Gene Symbol: Pkdcc
Description: protein kinase domain containing, cytoplasmic
Alias: AI115348, AW548124, Adtk1, ESTM17, MAd1, Sgk493, Vlk, X83346, extracellular tyrosine-protein kinase PKDCC, protein kinase domain-containing protein, cytoplasmic, protein kinase-like protein SgK493, sugen kinase 493, vertebrate lonesome kinase
Kinoshita M, Era T, Jakt L, Nishikawa S. The novel protein kinase Vlk is essential for stromal function of mesenchymal cells. Development. 2009;136:2069-79 pubmed publisher
..of mouse embryonic stem cells to mesendoderm, we identified a previously uncharacterized kinase, Vlk (vertebrate lonesome kinase), that is well conserved in vertebrates but has no homologs outside of the vertebrate lineage...
Bordoli M, Yum J, Breitkopf S, Thon J, Italiano J, Xiao J, et al
. A secreted tyrosine kinase acts in the extracellular environment. Cell. 2014;158:1033-1044 pubmed publisher
..Here, we show that VLK, a putative protein kinase previously shown to be essential in embryonic development, is a secreted protein kinase, ..
Imuta Y, Nishioka N, Kiyonari H, Sasaki H. Short limbs, cleft palate, and delayed formation of flat proliferative chondrocytes in mice with targeted disruption of a putative protein kinase gene, Pkdcc (AW548124). Dev Dyn. 2009;238:210-22 pubmed publisher
..FPCs and HCs support longitudinal bone growth. Here we show that a putative protein kinase gene, Pkdcc (AW548124), is required for longitudinal bone growth...
Sewell W, Sparrow D, Smith A, Gonzalez D, Rappaport E, Dunwoodie S, et al
. Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis. Dev Biol. 2009;329:400-9 pubmed publisher
..Towards identifying the role of Dll3 in regulating somitogenesis, Nrarp emerges as a potentially important regulator that requires Dll3 but not Lfng for normal function...
Probst S, Kraemer C, Demougin P, Sheth R, Martin G, Shiratori H, et al
. SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling. Development. 2011;138:1913-23 pubmed publisher
..In summary, SHH promotes distal progression of limb development by enhancing CYP26B1-mediated RA clearance as part of a signalling network linking the SHH/GREM1/AER-FGF feedback loop to the newly identified AER-FGF/CYP26B1/RA module. ..
Gonçalves L, Filipe M, Marques S, Salgueiro A, Becker J, Belo J. Identification and functional analysis of novel genes expressed in the Anterior Visceral Endoderm. Int J Dev Biol. 2011;55:281-95 pubmed publisher
..From those four selected genes, one, denominated Adtk1, was chosen to be functionally characterized by targeted inactivation in ES cells...
Probst S, Zeller R, Zuniga A. The hedgehog target Vlk genetically interacts with Gli3 to regulate chondrocyte differentiation during mouse long bone development. Differentiation. 2013;85:121-30 pubmed publisher
..In the absence of Hh signalling, the expression of Vlk (vertebrate lonesome kinase, also called Pkdcc) is increased...