Plau

Summary

Gene Symbol: Plau
Description: plasminogen activator, urokinase
Alias: u-PA, uPA, urokinase-type plasminogen activator, U-plasminogen activator
Species: mouse

Top Publications

  1. ncbi The urokinase/urokinase receptor system mediates the IgG immune complex-induced inflammation in lung
    Nelli Shushakova
    Department of Nephrology, Medical School Hannover, Hannover, Germany
    J Immunol 175:4060-8. 2005
  2. pmc Regulation of urokinase-type plasminogen activator gene transcription by macrophage colony-stimulating factor
    K J Stacey
    Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    Mol Cell Biol 15:3430-41. 1995
  3. ncbi Physiological consequences of loss of plasminogen activator gene function in mice
    P Carmeliet
    Whitehead Institute of Biomedical Research, Cambridge, Massachusetts 02142
    Nature 368:419-24. 1994
  4. pmc Ovulation efficiency is reduced in mice that lack plasminogen activator gene function: functional redundancy among physiological plasminogen activators
    G Leonardsson
    Department of Medical Biochemistry and Biophysics, Umea University, Sweden
    Proc Natl Acad Sci U S A 92:12446-50. 1995
  5. ncbi Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
    P Carmeliet
    Centre for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
    Nat Genet 17:439-44. 1997
  6. pmc Receptor-independent role of urokinase-type plasminogen activator in pericellular plasmin and matrix metalloproteinase proteolysis during vascular wound healing in mice
    P Carmeliet
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    J Cell Biol 140:233-45. 1998
  7. pmc Exacerbation of antigen-induced arthritis in urokinase-deficient mice
    N Busso
    Centre Hospitalier Universitaire Vaudois, Laboratoire de Rhumatologie, 1011 Lausanne, Switzerland
    J Clin Invest 102:41-50. 1998
  8. ncbi Lactational competence and involution of the mouse mammary gland require plasminogen
    L R Lund
    Finsen Laboratory, Copenhagen University Hospital, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Development 127:4481-92. 2000
  9. ncbi The plasminogen activator system: biology and regulation
    J P Irigoyen
    Friedrich Miescher Institute, Basel, Switzerland
    Cell Mol Life Sci 56:104-32. 1999
  10. ncbi Tissue-type plasminogen activator deficiency exacerbates arthritis
    Y H Yang
    Department of Medicine, Arthritis and Inflammation Research Centre, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Immunol 167:1047-52. 2001

Research Grants

  1. THE ROLE OF UROKINASE IN LUNG T LYMPHOCYTE RESPONSES
    MARGARET GYETKO; Fiscal Year: 2003
  2. PLASMIN, FIBRIN, AND METALLOPROTEINASES IN LUNG FIBROSIS
    Thomas Sisson; Fiscal Year: 2004
  3. The Mechanism of IVIG Action in Pemphigus
    Zhi Liu; Fiscal Year: 2006
  4. Mechanisms of cardiac fibrosis
    April Stempien Otero; Fiscal Year: 2006
  5. Biomarkers for VEGF and mTOR Blockade in Advanced Renal Cancer
    Jaime Merchan; Fiscal Year: 2007
  6. PATHOLOGICAL CONSEQUENCES OF THE PLASMINOGEN SYSTEM
    Victoria Ploplis; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications114 found, 100 shown here

  1. ncbi The urokinase/urokinase receptor system mediates the IgG immune complex-induced inflammation in lung
    Nelli Shushakova
    Department of Nephrology, Medical School Hannover, Hannover, Germany
    J Immunol 175:4060-8. 2005
    ..by the cell surface-specific receptor (uPAR), a binding partner for the urokinase-type plasminogen activator (uPA)...
  2. pmc Regulation of urokinase-type plasminogen activator gene transcription by macrophage colony-stimulating factor
    K J Stacey
    Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    Mol Cell Biol 15:3430-41. 1995
    The mouse urokinase-type plasminogen activator (uPA) gene was used as a model macrophage colony-stimulating factor 1 (CSF-1)-inducible gene to investigate CSF-1 signalling pathways...
  3. ncbi Physiological consequences of loss of plasminogen activator gene function in mice
    P Carmeliet
    Whitehead Institute of Biomedical Research, Cambridge, Massachusetts 02142
    Nature 368:419-24. 1994
    ..Mice with combined t-PA and u-PA deficiency suffer extensive spontaneous fibrin deposition, with its associated effects on growth, fertility and survival...
  4. pmc Ovulation efficiency is reduced in mice that lack plasminogen activator gene function: functional redundancy among physiological plasminogen activators
    G Leonardsson
    Department of Medical Biochemistry and Biophysics, Umea University, Sweden
    Proc Natl Acad Sci U S A 92:12446-50. 1995
    ..single-deficient mice lacking tissue-type plasminogen activator (tPA), urokinase-type plasminogen activator (uPA), or PA inhibitor type 1(PAI-1) gene function were recently found to have normal reproduction, although mice with a ..
  5. ncbi Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
    P Carmeliet
    Centre for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
    Nat Genet 17:439-44. 1997
    ..18), singly or combined with a deficiency of t-PA (Apoe-/-:Plat-/-) or of u-PA (Apoe-/-:Plau-/-; ref...
  6. pmc Receptor-independent role of urokinase-type plasminogen activator in pericellular plasmin and matrix metalloproteinase proteolysis during vascular wound healing in mice
    P Carmeliet
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    J Cell Biol 140:233-45. 1998
    ..Taken together, these results suggest that binding of u-PA to u-PAR is not required to provide sufficient pericellular u-PA-mediated plasmin proteolysis to allow cellular migration into a vascular wound...
  7. pmc Exacerbation of antigen-induced arthritis in urokinase-deficient mice
    N Busso
    Centre Hospitalier Universitaire Vaudois, Laboratoire de Rhumatologie, 1011 Lausanne, Switzerland
    J Clin Invest 102:41-50. 1998
    In rheumatoid arthritis, synovial expression of urokinase (uPA) activity is greatly increased (Busso, N., V. Péclat, A. So, and A. -P. Sappino. 1997. Ann. Rheum. Dis. 56:550- 557)...
  8. ncbi Lactational competence and involution of the mouse mammary gland require plasminogen
    L R Lund
    Finsen Laboratory, Copenhagen University Hospital, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Development 127:4481-92. 2000
    ..These data demonstrate a critical, dose-dependent requirement for Plg in lactational differentiation and mammary gland remodeling during involution...
  9. ncbi The plasminogen activator system: biology and regulation
    J P Irigoyen
    Friedrich Miescher Institute, Basel, Switzerland
    Cell Mol Life Sci 56:104-32. 1999
    ..Thus, modulation of mRNA stability is an important factor in overall regulation. This review summarizes current understanding of the biology and regulation of genes involved in plasminogen activation at different levels...
  10. ncbi Tissue-type plasminogen activator deficiency exacerbates arthritis
    Y H Yang
    Department of Medicine, Arthritis and Inflammation Research Centre, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Immunol 167:1047-52. 2001
    ..Fibrin deposition appeared to parallel disease severity under the various conditions, suggesting that PA-mediated fibrinolysis may be normally playing a protective role in inflammatory joint disease...
  11. ncbi Urokinase-type plasminogen activator is required for the generation of a type 1 immune response to pulmonary Cryptococcus neoformans infection
    Margaret R Gyetko
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Immunol 168:801-9. 2002
    Urokinase-type plasminogen activator (uPA)(-/-) mice cannot mount protective host defenses during infection with the opportunistic yeast Cryptococcus neoformans (52D). Because effective host defense against C...
  12. pmc Differing roles for urokinase and tissue-type plasminogen activator in collagen-induced arthritis
    Andrew D Cook
    Arthritis and Inflammation Research Center, University of Melbourne, Department of Medicine, Victoria, Australia
    Am J Pathol 160:917-26. 2002
    ..Our data highlight the complexities of PA function, and suggest that approaches either to target u-PA or to enhance local t-PA activity in joints may be of therapeutic benefit in rheumatoid arthritis...
  13. ncbi Urokinase receptor is necessary for adequate host defense against pneumococcal pneumonia
    Anita W Rijneveld
    Department of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 168:3507-11. 2002
    ..We investigated the role of uPAR and urokinase plasminogen activator (uPA) during pneumonia caused by a beta(2) integrin-independent respiratory pathogen, Streptococcus pneumoniae...
  14. ncbi Urokinase is required for the formation of mactinin, an alpha-actinin fragment that promotes monocyte/macrophage maturation
    Sharon Luikart
    Veterans Affairs Medical Center, Minneapolis, MN, USA
    Biochim Biophys Acta 1591:99-107. 2002
    ..For in vivo tests, inflammatory fluid (from bronchoalvelolar lavage) was collected from uPA (urokinase) knockout mice and their wild-type counterparts after intratracheal challenge with Pneumocystis carinii...
  15. ncbi The urokinase plasminogen activator: an interesting way to improve myoblast migration following their transplantation
    E el Fahime
    Unité de Recherche en Génétique Humaine, Centre hospitalier de l Universite Laval, Ste Foy, Quebec, G1V 4G2, Canada
    Exp Cell Res 280:169-78. 2002
    ..Here, we studied the role of urokinase plasminogen activator (uPA) in this process...
  16. ncbi Receptor-independent role of the urokinase-type plasminogen activator during arteriogenesis
    E Deindl
    Max Planck Institute, Department of Exp Cardiology, Benekestrasse 2, D 61231 Bad Nauheim, Germany
    FASEB J 17:1174-6. 2003
    To define the role of the plasminogen activators (PAs) urokinase PA (uPA) and tissue PA (tPA) as well as the uPA receptor (uPAR) in arteriogenesis, we investigated their impact in a rabbit and mouse model of adaptive collateral artery ..
  17. ncbi Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activation
    Edward Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 170:5644-51. 2003
    Urokinase plasminogen activator (uPA) is a serine protease that catalyzes the conversion of plasminogen to plasmin...
  18. ncbi Urokinase-deficient and urokinase receptor-deficient mice have impaired neutrophil antimicrobial activation in vitro
    Margaret R Gyetko
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, 3916 Taubman Center Medical Center Drive, Ann Arbor, MI 48109 0360, USA
    J Leukoc Biol 76:648-56. 2004
    Leukocytes express both urokinase-type plasminogen activator (uPA) and the urokinase receptor (uPAR, CD87). We have shown that neutrophil recruitment to the lung during P...
  19. ncbi Reduced metastasis of transgenic mammary cancer in urokinase-deficient mice
    Kasper Almholt
    Finsen Laboratory, Rigshospitalet 8621, Strand boulevarden 49, DK 2100 Copenhagen, Denmark
    Int J Cancer 113:525-32. 2005
    ..Proteolytically active plasmin is generated from inactive plasminogen by one of 2 activators, uPA or tPA. We now find that uPA deficiency alone significantly reduces metastasis >7-fold in the MMTV-PymT model...
  20. ncbi Mice deficient in plasminogen activator inhibitor-1 have improved skeletal muscle regeneration
    Timothy J Koh
    Department of Movement Sciences M C 194, University of Illinois at Chicago, 901 W Roosevelt Rd, Chicago, Illinois 60608, USA
    Am J Physiol Cell Physiol 289:C217-23. 2005
    ..Specifically, mice deficient in either urokinase-type plasminogen activator (uPA-/- mice) or plasminogen demonstrate markedly impaired muscle regeneration after injury...
  21. pmc The plasminogen activator/plasmin system is essential for development of the joint inflammatory phase of collagen type II-induced arthritis
    Jinan Li
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Am J Pathol 166:783-92. 2005
    ..used the autoimmune collagen type II (CII)-induced arthritis (CIA) model and mice deficient for urokinase-type PA (uPA) or plasminogen to investigate the role of the PA system for development of arthritis...
  22. ncbi The effect of tissue type-plasminogen activator deletion and associated fibrin(ogen) deposition on macrophage localization in peritoneal inflammation
    Andrew D Cook
    Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Royal Parade, Parkville, 3010, Victoria, Australia
    Thromb Haemost 95:659-67. 2006
    ..Peritoneal inflammation in t-PA-/- mice represents a useful model to study the progression of intra-abdominal adhesions during surgery and clinical peritonitis...
  23. pmc Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice
    Leif R Lund
    Finsen Laboratory, Rigshospitalet, Strandboulevarden 49, Copenhagen, Denmark
    EMBO J 25:2686-97. 2006
    Simultaneous ablation of the two known activators of plasminogen (Plg), urokinase-type (uPA) and the tissue-type (tPA), results in a substantial delay in skin wound healing...
  24. ncbi Involvement of the urokinase kringle domain in lipopolysaccharide-induced acute lung injury
    Xue Qing Wang
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, and Health Services Center, Denver, CO 80262, USA
    J Immunol 177:5550-7. 2006
    Urokinase plasminogen activator (uPA) plays a major role in fibrinolytic processes and also can potentiate LPS-induced neutrophil activation through interactions with its kringle domain (KD)...
  25. pmc Intraperitoneal injection of a hairpin RNA-expressing plasmid targeting urokinase-type plasminogen activator (uPA) receptor and uPA retards angiogenesis and inhibits intracranial tumor growth in nude mice
    Christopher S Gondi
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois 61605, USA
    Clin Cancer Res 13:4051-60. 2007
    The purpose of this study was to evaluate the therapeutic potential of using plasmid-expressed RNA interference (RNAi) targeting urokinase-type plasminogen activator (uPA) receptor (uPAR) and uPA to treat human glioma.
  26. doi Urokinase-type plasminogen activator receptor (uPAR) augments brain damage in a murine model of ischemic stroke
    Nobuo Nagai
    Department of Physiology, Kinki University School of Medicine, Ohnohigashi 377 2, Osakasayama, Osaka 589 8511, Japan
    Neurosci Lett 432:46-9. 2008
    ..by permanent middle cerebral artery (MCA) occlusion in mice with genetic deficiency of uPAR (uPAR(-/-)) or of uPA (uPA(-/-)). Brain damage at 3 days was smaller in uPAR(-/-) mice (4.5+/-1...
  27. ncbi Urokinase-type plasminogen activator plays essential roles in macrophage chemotaxis and skeletal muscle regeneration
    Scott C Bryer
    Department of Movement Sciences, University of Illinois, Chicago 60612, USA
    J Immunol 180:1179-88. 2008
    ..Mice deficient in urokinase-type plasminogen activator (uPA-/-) exhibit decreased accumulation of macrophages following muscle injury and severely impaired muscle regeneration...
  28. pmc Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvement
    Andrew D Cook
    Arthritis and Inflammation Research Centre, Department of Medicine, The University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia
    Arthritis Res Ther 12:R37. 2010
    ..The aim of the current study is to determine how u-PA might be acting in systemic arthritis models...
  29. pmc Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation
    Brian M Connolly
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 116:1593-603. 2010
    ..Here, we developed a new mouse strain (Plau(GFDhu/GFDhu)) in which the interaction between endogenous uPA and uPAR is selectively abrogated, whereas other ..
  30. pmc Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice
    Annika Jögi
    Finsen Laboratory, Copenhagen University Hospital, Copenhagen Biocenter, Copenhagen, Denmark
    PLoS ONE 5:e12746. 2010
    ..closure as have mice simultaneously lacking the two plasminogen activators, urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA)...
  31. pmc Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis in mice
    Yongzhi Guo
    Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
    PLoS ONE 6:e24774. 2011
    ..study, by using mice lacking genes for plasminogen, tissue-type plasminogen activator (tPA), and urokinase-type PA (uPA), we have investigated the functional roles of active plasmin in infection and sepsis...
  32. ncbi Urokinase is required for T lymphocyte proliferation and activation in vitro
    M R Gyetko
    Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, USA
    J Lab Clin Med 133:274-88. 1999
    We have previously demonstrated that urokinase-deficient (uPA-/-) mice do not increase lung T lymphocyte number and fail to mount protective immune responses during pulmonary Cryptococcus neoformans infection...
  33. ncbi Characterization of the murine plasminogen/urokinase-type plasminogen-activator system
    H R Lijnen
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Eur J Biochem 241:840-8. 1996
    ..However, quantitative differences were observed both in the presence of cells and in plasma which may contribute to a reduced u-PA-mediated fibrinolytic activity in the murine systems...
  34. ncbi Urokinase but not tissue plasminogen activator mediates arterial neointima formation in mice
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Circ Res 81:829-39. 1997
    ..Thus, u-PA plays a significant role in vascular wound healing and arterial neointima formation after injury, most likely by affecting cellular migration...
  35. ncbi Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infection
    M R Gyetko
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Immunol 165:1513-9. 2000
    Leukocytes express both urokinase-type plasminogen activator (uPA) and the urokinase receptor (uPAR, CD87). Evidence in vitro has implicated uPAR as a modulator of beta2 integrin function, particularly CR3 (CD11b/CD18, Mac-1)...
  36. ncbi Urokinase-dependent plasminogen activation is required for efficient skeletal muscle regeneration in vivo
    F Lluis
    Centre d Oncologia Molecular, Institut de Recerca Oncologica, Barcelona, Spain
    Blood 97:1703-11. 2001
    Plasminogen activators urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA) are extracellular proteases involved in various tissue remodeling processes...
  37. ncbi Plasmin activity is required for myogenesis in vitro and skeletal muscle regeneration in vivo
    Monica Suelves
    Centre d Oncologia Molecular, Institut de Recerca Oncologica, Barcelona, Spain
    Blood 99:2835-44. 2002
    ..is generated from proteolytic cleavage of the zymogen plasminogen (Plg) by urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA)...
  38. ncbi Localization of four new markers to pig chromosomes 1, 6, and 14 by radioactive in situ hybridization
    C H Mellink
    Laboratoire de Genetique Cellulaire, Centre INRA Toulouse, France
    Cytogenet Cell Genet 64:256-60. 1993
    ..for glucose regulated protein, 78kDal (GRP78), hormone-sensitive lipase (LIPE), plasminogen activator or urokinase (PLAU), and D-amino acid oxidase (DAO) were localized in the pig by radioactive in situ hybridization...
  39. pmc Urokinase is required for the pulmonary inflammatory response to Cryptococcus neoformans. A murine transgenic model
    M R Gyetko
    Department of Internal Medicine, Ann Arbor Veterans Affairs Medical Center and University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Clin Invest 97:1818-26. 1996
    Urokinase (uPA) is hypothesized to provide proteolytic activity enabling inflammatory cells to traverse tissues during recruitment, and it is implicated as a cytokine modulator...
  40. ncbi Sequence and chromosomal localization of mouse annexin XI
    M P Fernandez
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Oviedo, Spain
    Genomics 37:366-74. 1996
    ..The Anx11 gene localized to mouse chromosome 14 in close linkage with the Rarb, Plau, and Wnt5a genes near the centromere and 1.8 cM distal from the Anx7 gene...
  41. ncbi Genetic analysis of the plasminogen and coagulation system in mice
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Vlaams Interuniversitair Instituut voor Biotechnologie, Leuven, Belgium
    Haemostasis 26:132-53. 1996
    ....
  42. ncbi Urokinase is a positive regulator of epidermal proliferation in vivo
    P J Jensen
    Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia 19104 6142, USA
    J Invest Dermatol 112:240-4. 1999
    ..We recently proposed that a proteinase, urokinase-type plasminogen activator (uPA) may be added to this list, based on correlative evidence linking expression of uPA and murine epidermal ..
  43. pmc Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis
    S P Oh
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 97:2626-31. 2000
    ..Taken together, our results suggest that the balance between the ALK1 and ALK5 signaling pathways in endothelial cells plays a crucial role in determining vascular endothelial properties during angiogenesis...
  44. ncbi Inhibition of urokinase-type plasminogen activator delays expression of c-jun, activated transforming growth factor beta 1, and matrix metalloproteinase 2 during post-hepatectomy liver regeneration in mice
    Kazuhiko Nomura
    First Department of Surgery, Shinshu University School of Medicine, Asahi 3 1 1, Nagano, Matsumoto 390 8621, Japan
    J Hepatol 36:637-44. 2002
    ..In the present study, we investigated the effect of u-PA on liver regeneration after hepatectomy...
  45. ncbi Ablation of MEK kinase 1 suppresses intimal hyperplasia by impairing smooth muscle cell migration and urokinase plasminogen activator expression in a mouse blood-flow cessation model
    Yan Li
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Circulation 111:1672-8. 2005
    ..Although MEK kinase 1 (MEKK1) has been shown to regulate cell migration and urokinase plasminogen activator (uPA) expression, the precise role of MEKK1 in this process remains unknown.
  46. pmc Synergy between a plasminogen cascade and MMP-9 in autoimmune disease
    Zhi Liu
    Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:879-87. 2005
    ..to experimental BP, while mice deficient in Plg and both tissue Plg activator (tPA) and urokinase Plg activator (uPA) showed delayed and less intense blister formation induced by antibodies to BP180...
  47. ncbi Urokinase-type plasminogen activator mRNA is expressed in normal developing teeth and leads to abnormal incisor enamel in alpha MUPA transgenic mice
    Ruth Miskin
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel
    Transgenic Res 15:241-54. 2006
    The urokinase-type plasminogen activator (uPA) is a secreted, inducible serine protease implicated in extracellular proteolysis and tissue remodeling...
  48. doi A cyclic peptidylic inhibitor of murine urokinase-type plasminogen activator: changing species specificity by substitution of a single residue
    Lisbeth M Andersen
    Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, 8000 Aarhus C, Denmark
    Biochem J 412:447-57. 2008
    b>uPA (urokinase-type plasminogen activator) is a potential therapeutic target in a variety of pathological conditions, including cancer...
  49. pmc Regulation of airway contractility by plasminogen activators through N-methyl-D-aspartate receptor-1
    Taher Nassar
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, 513A Stellar Chance, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Am J Respir Cell Mol Biol 43:703-11. 2010
    ..Both tissue-type PA (tPA) and urokinase-type PA (uPA) bind to NMDA-R1 and reverse this effect, thereby enhancing Ach-induced tracheal contractility...
  50. pmc Modulation of cellular migration and survival by c-Myc through the downregulation of urokinase (uPA) and uPA receptor
    Daniela Alfano
    Institute of Genetics and Biophysics Adriano Buzzati Traverso, Consiglio Nazionale delle Ricerche CNR, Via P Castellino 111, 80131 Naples, Italy
    Mol Cell Biol 30:1838-51. 2010
    ..Transcriptome analysis revealed that urokinase (uPA) and uPA receptor (uPAR) were strongly downregulated by c-Myc...
  51. pmc Suppression of uPA and uPAR attenuates angiogenin mediated angiogenesis in endothelial and glioblastoma cell lines
    Hari Raghu
    Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, Peoria, Illinois, United States of America
    PLoS ONE 5:e12458. 2010
    In our earlier reports, we showed that downregulation of uPA and uPAR inhibited glioma tumor angiogenesis in SNB19 cells, and intraperitoneal injection of a hairpin shRNA expressing plasmid targeting uPA and uPAR inhibited angiogenesis ..
  52. pmc Urokinase-type plasminogen activator and arthritis progression: contrasting roles in systemic and monoarticular arthritis models
    Christine M De Nardo
    Department of Medicine, Arthritis and Inflammation Research Centre, The University of Melbourne, Royal Parade, Parkville, Melbourne, Victoria 3010, Australia
    Arthritis Res Ther 12:R199. 2010
    ....
  53. doi SMAD3 is essential for transforming growth factor-β1-induced urokinase type plasminogen activator expression and migration in transformed keratinocytes
    Jelena Kocic
    Laboratory for Experimental Hematology, Institute for Medical Research, University of Belgrade, Dr Subotica 4, PO Box 102, 11129 Belgrade, Serbia
    Eur J Cancer 48:1550-7. 2012
    ..In the present study, we analysed the role of TGF-β1-induced Smad3 activation in the urokinase type plasminogen activator (uPA) production, as well as in cell migration and E-cadherin downregulation in transformed PDV ..
  54. doi Neuroprotection by urokinase plasminogen activator in the hippocampus
    Eunsil Cho
    Asan Institute for Life Sciences, Asan Medical Center, Seoul 138 736, Republic of Korea
    Neurobiol Dis 46:215-24. 2012
    Tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), which are both used for thrombolytic treatment of acute ischemic stroke, are serine proteases that convert plasminogen to active plasmin...
  55. pmc Gene expression profiles in genetically different mice infected with Toxoplasma gondii: ALDH1A2, BEX2, EGR2, CCL3 and PLAU
    Hassan Ahmed Hassan Ahmed Ismail
    Department of Infection Biology, Research Institute for Medical Science, Chungnam National University School of Medicine, Daejeon 301 131, Korea
    Korean J Parasitol 50:7-13. 2012
    ..gondii infection is not known much. We selected 5 genes (ALDH1A2, BEX2, CCL3, EGR2 and PLAU) and compared the mRNA expression levels in the spleen, liver, lung and small intestine of genetically different ..
  56. pmc Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression
    Victoria Stepanova
    From the Departments of Pathology and Laboratory Medicine and
    J Biol Chem 291:15029-45. 2016
    Urokinase-type plasminogen activator (uPA) regulates angiogenesis and vascular permeability through proteolytic degradation of extracellular matrix and intracellular signaling initiated upon its binding to uPAR/CD87 and other cell ..
  57. pmc Regulation of lung injury and fibrosis by p53-mediated changes in urokinase and plasminogen activator inhibitor-1
    Yashodhar P Bhandary
    Texas Lung Injury Institute, Center for Biomedical Research, University of Texas Health Science Center at Tyler, Tyler, Texas 75708, USA
    Am J Pathol 183:131-43. 2013
    ..lung injury to understand the involvement of p53-mediated changes in urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) levels in the regulation of alveolar epithelial injury...
  58. ncbi Mapping HSA10 homologous loci in cattle
    D S Threadgill
    Department of Veterinary Pathology, Texas A and M University, College Station 77843
    Cytogenet Cell Genet 57:123-6. 1991
    ..on HSA10 and MMU10; retinol-binding protein 3 (RBP3) on HSA10 and MMU14; plasminogen activator, urokinase type (PLAU) on HSA10 and MMU14; and alpha-2-adrenergic receptor (ADRA2) on HSA10 and MMU19...
  59. pmc Constitutive expression of the urokinase plasminogen activator gene in murine RAW264 macrophages involves distal and 5' non-coding sequences that are conserved between mouse and pig
    A I Cassady
    Centre for Molecular Biology and Biotechnology, University of Queensland, Brisbane, Australia
    Nucleic Acids Res 19:6839-47. 1991
    The 5' flanking regions of the mouse and pig urokinase plasminogen activator (uPA) genes were sequenced and sequence homology interrupted by repeat elements was found to extend to -4.6kb in pig and -6.6kb in mouse...
  60. ncbi Genomic organization and chromosomal location of the mouse type I BMP-2/4 receptor
    Y Mishina
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston 77030
    Biochem Biophys Res Commun 206:310-7. 1995
    ..Bmpr is closely linked to Rbp3 in the region containing pugnose, a mutation that alters bone development. Knowledge of the genomic structure of Bmpr provides important information to create Bmpr-deficient mice...
  61. ncbi The murine mannose-binding protein genes (Mbl 1 and Mbl 2) localize to chromosomes 14 and 19
    R A White
    Section of Genetics, Children s Mercy Hospital UMKC School of Medicine 64108
    Mamm Genome 5:807-9. 1994
  62. ncbi Analysis of CAG trinucleotide repeats from mouse cDNA sequences
    C Abbott
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Ann Hum Genet 58:87-94. 1994
    ..Sinh1b maps very distally on the X chromosome, and Chat maps to chromosome 14...
  63. ncbi Mesenchymal-epithelial interactions and transforming growth factor-beta expression during mouse prostate morphogenesis
    T L Timme
    Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030
    Endocrinology 134:1039-45. 1994
    ....
  64. ncbi Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesis
    M Melnick
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles 90089 0641, USA
    Dev Dyn 211:11-25. 1998
    ..IGF-II receptor (IGF-IIR), IGF-IR, TGF-beta, plasminogen, plasminogen activators [urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA)], and Cdk4 in developing palates; 2) on embryonic day 14 (E14), which is a ..
  65. ncbi Chromosomal mapping of five mouse G protein gamma subunits
    G B Downes
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri, 63110, USA
    Genomics 57:173-6. 1999
    ..Combined with previous mapping studies, these data indicate that, with the possible exception of gamma1 and gamma11, the G protein gamma subunit genes are well dispersed within the mouse and human genomes...
  66. ncbi Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice
    N Nagai
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Center for Molecular and Vascular Biology, KU Leuven, Belgium
    Circulation 99:2440-4. 1999
    ..ischemic infarction (FCI) was studied in mice deficient in plasminogen (Plg-/-), in tissue or urokinase plasminogen activator (tPA-/- or uPA-/-), or in plasminogen activator inhibitor-1 or alpha2-antiplasmin (PAI-1(-/-) or alpha2-AP-/-).
  67. ncbi Urokinase mediates fibrinolysis in the pulmonary microvasculature
    K Bdeir
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Blood 96:1820-6. 2000
    The role of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in fibrinolysis remains unsettled...
  68. ncbi Heregulin inhibits proliferation via ERKs and phosphatidyl-inositol 3-kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells
    Lydia Puricelli
    Instituto de Oncologia Angel H Roffo, Universidad de Buenos Aires, Argentina
    Int J Cancer 100:642-53. 2002
    ..HRGbeta1 was also able to decrease the activity of urokinase-type plasminogen activator (uPA) and matrix metalloproteinase 9 (MMP-9), 2 key enzymes in the invasion and metastatic cascade...
  69. ncbi Plasminogen directs the pleiotropic effects of uPA in liver injury and repair
    Angela R Currier
    Division of Gastroenterology, Hepatology, and Nutrition, Children s Hospital Research Foundation and Department of Pediatrics, University of Cincinnati, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Physiol Gastrointest Liver Physiol 284:G508-15. 2003
    The urokinase-type plasminogen activator (uPA) plays a central role in liver repair. Nevertheless, the hepatic overexpression of uPA results in panlobular injury and neonatal mortality...
  70. ncbi Mice without uPA, tPA, or plasminogen genes are resistant to experimental choroidal neovascularization
    Jean Marie Rakic
    Department of Ophthalmology, University Hospital, Sart Tilman, Liege, Belgium
    Invest Ophthalmol Vis Sci 44:1732-9. 2003
    ..To evaluate the presence and potential involvement of members of the plasminogen/plasminogen activator (Plg/PA) system in the exudative form of age-related macular degeneration (AMD)...
  71. ncbi Overexpression of urokinase by macrophages or deficiency of plasminogen activator inhibitor type 1 causes cardiac fibrosis in mice
    Hideaki Moriwaki
    Department of Medicine, University of Washington, Seattle, WA 98195 7710, USA
    Circ Res 95:637-44. 2004
    ..Because absence of urokinase plasminogen activator (uPA) prevents development of cardiac fibrosis after experimental myocardial infarction in mice, we hypothesized that ..
  72. pmc Fibrin-induced skin fibrosis in mice deficient in tissue plasminogen activator
    Alexander de Giorgio-Miller
    Department of Medicine, University College London, Rayne Institute, London, UK
    Am J Pathol 167:721-32. 2005
    ..Collagen accumulation was significantly increased in the presence of inhibitor and in tPA-deficient, but not uPA-deficient, fibroblasts compared with controls...
  73. ncbi Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells
    Zhiyong Mi
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Carcinogenesis 27:1134-45. 2006
    ..OPN, integrin-linked kinase (ILK), matrix metalloproteinase-2 (MMP-2) and urokinase-type plasminogen activator (uPA) expression in contrast to 4T07 cells...
  74. ncbi c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells
    YongZhong Hou
    Department of Physiology, Kinki University School of Medicine, Ohnohigashi 377 2, Osakasayama, Osaka 589 8511, Japan
    Cardiovasc Res 75:186-94. 2007
    The purpose of this study was to investigate whether c-Myc regulates expression of urokinase plasminogen activator (uPA) on hypoxia-induced vascular smooth muscle cells (VSMCs).
  75. ncbi Male fertility and protein C inhibitor/plasminogen activator inhibitor-3 (PCI): localization of PCI in mouse testis and failure of single plasminogen activator knockout to restore spermatogenesis in PCI-deficient mice
    Pavel Uhrin
    Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
    Fertil Steril 88:1049-57. 2007
    ..To investigate the mechanisms responsible for the testicular abnormalities and infertility of previously generated male protein C inhibitor (PCI)-deficient mice...
  76. ncbi Lack of urokinase plasminogen activator promotes progression and instability of atherosclerotic lesions in apolipoprotein E-knockout mice
    Claudia Dellas
    Department of Cardiology and Pulmonology, Georg August University School of Medicine, Robert Koch Strasse 40, 37099 Goettingen, Germany
    Thromb Haemost 98:220-7. 2007
    Urokinase plasminogen activator (uPA) is strongly expressed in atherosclerotic lesions, but the overall effect of the protease on plaque composition and growth remains controversial...
  77. ncbi Urokinase-type plasminogen activator and macrophages are required for skeletal muscle hypertrophy in mice
    Dana M DiPasquale
    Department of Movement Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am J Physiol Cell Physiol 293:C1278-85. 2007
    ..The hypothesis of this study was that the extracellular serine protease, urokinase-type plasminogen activator (uPA), is required for muscle hypertrophy, in part by promoting macrophage accumulation in muscle subjected to increased ..
  78. ncbi A urokinase-type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice
    V A Ploplis
    WM Keck Center for Transgene Research, University of Notre Dame, Notre Dame, IN 46556, USA
    J Pathol 213:266-74. 2007
    ..In the current study, a mouse model of colon cancer, Apc(Min/+), with an additional deficiency of uPA (Apc(Min/+)/Plau-/-) was used to determine the effects of uPA on tumour initiation and growth...
  79. ncbi Modification of kidney barrier function by the urokinase receptor
    Changli Wei
    Nephrology Division and Program in Glomerular Disease, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Med 14:55-63. 2008
    ..Blockade of alphavbeta3 integrin reduces podocyte motility in vitro and lowers proteinuria in mice. Our findings show a physiological role for uPAR signaling in the regulation of kidney permeability...
  80. ncbi Intracellular localization of protein C inhibitor (PCI) and urinary plasminogen activator in renal tubular epithelial cells from humans and human PCI gene transgenic mice
    Zhenhu Song
    Department of Molecular Pathobiology, Mie University Graduate School of Medicine, Tsu City, Mie 514 8507, Japan
    Histochem Cell Biol 128:293-300. 2007
    Urinary plasminogen activator (uPA) is a serine protease that plays important roles in various extracellular proteolytic processes...
  81. ncbi Renal urokinase-type plasminogen activator (uPA) receptor but not uPA deficiency strongly attenuates ischemia reperfusion injury and acute kidney allograft rejection
    Faikah Gueler
    Department of Nephrology, Medical School Hannover, Hannover, Germany
    J Immunol 181:1179-89. 2008
    ..rejection are apoptosis and inflammation, processes highly regulated by the urokinase-type plasminogen activator (uPA) and its specific receptor (uPAR)...
  82. pmc SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis
    Nesrine El-Bizri
    Cardiopulmonary Research Program, Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine, Stanford, California, CA, USA
    Development 135:2981-91. 2008
    ..Thus, loss of Bmpr1a, by decreasing MMP2 and/or MMP9 activity, can account for vascular dilatation and persistence of brain microvessels, leading to the impaired organogenesis documented in the brain...
  83. doi Plasminogen activators are involved in the degradation of bone by osteoclasts
    Vincent Everts
    Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam ACTA, Universiteit van Amsterdam and Vrije Universiteit, Research Institute MOVE, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Bone 43:915-20. 2008
    ..findings suggest that the two types of plasminogen activators (PA), the tissue- and urokinase-type PA (tPA and uPA, respectively) are also involved in this process...
  84. doi Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator
    Tina Van Den Broeck
    Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium
    Blood 112:5046-51. 2008
    ..triggering of Ly49E by the completely distinct, non-MHC-related protein urokinase plasminogen activator (uPA)...
  85. pmc The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi
    Joppe W R Hovius
    Center for Experimental and Molecular Medicine CEMM, Academic Medical Center, University of Amsterdam, AMC, Amsterdam, The Netherlands
    PLoS Pathog 5:e1000447. 2009
    ..uPAR not only acts as a proteinase receptor, but can also, dependently or independently of ligation to uPA, directly affect leukocyte function...
  86. pmc Overexpression of urokinase by plaque macrophages causes histological features of plaque rupture and increases vascular matrix metalloproteinase activity in aged apolipoprotein e-null mice
    Jie Hong Hu
    Department of Medicine, University of Washington School of Medicine, Seattle 98159 7710, USA
    Circulation 121:1637-44. 2010
    The mechanisms of atherosclerotic plaque rupture are poorly understood. Urokinase-type plasminogen activator (uPA) is expressed at elevated levels by macrophages in advanced human plaques...
  87. doi Urokinase-type plasminogen activator contributes to heterogeneity of macrophages at the border of damaged site during liver repair in mice
    N Kawao
    Department of Physiology, Kinki University Faculty of Medicine, Osakasayama, Japan
    Thromb Haemost 105:892-900. 2011
    ..These data indicate that u-PA mediates the accumulation of macrophages and their phenotypic heterogeneity at the border of damaged sites through u-PAR-independent mechanisms...
  88. pmc Plasminogen activator promotes recovery following spinal cord injury
    NICHOLAS SEEDS
    Department of Biochemistry and Molecular Genetics, and Neuroscience Program, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Cell Mol Neurobiol 31:961-7. 2011
    ..genes in the plasminogen activator/plasmin system has shown that induction of urokinase plasminogen activator (uPA) is required during the first hour after a C2-hemisection for the acquisition of the CPP response...
  89. ncbi A Tcra congenic mouse: V alpha epitope expression is influenced by both Tcra haplotypes and background genes
    L Gleditsch
    Institute of Immunology and Rheumatology, University of Oslo, Norway
    Immunogenetics 35:153-60. 1992
    ..However, BALB/c mice have fewer V beta 11+ T cells than B10.D2 and B10.D2-Tcraa, therefore, the BALB/c genome must harbor a V beta 11 deleting gene(s) in addition to those described so far...
  90. ncbi An interspecific backcross linkage map of the proximal half of mouse chromosome 14
    J D Ceci
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
    Genomics 6:673-8. 1990
    ..Loci that were mapped in this study include Bmp-1, Ctla-1, Hap, hr, Plau, Psp-2, Rib-1, and Tcra...
  91. ncbi The murine urokinase-type plasminogen activator gene
    S J Degen
    Division of Basic Science Research, Children s Hospital Research Foundation, Cincinnati, Ohio 45229
    Biochemistry 26:8270-9. 1987
    The murine urokinase-type plasminogen activator (uPA) gene has been isolated from a BALB/c liver DNA cosmid library and its nucleotide sequence established. The gene is organized into 11 exons comprising 34...
  92. ncbi Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome
    A Patapoutian
    Division of Biology 156 29, California Institute of Technology, Pasadena 91125, USA
    Development 121:3347-58. 1995
    ..Finally, a later and relatively mild phenotype was detected in intercostal muscles of newborn animals...
  93. ncbi Developmental expression of mouse stromelysin-3 mRNA
    O Lefebvre
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM U184 ULP, Illkirch, C U de Strasbourg, France
    Development 121:947-55. 1995
    ....
  94. ncbi Localization of urokinase-type plasminogen activator mRNA in the adult mouse brain
    T Masos
    Department of Biochemistry, Weizmann Institute of Science, Rehovot, Israel
    Brain Res Mol Brain Res 35:139-48. 1996
    Urokinase-type plasminogen activator (uPA) is an inducible serine protease, secreted by a variety of cell types, that functions in fibrinolysis and has been implicated also in events such as cell migration and tissue remodeling and ..
  95. pmc A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state
    H Weiler-Guettler
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 101:1983-91. 1998
    ..The thrombomodulin-deficient animals provide a murine model to examine known or identify unknown genetic and environmental factors that lead to the development of thrombosis...
  96. pmc Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition
    D J Pinsky
    Columbia University College of Physicians and Surgeons, New York 10032, USA
    J Clin Invest 102:919-28. 1998
    ..in contrast, transcripts for both tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) decreased under hypoxic conditions...
  97. pmc JunB is essential for mammalian placentation
    M Schorpp-Kistner
    Deutsches Krebsforschungszentrum Heidelberg, Abteilung für Signaltransduktion und Wachstumskontrolle, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    EMBO J 18:934-48. 1999
    ..JunB causes a deregulation of proliferin, matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator (uPA) gene expression, resulting in a defective neovascularization of the decidua...
  98. pmc A murine model of myocardial microvascular thrombosis
    P D Christie
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 104:533-9. 1999
    ..TM) gene, the tissue-type plasminogen activator (tPA) gene, and the urokinase-type plasminogen activator (uPA) gene...
  99. pmc The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system
    C M Swaisgood
    Joseph J Jacobs Center for Thrombosis and Vascular Biology and the Department of Molecular Cardiology, Cleveland Clinic Foundation, OH, USA
    Am J Pathol 157:177-87. 2000
    ..Absence of these two components of the fibrinolytic system, either urokinase or plasminogen, results in accelerated fibrosis...
  100. ncbi Mouse carotid artery ligation induces platelet-leukocyte-dependent luminal fibrin, required for neointima development
    T Kawasaki
    Center for Molecular and Vascular Biology, University of Leuven, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Circ Res 88:159-66. 2001
    ..Delayed coagulation then results in formation of a fibrin matrix, which is used by smooth muscle cells to migrate into the lumen...
  101. ncbi Deficiency of urokinase-type plasminogen activator-mediated plasmin generation impairs vascular remodeling during hypoxia-induced pulmonary hypertension in mice
    M Levi
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
    Circulation 103:2014-20. 2001
    ..Chronic hypoxia results in the development of pulmonary hypertension and subsequent right heart failure. A role of the plasminogen system in the pathogenesis of pulmonary hypertension and pulmonary vascular remodeling has been suggested...

Research Grants6

  1. THE ROLE OF UROKINASE IN LUNG T LYMPHOCYTE RESPONSES
    MARGARET GYETKO; Fiscal Year: 2003
    We have demonstrated that uPA is required for effective pulmonary defense against Cryptococcus neoformans (C. neo) infection in vivo. Host defense against C. neo is absolutely T cell dependent...
  2. PLASMIN, FIBRIN, AND METALLOPROTEINASES IN LUNG FIBROSIS
    Thomas Sisson; Fiscal Year: 2004
    ..This impaired activity occurs from an imbalance between urokinase-type plasminogen activator (uPA) and its major inhibitor, plasminogen activator inhibitor-1 (PAI-1)...
  3. The Mechanism of IVIG Action in Pemphigus
    Zhi Liu; Fiscal Year: 2006
    ..The overall goal of this project is to study the mechanisms of WIG action in autoantibody-mediated diseases and develop novel therapies to replace current immunosuppressive treatments, which confer severe side effects. ..
  4. Mechanisms of cardiac fibrosis
    April Stempien Otero; Fiscal Year: 2006
    ..Recent work in the Dichek lab has indicated a possible role for urokinase plasminogen activator(uPA) in cardiac fibrosis...
  5. Biomarkers for VEGF and mTOR Blockade in Advanced Renal Cancer
    Jaime Merchan; Fiscal Year: 2007
    ..This information will be extremely useful for the design of future trials using these agents in renal and other cancers and for future clinical practice. [unreadable] [unreadable] [unreadable]..
  6. PATHOLOGICAL CONSEQUENCES OF THE PLASMINOGEN SYSTEM
    Victoria Ploplis; Fiscal Year: 2010
    ..2.) Characterize early and late stage events of cardiac fibrosis in PAI-1-/- and uPA-/-/PAI-1-/- mice...