstein D, Fishman G, et al. Proliferation of adult sertoli cells following conditional knockout of the Gap junctional protein GJA1 (connexin 43) in mice. Biol Reprod. 2007;76:804-12 pubmed
    ..SC-Cx43 KO mice showed continued Sertoli cell proliferation and delayed maturation in adulthood, indicating that CX43 plays key roles in Sertoli cell development. ..
  9. Denolet E, De Gendt K, Allemeersch J, Engelen K, Marchal K, Van Hummelen P, et al. The effect of a sertoli cell-selective knockout of the androgen receptor on testicular gene expression in prepubertal mice. Mol Endocrinol. 2006;20:321-34 pubmed
    ..Moreover, they suggest that protease inhibitors and other proteins related to tubular restructuring and cell junction dynamics may be controlled in part by androgens. ..

More Information


  1. O Shaughnessy P, Verhoeven G, De Gendt K, Monteiro A, Abel M. Direct action through the sertoli cells is essential for androgen stimulation of spermatogenesis. Endocrinology. 2010;151:2343-8 pubmed publisher
    ..T increased germ cell numbers in hpg.SCARKO and hpg.ARKO mice, but this was associated with stimulation of FSH release. Results show that androgen stimulation of spermatogenesis requires direct androgen action on the Sertoli cells. ..
  2. Carette D, Weider K, Gilleron J, Giese S, Dompierre J, Bergmann M, et al. Major involvement of connexin 43 in seminiferous epithelial junction dynamics and male fertility. Dev Biol. 2010;346:54-67 pubmed publisher
  3. Brehm R, Zeiler M, Rüttinger C, Herde K, Kibschull M, Winterhager E, et al. A sertoli cell-specific knockout of connexin43 prevents initiation of spermatogenesis. Am J Pathol. 2007;171:19-31 pubmed
    ..Our data demonstrate for the first time that cx43 expression in SCs is an absolute requirement for normal testicular development and spermatogenesis. ..
  4. De Gendt K, Swinnen J, Saunders P, Schoonjans L, Dewerchin M, Devos A, et al. A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. Proc Natl Acad Sci U S A. 2004;101:1327-32 pubmed
    ..It is concluded that cell-autonomous action of the AR in SC is an absolute requirement for androgen maintenance of complete spermatogenesis, and that spermatocyte/spermatid development/survival critically depends on androgens. ..
  5. O Shaughnessy P, Monteiro A, Verhoeven G, De Gendt K, Abel M. Occurrence of testicular microlithiasis in androgen insensitive hypogonadal mice. Reprod Biol Endocrinol. 2009;7:88 pubmed publisher
    ..Importantly, this model will provide a means with which to identify the mechanisms of TM development and the underlying changes in protein and gene expression. ..
  6. Weider K, Bergmann M, Giese S, Guillou F, Failing K, Brehm R. Altered differentiation and clustering of Sertoli cells in transgenic mice showing a Sertoli cell specific knockout of the connexin 43 gene. Differentiation. 2011;82:38-49 pubmed publisher
  7. Wang R, Yeh S, Chen L, Lin H, Zhang C, Ni J, et al. Androgen receptor in sertoli cell is essential for germ cell nursery and junctional complex formation in mouse testes. Endocrinology. 2006;147:5624-33 pubmed
    ..5, which contributed to functional defects in production and/or secretion of specific proteases, transport proteins, and paracrine factors of SC, leading to impairment of its germ cells' nursery functions. ..
  8. Kashimada K, Svingen T, Feng C, Pelosi E, Bagheri Fam S, Harley V, et al. Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice. FASEB J. 2011;25:3561-9 pubmed publisher
    ..These data support the hypothesis that SOX9 and SF1 ensure the male fate of germ cells by up-regulating Cyp26b1 and that FOXL2 acts to antagonize Cyp26b1 expression in ovaries. ..
  9. Willems A, Batlouni S, Esnal A, Swinnen J, Saunders P, Sharpe R, et al. Selective ablation of the androgen receptor in mouse sertoli cells affects sertoli cell maturation, barrier formation and cytoskeletal development. PLoS ONE. 2010;5:e14168 pubmed publisher
    ..It is concluded that absence of a functional AR in SC impedes the remodeling of testicular tubules expected at the onset of spermatogenesis and interferes with the creation of the specific environment needed for germ cell development. ..
  10. Raverdeau M, Gely Pernot A, Féret B, Dennefeld C, Benoit G, Davidson I, et al. Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis. Proc Natl Acad Sci U S A. 2012;109:16582-7 pubmed publisher
  11. Guillermet Guibert J, Smith L, Halet G, Whitehead M, Pearce W, Rebourcet D, et al. Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells. PLoS Genet. 2015;11:e1005304 pubmed publisher
    ..This developmental pathway may become active in prostate cancer where p110β and AR have previously been reported to functionally interact. ..
  12. Ophoff J, Callewaert F, Venken K, De Gendt K, Ohlsson C, Gayan Ramirez G, et al. Physical activity in the androgen receptor knockout mouse: evidence for reversal of androgen deficiency on cancellous bone. Biochem Biophys Res Commun. 2009;378:139-44 pubmed publisher
    ..Thus, voluntary running in ARKO mice was able to reduce cancellous bone resorption, suggesting that sustained exercise may potentially compensate the effects of androgen disruption on cancellous bone. ..
  13. Li H, MacLean G, Cameron D, Clagett Dame M, Petkovich M. Cyp26b1 expression in murine Sertoli cells is required to maintain male germ cells in an undifferentiated state during embryogenesis. PLoS ONE. 2009;4:e7501 pubmed publisher
  14. Archambeault D, Yao H. Activin A, a product of fetal Leydig cells, is a unique paracrine regulator of Sertoli cell proliferation and fetal testis cord expansion. Proc Natl Acad Sci U S A. 2010;107:10526-31 pubmed publisher
    ..Our findings challenge the paradigm that fetal testis development is solely under the control of Sertoli cells, by uncovering an active and essential role of fetal Leydig cells during testis cord morphogenesis...
  15. Wang B, Qi T, Chen S, Ye L, Huang Z, Li H. RFX1 maintains testis cord integrity by regulating the expression of Itga6 in male mouse embryos. Mol Reprod Dev. 2016;83:606-14 pubmed publisher
    ..Taken together, RFX1 transcriptionally targets Itga6 in Sertoli cells, thereby, helping maintain the integrity of the basal lamina during testis cord development. Mol. Reprod. Dev. 83: 606-614, 2016. © 2016 Wiley Periodicals, Inc. ..
  16. Bao J, Tang C, Yuan S, Porse B, Yan W. UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome. Development. 2015;142:352-62 pubmed publisher
    ..Our data demonstrate an essential role of UPF2-mediated NMD in prepubertal SC development and male fertility. ..
  17. Vernet N, Dennefeld C, Guillou F, Chambon P, Ghyselinck N, Mark M. Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells. EMBO J. 2006;25:5816-25 pubmed
  18. Garcia T, Farmaha J, Kow S, Hofmann M. RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche. Development. 2014;141:4468-78 pubmed publisher
  19. Bertoldo M, Guibert E, Faure M, Guillou F, Ramé C, Nadal Desbarats L, et al. Specific deletion of AMP-activated protein kinase (α1AMPK) in mouse Sertoli cells modifies germ cell quality. Mol Cell Endocrinol. 2016;423:96-112 pubmed publisher
    ..In conclusion, these results suggest that dysregulation of the energy sensing machinery exclusively through disruption of α1AMPK in Sertoli cells translates to a reduction in the quality of germ cells and fertility. ..
  20. Lim P, Robson M, Spaliviero J, McTavish K, Jimenez M, Zajac J, et al. Sertoli cell androgen receptor DNA binding domain is essential for the completion of spermatogenesis. Endocrinology. 2009;150:4755-65 pubmed publisher
    ..Nongenomic or AR-DBD-independent pathways appear secondary or play no major independent role in SC function. ..
  21. Batista F, Lu L, Williams S, Stanley P. Complex N-glycans are essential, but core 1 and 2 mucin O-glycans, O-fucose glycans, and NOTCH1 are dispensable, for mammalian spermatogenesis. Biol Reprod. 2012;86:179 pubmed publisher
    ..Therefore, although core 1 and 2 mucin O-glycans, NOTCH1, POFUT1, O-fucose glycans, and Notch signaling are dispensable, MGAT1 and complex N-glycans are essential for spermatogenesis. ..
  22. Romero Y, Vuandaba M, Suarez P, Grey C, Calvel P, Conne B, et al. The Glucocorticoid-induced leucine zipper (GILZ) Is essential for spermatogonial survival and spermatogenesis. Sex Dev. 2012;6:169-77 pubmed publisher
    ..Overall, these data emphasize the essential role played by GILZ in mediating spermatogonial survival and spermatogenesis. ..
  23. Huyghe S, Schmalbruch H, De Gendt K, Verhoeven G, Guillou F, Van Veldhoven P, et al. Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility in mice. Endocrinology. 2006;147:2228-36 pubmed
    ..In conclusion, the present data demonstrate that peroxisomal beta-oxidation is essential for lipid homeostasis in the testis and for male fertility. ..
  24. Wen Q, Zheng Q, Li X, Hu Z, Gao F, Cheng C, et al. Wt1 dictates the fate of fetal and adult Leydig cells during development in the mouse testis. Am J Physiol Endocrinol Metab. 2014;307:E1131-43 pubmed publisher
    ..In summary, FLC-like cells in mutant testes are putative FLCs that remain mitotically active in adult mice, illustrating that Wt1 dictates the fate of FLC and ALC during postnatal testis development. ..
  25. Chang H, Gao F, Guillou F, Taketo M, Huff V, Behringer R. Wt1 negatively regulates beta-catenin signaling during testis development. Development. 2008;135:1875-85 pubmed publisher
    ..However, the suppression of beta-catenin signaling in these cells is essential for proper testis formation and Wt1 is a negative regulator of beta-catenin signaling during this developmental process. ..
  26. Chatonnet F, Livera G, Fumel B, FouchÉCourt S, Flamant F. Direct and indirect consequences on gene expression of a thyroid hormone receptor alpha 1 mutation restricted to Sertoli cells. Mol Reprod Dev. 2014;81:1159-66 pubmed publisher
    ..This differential analysis provides genetic clues to the initial testicular defects resulting from disrupted thyroid hormone signaling, and suggests that Sertoli cells influence germ cells soon after their birth. ..
  27. Kim G, Georg I, Scherthan H, Merkenschlager M, Guillou F, Scherer G, et al. Dicer is required for Sertoli cell function and survival. Int J Dev Biol. 2010;54:867-75 pubmed publisher
    ..Taken together, the results of this study show that Dicer is required for Sertoli cell function and survival and for spermatogenesis in mice. ..
  28. O Shaughnessy P, Monteiro A, Verhoeven G, De Gendt K, Abel M. Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors. Reproduction. 2010;139:177-84 pubmed publisher
  29. Le Borgne M, Chartier N, Buchet Poyau K, Destaing O, Faurobert E, Thibert C, et al. The RNA-binding protein Mex3b regulates the spatial organization of the Rap1 pathway. Development. 2014;141:2096-107 pubmed publisher
    ..Overall, these findings implicate Mex3b in the spatial organization of the Rap1 pathway that orchestrates Sertoli cell functions. ..
  30. Papaioannou M, Pitetti J, Ro S, Park C, Aubry F, Schaad O, et al. Sertoli cell Dicer is essential for spermatogenesis in mice. Dev Biol. 2009;326:250-9 pubmed publisher
    ..Overall, our results reveal novel essential roles played by the Dicer-dependent pathway in mammalian reproductive function, and thus pave the way for new insights into human infertility. ..
  31. Hazra R, Upton D, Jimenez M, Desai R, Handelsman D, Allan C. In vivo actions of the Sertoli cell glucocorticoid receptor. Endocrinology. 2014;155:1120-30 pubmed publisher
  32. Xiao Y, Karnati S, Qian G, Nenicu A, Fan W, Tchatalbachev S, et al. Cre-mediated stress affects sirtuin expression levels, peroxisome biogenesis and metabolism, antioxidant and proinflammatory signaling pathways. PLoS ONE. 2012;7:e41097 pubmed publisher
  33. MacDonald C, Grozdanov P. Nonsense in the testis: multiple roles for nonsense-mediated decay revealed in male reproduction. Biol Reprod. 2017;96:939-947 pubmed publisher
    ..These results suggest that chromatoid bodies play a specialized role in modulating the NMD machinery in postmeiotic spermatids. ..
  34. Rebourcet D, Darbey A, Monteiro A, Soffientini U, Tsai Y, Handel I, et al. Sertoli Cell Number Defines and Predicts Germ and Leydig Cell Population Sizes in the Adult Mouse Testis. Endocrinology. 2017;158:2955-2969 pubmed publisher
    ..A reduction in Sertoli cell number/proliferation at any age will therefore lead to a proportional decrease in germ cell and Leydig cell numbers, with likely consequential effects on fertility and health. ..
  35. Vernet N, Dennefeld C, Klopfenstein M, Ruiz A, Bok D, Ghyselinck N, et al. Retinoid X receptor beta (RXRB) expression in Sertoli cells controls cholesterol homeostasis and spermiation. Reproduction. 2008;136:619-26 pubmed publisher
    ..Altogether, these findings support the conclusion that RXRB heterodimerized with a RA-liganded RARA transduces signals required in SC for spermatid release...
  36. Herzog M, Wendling O, Guillou F, Chambon P, Mark M, Losson R, et al. TIF1? association with HP1 is essential for post-gastrulation development, but not for Sertoli cell functions during spermatogenesis. Dev Biol. 2011;350:548-58 pubmed publisher
    ..5 embryos and of Sertoli cells, an association that is lost upon TIF1? HP1box mutation. Altogether, these data provide strong evidence that nuclear organization plays key roles during early embryonic development. ..
  37. O Shaughnessy P, Monteiro A, Abel M. Testicular development in mice lacking receptors for follicle stimulating hormone and androgen. PLoS ONE. 2012;7:e35136 pubmed publisher
    ..Post-pubertally, germ cell numbers and spermatogenesis are dependent on FSH and androgen action through the Sertoli cells. ..
  38. Wen Q, Wang Y, Tang J, Cheng C, Liu Y. Sertoli Cell Wt1 Regulates Peritubular Myoid Cell and Fetal Leydig Cell Differentiation during Fetal Testis Development. PLoS ONE. 2016;11:e0167920 pubmed publisher
    ..In summary, Wt1 regulates the development of FLC and interstitial progenitor cell lineages through Notch signaling, and it also plays a role in PMC development. Collectively, these effects confer fetal testis compartmentalization. ..
  39. Zhang L, Chen M, Wen Q, Li Y, Wang Y, Wang Y, et al. Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation. Proc Natl Acad Sci U S A. 2015;112:4003-8 pubmed publisher
    ..This study thus provides a novel concept for somatic cell fate determination in testis development that may also represent an etiology of male infertility in human patients. ..
  40. Sen A, Hammes S. Granulosa cell-specific androgen receptors are critical regulators of ovarian development and function. Mol Endocrinol. 2010;24:1393-403 pubmed publisher
    ..These GC-specific ARs appear to promote preantral follicle growth and prevent follicular atresia; thus they are essential for normal follicular development and fertility. ..
  41. Gao F, Maiti S, Alam N, Zhang Z, Deng J, Behringer R, et al. The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis. Proc Natl Acad Sci U S A. 2006;103:11987-92 pubmed
    ..Our data, along with previous work demonstrating the role of Wt1 at early stages of gonadal development, thus indicate that Wt1 is essential at multiple steps in testicular development. ..
  42. Jiang X, Ma T, Zhang Y, Zhang H, Yin S, Zheng W, et al. Specific deletion of Cdh2 in Sertoli cells leads to altered meiotic progression and subfertility of mice. Biol Reprod. 2015;92:79 pubmed publisher
  43. Rabionet M, Bayerle A, Jennemann R, Heid H, Fuchser J, Marsching C, et al. Male meiotic cytokinesis requires ceramide synthase 3-dependent sphingolipids with unique membrane anchors. Hum Mol Genet. 2015;24:4792-808 pubmed publisher
    ..Hence, testis-specific SLs, which we also link to CerS3 in human testis, are quintessential for male fertility. ..
  44. Giese S, Hossain H, Markmann M, Chakraborty T, Tchatalbachev S, Guillou F, et al. Sertoli-cell-specific knockout of connexin 43 leads to multiple alterations in testicular gene expression in prepubertal mice. Dis Model Mech. 2012;5:895-913 pubmed publisher
    ..The candidate genes could represent helpful markers for investigators exploring human testicular biopsies from patients showing corresponding spermatogenic deficiencies and for studying the molecular mechanisms of human male sterility. ..
  45. Fumel B, Guerquin M, Livera G, Staub C, Magistrini M, Gauthier C, et al. Thyroid hormone limits postnatal Sertoli cell proliferation in vivo by activation of its alpha1 isoform receptor (TRalpha1) present in these cells and by regulation of Cdk4/JunD/c-myc mRNA levels in mice. Biol Reprod. 2012;87:16, 1-9 pubmed publisher
    ..Moreover, quantitative RT-PCR provided evidence that regulation of the Cdk4/JunD/c-myc pathway was involved in this negative control. ..
  46. Wang X, Ying P, Diao F, Wang Q, Ye D, Jiang C, et al. Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection. J Exp Med. 2013;210:1559-74 pubmed publisher
    ..Notably, this defect could be rescued by GGPP administration in EMCV-challenged mice. Our results suggest a novel mechanism by which mumps infection during childhood results in adult sterility. ..
  47. Garcia T, DeFalco T, Capel B, Hofmann M. Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence. Dev Biol. 2013;377:188-201 pubmed publisher
  48. Yamada K, Nomura N, Yamano A, Yamada Y, Wakamatsu N. Identification and characterization of splicing variants of PLEKHA5 (Plekha5) during brain development. Gene. 2012;492:270-5 pubmed publisher
    b>PLEKHA5 (pleckstrin homology domain-containing protein family A, member 5) belongs to the PLEKHA family (PLEKHA1-6); however, the properties of this protein remain poorly characterized...
  49. Chang H, Guillou F, Taketo M, Behringer R. Overactive beta-catenin signaling causes testicular sertoli cell tumor development in the mouse. Biol Reprod. 2009;81:842-9 pubmed publisher
    ..These studies show a causal link between overactive WNT/beta-catenin signaling and Sertoli cell tumor development and provide a novel mouse model for the study of Sertoli cell tumor biology...
  50. Chen S, Chen M, Wang X, Zhang J, Wen Q, Ji S, et al. The Wilms tumor gene, Wt1, maintains testicular cord integrity by regulating the expression of Col4a1 and Col4a2. Biol Reprod. 2013;88:56 pubmed publisher
  51. Hogarth C, Evans E, Onken J, Kent T, Mitchell D, Petkovich M, et al. CYP26 Enzymes Are Necessary Within the Postnatal Seminiferous Epithelium for Normal Murine Spermatogenesis. Biol Reprod. 2015;93:19 pubmed publisher
    ..These data indicate that CYP26 activity within either Sertoli or germ cells is essential for the normal progression of spermatogenesis and that its loss can result in reduced male fertility. ..
  52. Barrionuevo F, Georg I, Scherthan H, Lecureuil C, Guillou F, Wegner M, et al. Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8. Dev Biol. 2009;327:301-12 pubmed publisher
    ..This study shows that testis cord differentiation is independent of Sox9, and that concerted Sox9 and Sox8 function in post E14.0 Sertoli cells is essential for the maintenance of testicular function. ..
  53. Naillat F, Veikkolainen V, Miinalainen I, Sipila P, Poutanen M, Elenius K, et al. ErbB4, a receptor tyrosine kinase, coordinates organization of the seminiferous tubules in the developing testis. Mol Endocrinol. 2014;28:1534-46 pubmed publisher
    ..Thus, the ErbB4 receptor tyrosine kinase promotes seminiferous tubule development by controlling Sertoli cell and germ cell adhesion. ..
  54. Rebourcet D, O Shaughnessy P, Monteiro A, Milne L, Cruickshanks L, Jeffrey N, et al. Sertoli cells maintain Leydig cell number and peritubular myoid cell activity in the adult mouse testis. PLoS ONE. 2014;9:e105687 pubmed publisher
    ..This has implications for our understanding of male reproductive disorders and wider androgen-related conditions affecting male health. ..
  55. Moniot B, Declosmenil F, Barrionuevo F, Scherer G, Aritake K, Malki S, et al. The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation. Development. 2009;136:1813-21 pubmed publisher
    ..This mechanism participates together with FGF9 as an amplification system of Sox9 gene expression and activity during mammalian testicular organogenesis. ..
  56. Godmann M, Katz J, Guillou F, Simoni M, Kaestner K, Behr R. Krüppel-like factor 4 is involved in functional differentiation of testicular Sertoli cells. Dev Biol. 2008;315:552-66 pubmed publisher
    ..In summary, KLF4 plays a significant role for proper and timely Sertoli cell differentiation in pubertal mice. ..
  57. De Gendt K, Verhoeven G, Amieux P, Wilkinson M. Genome-wide identification of AR-regulated genes translated in Sertoli cells in vivo using the RiboTag approach. Mol Endocrinol. 2014;28:575-91 pubmed publisher
    ..Taken together, our results identified novel classes of genes expressed in a hormone-dependent manner in different testicular cell subsets and highlight a new approach to analyze cell type-specific gene regulation. ..
  58. Chen M, Zhang L, Cui X, Lin X, Li Y, Wang Y, et al. Wt1 directs the lineage specification of sertoli and granulosa cells by repressing Sf1 expression. Development. 2017;144:44-53 pubmed publisher
    ..Without Wt1, the expression of Sf1 was upregulated and the somatic cells differentiated into steroidogenic cells instead of supporting cells. Our study uncovers a novel mechanism of somatic cell differentiation during gonad development. ..
  59. De Gendt K, Denolet E, Willems A, Daniëls V, Clinckemalie L, Denayer S, et al. Expression of Tubb3, a beta-tubulin isotype, is regulated by androgens in mouse and rat Sertoli cells. Biol Reprod. 2011;85:934-45 pubmed publisher
  60. Eom T, Zhang C, Wang H, Lay K, Fak J, Noebels J, et al. NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. elife. 2013;2:e00178 pubmed publisher
    ..The data reveal a hidden means of dynamic RNA regulation linking electrical activity to splicing and protein output, and of mediating homeostatic excitation/inhibition balance in neurons.DOI: ..
  61. Georg I, Barrionuevo F, Wiech T, Scherer G. Sox9 and Sox8 are required for basal lamina integrity of testis cords and for suppression of FOXL2 during embryonic testis development in mice. Biol Reprod. 2012;87:99 pubmed publisher
    ..This study shows that Sox9 and Sox8 maintain integrity of the basal lamina to prevent testis cord disintegration and that both factors actively suppress the ovarian program during early testis development. ..