Pknox1

Summary

Gene Symbol: Pknox1
Description: Pbx/knotted 1 homeobox
Alias: D17Wsu76e, PREP1, PBX/knotted homeobox 1, homeobox protein PKNOX1
Species: mouse

Top Publications

  1. pmc Homeodomain transcription factor and tumor suppressor Prep1 is required to maintain genomic stability
    Giorgio Iotti
    IFOM Istituto Fondazione Italiana per la Ricerca sul Cancro di Oncologia Molecolare, 20139 Milan, Italy
    Proc Natl Acad Sci U S A 108:E314-22. 2011
  2. pmc p160 Myb-binding protein interacts with Prep1 and inhibits its transcriptional activity
    Victor M Diaz
    Molecular Genetics Unit, Department of Molecular Biology and Functional Genomics, Università Vita Salute San Raffaele and DIBIT, H San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Mol Cell Biol 27:7981-90. 2007
  3. doi Prep1 (pKnox1)-deficiency leads to spontaneous tumor development in mice and accelerates EmuMyc lymphomagenesis: a tumor suppressor role for Prep1
    E Longobardi
    Universita Vita Salute San Raffaele, Via Olgettina 60, Milano 20132, Italy
    Mol Oncol 4:126-34. 2010
  4. pmc Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1
    Mohamad Zubair
    Division of Sex Differentiation, National Institute for Basic Biology, Myodaiji cho, Okazaki 444 8787, Japan
    Mol Cell Biol 26:4111-21. 2006
  5. doi The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells
    Luis C Fernandez-Diaz
    IFOM, FIRC Institute of Molecular Oncology Foundation, IFOM IEO Campus, Via Adamello 16, Milan, Italy
    Development 137:3393-403. 2010
  6. ncbi Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation
    L Selleri
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 128:3543-57. 2001
  7. pmc Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1
    P S Knoepfler
    Department of Pathology, University of California at San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 94:14553-8. 1997
  8. pmc Prep1 directly regulates the intrinsic apoptotic pathway by controlling Bcl-XL levels
    Nicola Micali
    Laboratory of Molecular Genetics, DIBIT, S Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Mol Cell Biol 29:1143-51. 2009
  9. ncbi Expression of Hox cofactor genes during mouse ovarian follicular development and oocyte maturation
    J Carlos Villaescusa
    Department of Cell Biology and Functional Genomics, DIBIT, H San Raffaele, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Gene 330:1-7. 2004
  10. ncbi PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C
    J Berthelsen
    Unit of Molecular Genetics, H S Raffaele, Milan, Italy
    Genomics 47:323-4. 1998

Scientific Experts

  • Paola Sgadò
  • Muriel Davisson
  • L Selleri
  • P S Knoepfler
  • Francesco Blasi
  • Giorgio Iotti
  • Elisabetta Ferretti
  • Elena Longobardi
  • Nicola Micali
  • J Carlos Villaescusa
  • Victor M Diaz
  • Xin Zhang
  • Francesco Oriente
  • Dmitry Penkov
  • Luis C Fernandez-Diaz
  • Patrizia Di Rosa
  • Carmelo Ferrai
  • Sheldon Rowan
  • Richard L Maas
  • Wendy Sonnet
  • Andre J Faure
  • Christian Carbe
  • Richard Bisaillon
  • René Rezsohazy
  • E Longobardi
  • Claudia Miele
  • Angela Cassese
  • Rediet Zewdu
  • Massimo P Crippa
  • Francesco Beguinot
  • Salvatore Iovino
  • Pietro Formisano
  • F Blasi
  • Yingzi Yue
  • Terence D Capellini
  • Xavier Lampe
  • Michel A Wassef
  • Silvia Mori
  • Angela Bachi
  • Hirotaka Yoshioka
  • Sungbo Shim
  • Elaine Y Chung
  • Annarita Miccio
  • Anna Mondino
  • Andrea Brendolan
  • Giuliana Ferrari
  • Mohamad Zubair
  • Li Pan
  • Dmitri Penkov
  • Shaun Heaney
  • Janice S Bailey
  • Sheng Hao Chao
  • E Ferretti
  • J Berthelsen
  • Klaus Haller
  • Livia Modica
  • Paul Flicek
  • Robert G Ramsay
  • Maurilio Ponzoni
  • Kristina Hertzler-Schaefer
  • Stefania Mejetta
  • Isabelle Donnay
  • Michael D Wilson
  • Stephen Watt
  • Huiling Xu
  • Petra C Schwalie
  • Duncan T Odom
  • Dominic Schmidt
  • Courtney Karner
  • Jean M Hebert
  • Michael J Depew
  • Victoria Wells
  • Leila Dardaei
  • Paola Ungaro
  • Jana Krosl
  • Michael J Dixon
  • Jill Dixon
  • Guy Sauvageau
  • Serena Cabaro
  • Brian T Wilhelm
  • Matthew J Anderson
  • Francesca De Santis
  • Trevor Williams
  • Bingsi Li
  • Silvia Masella
  • Neal G Copeland
  • F Bianchi
  • L C Fernandez-Diaz
  • M Caniatti
  • Salil A Lachke

Detail Information

Publications42

  1. pmc Homeodomain transcription factor and tumor suppressor Prep1 is required to maintain genomic stability
    Giorgio Iotti
    IFOM Istituto Fondazione Italiana per la Ricerca sul Cancro di Oncologia Molecolare, 20139 Milan, Italy
    Proc Natl Acad Sci U S A 108:E314-22. 2011
    b>Prep1 is a homeodomain transcription factor that is essential in embryonic development and functions in the adult as a tumor suppressor...
  2. pmc p160 Myb-binding protein interacts with Prep1 and inhibits its transcriptional activity
    Victor M Diaz
    Molecular Genetics Unit, Department of Molecular Biology and Functional Genomics, Università Vita Salute San Raffaele and DIBIT, H San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Mol Cell Biol 27:7981-90. 2007
    b>Prep1 is known to interact in vivo with Pbx1 to regulate development and organogenesis. We have identified a novel Prep1-interacting protein, p160 c-Myb binding protein (p160)...
  3. doi Prep1 (pKnox1)-deficiency leads to spontaneous tumor development in mice and accelerates EmuMyc lymphomagenesis: a tumor suppressor role for Prep1
    E Longobardi
    Universita Vita Salute San Raffaele, Via Olgettina 60, Milano 20132, Italy
    Mol Oncol 4:126-34. 2010
    The Prep1 homeodomain transcription factor is essential for embryonic development. 25% of hypomorphic Prep1(i/i) embryos, expressing the gene at 2% of the normal levels, survive pregnancy and live a normal-length life...
  4. pmc Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1
    Mohamad Zubair
    Division of Sex Differentiation, National Institute for Basic Biology, Myodaiji cho, Okazaki 444 8787, Japan
    Mol Cell Biol 26:4111-21. 2006
    ..Using transgenic mice with lacZ driven by the FAdE, we clearly identified a fetal adrenal cortex in mice, and the X zone is the fetal adrenal cells accumulated at the juxtamedullary region after birth...
  5. doi The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells
    Luis C Fernandez-Diaz
    IFOM, FIRC Institute of Molecular Oncology Foundation, IFOM IEO Campus, Via Adamello 16, Milan, Italy
    Development 137:3393-403. 2010
    Disruption of mouse Prep1, which codes for a homeodomain transcription factor, leads to embryonic lethality during post-implantation stages...
  6. ncbi Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation
    L Selleri
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 128:3543-57. 2001
    ..This impacts on the rate of endochondral ossification and bone formation and suggests a mechanistic basis for most of the observed skeletal malformations...
  7. pmc Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1
    P S Knoepfler
    Department of Pathology, University of California at San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 94:14553-8. 1997
    ..Here, we demonstrate that both Meis1 and its relative, pKnox1, dimerize with Pbx1 on the same TGATTGAC motif selected by dimers of Pbx proteins and unidentified partner(s) in ..
  8. pmc Prep1 directly regulates the intrinsic apoptotic pathway by controlling Bcl-XL levels
    Nicola Micali
    Laboratory of Molecular Genetics, DIBIT, S Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Mol Cell Biol 29:1143-51. 2009
    The Prep1 homeodomain transcription factor is essential in embryonic development. Prep1 hypomorphic mutant mouse (Prep1(i/i)) embryos (embryonic day 9...
  9. ncbi Expression of Hox cofactor genes during mouse ovarian follicular development and oocyte maturation
    J Carlos Villaescusa
    Department of Cell Biology and Functional Genomics, DIBIT, H San Raffaele, Universita Vita Salute San Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Gene 330:1-7. 2004
    ....
  10. ncbi PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C
    J Berthelsen
    Unit of Molecular Genetics, H S Raffaele, Milan, Italy
    Genomics 47:323-4. 1998
  11. pmc Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype
    Elisabetta Ferretti
    Laboratory of Molecular Genetics, DIBIT, Via Olgettina 58, 20132 Milano, Italy
    Mol Cell Biol 26:5650-62. 2006
    The interaction of Prep1 and Pbx homeodomain transcription factors regulates their activity, nuclear localization, and likely, function in development...
  12. pmc Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity
    Y Jacobs
    Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA
    Mol Cell Biol 19:5134-42. 1999
    ..Pbx proteins also stably heterodimerize and bind DNA with Meis and Pknox1-Prep1, additional members of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins that ..
  13. pmc Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors
    Dmitri Penkov
    Molecular Genetics Unit, Universita Vita Salute San Raffaele, Milan, Italy
    Mol Cell Biol 25:10768-81. 2005
    b>Prep1 is a homeodomain transcription factor that acts by dimerizing with Pbx. Since Prep1 null embryos die at gastrulation, we studied Prep1(i/i) hypomorphic mice to study the physiological role of Prep1...
  14. ncbi The homeodomain transcription factor Prep1 (pKnox1) is required for hematopoietic stem and progenitor cell activity
    Patrizia Di Rosa
    Laboratory of Molecular Genetics, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy
    Dev Biol 311:324-34. 2007
    ..Miccio, A., Micali, N., Selleri, L., Ferrari G., Blasi, F. (2006). Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype. Mol. Cell. Biol...
  15. pmc Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism
    Francesco Oriente
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Via Sergio Pansini, 5, Naples 80131, Italy
    Mol Cell Biol 28:5634-45. 2008
    We have examined glucose homeostasis in mice hypomorphic for the homeotic transcription factor gene Prep1. Prep1-hypomorphic (Prep1(i/i)) mice exhibit an absolute reduction in circulating insulin levels but normal glucose tolerance...
  16. pmc Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1
    Elaine Y Chung
    Department of Microbiology and Immunology, Medical College of Cornell University, New York, NY 10065, USA
    Immunity 27:952-64. 2007
    ..This study establishes a role of two developmentally critical factors (Pbx1 and Prep-1) in the regulation of homeostasis in the immune system...
  17. pmc Reduction of Prep1 levels affects differentiation of normal and malignant B cells and accelerates Myc driven lymphomagenesis
    Giorgio Iotti
    Laboratory of Transcriptional Regulation in Development and Cancer, Fondazione Istituto FIRC di Oncologia Molecolare, Milano, Italy
    PLoS ONE 7:e48353. 2012
    The Prep1 homeodomain transcription factor has recently been recognized as a tumor suppressor. Among other features, haploinsufficiency of Prep1 is able to strongly accelerate the B-lymphomagenesis in EμMyc mice...
  18. pmc Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules
    Andre J Faure
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
    Genome Res 22:2163-75. 2012
    ..Finally, we observe that the presence of mirrored CTCF binding events at promoters and their nearby cohesin-bound enhancers is associated with elevated expression levels...
  19. doi Characterization of TALE genes expression during the first lineage segregation in mammalian embryos
    Wendy Sonnet
    Embryologie Moléculaire et Cellulaire Animale, Institut des Sciences de la Vie, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Dev Dyn 241:1827-39. 2012
    ..However, very little is known about the expression and function of Meis, Pbx, and Prep genes during early development...
  20. doi C-terminal domain of MEIS1 converts PKNOX1 (PREP1) into a HOXA9-collaborating oncoprotein
    Richard Bisaillon
    University of Montreal, Montreal, QC, Canada
    Blood 118:4682-9. 2011
    The three-amino-acid loop extension (TALE) class homeodomain proteins MEIS1 and PKNOX1 (PREP1) share the ability to interact with PBX and HOX family members and bind similar DNA sequences but appear to play opposing roles in tumor ..
  21. pmc The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development
    Christian Carbe
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Dev Biol 363:320-9. 2012
    ..Finally, we generated conditional knockouts of Prep1 in the lens and pancreas, but surprisingly, did not observe any developmental defects...
  22. pmc The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons
    Paola Sgadò
    Laboratory of Molecular Neuropathology, Centre for Integrative Biology, University of Trento, Trento, Italy
    Neural Dev 7:24. 2012
    ....
  23. pmc Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity
    Sheldon Rowan
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 24:980-5. 2010
    ..Pax6 is a dosage-sensitive gene essential for eye development. Here, we identify the Prep1 (pKnox1) transcription factor as a critical dose-dependent upstream regulator of Pax6 expression during lens formation...
  24. pmc A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis
    Elisabetta Ferretti
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10065, USA
    Dev Cell 21:627-41. 2011
    ..Dysregulation of this network leads to localized suppression of midfacial apoptosis and CL/P. Ectopic Wnt ectodermal expression in Pbx mutants rescues the clefting, opening avenues for tissue repair...
  25. pmc Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress
    Nicola Micali
    Laboratory of Molecular Dynamics of the Nucleus, Division of Genetics and Cell Biology, S Raffaele Scientific Institute, Via Olgettina 60, Milan, Italy
    Nucleic Acids Res 38:3595-604. 2010
    PREP1 (PKNOX1) maps in the Down syndrome (DS) critical region of chromosome 21, is overexpressed in some DS tissues and might be involved in the DS phenotype...
  26. pmc Cytoplasmic Prep1 interacts with 4EHP inhibiting Hoxb4 translation
    J Carlos Villaescusa
    IFOM, FIRC Institute of Molecular Oncology, Milano, Italy
    PLoS ONE 4:e5213. 2009
    ..They are regulated mostly at the transcriptional level. In particular, Prep1 regulates Hox transcription in association with Pbx proteins...
  27. pmc Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase
    Francesco Oriente
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Universita degli Studi di Napoli Federico II, Naples, Italy
    Diabetes 60:138-47. 2011
    We investigated the function of the Prep1 gene in insulin-dependent glucose homeostasis in liver.
  28. doi Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors
    Michel A Wassef
    INSERM, U784, Laboratoire de Génétique Moléculaire du Développement and 46 rue d Ulm, 75230 Paris, France
    Development 135:3369-78. 2008
    ..We propose a model for the complex regulation of Krox20, involving a novel mode of initiation, positive and negative controls by Hox proteins, and multiple direct and indirect autoregulatory loops...
  29. pmc Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis
    Xin Zhang
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 16:2097-107. 2002
    ..Therefore, despite the striking evolutionary conservation of Pax6 function, Pax6 expression in the vertebrate lens is uniquely regulated...
  30. ncbi Prep2: cloning and expression of a new prep family member
    Klaus Haller
    McGill Cancer Centre, McGill University, Montreal, Quebec, Canada
    Dev Dyn 225:358-64. 2002
    We describe Prep2, a new murine homeobox-containing gene closely related to Prep1. The PREP2 protein belongs to the three amino acid loop extension (TALE) superclass of homeodomain-containing proteins and encodes a polypeptide of 462 ..
  31. pmc Identification of homeodomain proteins, PBX1 and PREP1, involved in the transcription of murine leukemia virus
    Sheng Hao Chao
    Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Mol Cell Biol 23:831-41. 2003
    ..in the PCE completely inhibited viral transcription whereas overexpression of PBX1 and a PBX1-associated protein, PREP1, enhanced viral transcription...
  32. pmc Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1
    Janice S Bailey
    Department of Reproductive Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0674, USA
    Mol Endocrinol 18:1158-70. 2004
    ..the protein complex binding to the -134 site contains Smad4 in association with the homeodomain proteins Pbx1 and Prep1. Using glutathione S-transferase interaction assays, we demonstrate that Pbx1 and Prep1 interact with Smads 2 and ..
  33. ncbi Evolutionary breakpoints on human chromosome 21
    M T Davisson
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 78:99-106. 2001
    ..These data suggest that there may be as few as 21 functional genes in the mouse chromosome 17 segment. This information is important for defining existing and constructing more complete mouse models of Down syndrome...
  34. ncbi Activation of the rat renin promoter by HOXD10.PBX1b.PREP1, Ets-1, and the intracellular domain of notch
    Li Pan
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263 0001, USA
    J Biol Chem 280:20860-6. 2005
    ..Finally, we show that the intracellular domain of Notch1, Ets-1, and HOXD10.PBX1b.PREP1 activate the rat renin promoter cooperatively in COS-7 cells...
  35. ncbi Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development
    Xin Zhang
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 W Walnut St, IB244, Indianapolis, IN 46202, USA
    Dev Biol 300:748-57. 2006
    ..As Meis homeoproteins have been previously demonstrated to regulate Pax6 expression during lens development, these results suggest a conserved mechanism of Pax6 regulation by Meis homeoproteins in two different organs...
  36. ncbi Purification of the Prep1 interactome identifies novel pathways regulated by Prep1
    Victor M Diaz
    Molecular Genetics Unit, Department of Molecular Biology and Functional Genomics, Università Vita Salute San Raffaele and DIBIT, H San Raffaele, Milan, Italy
    Proteomics 7:2617-23. 2007
    b>Prep1 homeodomain transcription factor interacts with Pbx proteins to regulate oculogenesis, angiogenesis, and hematopoiesis in mice...
  37. pmc In vivo analysis of developmentally and evolutionarily dynamic protein-DNA interactions regulating transcription of the Pgk2 gene during mammalian spermatogenesis
    Hirotaka Yoshioka
    Department of Biology, University of Texas at San Antonio, San Antonio, Texas 78249, USA
    Mol Cell Biol 27:7871-85. 2007
    ..We found that genes encoding the testis-specific homeodomain factor PBX4 and its coactivator, PREP1, are expressed in patterns that mirror expression of the Pgk2 gene and that these factors become bound to the Pgk2 ..
  38. pmc Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalon
    Sungbo Shim
    Department of Biological Science, Sookmyung Women s University, Chungpa dong 2 Ka, Yongsan Ku, Seoul 140 742, South Korea
    Mol Cell Biol 27:1614-30. 2007
    ..These studies strongly suggest that Meis and Pbx homeobox transcription factors tightly associate with the ephA8 regulatory sequence and require an additional unidentified regulator to ensure the specific activation of ephA8...
  39. pmc An ultraconserved Hox-Pbx responsive element resides in the coding sequence of Hoxa2 and is active in rhombomere 4
    Xavier Lampe
    Unit of Developmental Genetics, Universite Catholique de Louvain, 1200 Brussels, Belgium, Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104 CNRS Inserm ULP, College de France, BP 10142 CU de Strasbourg, 67404 Illkirch Cedex, France
    Nucleic Acids Res 36:3214-25. 2008
    ..In this respect, our data further support the idea that extreme conservation of UCE sequences may be the result of multiple superposed functional and evolutionary constraints...
  40. pmc Cytosolic sequestration of Prep1 influences early stages of T cell development
    Dmitry Penkov
    Molecular Genetics Unit, San Raffaele Scientific Institute and Universita Vita Salute San Raffaele, Milan, Italy
    PLoS ONE 3:e2424. 2008
    b>Prep1 and Pbx2 are the main homeodomain DNA-binding proteins of the TALE (three amino acid loop extension) family expressed in the thymus...
  41. doi Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome
    Terence D Capellini
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Dev Biol 321:500-14. 2008
    ....
  42. ncbi The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse
    E Ferretti
    Molecular Genetics Unit, Department of Biology and Biotechnology DIBIT, H S San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy
    Mech Dev 83:53-64. 1999
    Human PREP1, a novel homeodomain protein of the TALE super-family, forms a stable DNA-binding complex with PBX proteins in solution, a ternary complex with PBX and HOXB1 on DNA, and is able to act as a co-activator in the transcription ..