Plaur

Summary

Gene Symbol: Plaur
Description: plasminogen activator, urokinase receptor
Alias: Cd87, u-PAR, uPAR, urokinase plasminogen activator surface receptor, urokinase plasminogen activator receptor
Species: mouse
Products:     Plaur

Top Publications

  1. Dewerchin M, Nuffelen A, Wallays G, Bouche A, Moons L, Carmeliet P, et al. Generation and characterization of urokinase receptor-deficient mice. J Clin Invest. 1996;97:870-8 pubmed
    ..u-PAR-1- peritoneal macrophages had a threefold decreased initial rate of u-PA-mediated plasminogen activation in vitro but degraded extracellular matrix proteins in vitro as efficiently as u-PAR-1- macrophages. ..
  2. Chavakis T, Kanse S, May A, Preissner K. Haemostatic factors occupy new territory: the role of the urokinase receptor system and kininogen in inflammation. Biochem Soc Trans. 2002;30:168-73 pubmed
    ..The direct and indirect contributions of the urokinase-type plasminogen activator receptor (uPAR) system in inflammatory processes, as they relate to recruitment of leukocytes, define novel functions and could ..
  3. Andolfo A, English W, Resnati M, Murphy G, Blasi F, Sidenius N. Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose epitopes not present in the intact soluble receptor. Thromb Haemost. 2002;88:298-306 pubmed
    Proteolytic cleavage of the urokinase plasminogen activator receptor (uPA(R)) prevents the binding of uPA and vitronectin while generating biologically active uPAR fragments...
  4. Zhang G, Kim H, Cai X, Lopez Guisa J, Carmeliet P, Eddy A. Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy. J Am Soc Nephrol. 2003;14:1234-53 pubmed
    Interstitial cells have been implicated in the pathogenesis of renal fibrosis. Given that the urokinase receptor (uPAR) is known to play a role in cell adhesion, migration, and angiogenesis, the present study was designed to evaluate the ..
  5. Bugge T, Suh T, Flick M, Daugherty C, Rømer J, Solberg H, et al. The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility. J Biol Chem. 1995;270:16886-94 pubmed
    The urokinase-type plasminogen activator receptor (uPAR) gene was disrupted in mice in order to explore the role of cell surface-associated plasminogen activation in development and hemostasis...
  6. East E, Baker D, Pryce G, Lijnen H, Cuzner M, Gveric D. A role for the plasminogen activator system in inflammation and neurodegeneration in the central nervous system during experimental allergic encephalomyelitis. Am J Pathol. 2005;167:545-54 pubmed
    ..Using mice deficient in tissue-type plasminogen activator (tPA-/-) and urokinase plasminogen activator receptor (uPAR-/-), we investigated the involvement of the PA system on the clinical and pathological ..
  7. Gondi C, Lakka S, Dinh D, Olivero W, Gujrati M, Rao J. Intraperitoneal injection of a hairpin RNA-expressing plasmid targeting urokinase-type plasminogen activator (uPA) receptor and uPA retards angiogenesis and inhibits intracranial tumor growth in nude mice. Clin Cancer Res. 2007;13:4051-60 pubmed
    ..of using plasmid-expressed RNA interference (RNAi) targeting urokinase-type plasminogen activator (uPA) receptor (uPAR) and uPA to treat human glioma...
  8. May A, Kanse S, Lund L, Gisler R, Imhof B, Preissner K. Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo. J Exp Med. 1998;188:1029-37 pubmed
    The urokinase receptor (CD87; uPAR) is found in close association with beta 2 integrins on leukocytes. We studied the functional consequence of this association for leukocyte adhesion and migration...
  9. Vallabhaneni K, Tkachuk S, Kiyan Y, Shushakova N, Haller H, Dumler I, et al. Urokinase receptor mediates mobilization, migration, and differentiation of mesenchymal stem cells. Cardiovasc Res. 2011;90:113-21 pubmed publisher
    ..Our study was designed to elucidate a probable role for the multifunctional urokinase (uPA)/urokinase receptor (uPAR) system in MSC regulation...
  10. Roelofs J, Rouschop K, Teske G, Claessen N, Weening J, van der Poll T, et al. The urokinase plasminogen activator receptor is crucially involved in host defense during acute pyelonephritis. Kidney Int. 2006;70:1942-7 pubmed
    The urokinase plasminogen activator receptor (uPAR) is expressed at the cell surface of inflammatory cells and plays an important role in neutrophil migration...

Detail Information

Publications83

  1. Dewerchin M, Nuffelen A, Wallays G, Bouche A, Moons L, Carmeliet P, et al. Generation and characterization of urokinase receptor-deficient mice. J Clin Invest. 1996;97:870-8 pubmed
    ..u-PAR-1- peritoneal macrophages had a threefold decreased initial rate of u-PA-mediated plasminogen activation in vitro but degraded extracellular matrix proteins in vitro as efficiently as u-PAR-1- macrophages. ..
  2. Chavakis T, Kanse S, May A, Preissner K. Haemostatic factors occupy new territory: the role of the urokinase receptor system and kininogen in inflammation. Biochem Soc Trans. 2002;30:168-73 pubmed
    ..The direct and indirect contributions of the urokinase-type plasminogen activator receptor (uPAR) system in inflammatory processes, as they relate to recruitment of leukocytes, define novel functions and could ..
  3. Andolfo A, English W, Resnati M, Murphy G, Blasi F, Sidenius N. Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose epitopes not present in the intact soluble receptor. Thromb Haemost. 2002;88:298-306 pubmed
    Proteolytic cleavage of the urokinase plasminogen activator receptor (uPA(R)) prevents the binding of uPA and vitronectin while generating biologically active uPAR fragments...
  4. Zhang G, Kim H, Cai X, Lopez Guisa J, Carmeliet P, Eddy A. Urokinase receptor modulates cellular and angiogenic responses in obstructive nephropathy. J Am Soc Nephrol. 2003;14:1234-53 pubmed
    Interstitial cells have been implicated in the pathogenesis of renal fibrosis. Given that the urokinase receptor (uPAR) is known to play a role in cell adhesion, migration, and angiogenesis, the present study was designed to evaluate the ..
  5. Bugge T, Suh T, Flick M, Daugherty C, Rømer J, Solberg H, et al. The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility. J Biol Chem. 1995;270:16886-94 pubmed
    The urokinase-type plasminogen activator receptor (uPAR) gene was disrupted in mice in order to explore the role of cell surface-associated plasminogen activation in development and hemostasis...
  6. East E, Baker D, Pryce G, Lijnen H, Cuzner M, Gveric D. A role for the plasminogen activator system in inflammation and neurodegeneration in the central nervous system during experimental allergic encephalomyelitis. Am J Pathol. 2005;167:545-54 pubmed
    ..Using mice deficient in tissue-type plasminogen activator (tPA-/-) and urokinase plasminogen activator receptor (uPAR-/-), we investigated the involvement of the PA system on the clinical and pathological ..
  7. Gondi C, Lakka S, Dinh D, Olivero W, Gujrati M, Rao J. Intraperitoneal injection of a hairpin RNA-expressing plasmid targeting urokinase-type plasminogen activator (uPA) receptor and uPA retards angiogenesis and inhibits intracranial tumor growth in nude mice. Clin Cancer Res. 2007;13:4051-60 pubmed
    ..of using plasmid-expressed RNA interference (RNAi) targeting urokinase-type plasminogen activator (uPA) receptor (uPAR) and uPA to treat human glioma...
  8. May A, Kanse S, Lund L, Gisler R, Imhof B, Preissner K. Urokinase receptor (CD87) regulates leukocyte recruitment via beta 2 integrins in vivo. J Exp Med. 1998;188:1029-37 pubmed
    The urokinase receptor (CD87; uPAR) is found in close association with beta 2 integrins on leukocytes. We studied the functional consequence of this association for leukocyte adhesion and migration...
  9. Vallabhaneni K, Tkachuk S, Kiyan Y, Shushakova N, Haller H, Dumler I, et al. Urokinase receptor mediates mobilization, migration, and differentiation of mesenchymal stem cells. Cardiovasc Res. 2011;90:113-21 pubmed publisher
    ..Our study was designed to elucidate a probable role for the multifunctional urokinase (uPA)/urokinase receptor (uPAR) system in MSC regulation...
  10. Roelofs J, Rouschop K, Teske G, Claessen N, Weening J, van der Poll T, et al. The urokinase plasminogen activator receptor is crucially involved in host defense during acute pyelonephritis. Kidney Int. 2006;70:1942-7 pubmed
    The urokinase plasminogen activator receptor (uPAR) is expressed at the cell surface of inflammatory cells and plays an important role in neutrophil migration...
  11. Rijneveld A, Levi M, Florquin S, Speelman P, Carmeliet P, van der Poll T. Urokinase receptor is necessary for adequate host defense against pneumococcal pneumonia. J Immunol. 2002;168:3507-11 pubmed
    ..Previous work has indicated that the urokinase plasminogen activator receptor (uPAR) may also play a role in this mechanism, presumably by an interaction with the beta(2) ..
  12. Kiyan Y, Limbourg A, Kiyan R, Tkachuk S, Limbourg F, Ovsianikov A, et al. Urokinase receptor associates with myocardin to control vascular smooth muscle cells phenotype in vascular disease. Arterioscler Thromb Vasc Biol. 2012;32:110-22 pubmed publisher
    The urokinase-type plasminogen activator (uPA) and its specific receptor (uPAR) are a potent multifunctional system involved in vascular remodeling...
  13. Wiersinga W, Kager L, Hovius J, van der Windt G, de Vos A, Meijers J, et al. Urokinase receptor is necessary for bacterial defense against pneumonia-derived septic melioidosis by facilitating phagocytosis. J Immunol. 2010;184:3079-86 pubmed publisher
    Urokinase receptor (urokinase-type plasminogen activator receptor [uPAR], CD87), a GPI-anchored protein, is considered to play an important role in inflammation and fibrinolysis...
  14. Lin L, Gardsvoll H, Huai Q, Huang M, Ploug M. Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy. J Biol Chem. 2010;285:10982-92 pubmed publisher
    ..affinity interaction between the urokinase-type plasminogen activator (uPA) and its glycolipid-anchored receptor (uPAR) is decisive for cell surface-associated plasminogen activation...
  15. Bugge T, Flick M, Danton M, Daugherty C, Romer J, Dano K, et al. Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator. Proc Natl Acad Sci U S A. 1996;93:5899-904 pubmed
    ..availability of gene-targeted mice deficient in the urokinase-type plasminogen activator (uPA), urokinase receptor (uPAR), tissue-type plasminogen activator (tPA), and plasminogen permits a critical, genetic-based analysis of the ..
  16. Tjwa M, Sidenius N, Moura R, Jansen S, Theunissen K, Andolfo A, et al. Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells. J Clin Invest. 2009;119:1008-18 pubmed publisher
    ..These findings identify MuPAR and plasmin as regulators of the proliferation, marrow pool size, homing, engraftment, and mobilization of HSPCs and possibly also of HSCs. ..
  17. Deindl E, Ziegelhoffer T, Kanse S, Fernandez B, Neubauer E, Carmeliet P, et al. Receptor-independent role of the urokinase-type plasminogen activator during arteriogenesis. FASEB J. 2003;17:1174-6 pubmed
    ..the role of the plasminogen activators (PAs) urokinase PA (uPA) and tissue PA (tPA) as well as the uPA receptor (uPAR) in arteriogenesis, we investigated their impact in a rabbit and mouse model of adaptive collateral artery growth...
  18. Pulukuri S, Gondi C, Lakka S, Jutla A, Estes N, Gujrati M, et al. RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo. J Biol Chem. 2005;280:36529-40 pubmed
    ..Urokinase plasminogen activator-(uPA) and its receptor (uPAR)-mediated signaling have been implicated in tumor cell invasion, survival, and metastasis in a variety of cancers...
  19. Jo M, Takimoto S, Montel V, Gonias S. The urokinase receptor promotes cancer metastasis independently of urokinase-type plasminogen activator in mice. Am J Pathol. 2009;175:190-200 pubmed publisher
    The urokinase receptor (uPAR) promotes metastasis of human malignancies; however, its mechanism of action remains incompletely understood...
  20. Lakka S, Gondi C, Dinh D, Olivero W, Gujrati M, Rao V, et al. Specific interference of urokinase-type plasminogen activator receptor and matrix metalloproteinase-9 gene expression induced by double-stranded RNA results in decreased invasion, tumor growth, and angiogenesis in gliomas. J Biol Chem. 2005;280:21882-92 pubmed
    ..the effectiveness of adenovirus-mediated expression of antisense urokinase-type plasminogen activator receptor (uPAR) and matrix metalloproteinase-9 (MMP-9) in inhibiting tumor invasion in vitro and ex vivo...
  21. Gardsvoll H, Gilquin B, Le Du M, Ménez A, Jørgensen T, Ploug M. Characterization of the functional epitope on the urokinase receptor. Complete alanine scanning mutagenesis supplemented by chemical cross-linking. J Biol Chem. 2006;281:19260-72 pubmed
    ..between the serine protease urokinase-type plasminogen activator (uPA) and its glycolipid-anchored receptor (uPAR) represents one of the key regulatory steps in cell surface-associated plasminogen activation...
  22. Coleman J, Benach J. The urokinase receptor can be induced by Borrelia burgdorferi through receptors of the innate immune system. Infect Immun. 2003;71:5556-64 pubmed
    Monocytic cells exposed to Borrelia burgdorferi, through unknown receptors, overexpress the urokinase receptor (uPAR), a key mediator of the plasminogen activation system...
  23. Park Y, Liu G, Tsuruta Y, Lorne E, Abraham E. Participation of the urokinase receptor in neutrophil efferocytosis. Blood. 2009;114:860-70 pubmed publisher
    The urokinase receptor (uPAR) plays an important role in regulation of fibronolysis, cell migration, and adhesion. In this study, we examined whether uPAR plays a role in modulating efferocytosis of neutrophils...
  24. Gyetko M, Aizenberg D, Mayo Bond L. Urokinase-deficient and urokinase receptor-deficient mice have impaired neutrophil antimicrobial activation in vitro. J Leukoc Biol. 2004;76:648-56 pubmed
    Leukocytes express both urokinase-type plasminogen activator (uPA) and the urokinase receptor (uPAR, CD87). We have shown that neutrophil recruitment to the lung during P...
  25. van Zoelen M, Florquin S, de Beer R, Pater J, Verstege M, Meijers J, et al. Urokinase plasminogen activator receptor-deficient mice demonstrate reduced hyperoxia-induced lung injury. Am J Pathol. 2009;174:2182-9 pubmed publisher
    ..Hyperoxia-induced lung injury is characterized by neutrophil infiltration into the lungs. The urokinase plasminogen activator receptor (uPAR) has been deemed important for leukocyte trafficking...
  26. Nalla A, Asuthkar S, Bhoopathi P, Gujrati M, Dinh D, Rao J. Suppression of uPAR retards radiation-induced invasion and migration mediated by integrin ?1/FAK signaling in medulloblastoma. PLoS ONE. 2010;5:e13006 pubmed publisher
    ..RT-PCR analysis confirmed increased expression of uPA, uPAR, focal adhesion kinase (FAK), N-Cadherin and integrin subunits (e.g., ?3, ?5 and ?1) in irradiated cells...
  27. Ragno P. The urokinase receptor: a ligand or a receptor? Story of a sociable molecule. Cell Mol Life Sci. 2006;63:1028-37 pubmed
    ..b>uPAR ligands and interactors and the functional consequences of the multiple binding capability of this intriguing ..
  28. Hodjat M, Haller H, Dumler I, Kiyan Y. Urokinase receptor mediates doxorubicin-induced vascular smooth muscle cell senescence via proteasomal degradation of TRF2. J Vasc Res. 2013;50:109-23 pubmed publisher
    ..We observed that expression of urokinase receptor (uPAR) was upregulated in response to doxorubicin...
  29. Gyetko M, Sud S, Kendall T, Fuller J, Newstead M, Standiford T. Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infection. J Immunol. 2000;165:1513-9 pubmed
    Leukocytes express both urokinase-type plasminogen activator (uPA) and the urokinase receptor (uPAR, CD87). Evidence in vitro has implicated uPAR as a modulator of beta2 integrin function, particularly CR3 (CD11b/CD18, Mac-1)...
  30. Nagai N, Okada K, Kawao N, Ishida C, Ueshima S, Collen D, et al. Urokinase-type plasminogen activator receptor (uPAR) augments brain damage in a murine model of ischemic stroke. Neurosci Lett. 2008;432:46-9 pubmed publisher
    Urokinase-type plasminogen activator receptor (uPAR) is a key component of the plasminogen activation system at the cell surface...
  31. Hovius J, Bijlsma M, van der Windt G, Wiersinga W, Boukens B, Coumou J, et al. The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi. PLoS Pathog. 2009;5:e1000447 pubmed publisher
    ..borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated...
  32. Alfano D, Votta G, Schulze A, Downward J, Caputi M, Stoppelli M, et al. Modulation of cellular migration and survival by c-Myc through the downregulation of urokinase (uPA) and uPA receptor. Mol Cell Biol. 2010;30:1838-51 pubmed publisher
    ..Transcriptome analysis revealed that urokinase (uPA) and uPA receptor (uPAR) were strongly downregulated by c-Myc...
  33. Cunningham O, Campion S, Perry V, Murray C, Sidenius N, Docagne F, et al. Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation. Glia. 2009;57:1802-14 pubmed publisher
    The urokinase plasminogen activator (uPA) receptor (uPAR) is a GPI-linked cell surface protein that facilitates focused plasmin proteolytic activity at the cell surface...
  34. Bifulco K, Longanesi Cattani I, Franco P, Pavone V, Mugione P, Di Carluccio G, et al. Single amino acid substitutions in the chemotactic sequence of urokinase receptor modulate cell migration and invasion. PLoS ONE. 2012;7:e44806 pubmed publisher
    The receptor for urokinase-type plasminogen activator (uPAR) plays an important role in controlling cell migration...
  35. Burk J, Burggraf D, Vosko M, Dichgans M, Hamann G. Protection of cerebral microvasculature after moderate hypothermia following experimental focal cerebral ischemia in mice. Brain Res. 2008;1226:248-55 pubmed publisher
    ..These protective effects in an additional animal model of ischemia and reperfusion strongly recommend hypothermia as a potential beneficial treatment for stroke. ..
  36. Oh S, Seki T, Goss K, Imamura T, Yi Y, Donahoe P, et al. Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci U S A. 2000;97:2626-31 pubmed
    ..Taken together, our results suggest that the balance between the ALK1 and ALK5 signaling pathways in endothelial cells plays a crucial role in determining vascular endothelial properties during angiogenesis. ..
  37. Lund I, Nielsen B, Almholt K, Rønø B, Hald A, Illemann M, et al. Concomitant lack of MMP9 and uPA disturbs physiological tissue remodeling. Dev Biol. 2011;358:56-67 pubmed publisher
    ..Gestation was also affected by simultaneous lack of MMP9 and the uPA receptor (uPAR)...
  38. Zhou Q, Xiao J, Jiang D, Wang R, Vembaiyan K, Wang A, et al. Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat Med. 2011;17:1003-9 pubmed publisher
    ..Combining SOICR inhibition with optimal beta blockade has the potential to provide antiarrhythmic therapy that can be tailored to individual patients. ..
  39. Yang A, Dai J, Xie Z, Colman R, Wu Q, Birge R, et al. High molecular weight kininogen binds phosphatidylserine and opsonizes urokinase plasminogen activator receptor-mediated efferocytosis. J Immunol. 2014;192:4398-408 pubmed publisher
    ..In this study, we found that urokinase plasminogen activator receptor (uPAR) plays an important role in internalization of apoptotic cells and also characterized the ..
  40. Alexander R, Prager G, Mihaly Bison J, Uhrin P, Sunzenauer S, Binder B, et al. VEGF-induced endothelial cell migration requires urokinase receptor (uPAR)-dependent integrin redistribution. Cardiovasc Res. 2012;94:125-35 pubmed publisher
    ..degradation of extracellular matrix provided by the urokinase plasminogen activator/urokinase receptor (uPA/uPAR) system and regulation of cell migration provided by integrin-matrix interaction...
  41. Semina E, Rubina K, Sysoeva V, Makarevich P, Parfyonova Y, Tkachuk V. [UROKINASE SYSTEM INVOLVES IN VASCULAR CELLS MIGRATION AND REGULATES THE GROWTH AND BRANCHING OF CAPILLARIES]. Tsitologiia. 2015;57:689-98 pubmed
    Urokinase system representing urokinase-type plasminogen activator (urokinase, uPA) and urokinase re- ceptor (uPAR) plays an important regulatory role in the vascular wall and has the ability to run a proteolytic cascade, degradation of ..
  42. Sonoda K, Nakamura T, Young H, Hart D, Carmeliet P, Stein Streilein J. NKT cell-derived urokinase-type plasminogen activator promotes peripheral tolerance associated with eye. J Immunol. 2007;179:2215-22 pubmed
    ..We postulate that the mechanism of action of uPA is through its binding to the uPAR receptor, and enzymatic cleavage of plasminogen to plasmin, which in turn activates latent TGFbeta...
  43. Raghu H, Lakka S, Gondi C, Mohanam S, Dinh D, Gujrati M, et al. Suppression of uPA and uPAR attenuates angiogenin mediated angiogenesis in endothelial and glioblastoma cell lines. PLoS ONE. 2010;5:e12458 pubmed publisher
    In our earlier reports, we showed that downregulation of uPA and uPAR inhibited glioma tumor angiogenesis in SNB19 cells, and intraperitoneal injection of a hairpin shRNA expressing plasmid targeting uPA and uPAR inhibited angiogenesis in ..
  44. Kotipatruni R, Nalla A, Asuthkar S, Gondi C, Dinh D, Rao J. Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastoma. PLoS ONE. 2012;7:e44798 pubmed publisher
    ..Matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator receptor (uPAR) are over expressed in several cancers and well established for their roles in tumor ..
  45. Bae M, Bissonette G, Mars W, Michalopoulos G, Achim C, Depireux D, et al. Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility. Exp Neurol. 2010;221:129-35 pubmed publisher
    ..Adult mice lacking the urokinase plasminogen activator receptor (Plaur) have decreased numbers of neocortical GABAergic interneurons and spontaneous seizures, ..
  46. Al Hassan N, Behzadian A, Caldwell R, Ivanova V, Syed V, Motamed K, et al. Differential roles of uPAR in peritoneal ovarian carcinomatosis. Neoplasia. 2012;14:259-70 pubmed
    ..b>Urokinase plasminogen activator receptor (uPAR) is a multifunctional receptor involved in a myriad of tumor cell processes...
  47. Odet F, Guyot R, Leduque P, le Magueresse Battistoni B. Evidence for similar expression of protein C inhibitor and the urokinase-type plasminogen activator system during mouse testis development. Endocrinology. 2004;145:1481-9 pubmed
    ..PC and tissue-type PA showed no variation between sexes. By contrast, urokinase-type PA and its receptor (uPAR; which dictates the site and extent of proteolysis) exhibited sex differences from 13.5-14.5 d postcoitum...
  48. Pirazzoli V, Ferraris G, Sidenius N. Direct evidence of the importance of vitronectin and its interaction with the urokinase receptor in tumor growth. Blood. 2013;121:2316-23 pubmed publisher
    Extensive evidence implicates the urokinase plasminogen activator receptor (uPAR) in tumor growth, invasion, and metastasis...
  49. LaRusch G, Merkulova A, Mahdi F, Shariat Madar Z, Sitrin R, Cines D, et al. Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through ?1-integrin and VEGFR2. Am J Physiol Heart Circ Physiol. 2013;305:H305-20 pubmed publisher
    ..Peptides from domain 2 of the urokinase plasminogen activator receptor (uPAR) or domain 5 of high-molecular-weight kininogen compete with ScuPA for the induction of ..
  50. Degryse B, Resnati M, Czekay R, Loskutoff D, Blasi F. Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor. J Biol Chem. 2005;280:24792-803 pubmed
    We investigated the interaction between the urokinase receptor (uPAR) and the integrin alphavbeta3. Vitronectin (VN) induces cell migration by binding to alphavbeta3, but expression of the uPAR boosts its efficacy...
  51. Piguet P, Vesin C, Da Laperousaz C, Rochat A. Role of plasminogen activators and urokinase receptor in platelet kinetics. Hematol J. 2000;1:199-205 pubmed
    ..deficient mice to explore the role of urokinase (uPA) and tissue type (tPA) PAs, as well as the uPA receptor (uPAR, CD87) in platelet kinetics. Platelet shape and number were investigated by flow cytometry...
  52. Eagleson K, Campbell D, Thompson B, BERGMAN M, Levitt P. The autism risk genes MET and PLAUR differentially impact cortical development. Autism Res. 2011;4:68-83 pubmed publisher
    ..We previously identified two ASD risk genes encoding the receptor tyrosine kinase MET and the urokinase plasminogen activator receptor (PLAUR), which is thought to modulate availability of the MET ligand...
  53. Kenny S, Gamble J, Lyons S, Vlatkovic N, Dimaline R, Varro A, et al. Gastric expression of plasminogen activator inhibitor (PAI)-1 is associated with hyperphagia and obesity in mice. Endocrinology. 2013;154:718-26 pubmed publisher
    ..and behavioral characteristics of these and mice null for PAI-1 or a putative receptor, urokinase plasminogen activator receptor (uPAR)...
  54. Connolly B, Choi E, Gardsvoll H, Bey A, Currie B, Chavakis T, et al. Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation. Blood. 2010;116:1593-603 pubmed publisher
    The urokinase plasminogen activator receptor (uPAR) has emerged as a potential regulator of cell adhesion, cell migration, proliferation, differentiation, and cell survival in multiple physiologic and pathologic contexts...
  55. Zhang G, Kim H, Cai X, Lopez Guisa J, Alpers C, Liu Y, et al. Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathy. J Am Soc Nephrol. 2003;14:1254-71 pubmed
    The urokinase cellular receptor (uPAR) recognizes the N-terminal growth factor domain of urokinase-type plasminogen activator (uPA) and is expressed by several cell types...
  56. Wang T, Zhang H, Gyetko M, Parent J. Hepatocyte growth factor acts as a mitogen and chemoattractant for postnatal subventricular zone-olfactory bulb neurogenesis. Mol Cell Neurosci. 2011;48:38-50 pubmed publisher
    ..These results suggest that HGF influences multiple steps in postnatal forebrain neurogenesis. HGF is a mitogen for SVZ neural progenitors, and regulates their differentiation and olfactory bulb migration. ..
  57. Sato J, Schorey J, Ploplis V, Haalboom E, Krahule L, Castellino F. The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection. Am J Pathol. 2003;163:517-31 pubmed
    ..avium from lungs. Thus, plasmin(ogen) functions in limiting progressive fibrosis in the granuloma during a chronic mycobacterial infection. ..
  58. Levitt P. Disruption of interneuron development. Epilepsia. 2005;46 Suppl 7:22-8 pubmed
    ..The uPAR knockout mouse provides a unique opportunity to study the effects of interneuron disruption in vivo...
  59. Van Den Broeck T, Stevenaert F, Taveirne S, Debacker V, Vangestel C, Vandekerckhove B, et al. Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator. Blood. 2008;112:5046-51 pubmed publisher
    ..Our results suggest that uPA, besides its established role in fibrinolysis, tissue remodeling, and tumor metastasis, could be involved in NK cell-mediated immune surveillance and tumor escape. ..
  60. Suelves M, Vidal B, Serrano A, Tjwa M, Roma J, Lopez Alemany R, et al. uPA deficiency exacerbates muscular dystrophy in MDX mice. J Cell Biol. 2007;178:1039-51 pubmed
    ..These findings underscore the importance of uPA in muscular dystrophy. ..
  61. Bdeir K, Murciano J, Tomaszewski J, Koniaris L, Martinez J, Cines D, et al. Urokinase mediates fibrinolysis in the pulmonary microvasculature. Blood. 2000;96:1820-6 pubmed
    The role of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in fibrinolysis remains unsettled...
  62. Magnussen S, Hadler Olsen E, Costea D, Berg E, Jacobsen C, Mortensen B, et al. Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion. BMC Cancer. 2017;17:350 pubmed publisher
    Urokinase plasminogen activator (uPA) receptor (uPAR) is up-regulated at the invasive tumour front of human oral squamous cell carcinoma (OSCC), indicating a role for uPAR in tumour progression...
  63. Chen J, Chang L, Wu C, Tseng T, Lin J, Lin Y, et al. Significance of the urokinase-type plasminogen activator and its receptor in the progression of focal segmental glomerulosclerosis in clinical and mouse models. J Biomed Sci. 2016;23:24 pubmed publisher
    ..A deficiency of uPA accelerated the progression of Adriamycin-induced mouse FSGS model. Decrease of serum uPA levels may be an indicator of the progression of FSGS in clinical subjects and animal models. ..
  64. Eagleson K, Gravielle M, Schlueter McFadyen Ketchum L, Russek S, Farb D, Levitt P. Genetic disruption of the autism spectrum disorder risk gene PLAUR induces GABAA receptor subunit changes. Neuroscience. 2010;168:797-810 pubmed publisher
    ..The human gene encoding uPAR (PLAUR) has been shown recently to be associated with the risk of autism...
  65. Bolon I, Zhou H, Charron Y, Wohlwend A, Vassalli J. Plasminogen mediates the pathological effects of urokinase-type plasminogen activator overexpression. Am J Pathol. 2004;164:2299-304 pubmed
    Increased expression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) is associated with different pathological conditions...
  66. Eagleson K, Bonnin A, Levitt P. Region- and age-specific deficits in gamma-aminobutyric acidergic neuron development in the telencephalon of the uPAR(-/-) mouse. J Comp Neurol. 2005;489:449-66 pubmed
    ..have previously shown that in adult mice with a null mutation in the urokinase-type plasminogen activator receptor (uPAR) gene, maintained on a C57BL/6J/129Sv background, there is a selective loss of GABAergic interneurons in anterior ..
  67. Schuindt S, Oliveira B, Pimentel P, Resende T, Retamal C, DaMatta R, et al. Secretion of multi-protein migratory complex induced by Toxoplasma gondii infection in macrophages involves the uPA/uPAR activation system. Vet Parasitol. 2012;186:207-15 pubmed publisher
    ..gondii infected murine macrophages. We showed by immunoprecipitation assays that MMP-9, CD44 TIMP-1 and uPAR were secreted as a multi-protein complex by infected macrophages...
  68. Alfano M, Cinque P, Giusti G, Proietti S, Nebuloni M, Danese S, et al. Full-length soluble urokinase plasminogen activator receptor down-modulates nephrin expression in podocytes. Sci Rep. 2015;5:13647 pubmed publisher
    ..These in vitro data were confirmed in an in vivo uPAR knock out Plaur(-/-) mice model by demonstrating that the infusion of suPAR inhibits expression of nephrin and WT-1 in podocytes ..
  69. LaRusch G, Mahdi F, Shariat Madar Z, Adams G, Sitrin R, Zhang W, et al. Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis. Blood. 2010;115:5111-20 pubmed publisher
    ..XII (FXII) and high molecular weight kininogen (HK) mutually block each other's binding to the urokinase plasminogen activator receptor (uPAR). We investigated if FXII stimulates cells by interacting with uPAR. FXII (3-62nM) with 0...
  70. Prager G, Breuss J, Steurer S, Olcaydu D, Mihaly J, Brunner P, et al. Vascular endothelial growth factor receptor-2-induced initial endothelial cell migration depends on the presence of the urokinase receptor. Circ Res. 2004;94:1562-70 pubmed
    ..We now show that the cell surface receptor of the uPA-system, the urokinase receptor (uPAR), is redistributed to focal adhesions at the leading edge of endothelial cells in response to VEGF...
  71. Kanno Y, Kaneiwa A, Minamida M, Kanno M, Tomogane K, Takeuchi K, et al. The absence of uPAR is associated with the progression of dermal fibrosis. J Invest Dermatol. 2008;128:2792-7 pubmed publisher
    ..Urokinase-type plasminogen activator receptor (uPAR) not only functions as a proteinase receptor but also plays a role in cellular adhesion, differentiation, ..
  72. Bryer S, Fantuzzi G, Van Rooijen N, Koh T. Urokinase-type plasminogen activator plays essential roles in macrophage chemotaxis and skeletal muscle regeneration. J Immunol. 2008;180:1179-88 pubmed
    ..Overall, the results indicate that uPA plays a fundamental role in macrophage chemotaxis and that macrophage-derived uPA promotes efficient muscle regeneration. ..
  73. Ilkovitch D, Carrio R, Lopez D. uPA and uPA-receptor are involved in cancer-associated myeloid-derived suppressor cell accumulation. Anticancer Res. 2012;32:4263-70 pubmed
    ..and to investigate the role of the tumor-derived urokinase plasminogen activator (uPA) and its receptor (uPAR) on MDSC recruitment...
  74. Farris S, Hu J, Krishnan R, Emery I, Chu T, Du L, et al. Mechanisms of urokinase plasminogen activator (uPA)-mediated atherosclerosis: role of the uPA receptor and S100A8/A9 proteins. J Biol Chem. 2011;286:22665-77 pubmed publisher
    ..clinical studies, cell culture, and animal models implicate the urokinase plasminogen activator (uPA)/uPA receptor (uPAR)/plasminogen system in the development of atherosclerosis and aneurysms...
  75. Gaultier A, Hollister M, Reynolds I, Hsieh E, Gonias S. LRP1 regulates remodeling of the extracellular matrix by fibroblasts. Matrix Biol. 2010;29:22-30 pubmed publisher
    ..for diverse proteases, protease inhibitors, and other plasma membrane proteins, including the urokinase receptor (uPAR). LRP1 also functions in cell-signaling and regulates gene expression...
  76. Thurison T, Almholt K, Gårdsvoll H, Ploug M, Høyer Hansen G, Lund I. Urokinase receptor cleavage correlates with tumor volume in a transgenic mouse model of breast cancer. Mol Carcinog. 2016;55:717-31 pubmed publisher
    ..The linker region between domains I and II of the intact, three domain urokinase receptor uPAR(I-III) is highly susceptible to proteolytic cleavage and the resulting cleaved uPAR forms are strong prognostic ..
  77. Kawao N, Nagai N, Tamura Y, Horiuchi Y, Okumoto K, Okada K, et al. Urokinase-type plasminogen activator and plasminogen mediate activation of macrophage phagocytosis during liver repair in vivo. Thromb Haemost. 2012;107:749-59 pubmed publisher
    ..Furthermore, u-PA plays a critical role in the induction of macrophage polarity by affecting the microenvironment at the edge of damaged tissue. ..
  78. Bolkvadze T, Puhakka N, Pitkänen A. Epileptogenesis after traumatic brain injury in Plaur-deficient mice. Epilepsy Behav. 2016;60:187-196 pubmed publisher
    ..Accordingly, mutations in the Plaur gene, which encodes uPAR, have been linked to language deficits, autism, and epilepsy, both in mouse and human...
  79. Shi H, Liu L, Liu L, Geng J, Chen L. Inhibition of tumor growth by ?-elemene through downregulation of the expression of uPA, uPAR, MMP-2, and MMP-9 in a murine intraocular melanoma model. Melanoma Res. 2015;25:15-21 pubmed publisher
    ..The mRNA expression levels of the urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), matrix metalloproteinase (MMP)-2, and MMP-9 were assayed by real-time PCR, and the protein expression levels of ..
  80. Wu F, Catano M, Echeverry R, Torre E, Haile W, An J, et al. Urokinase-type plasminogen activator promotes dendritic spine recovery and improves neurological outcome following ischemic stroke. J Neurosci. 2014;34:14219-32 pubmed publisher
    ..uPA) is a serine proteinase that plays a central role in tissue remodeling via binding to the urokinase plasminogen activator receptor (uPAR)...
  81. Solberg H, Løber D, Eriksen J, Ploug M, Rønne E, Behrendt N, et al. Identification and characterization of the murine cell surface receptor for the urokinase-type plasminogen activator. Eur J Biochem. 1992;205:451-8 pubmed
    ..abstract truncated at 400 words) ..
  82. Nishii K, Nakaseko C, Jiang M, Shimizu N, Takeuchi M, Schneider W, et al. The soluble form of LR11 protein is a regulator of hypoxia-induced, urokinase-type plasminogen activator receptor (uPAR)-mediated adhesion of immature hematological cells. J Biol Chem. 2013;288:11877-86 pubmed publisher
    ..and pool size of HSPCs in the BM is the hypoxia-induced urokinase-type plasminogen activator receptor (uPAR)...
  83. Rivellini C, Dina G, Porrello E, Cerri F, Scarlato M, Domi T, et al. Urokinase plasminogen receptor and the fibrinolytic complex play a role in nerve repair after nerve crush in mice, and in human neuropathies. PLoS ONE. 2012;7:e32059 pubmed publisher
    ..The urokinase plasminogen receptor (uPAR) is a major component of the fibrinolytic complex, and binding to urokinase plasminogen activator (uPA) promotes ..