Plcg1

Summary

Gene Symbol: Plcg1
Description: phospholipase C, gamma 1
Alias: AI894140, Cded, Plc-1, Plc-gamma1, Plcg-1, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, PLC-gamma-1, cell differentiation and embryonic development, phosphoinositide phospholipase C-gamma-1
Species: mouse
Products:     Plcg1

Top Publications

  1. Gärtner A, Polnau D, Staiger V, Sciarretta C, Minichiello L, Thoenen H, et al. Hippocampal long-term potentiation is supported by presynaptic and postsynaptic tyrosine receptor kinase B-mediated phospholipase Cgamma signaling. J Neurosci. 2006;26:3496-504 pubmed
    ..Blockade of presynaptic or postsynaptic signaling alone did not result in a significant reduction of LTP. ..
  2. Ji Q, Ermini S, Baulida J, Sun F, Carpenter G. Epidermal growth factor signaling and mitogenesis in Plcg1 null mouse embryonic fibroblasts. Mol Biol Cell. 1998;9:749-57 pubmed
    ..b>Plcg1(-/-) embryos die at embryonic day 9; however, cells derived from these embryos proliferate as well as cells from ..
  3. Regunathan J, Chen Y, Kutlesa S, Dai X, Bai L, Wen R, et al. Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells. J Immunol. 2006;177:5365-76 pubmed
    ..Our results strongly demonstrate that PLCgamma1 and PLCgamma2 play nonredundant and obligatory roles in NK cell ontogeny and in its effector functions. ..
  4. Minichiello L, Calella A, Medina D, Bonhoeffer T, Klein R, Korte M. Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron. 2002;36:121-37 pubmed
    ..Our results provide genetic evidence that TrkB mediates hippocampal plasticity via recruitment of PLCgamma, and by subsequent phosphorylation of CaMKIV and CREB. ..
  5. Fu G, Chen Y, Schuman J, Wang D, Wen R. Phospholipase C?2 plays a role in TCR signal transduction and T cell selection. J Immunol. 2012;189:2326-32 pubmed publisher
    ..Taken together, these data demonstrate that PLC?2 participates in TCR signal transduction and plays a role in T cell selection. ..
  6. Ji Q, Winnier G, Niswender K, Horstman D, Wisdom R, Magnuson M, et al. Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development. Proc Natl Acad Sci U S A. 1997;94:2999-3003 pubmed
    ..examine the biological function of this protein, homologous recombination has been used to selectively disrupt the Plcg1 gene in mice. Homozygous disruption of Plcg1 results in embryonic lethality at approximately embryonic day (E) 9.0...
  7. Reddi A, Ying G, Duan L, Chen G, Dimri M, Douillard P, et al. Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation. J Biol Chem. 2007;282:29336-47 pubmed
  8. Bachmaier K, Krawczyk C, Kozieradzki I, Kong Y, Sasaki T, Oliveira dos Santos A, et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 2000;403:211-6 pubmed
    ..Cbl-b is thus a key regulator of activation thresholds in mature lymphocytes and immunological tolerance and autoimmunity. ..
  9. Wen R, Chen Y, Schuman J, Fu G, Yang S, Zhang W, et al. An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion. EMBO J. 2004;23:4007-17 pubmed
    ..These studies reveal an essential role of PLCgamma1, distinct from that of PLCgamma2, in B-cell development. ..

More Information

Publications96

  1. Clarkson N, Brown M. Inhibition and activation by CD244 depends on CD2 and phospholipase C-gamma1. J Biol Chem. 2009;284:24725-34 pubmed publisher
    ..We identify a novel signaling mechanism for CD244 through its potential to recruit phospholipase C-gamma1 via the conserved phosphorylated tyrosine motif in the tail of the adaptor protein EAT-2, which we show is important for function. ..
  2. Sommers C, Park C, Lee J, Feng C, Fuller C, Grinberg A, et al. A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science. 2002;296:2040-3 pubmed
    ..In contrast, TCR-induced Erk activation was intact. These results identify a critical role for integrated PLC-gamma1 and Ras-Erk signaling through LAT in T cell development and homeostasis. ..
  3. Fu G, Chen Y, Yu M, Podd A, Schuman J, He Y, et al. Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance. J Exp Med. 2010;207:309-18 pubmed publisher
    ..Importantly, PLCgamma1 deficiency impairs the development and function of FoxP3(+) regulatory T cells, causing inflammatory/autoimmune symptoms. Therefore, PLCgamma1 is essential for T cell development, activation, and tolerance. ..
  4. Liao H, Kume T, McKay C, Xu M, Ihle J, Carpenter G. Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice. J Biol Chem. 2002;277:9335-41 pubmed
    Mice nullizygous for Plcg1 cease growing at early to mid-gestation...
  5. Gorjestani S, Yu M, Tang B, Zhang D, Wang D, Lin X. Phospholipase C?2 (PLC?2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses. J Biol Chem. 2011;286:43651-9 pubmed publisher
    ..albicans infection in vivo. Together, these findings demonstrate that PLC?2 plays a critical role in CLR-induced signaling pathways, governing antifungal innate immune responses. ..
  6. Vigorito E, Kovesdi D, Turner M. Synergistic activation of PKD by the B cell antigen receptor and CD19 requires PI3K, Vav1 and PLCgamma. Cell Signal. 2006;18:1455-60 pubmed
    ..These findings show that Vav proteins and PI3K regulation of PLCgamma contributes to the activation of PKD in response to BCR and or CD19 cross-linking. ..
  7. Jones N, Peak J, Brader S, Eccles S, Katan M. PLCgamma1 is essential for early events in integrin signalling required for cell motility. J Cell Sci. 2005;118:2695-706 pubmed
    ..This suggests a more general role for PLCgamma1 in cell motility, functioning as a mediator of both growth factor and integrin-initiated signals. ..
  8. Moenning A, Jäger R, Egert A, Kress W, Wardelmann E, Schorle H. Sustained platelet-derived growth factor receptor alpha signaling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway. Mol Cell Biol. 2009;29:881-91 pubmed publisher
    ..Thus, we show for the first time that PDGFRalpha signaling stimulates osteogenesis of NCC-derived osteoblasts by activating the PLC-gamma pathway, suggesting an involvement of this pathway in the etiology of human craniosynostosis. ..
  9. Choi M, Lee I, Kim G, Kim B, Han Y, Yu D, et al. Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II. Nature. 2005;435:347-53 pubmed
    ..These results demonstrate a localized role for endogenous H2O2 in PDGF signalling, and indicate a biological function of Prx II in cardiovascular disease. ..
  10. Pérez Quintero L, Roncagalli R, Guo H, Latour S, Davidson D, Veillette A. EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase C?, Ca++, and Erk, leading to granule polarization. J Exp Med. 2014;211:727-42 pubmed publisher
    ..Hence, EAT-2 promotes NK cell activation by molecular and cellular mechanisms distinct from those of SAP. These findings explain the cooperative and essential function of these two adaptors in NK cell activation. ..
  11. Makranz C, Cohen G, Baron A, Levidor L, Kodama T, Reichert F, et al. Phosphatidylinositol 3-kinase, phosphoinositide-specific phospholipase-Cgamma and protein kinase-C signal myelin phagocytosis mediated by complement receptor-3 alone and combined with scavenger receptor-AI/II in macrophages. Neurobiol Dis. 2004;15:279-86 pubmed
    ..This pathway may thus be targeted for in vivo modulation, which may explain differences in the efficiency of CR3/MAC-1-mediated myelin phagocytosis in different pathological conditions. ..
  12. Liu Y, Yang C, Chen M, Sun S, Tzeng S. Ca(2+)-dependent reduction of glutamate aspartate transporter GLAST expression in astrocytes by P2X(7) receptor-mediated phosphoinositide 3-kinase signaling. J Neurochem. 2010;113:213-27 pubmed publisher
  13. Sciarretta C, Fritzsch B, Beisel K, Rocha Sanchez S, Buniello A, Horn J, et al. PLC?-activated signalling is essential for TrkB mediated sensory neuron structural plasticity. BMC Dev Biol. 2010;10:103 pubmed publisher
    ..Dysfunction of the vestibular system can severely affect a person's quality of life. Therefore, understanding the molecular basis of vestibular neuron survival, maintenance, and innervation of the target sensory epithelia is fundamental...
  14. Choi J, Kim H, Kim S, Yang Y, Bae Y, Chang J, et al. Phospholipase Cgamma1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B. Nat Cell Biol. 2006;8:1389-97 pubmed
    ..These results suggest that PLCgamma1 has a key function in the regulation of growth hormone-mediated signalling by negatively regulating Jak2 activation. ..
  15. Hu X, Cheng X, Cai L, Tan G, Xu L, Feng X, et al. Conditional deletion of NRSF in forebrain neurons accelerates epileptogenesis in the kindling model. Cereb Cortex. 2011;21:2158-65 pubmed publisher
    ..Furthermore, the derepression of BDNF was associated by activation of PLC? and PI(3)K signaling pathways. These findings indicate that NRSF functions as an intrinsic repressor of limbic epileptogenesis. ..
  16. Yang Y, Jung J, Kim S, Hamada K, Suzuki A, Kim H, et al. Forebrain-specific ablation of phospholipase C?1 causes manic-like behavior. Mol Psychiatry. 2017;22:1473-1482 pubmed publisher
    ..Despite a possible association between BD and the gene encoding phospholipase C?1 (PLCG1), its etiological basis remains unclear...
  17. Avazeri N, Courtot A, Lefevre B. Regulation of spontaneous meiosis resumption in mouse oocytes by various conventional PKC isozymes depends on cellular compartmentalization. J Cell Sci. 2004;117:4969-78 pubmed
    ..Further investigations are however necessary to discover the molecular targets of these cPKCs to better understand the links with the cell cycle progression. ..
  18. Reith A, Ellis C, Lyman S, Anderson D, Williams D, Bernstein A, et al. Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. EMBO J. 1991;10:2451-9 pubmed
    ..showed increased autophosphorylation and enhanced association with phosphatidylinositol (PI) 3' kinase and PLC gamma 1, when stimulated with recombinant soluble Steel factor...
  19. Kanazawa H, Ohsawa K, Sasaki Y, Kohsaka S, Imai Y. Macrophage/microglia-specific protein Iba1 enhances membrane ruffling and Rac activation via phospholipase C-gamma -dependent pathway. J Biol Chem. 2002;277:20026-32 pubmed
    ..These results indicate the existence of a novel signaling pathway where PLC-gamma activates Rac in a manner dependent on Iba1. ..
  20. Martelli A, Lach S, Grill V, Gilmour R, Cocco L, Narducci P, et al. Expression and immunohistochemical localization of eight phospholipase C isoforms in adult male mouse cerebellar cortex. Acta Histochem. 1996;98:131-41 pubmed
  21. Irusta P, DiMaio D. A single amino acid substitution in a WW-like domain of diverse members of the PDGF receptor subfamily of tyrosine kinases causes constitutive receptor activation. EMBO J. 1998;17:6912-23 pubmed
    ..The results suggest that the cytoplasmic juxtamembrane domain plays a role in the regulation of receptor activity and function, perhaps by participating in protein-protein interactions. ..
  22. Schlaepfer D, Hanks S, Hunter T, van der Geer P. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature. 1994;372:786-91 pubmed
    ..Phosphorylation of FAK at Tyr 925 upon fibronectin stimulation creates an SH2-binding site for GRB2 which may link integrin engagement to the activation of the Ras/MAPK signal transduction pathway. ..
  23. Yohannan J, Wienands J, Coggeshall K, Justement L. Analysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22. J Biol Chem. 1999;274:18769-76 pubmed
    ..This finding suggests that PLCgamma and PI3K may be recruited to CD22 either through a direct interaction with Tyr863 or indirectly through an association with one or more intermediate proteins. ..
  24. Altman A, Kaminski S, Busuttil V, Droin N, Hu J, Tadevosyan Y, et al. Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway. Eur J Immunol. 2004;34:2001-11 pubmed
    ..Moreover, they identify Tec as a key point downstream of PKCtheta, where TCR- and PKCtheta-induced signaling pathways, leading to AP-1 versus NF-kappaB activation, diverge in T cells. ..
  25. Maddens S, Charruyer A, Plo I, Dubreuil P, Berger S, Salles B, et al. Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect. Blood. 2002;100:1294-301 pubmed
    ..Moreover, SCF did not protect 32D-KitYF728 cells (lacking a functional docking site for PLC gamma 1), from IR-induced SM cycle...
  26. Sillman A, Monroe J. Association of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytes. J Biol Chem. 1995;270:11806-11 pubmed
    ..We have used a fusion protein containing the tandem src homology-2 (SH2) domains of phospholipase C gamma 1 (PLC gamma 1) to identify B cell kinases which associate with PLC gamma 1...
  27. Wang Q, Downey G, Herrera Abreu M, Kapus A, McCulloch C. SHP-2 modulates interleukin-1-induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1. J Biol Chem. 2005;280:8397-406 pubmed
    ..Focal adhesions co-localizing with the endoplasmic reticulum may provide molecular staging sites required for ERK activation. ..
  28. Kumari S, Depoil D, Martinelli R, Judokusumo E, Carmona G, Gertler F, et al. Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway. elife. 2015;4: pubmed publisher
    ..We conclude that WASP generates a dynamic F-actin architecture in the context of the immunological synapse, which then amplifies the downstream signals required for an optimal immune response. ..
  29. Shirane M, Sawa H, Kobayashi Y, Nakano T, Kitajima K, Shinkai Y, et al. Deficiency of phospholipase C-gamma1 impairs renal development and hematopoiesis. Development. 2001;128:5173-80 pubmed
    ..These data suggest that PLC-gamma1 plays an essential role in the renal development and hematopoiesis in vivo. ..
  30. Chen X, Li X, Gu W, Wang D, Chen Y, Guo X. LAT alleviates Th2/Treg imbalance in an OVA-induced allergic asthma mouse model through LAT-PLC-?1 interaction. Int Immunopharmacol. 2017;44:9-15 pubmed publisher
    ..LAT-PLC-?1 interaction may contribute to LAT activity in vivo and LAT protects against asthma partly via Raf-MEK-ERK and PI3K-AKT-CREB pathways. The delivery of LAT DNA could offer a novel and safe strategy for asthma prevention. ..
  31. Yadav V, Song T, Joseph L, Mei L, Zheng Y, Wang Y. Important role of PLC-γ1 in hypoxic increase in intracellular calcium in pulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2013;304:L143-51 pubmed publisher
  32. Johansson M, Taylor M, Jagodic M, Tus K, Schatzle J, Wakeland E, et al. Mapping of quantitative trait loci determining NK cell-mediated resistance to MHC class I-deficient bone marrow grafts in perforin-deficient mice. J Immunol. 2006;177:7923-9 pubmed
    ..This study describes the first important step toward identifying BM graft resistance gene(s). ..
  33. Athman R, Louvard D, Robine S. Villin enhances hepatocyte growth factor-induced actin cytoskeleton remodeling in epithelial cells. Mol Biol Cell. 2003;14:4641-53 pubmed
    ..Collectively, these data demonstrate that villin acts as a regulator of HGF-induced actin dynamics. ..
  34. Muthusamy N, Park D, Rho H, Rhee S, Subbarao B. Impaired antigen receptor induced calcium mobilization in a phospholipase C-gamma1 deficient B cell line. Immunol Lett. 2003;90:203-7 pubmed
    ..The possible use for L1.2 cells in testing the regulation of PLC-gamma(1) and PLC-gamma(2) dependent calcium mobilization in B lymphocytes is discussed. ..
  35. Khullar M, Singh R, Smriti M, Ganguly N. Anaerobiosis-induced virulence of Salmonella enterica subsp. enterica serovar Typhimurium: role of phospholipase Cgamma signalling cascade. J Med Microbiol. 2003;52:741-5 pubmed
    ..These enhanced cell signals may contribute to the increased virulence of S. Typhimurium grown anaerobically. ..
  36. Williamson C, Dutton E, Abbott C, Beechey C, Ball S, Peters J. Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1, Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal imprinting region of mouse chromosome 2 are not monoallelically expressed. Genet Res. 1995;65:83-93 pubmed
    ..Mc3r and Ntsr) where a defect could lead to neurological and probably behavioural problems, and 3 genes (Cd40, Plcg1 and Rcad) that are less obvious candidates but sequence information was available for designing primers to test ..
  37. Yu M, Chen Y, Zeng H, Zheng Y, Fu G, Zhu W, et al. PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development. Nat Commun. 2017;8:1457 pubmed publisher
    ..Thus, IL-7 receptor controls early B lymphopoiesis through activation of mTOR via PLCγ/DAG/PKC signaling, not via Akt/Rheb signaling. ..
  38. Yoshida K, Yamashita Y, Miyazato A, Ohya K, Kitanaka A, Ikeda U, et al. Mediation by the protein-tyrosine kinase Tec of signaling between the B cell antigen receptor and Dok-1. J Biol Chem. 2000;275:24945-52 pubmed
    ..Furthermore, overexpression of Dok-1 inhibited activation of the c-fos promoter induced by stimulation of the BCR. These results suggest that Tec is an important mediator of signaling from the BCR to Dok-1. ..
  39. Kortum R, Rouquette Jazdanian A, Miyaji M, Merrill R, Markegard E, Pinski J, et al. A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice. J Immunol. 2013;190:147-58 pubmed publisher
    ..Moreover, LAT-Y136F T cells showed ERK activation that was dependent on Lck and/or Fyn, protein kinase C-θ, and RasGRP1. These data demonstrate a novel route to Ras activation in vivo in a pathological setting. ..
  40. Huang Z, Marsiglia W, Basu Roy U, Rahimi N, Ilghari D, Wang H, et al. Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ. Mol Cell. 2016;61:98-110 pubmed publisher
  41. Li Y, Wu G, Dawe G, Zeng L, Cui S, Loers G, et al. Cell surface sialylation and fucosylation are regulated by L1 via phospholipase Cgamma and cooperate to modulate neurite outgrowth, cell survival and migration. PLoS ONE. 2008;3:e3841 pubmed publisher
    ..Neuronal surface sialylation and fucosylation are regulated via PLCgamma by L1, modulating neurite outgrowth, cell survival and migration. ..
  42. He F, Soriano P. Dysregulated PDGFRα signaling alters coronal suture morphogenesis and leads to craniosynostosis through endochondral ossification. Development. 2017;144:4026-4036 pubmed publisher
    ..Our results thus identify a novel mechanism underlying calvarial development in craniosynostosis. ..
  43. Chang J, Seok H, Kwon T, Min D, Ahn B, Lee Y, et al. Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity. J Biol Chem. 2002;277:19697-702 pubmed
    ..Taken together, our data show that EF-1alpha plays a direct role in phosphoinositide metabolism of cellular signaling by regulating PLC-gamma1 activity via a split PH domain. ..
  44. Wouters M, Roeder J, Tharayil V, Stanich J, Strege P, Lei S, et al. Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B. J Biol Chem. 2009;284:21177-84 pubmed publisher
    ..The data demonstrate that the 5-HT(2B) receptor-induced proliferative response of ICC is through phospholipase C, [Ca(2+)](i), and PKCgamma, implicating this PKC isoform in the regulation of cellular proliferation. ..
  45. Reppschläger K, Gosselin J, Dangelmaier C, Thomas D, Carpino N, McKenzie S, et al. TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk. J Biol Chem. 2016;291:22427-22441 pubmed
    ..Putative biological functions of TULA-2-mediated dephosphorylation of Tyr(P)346 may include deactivation of receptor-activated Syk or suppression of Syk activation by suboptimal stimulation. ..
  46. Shen E, Fan J, Chen R, Yee S, Peng T. Phospholipase Cgamma1 signalling regulates lipopolysaccharide-induced cyclooxygenase-2 expression in cardiomyocytes. J Mol Cell Cardiol. 2007;43:308-18 pubmed
    ..The Src family is responsible for PLCgamma1 activation, which signals the ERK1/2 MAPK pathway, resulting in COX-2 production in LPS-stimulated cardiomyocytes. ..
  47. Xie Q, Joseph R, Fulton D, Andreotti A. Substrate recognition of PLC?1 via a specific docking surface on Itk. J Mol Biol. 2013;425:683-96 pubmed publisher
    ..Comparing these results to other well-characterized kinase/substrate systems suggests that the G helix is a general structural feature used by kinases for substrate recognition during signaling. ..
  48. Mishra L, Yu P, Cai T, Monga S, Mishra B. Genomic structure, chromosomal mapping, and muscle-specific expression of a PH domain-associated intronless gene, cded/lior. Mamm Genome. 1999;10:62-7 pubmed
    ..Mouse cded/lior was identified from subtraction hybridization of embryonic liver cDNA libraries as well as an adult mouse ..
  49. Dupont G, McGuinness O, Johnson M, Berridge M, Borgese F. Phospholipase C in mouse oocytes: characterization of beta and gamma isoforms and their possible involvement in sperm-induced Ca2+ spiking. Biochem J. 1996;316 ( Pt 2):583-91 pubmed
    ..Furthermore, immunodetection of PLC gamma 1 using monoclonal antibodies reveals that PLC gamma 1 protein is present in mature mouse oocytes, ruling out the ..
  50. Luo H, Yu G, Tremblay J, Wu J. EphB6-null mutation results in compromised T cell function. J Clin Invest. 2004;114:1762-73 pubmed
    ..Further downstream, in the absence of EphB6, ZAP-70 activation, LAT phosphorylation, the association of PLCgamma1 with SLP-76, and p44/42 MAPK activation were diminished. Thus, we have shown that EphB6 is pivotal in T cell function. ..
  51. Dehvari N, Sandebring A, Flores Morales A, Mateos L, Chuan Y, Goldberg M, et al. Parkin-mediated ubiquitination regulates phospholipase C-gamma1. J Cell Mol Med. 2009;13:3061-8 pubmed publisher
    ..This finding could be of relevance for finding novel pathogenic mechanisms leading to PD. ..
  52. Wen R, Jou S, Chen Y, Hoffmeyer A, Wang D. Phospholipase C gamma 2 is essential for specific functions of Fc epsilon R and Fc gamma R. J Immunol. 2002;169:6743-52 pubmed
    ..Moreover, PLCgamma2 plays a nonredundant role in Fc(gamma)R-mediated inflammatory skin reaction. ..
  53. Kim K, Giannakopoulos N, Virgin H, Zhang D. Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation. Mol Cell Biol. 2004;24:9592-600 pubmed
    ..This method provides an easy and effective way to identify new targets for the ISGylation system and will facilitate related studies. ..
  54. Yang Z, Kim S, Mahajan S, Zamani A, Faccio R. Phospholipase C?1 (PLC?1) Controls Osteoclast Numbers via Colony-stimulating Factor 1 (CSF-1)-dependent Diacylglycerol/?-Catenin/CyclinD1 Pathway. J Biol Chem. 2017;292:1178-1186 pubmed publisher
    ..Taken together, our study shows that PLC?1 controls OC numbers via a CSF-1-dependent DAG/?-catenin/cyclinD1 pathway. ..
  55. Sullivan S, Zhu M, Bao S, Lewis C, Ou Yang C, Zhang W. The role of LAT-PLC?1 interaction in ?? T cell development and homeostasis. J Immunol. 2014;192:2865-74 pubmed publisher
    ..Our data indicated that a unique subset of CD4 ?? T cells can hyperproliferate in LATY136F mice and suggested that LAT-PLC?1 signaling may function differently in various subsets of ?? T cells. ..
  56. Rantamäki T, Hendolin P, Kankaanpää A, Mijatovic J, Piepponen P, Domenici E, et al. Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain. Neuropsychopharmacology. 2007;32:2152-62 pubmed
    ..In conclusion, our data suggest that rapid activation of the TrkB neurotrophin receptor and PLCgamma1 signaling is a common mechanism for all antidepressant drugs. ..
  57. Fiume R, Ramazzotti G, Faenza I, Piazzi M, Bavelloni A, Billi A, et al. Nuclear PLCs affect insulin secretion by targeting PPAR? in pancreatic ? cells. FASEB J. 2012;26:203-10 pubmed publisher
    ..These findings highlight a novel pathway by which nuclear PLCs affect insulin secretion and identify PPAR? as a novel molecular target of nuclear PLCs. ..
  58. Fu G, Yu M, Chen Y, Zheng Y, Zhu W, Newman D, et al. Phospholipase C?1 is required for pre-TCR signal transduction and pre-T cell development. Eur J Immunol. 2017;47:74-83 pubmed publisher
    ..Further study showed that deficiency of PLC?1 impaired pre-TCR mediated Ca2+ flux and Erk activation. Thus our studies demonstrate that PLC?1 is important for pre-TCR mediated signal transduction and pre-T cell development. ..
  59. Yang B, Ma T, Xu Z, Verkman A. cDNA and genomic cloning of mouse aquaporin-2: functional analysis of an orthologous mutant causing nephrogenic diabetes insipidus. Genomics. 1999;57:79-83 pubmed
    ..The chemical chaperone glycerol produced a redistribution of Aqp2-T126M from ER to plasma membrane/endosomes. These results establish a basis for an Aqp2-T126M transgenic knock-in model of NDI. ..
  60. Kusuyama J, Kamisono A, ChangHwan S, Amir M, Bandow K, Eiraku N, et al. Spleen tyrosine kinase influences the early stages of multilineage differentiation of bone marrow stromal cell lines by regulating phospholipase C gamma activities. J Cell Physiol. 2017;: pubmed publisher
    ..Taken together, these results indicate that Syk-PLC? signaling has a dual role in regulating the initial stage of adipogenic and osteogenic differentiation of BMSCs. ..
  61. Takamura A, Higaki K, Ninomiya H, Takai T, Matsuda J, Iida M, et al. Lysosomal accumulation of Trk protein in brain of GM? -gangliosidosis mouse and its restoration by chemical chaperone. J Neurochem. 2011;118:399-406 pubmed publisher
    ..These findings indicate that G(M1) accumulation in rafts causes activation of Trk signaling, which may participate in the pathogenesis of G(M1) -gangliosidosis. ..
  62. Margolis B, Silvennoinen O, Comoglio F, Roonprapunt C, Skolnik E, Ullrich A, et al. High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. Proc Natl Acad Sci U S A. 1992;89:8894-8 pubmed
    ..Use of this expression/cloning system should increase our ability to identify downstream modulators of growth factor action. ..
  63. Amin A, Ichigotani Y, Oo M, Biswas M, Yuan H, Huang P, et al. The PLC-PKC cascade is required for IL-1beta-dependent Erk and Akt activation: their role in proliferation. Int J Oncol. 2003;23:1727-31 pubmed
    ..Taken together, our results suggest that a SHPS-1-PLC-gamma complex activate the PLC-PKC cascade, which is required for the activation of IL-1beta-dependent Erk and Akt signalings and cell proliferation. ..
  64. Akbulut S, Reddi A, Aggarwal P, Ambardekar C, Canciani B, Kim M, et al. Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C. Mol Biol Cell. 2010;21:3487-96 pubmed publisher
    ..These data highlight an important action of Spry, which may allow these proteins to influence signaling through multiple receptors. ..
  65. Williamson C, Beechey C, Ball S, Dutton E, Cattanach B, Tease C, et al. Localisation of the imprinted gene neuronatin, Nnat, confirms and refines the location of a second imprinting region on mouse chromosome 2. Cytogenet Cell Genet. 1998;81:73-8 pubmed
    ..It maps close to agouti, some alleles of which show differential expression according to parental origin. The localisation of Nnat to band H1 confirms and refines the map location of a second imprinting region on mouse Chr 2. ..
  66. Wang Q, Siminovitch K, Downey G, McCulloch C. Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLC? at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression. Biochem J. 2013;449:771-82 pubmed publisher
  67. Epple H, Cremasco V, Zhang K, Mao D, Longmore G, Faccio R. Phospholipase Cgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase. Mol Cell Biol. 2008;28:3610-22 pubmed publisher
    ..Based on these results, we propose that PLCgamma2 influences Src activation by mediating the localization of Src to the integrin complex and thereby regulating integrin-mediated functions in the osteoclast. ..
  68. Sase H, Watabe T, Kawasaki K, Miyazono K, Miyazawa K. VEGFR2-PLCgamma1 axis is essential for endothelial specification of VEGFR2+ vascular progenitor cells. J Cell Sci. 2009;122:3303-11 pubmed publisher
    ..Taken together, these findings indicate that VEGFR2-PLCgamma1 signal relay gives rise to the unique function of VEGFR2, thus enabling endothelial differentiation from vascular progenitors. ..
  69. Jamison J, Lauffenburger D, Wang J, Wells A. PKC? localization at the membrane increases matrix traction force dependent on PLC?1/EGFR signaling. PLoS ONE. 2013;8:e77434 pubmed publisher
    ..From these results membrane tethering of PKC? leads to increased force exertion on ECM. Furthermore, our data show PLC?1 regulation of PKC?, at least in part, drives transcellular contractility in fibroblasts. ..
  70. Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz Romond T, Alitalo K, et al. Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J Cell Biol. 2001;154:345-54 pubmed
    ..Thus, we have identified a subclass of p62dok proteins that are putative links with downstream effectors of c-Ret in neuronal differentiation. ..
  71. Roncagalli R, Hauri S, Fiore F, Liang Y, Chen Z, Sansoni A, et al. Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub. Nat Immunol. 2014;15:384-392 pubmed publisher
    ..Our findings provide a more complete model of TCR signaling in which CD6 constitutes a signaling hub that contributes to the diversification of TCR signaling. ..
  72. Kane L, Watkins S. Dynamic regulation of Tec kinase localization in membrane-proximal vesicles of a T cell clone revealed by total internal reflection fluorescence and confocal microscopy. J Biol Chem. 2005;280:21949-54 pubmed
  73. Kim Y, Ok C, Park J, Lee H, Bae Y. Phospholipase C?1 suppresses foreign body giant cell formation by maintaining RUNX1 expression in macrophages. Biochem Biophys Res Commun. 2017;482:1025-1029 pubmed publisher
    ..Taken together, we suggest that PLC?1 plays a role in the foreign body response by regulating the RUNX1/PU.1/DC-STAMP axis in macrophages. ..
  74. Ishijima Y, Ohmori S, Uenishi A, Ohneda K. GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-?1. Genes Cells. 2012;17:285-301 pubmed publisher
    ..These data indicate that PLC-?1 is a target gene of GATA factors in mast cells and provide evidence that GATA1 and GATA2 control antigen-mediated mast cell degranulation by regulating the expression of PLC-?1. ..
  75. Bai X, Deng F, Liu A, Zou Z, Wang Y, Ke Z, et al. Phospholipase C-gamma1 is required for cell survival in oxidative stress by protein kinase C. Biochem J. 2002;363:395-401 pubmed
    ..survival signalling in oxidative stress by using mouse embryonic fibroblasts genetically deficient in PLC-gamma1 (Plcg1(-/-)) and its wild type (Plcg1(+/+))...
  76. Hwang J, Oh Y, Shin K, Kim H, Ryu S, Suh P. Molecular cloning and characterization of a novel phospholipase C, PLC-eta. Biochem J. 2005;389:181-6 pubmed
    ..These results suggest that PLC-eta may perform fundamental roles in the brain. ..
  77. Zheng Y, Adams T, Zhi H, Yu M, Wen R, Newman P, et al. Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1. PLoS ONE. 2015;10:e0119739 pubmed publisher
  78. Ballif B, Arnaud L, Arthur W, Guris D, Imamoto A, Cooper J. Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. Curr Biol. 2004;14:606-10 pubmed
    ..C3G and Rap1 regulate adhesion of fibroblasts and other cell types. Regulation of Crk/CrkL, C3G, and Rap1 by Reelin may be involved in coordinating neuron migrations during brain development. ..
  79. Irarrazabal C, Gallazzini M, Schnetz M, Kunin M, Simons B, Williams C, et al. Phospholipase C-gamma1 is involved in signaling the activation by high NaCl of the osmoprotective transcription factor TonEBP/OREBP. Proc Natl Acad Sci U S A. 2010;107:906-11 pubmed publisher
  80. Tkaczyk C, Beaven M, Brachman S, Metcalfe D, Gilfillan A. The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase. J Biol Chem. 2003;278:48474-84 pubmed
    ..Here we report evidence that the PLC gamma 1-dependent pathway of Fc epsilon RI-mediated activation of mast cells is independent of PI 3-kinase activation...
  81. Yoon S, Lee Y, Kim H, Lee Z, Hyung S, Lee S, et al. Lyn inhibits osteoclast differentiation by interfering with PLCgamma1-mediated Ca2+ signaling. FEBS Lett. 2009;583:1164-70 pubmed publisher
    ..Our study provides the first evidence of the involvement of Lyn in the negative regulation of osteoclastogenesis by RANKL. ..
  82. Fu G, Vallee S, Rybakin V, McGuire M, Ampudia J, Brockmeyer C, et al. Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol. 2009;10:848-56 pubmed publisher
    ..In support of the idea that Themis is involved in TCR signaling, this protein was phosphorylated quickly after TCR stimulation and was needed for optimal TCR-driven calcium mobilization and activation of the kinase Erk. ..
  83. Halupa A, Chohan M, Stickle N, Beattie B, Miller B, Barber D. Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase Cgamma. Exp Cell Res. 2005;309:1-11 pubmed
    ..Hence, we have identified a novel adapter function for PLCgamma1 in EPO signaling in which recruitment of PLCgamma1 to EPO-R may lead to activation of the ERK pathway. ..
  84. Arnould M, Tassa A, Ferrand A, Archer E, Esteve J, Pénalba V, et al. The G-protein-coupled CCK2 receptor associates with phospholipase Cgamma1. FEBS Lett. 2004;568:89-93 pubmed
    ..A specific interaction was demonstrated using surface plasmon resonance, confirmed in a cellular system and by molecular modeling. ..
  85. He X, Pan E, Sciarretta C, Minichiello L, McNamara J. Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis. J Neurosci. 2010;30:6188-96 pubmed publisher
    ..Elucidating signaling pathways activated by a cell membrane receptor in animal models of CNS disorders promises to reveal novel targets for specific and effective therapeutic intervention. ..
  86. Koponen E, Voikar V, Riekki R, Saarelainen T, Rauramaa T, Rauvala H, et al. Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning. Mol Cell Neurosci. 2004;26:166-81 pubmed
    ..TK+ mice. Altogether, overexpression of the trkB.TK+ receptor postnatally leads to selective activation of trkB signaling pathways and enhanced learning and memory. ..
  87. Hayashi H, Campenot R, Vance D, Vance J. Protection of neurons from apoptosis by apolipoprotein E-containing lipoproteins does not require lipoprotein uptake and involves activation of phospholipase Cgamma1 and inhibition of calcineurin. J Biol Chem. 2009;284:29605-13 pubmed publisher