Plcg2

Summary

Gene Symbol: Plcg2
Description: phospholipase C, gamma 2
Alias: PLC-gamma-2, PLCgamma2, Plcg-2, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, phosphoinositide phospholipase C-gamma-2
Species: mouse
Products:     Plcg2

Top Publications

  1. Wen R, Chen Y, Bai L, Fu G, Schuman J, Dai X, et al. Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis. Mol Cell Biol. 2006;26:9364-76 pubmed
    Phospholipase Cgamma2 (PLCgamma2) is a critical signaling effector of the B-cell receptor (BCR)...
  2. Weber M, Treanor B, Depoil D, Shinohara H, Harwood N, Hikida M, et al. Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen. J Exp Med. 2008;205:853-68 pubmed publisher
    ..We identify a key role for phospholipase C-gamma2 (PLCgamma2), Vav, B cell linker, and Bruton's tyrosine kinase in the formation of highly coordinated "..
  3. Regunathan J, Chen Y, Kutlesa S, Dai X, Bai L, Wen R, et al. Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells. J Immunol. 2006;177:5365-76 pubmed
    ..Lack of PLCgamma2 significantly impaired the ability of lineage-committed NK precursor cells to acquire subset-specific Ly49 ..
  4. Jakus Z, Simon E, Frommhold D, Sperandio M, Mócsai A. Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis. J Exp Med. 2009;206:577-93 pubmed publisher
    ..b>PLCgamma2(-/-) neutrophils are completely defective in beta(2) integrin or Fcgamma receptor-mediated functional responses ..
  5. Rathore V, Wang D, Newman D, Newman P. Phospholipase Cgamma2 contributes to stable thrombus formation on VWF. FEBS Lett. 2004;573:26-30 pubmed
    Though phospholipase C PLCgamma2 is known to play an important role in platelet activation by collagen and fibrinogen, its importance in GPIb-mediated platelet activation is less well understood...
  6. Mueller H, Stadtmann A, Van Aken H, Hirsch E, Wang D, Ley K, et al. Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways. Blood. 2010;115:3118-27 pubmed publisher
    ..Galpha(i)-independent neutrophil recruitment into the inflamed peritoneal cavity was reduced in Btk(-/-) and Plcg2(-/-) mice...
  7. Graham D, Robertson C, Bautista J, Mascarenhas F, Diacovo M, Montgrain V, et al. Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice. J Clin Invest. 2007;117:3445-52 pubmed
    ..Taken together, our data indicate that integrin-dependent signals generated during neutrophil adhesion contribute to the activation of NADPH oxidase by a variety of distinct effector pathways, all of which require Vav. ..
  8. Xu S, Huo J, Lee K, Kurosaki T, Lam K. Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells. J Biol Chem. 2009;284:7038-46 pubmed publisher
    ..particulate curdlan, which specifically engages Dectin-1, results in the phosphorylation of both PLCgamma1 and PLCgamma2. However, we show that PLCgamma2 is the critical enzyme for Dectin-1 signaling in DCs...
  9. Munnix I, Strehl A, Kuijpers M, Auger J, van der Meijden P, van Zandvoort M, et al. The glycoprotein VI-phospholipase Cgamma2 signaling pathway controls thrombus formation induced by collagen and tissue factor in vitro and in vivo. Arterioscler Thromb Vasc Biol. 2005;25:2673-8 pubmed
    ..modules: glycoprotein VI (GPVI), FcR gamma-chain, Src kinases, adaptor protein LAT, and phospholipase Cgamma2 (PLCgamma2)...

More Information

Publications78

  1. Zhang K, Kim S, Cremasco V, Hirbe A, Collins L, Piwnica Worms D, et al. CD8+ T cells regulate bone tumor burden independent of osteoclast resorption. Cancer Res. 2011;71:4799-808 pubmed publisher
    ..Our findings show the important contribution of CD8(+) T cells in the regulation of bone metastases regardless of OC status, thus including T cells as critical regulators of tumor growth in bone. ..
  2. Oh Hora M, Johmura S, Hashimoto A, Hikida M, Kurosaki T. Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-gamma2 to Ras in B cell receptor signaling. J Exp Med. 2003;198:1841-51 pubmed
    ..This defective Ras activation is suppressed by the expression of RasGRP3 as a membrane-attached form, suggesting that phospholipase C-gamma2 regulates RasGRP3 localization and thereby Ras activation. ..
  3. Wonerow P, Pearce A, Vaux D, Watson S. A critical role for phospholipase Cgamma2 in alphaIIbbeta3-mediated platelet spreading. J Biol Chem. 2003;278:37520-9 pubmed
    ..The present study identifies phospholipase Cgamma2 (PLCgamma2) as an important target of the Src-dependent signaling cascade regulated by alphaIIbbeta3...
  4. Kim Y, Sekiya F, Poulin B, Bae Y, Rhee S. Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2. Mol Cell Biol. 2004;24:9986-99 pubmed
    ..Finally, phosphorylation of Y1217 and that of Y753 and Y759 occurred on different PLC-gamma2 molecules. ..
  5. Mao D, Epple H, Uthgenannt B, Novack D, Faccio R. PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2. J Clin Invest. 2006;116:2869-79 pubmed
    ..Importantly, targeted deletion of Plcg2 in mice led to an osteopetrotic phenotype. PLCgamma2, independent of PLCgamma1, was required for receptor activator of NF-kappaB ligand-induced (RANKL-induced) ..
  6. Hashimoto A, Takeda K, Inaba M, Sekimata M, Kaisho T, Ikehara S, et al. Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function. J Immunol. 2000;165:1738-42 pubmed
    ..In contrast, T cell development and TCR-mediated proliferation were normal. Taken together, PLC-gamma 2 is a critical component of BCR signaling pathways and is required to promote B cell development. ..
  7. Wang D, Feng J, Wen R, Marine J, Sangster M, Parganas E, et al. Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. Immunity. 2000;13:25-35 pubmed
    Many receptors activate phospholipase Cgamma1 or -gamma2. To assess the role of PLCgamma2, we derived enzyme-deficient mice...
  8. Hikida M, Johmura S, Hashimoto A, Takezaki M, Kurosaki T. Coupling between B cell receptor and phospholipase C-gamma2 is essential for mature B cell development. J Exp Med. 2003;198:581-9 pubmed
    ..Therefore, our data suggest that the BAFF-R-mediated survival signal, provided by PLC-gamma2, is not sufficient to promote B cell maturation, and that, in addition, activation of PLC-gamma2 by BCR is required for B cell development. ..
  9. Chen Y, Wang X, Di L, Fu G, Chen Y, Bai L, et al. Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis. J Biol Chem. 2008;283:29593-601 pubmed publisher
    Phospholipase Cgamma2 (PLCgamma2) is an important signaling effector of multiple receptors in the immune system...
  10. Ichise H, Ichise T, Ohtani O, Yoshida N. Phospholipase Cgamma2 is necessary for separation of blood and lymphatic vasculature in mice. Development. 2009;136:191-5 pubmed publisher
    ..lymphatic vessels, and identified a null mutation of the Plcg2 gene, which encodes phospholipase Cgamma2 (PLCgamma2), by positional candidate cloning...
  11. Wen R, Chen Y, Schuman J, Fu G, Yang S, Zhang W, et al. An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion. EMBO J. 2004;23:4007-17 pubmed
    ..Reduced expression of PLCgamma1, in the absence of PLCgamma2 (PLCgamma1+/-PLCgamma2-/-), impedes early B-cell development at the pro-B- to pre-B-cell transition and impairs ..
  12. Liao H, Kume T, McKay C, Xu M, Ihle J, Carpenter G. Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice. J Biol Chem. 2002;277:9335-41 pubmed
    ..Interestingly, these early embryos do express phospholipase C-gamma2, however, it is unable to substitute for the absence of phospholipase C-gamma1, which can be detected in its tyrosine-phosphorylated state. ..
  13. Fu G, Chen Y, Schuman J, Wang D, Wen R. Phospholipase C?2 plays a role in TCR signal transduction and T cell selection. J Immunol. 2012;189:2326-32 pubmed publisher
    ..Taken together, these data demonstrate that PLC?2 participates in TCR signal transduction and plays a role in T cell selection. ..
  14. Tassi I, Presti R, Kim S, Yokoyama W, Gilfillan S, Colonna M. Phospholipase C-gamma 2 is a critical signaling mediator for murine NK cell activating receptors. J Immunol. 2005;175:749-54 pubmed
    ..Two isoforms of PLCgamma have been identified, PLCgamma1 and PLCgamma2. Previously, in vitro studies indicated that activating NK cell receptors signal through both isoforms...
  15. Nonne C, Lenain N, Hechler B, Mangin P, Cazenave J, Gachet C, et al. Importance of platelet phospholipase Cgamma2 signaling in arterial thrombosis as a function of lesion severity. Arterioscler Thromb Vasc Biol. 2005;25:1293-8 pubmed
    ..To evaluate the role of adhesion receptors signaling in arterial thrombosis, PLCgamma2 knockout mice were studied in blood perfusion assays over fibrillar collagen and in a laser-induced mesenteric ..
  16. Mangin P, Nonne C, Eckly A, Ohlmann P, Freund M, Nieswandt B, et al. A PLC gamma 2-independent platelet collagen aggregation requiring functional association of GPVI and integrin alpha2beta1. FEBS Lett. 2003;542:53-9 pubmed
    The role of the phospholipase C (PLC)gamma 2 isotype in platelet activation was evaluated by studying PLC gamma 2 -/- mice. These mice have a prolonged bleeding time but their platelets respond normally to non-collagenous agonists...
  17. Tassi I, Cella M, Castro I, Gilfillan S, Khan W, Colonna M. Requirement of phospholipase C-gamma2 (PLCgamma2) for Dectin-1-induced antigen presentation and induction of TH1/TH17 polarization. Eur J Immunol. 2009;39:1369-78 pubmed publisher
    ..Here we show that Dectin-1 activates DC through phospholipase (PLC)gamma2 signaling. PLCgamma2-deficient DC were unable to expand antigen-specific T cells and induce T(H)1 and T(H)17 differentiation in ..
  18. Gorjestani S, Yu M, Tang B, Zhang D, Wang D, Lin X. Phospholipase C?2 (PLC?2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses. J Biol Chem. 2011;286:43651-9 pubmed publisher
    ..albicans infection in vivo. Together, these findings demonstrate that PLC?2 plays a critical role in CLR-induced signaling pathways, governing antifungal innate immune responses. ..
  19. Wen R, Jou S, Chen Y, Hoffmeyer A, Wang D. Phospholipase C gamma 2 is essential for specific functions of Fc epsilon R and Fc gamma R. J Immunol. 2002;169:6743-52 pubmed
    Phospholipase Cgamma2 (PLCgamma2) plays a critical role in the functions of the B cell receptor in B cells and of the FcRgamma chain-containing collagen receptor in platelets...
  20. Clements J, Lee J, Gross B, Yang B, Olson J, Sandra A, et al. Fetal hemorrhage and platelet dysfunction in SLP-76-deficient mice. J Clin Invest. 1999;103:19-25 pubmed
    ..These data provide one potential mechanism for the fetal hemorrhage observed in SLP-76-deficient mice and reveal that SLP-76 expression is required for optimal receptor-mediated signal transduction in platelets as well as T lymphocytes. ..
  21. Epple H, Cremasco V, Zhang K, Mao D, Longmore G, Faccio R. Phospholipase Cgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase. Mol Cell Biol. 2008;28:3610-22 pubmed publisher
    ..Here, we demonstrate an important role for phospholipase C gamma 2 (PLCgamma2) in Src activation in the osteoclast...
  22. Caraux A, Kim N, Bell S, Zompi S, Ranson T, Lesjean Pottier S, et al. Phospholipase C-gamma2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells. Blood. 2006;107:994-1002 pubmed
    ..b>Plcg2-/- mice could not reject MHC class I-deficient lymphoma cells nor could they control CMV infection, but they ..
  23. Stadtmann A, Brinkhaus L, Mueller H, Rossaint J, Bolomini Vittori M, Bergmeier W, et al. Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling. Eur J Immunol. 2011;41:2074-85 pubmed publisher
    ..However, the distal signaling pathway linking PLC?2 (Plcg2) to ?L?2-activation is unknown...
  24. Aki D, Minoda Y, Yoshida H, Watanabe S, Yoshida R, Takaesu G, et al. Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells. Genes Cells. 2008;13:199-208 pubmed publisher
    ..a Gram-positive bacterial component, a TLR4 ligand induced tyrosine phosphorylation of phospholipase Cgamma-2 (PLCgamma2), leading to intracellular free Ca2+ mobilization in bone marrow-derived macrophages (BMMphi) and bone marrow-..
  25. Reppschläger K, Gosselin J, Dangelmaier C, Thomas D, Carpino N, McKenzie S, et al. TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk. J Biol Chem. 2016;291:22427-22441 pubmed
    ..Putative biological functions of TULA-2-mediated dephosphorylation of Tyr(P)346 may include deactivation of receptor-activated Syk or suppression of Syk activation by suboptimal stimulation. ..
  26. Hernandez D, Egan S, Yulug I, Fisher E. Mapping the gene that encodes phosphatidylinositol-specific phospholipase C-gamma 2 in the human and the mouse. Genomics. 1994;23:504-7 pubmed
    We have mapped the PLCG2 gene, which encodes the enzyme phosphatidyl inositol-specific phospholipase C-gamma 2...
  27. Rabie T, Varga Szabo D, Bender M, Pozgaj R, Lanza F, Saito T, et al. Diverging signaling events control the pathway of GPVI down-regulation in vivo. Blood. 2007;110:529-35 pubmed
    ..activation motif (ITAM) via the adaptor LAT leading to the activation of phospholipase Cgamma2 (PLCgamma2)...
  28. Elvers M, Pozgaj R, Pleines I, May F, Kuijpers M, Heemskerk J, et al. Platelet hyperreactivity and a prothrombotic phenotype in mice with a gain-of-function mutation in phospholipase Cgamma2. J Thromb Haemost. 2010;8:1353-63 pubmed publisher
    ..activation involves different signaling pathways leading to the activation of phospholipase C (PLC) beta or PLCgamma2. Activated PLC produces inositol 1,4,5-trisphosphate and diacylglycerol, which trigger Ca(2+) mobilization and ..
  29. Yen T, Lu W, Lien L, Thomas P, Lee T, Chiu H, et al. Amarogentin, a secoiridoid glycoside, abrogates platelet activation through PLC ? 2-PKC and MAPK pathways. Biomed Res Int. 2014;2014:728019 pubmed publisher
    ..Our findings suggest that amarogentin may offer therapeutic potential for preventing or treating thromboembolic disorders. ..
  30. Yu P, Wellmann U, Kunder S, Quintanilla Martinez L, Jennen L, Dear N, et al. Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLE. Int Immunol. 2006;18:1211-9 pubmed
    ..These results suggest that engagement of a TLR9-independent DNA activation pathway may promote autoimmunity, while TLR9 signaling can ameliorate SLE-like immune pathology in vivo. ..
  31. Mangin P, Yuan Y, Goncalves I, Eckly A, Freund M, Cazenave J, et al. Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA. J Biol Chem. 2003;278:32880-91 pubmed
    ..However, decreased shape change and Ca2+ mobilization were observed in mice lacking PLC gamma 2, demonstrating that this isotype played an important, albeit incomplete, role in GPIb signaling...
  32. Block H, Herter J, Rossaint J, Stadtmann A, Kliche S, Lowell C, et al. Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. J Exp Med. 2012;209:407-21 pubmed publisher
    ..Thus, SLP-76 and ADAP are involved in E-selectin-mediated integrin activation and neutrophil recruitment to inflamed kidneys, which may underlie the development of life-threatening ischemia-reperfusion-induced AKI in humans...
  33. Capietto A, Kim S, Sanford D, Linehan D, Hikida M, Kumosaki T, et al. Down-regulation of PLC?2-?-catenin pathway promotes activation and expansion of myeloid-derived suppressor cells in cancer. J Exp Med. 2013;210:2257-71 pubmed publisher
  34. Abe K, Fuchs H, Boersma A, Hans W, Yu P, Kalaydjiev S, et al. A novel N-ethyl-N-nitrosourea-induced mutation in phospholipase C?2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model. Arthritis Rheum. 2011;63:1301-11 pubmed publisher
    ..A novel missense mutation in the phospholipase C?2 gene (Plcg2) was identified in Ali14/+ mice...
  35. Larson M, Watson S. Regulation of proplatelet formation and platelet release by integrin alpha IIb beta3. Blood. 2006;108:1509-14 pubmed
    ..These results demonstrate that fibrinogen is able to regulate proplatelet formation via integrin alpha IIb beta3. ..
  36. Kroczek C, Lang C, Brachs S, Grohmann M, Dütting S, Schweizer A, et al. Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts. J Immunol. 2010;184:3665-76 pubmed publisher
    ..kinase (Syk) tyrosine phosphorylation and activity as well as SLP65/BLNK/BASH and phospholipase C gamma2 (PLCgamma2) tyrosine phosphorylation...
  37. Faccio R, Cremasco V. PLCgamma2: where bone and immune cells find their common ground. Ann N Y Acad Sci. 2010;1192:124-30 pubmed publisher
    ..In this context, PLCgamma2 seems to be a promising target...
  38. Kusuyama J, Kamisono A, ChangHwan S, Amir M, Bandow K, Eiraku N, et al. Spleen tyrosine kinase influences the early stages of multilineage differentiation of bone marrow stromal cell lines by regulating phospholipase C gamma activities. J Cell Physiol. 2017;: pubmed publisher
    ..Taken together, these results indicate that Syk-PLC? signaling has a dual role in regulating the initial stage of adipogenic and osteogenic differentiation of BMSCs. ..
  39. Pearce A, Wilde J, Doody G, Best D, Inoue O, Vigorito E, et al. Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C. Blood. 2002;100:3561-9 pubmed
    ..The present study has provided evidence for a possible role of Vav1 but not Vav2 in the later stages of platelet aggregation. ..
  40. Gossmann J, Stolte M, Lohoff M, Yu P, Moll R, Finkernagel F, et al. A Gain-Of-Function Mutation in the Plcg2 Gene Protects Mice from Helicobacter felis-Induced Gastric MALT Lymphoma. PLoS ONE. 2016;11:e0150411 pubmed publisher
    ..Phospholipase C gamma 2 (PLCG2) is important for B-cell survival and proliferation...
  41. Liu J, Pestina T, Berndt M, Jackson C, Gartner T. Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an alphaIIbbeta3- and aggregation-independent manner. Blood. 2005;106:2750-6 pubmed
    ..in Lyn, Src, Syk, Src homology 2 (SH2) domain-containing leukocyte protein 76 (SLP-76), phospholipase Cgamma2 (PLCgamma2), linker for activation of T cells (LAT), or Fc receptor gamma-chain (FcRgamma-chain) were used for these ..
  42. Ahn E, Lee H, Yun Y. LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation. Blood. 2006;107:1521-7 pubmed
    ..Taken together, these results establish that LIME is an essential transmembrane adaptor linking BCR ligation to the downstream signaling events that lead to B-cell activation. ..
  43. Kalia N, Auger J, Atkinson B, Watson S. Critical role of FcR gamma-chain, LAT, PLCgamma2 and thrombin in arteriolar thrombus formation upon mild, laser-induced endothelial injury in vivo. Microcirculation. 2008;15:325-35 pubmed publisher
    The role of collagen receptor complex GPVI-FcR gamma-chain, PLCgamma2 and LAT in laser-induced thrombosis is unclear. Controversy surrounds whether collagen is exposed in this model or whether thrombosis is dependent on thrombin...
  44. Wen R, Chen Y, Xue L, Schuman J, Yang S, Morris S, et al. Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells. J Biol Chem. 2003;278:43654-62 pubmed
    b>PLCgamma2 plays a critical role in B cell receptor (BCR) signaling and its targeted deletion results in defective B cell development and function...
  45. Hikida M, Casola S, Takahashi N, Kaji T, Takemori T, Rajewsky K, et al. PLC-gamma2 is essential for formation and maintenance of memory B cells. J Exp Med. 2009;206:681-9 pubmed publisher
    ..Collectively, our data suggest that PLC-gamma2 conveys a survival signal to GC and memory B cells and that this signal is required for a productive secondary immune response. ..
  46. Cook M, Vinuesa C, Goodnow C. ENU-mutagenesis: insight into immune function and pathology. Curr Opin Immunol. 2006;18:627-33 pubmed
    ..More than 20 of the phenotypes that exhibit a simple (Mendelian) pattern of inheritance have been mapped. Novel alleles have revealed new pathways of host defense, allergy and autoimmunity. ..
  47. Yu P, Constien R, Dear N, Katan M, Hanke P, Bunney T, et al. Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry. Immunity. 2005;22:451-65 pubmed
    ..mutagenesis to discover new immune regulators, we identified a point mutation in the murine phospholipase Cg2 (Plcg2) gene that leads to severe spontaneous inflammation and autoimmunity...
  48. Hoek K, Antony P, Lowe J, Shinners N, Sarmah B, Wente S, et al. Transitional B cell fate is associated with developmental stage-specific regulation of diacylglycerol and calcium signaling upon B cell receptor engagement. J Immunol. 2006;177:5405-13 pubmed
  49. Jou S, Carpino N, Takahashi Y, Piekorz R, Chao J, Carpino N, et al. Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. Mol Cell Biol. 2002;22:8580-91 pubmed
    ..Germinal center formation in the spleen in response to antigen stimulation is disrupted. These results define a nonredundant signaling pathway(s) utilizing the delta isoform of p110 PI3K for the development and function of B cells. ..
  50. Hidano S, Sasanuma H, Ohshima K, Seino K, Kumar L, Hayashi K, et al. Distinct regulatory functions of SLP-76 and MIST in NK cell cytotoxicity and IFN-gamma production. Int Immunol. 2008;20:345-52 pubmed publisher
    ..IFN-gamma production depends on phospholipase C (PLC) gamma 2, YAC-1 cell-triggered IFN-gamma production is PLC gamma 2- and Syk/ZAP-70 independent and nuclear factor-kappa B mediated...
  51. Hempel W, DeFranco A. Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991;146:3713-20 pubmed
    ..All the B cell lines tested expressed high levels of PLC alpha and PLC gamma 2 mRNA, whereas PLC beta and PLC delta mRNA expression were undetectable by both Northern blot and PCR analysis...
  52. Arnold C, Pirie E, Dosenovic P, McInerney G, Xia Y, Wang N, et al. A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. Proc Natl Acad Sci U S A. 2012;109:12286-93 pubmed publisher
    ..All of the mutations identified to date directly affect lymphocyte development or function; none have an exclusive effect on cells of the innate immune system. ..
  53. Lietman S, Yin L, Levine M. SH3BP2 mutations potentiate osteoclastogenesis via PLC?. J Orthop Res. 2010;28:1425-30 pubmed publisher
    ..The consequent activation of calcineurin and NFAT proteins induces the excessive osteoclastic phenotype of cherubism. ..
  54. Argeson A, Druck T, Veronese M, Knopf J, Buchberg A, Huebner K, et al. Phospholipase C gamma-2 (Plcg2) and phospholipase C gamma-1 (Plcg1) map to distinct regions in the human and mouse genomes. Genomics. 1995;25:29-35 pubmed
    The phospholipase C gamma-2 (Plcg2) gene encodes an enzyme that plays a crucial role in intracellular signal transduction pathways...
  55. Pleines I, Elvers M, Strehl A, Pozgajova M, Varga Szabo D, May F, et al. Rac1 is essential for phospholipase C-gamma2 activation in platelets. Pflugers Arch. 2009;457:1173-85 pubmed publisher
    ..injury is triggered through different signaling pathways leading to activation of phospholipase (PL) Cbeta or PLCgamma2. Active PLCs trigger Ca(2+) mobilization and entry, which is a prerequisite for adhesion, secretion, and ..
  56. Pleiman C, Clark M, Gauen L, Winitz S, Coggeshall K, Johnson G, et al. Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-ki. Mol Cell Biol. 1993;13:5877-87 pubmed
    ..p42 (microtubule-associated protein kinase) (MAPK), phospholipases C-gamma 1 (PLC gamma 1) and C-gamma 2 (PLC gamma 2), phosphatidylinositol 3-kinase (PI 3-K), and p21ras-GTPase-activating protein (GAP)...
  57. Mazharian A, Thomas S, Dhanjal T, Buckley C, Watson S. Critical role of Src-Syk-PLC{gamma}2 signaling in megakaryocyte migration and thrombopoiesis. Blood. 2010;116:793-800 pubmed publisher
    ..We also demonstrate that these responses are inhibited in primary phospholipase C gamma2 (PLCgamma2)-deficient MKs...
  58. Bai L, Chen Y, He Y, Dai X, Lin X, Wen R, et al. Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing. Mol Cell Biol. 2007;27:5957-67 pubmed
    Phospholipase Cgamma2 (PLCgamma2) is critical for pre-B-cell receptor (pre-BCR) and BCR signaling...
  59. Ragab A, Severin S, Gratacap M, Aguado E, Malissen M, Jandrot Perrus M, et al. Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation. Blood. 2007;110:2466-74 pubmed
    ..Interestingly, single mutation of the tyrosine 136 results in the loss of phospholipase C gamma2 (PLCgamma2) activation without affecting its PI3K-dependent membrane association, and is sufficient to impair platelet ..
  60. Decker C, Yang Z, Rimer R, Park Min K, Macaubas C, Mellins E, et al. Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass. Proc Natl Acad Sci U S A. 2015;112:15654-9 pubmed publisher
    ..In sum, these findings identify an essential role for Tmem178 to maintain skeletal mass and limit pathological bone loss. ..
  61. Everett K, Bunney T, Yoon Y, Rodrigues Lima F, Harris R, Driscoll P, et al. Characterization of phospholipase C gamma enzymes with gain-of-function mutations. J Biol Chem. 2009;284:23083-93 pubmed publisher
    Phospholipase C gamma isozymes (PLC gamma 1 and PLC gamma 2) have a crucial role in the regulation of a variety of cellular functions. Both enzymes have also been implicated in signaling events underlying aberrant cellular responses...
  62. Decker C, Hesker P, Zhang K, Faccio R. Targeted inhibition of phospholipase C ?2 adaptor function blocks osteoclastogenesis and protects from pathological osteolysis. J Biol Chem. 2013;288:33634-41 pubmed publisher
    ..Collectively, these data indicate that inflammatory osteolysis can be abrogated by treatment with a molecule composed of the tandem SH2 domains of PLC?2. ..
  63. Pearce A, Senis Y, Billadeau D, Turner M, Watson S, Vigorito E. Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen. J Biol Chem. 2004;279:53955-62 pubmed
    ..We have reported in platelets, however, that Vav1 and Vav2 are not required for activation of PLC gamma 2 in response to stimulation of the ITAM-coupled collagen receptor glycoprotein VI (GPVI)...
  64. Jarvis G, Best D, Watson S. Glycoprotein VI/Fc receptor gamma chain-independent tyrosine phosphorylation and activation of murine platelets by collagen. Biochem J. 2004;383:581-8 pubmed
    ..These results illustrate a novel mechanism of platelet activation by collagen which is independent of the GPVI-FcRgamma chain complex, and is facilitated by binding of collagen to integrin alpha2beta1. ..
  65. Bell S, Vigorito E, McAdam S, Reynolds H, Caraux A, Colucci F, et al. PLCgamma2 regulates Bcl-2 levels and is required for survival rather than differentiation of marginal zone and follicular B cells. Eur J Immunol. 2004;34:2237-47 pubmed
    ..Introduction of a bcl-2 transgene restored the numbers of MZ, T3 and follicular B cells in PLCgamma2(-/-) mice...
  66. Leon C, Barbosa C, Justo G, Borelli P, Resende J, de Oliveira J, et al. Requirement for PLC?2 in IL-3 and GM-CSF-stimulated MEK/ERK phosphorylation in murine and human hematopoietic stem/progenitor cells. J Cell Physiol. 2011;226:1780-92 pubmed publisher
    ..Taken together, these data indicate a role for PLC?2 and Ca(2+) signaling through the modulation of MEK in both murine and human hematopoietic stem/progenitor cells. ..
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    ..These data showed that SAP secures NK cell activation by a dichotomous molecular mechanism, which is required for conjugate formation. These findings may have implications for the role of SAP in other immune cell types. ..
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    ..Hence, we have identified a novel adapter function for PLCgamma1 in EPO signaling in which recruitment of PLCgamma1 to EPO-R may lead to activation of the ERK pathway. ..
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    ..Together, our results highlight the critical importance of pre-BCR and BCR receptor levels for the normal development of B-lymphocyte subpopulations in the context of intact VDJ recombination and a diverse antibody repertoire. ..