Gene Symbol: Pirt
Description: phosphoinositide-interacting regulator of transient receptor potential channels
Alias: A530088H08Rik, phosphoinositide-interacting protein
Species: mouse
Products:     Pirt

Top Publications

  1. Patel K, Liu Q, Meeker S, Undem B, Dong X. Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch. PLoS ONE. 2011;6:e20559 pubmed publisher
    ..Here we show that Pirt, known to play a vital part in sensing pain through modulation of the transient receptor potential vanilloid 1 (..
  2. Kim A, Tang Z, Liu Q, Patel K, Maag D, Geng Y, et al. Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1. Cell. 2008;133:475-85 pubmed publisher
    ..Its channel activity can be modulated by several mechanisms. Here we identify a membrane protein, Pirt, as a regulator of TRPV1...
  3. Dykes I, Tempest L, Lee S, Turner E. Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation. J Neurosci. 2011;31:9789-99 pubmed publisher
  4. Emery E, Luiz A, Sikandar S, Magnúsdóttir R, Dong X, Wood J. In vivo characterization of distinct modality-specific subsets of somatosensory neurons using GCaMP. Sci Adv. 2016;2:e1600990 pubmed
    ..Together, these studies define polymodality as an infrequent feature of nociceptive neurons in normal animals. ..
  5. Tang M, Wu G, Dong X, Tang Z. Phosphoinositide interacting regulator of TRP (Pirt) enhances TRPM8 channel activity in vitro via increasing channel conductance. Acta Pharmacol Sin. 2016;37:98-104 pubmed publisher
    b>Pirt is a two-transmembrane domain protein that regulates the function of a variety of ion channels. Our previous study indicated that Pirt acts as a positive endogenous regulator of the TRPM8 channel...
  6. Reddy V, Sun S, Azimi E, Elmariah S, Dong X, Lerner E. Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs. Nat Commun. 2015;6:7864 pubmed publisher
    ..The findings also implicate proteases as ligands to members of this orphan receptor family while providing new insights into how cysteine proteases contribute to itch. ..
  7. Wu A, Dvoryanchikov G, Pereira E, Chaudhari N, Roper S. Breadth of tuning in taste afferent neurons varies with stimulus strength. Nat Commun. 2015;6:8171 pubmed publisher
    ..Altogether, our data suggest that taste is encoded by activity in patterns of peripheral sensory neurons and challenge the notion of strict labelled line coding. ..
  8. Wang C, Wang Z, Yang Y, Zhu C, Wu G, Yu G, et al. Pirt contributes to uterine contraction-induced pain in mice. Mol Pain. 2015;11:57 pubmed publisher
    ..The phosphoinositide-interacting regulator of TRP (Pirt) may act as a regulatory subunit of TRPV1...
  9. Weng Y, An R, Cassin J, Joseph J, Mi R, Wang C, et al. An Intrinsic Epigenetic Barrier for Functional Axon Regeneration. Neuron. 2017;94:337-346.e6 pubmed publisher
    ..Together, our study suggests an epigenetic barrier that can be removed by active DNA demethylation to permit axon regeneration in the adult mammalian nervous system. ..

More Information


  1. Gao X, Feng J, Wang W, Xiang Z, Liu X, Zhu C, et al. Pirt reduces bladder overactivity by inhibiting purinergic receptor P2X3. Nat Commun. 2015;6:7650 pubmed publisher
    b>Pirt is a transmembrane protein predominantly expressed in peripheral neurons. However, the physiological and pathological roles of Pirt in hollow viscus are largely unknown...
  2. Tang Z, Kim A, Masuch T, Park K, Weng H, Wetzel C, et al. Pirt functions as an endogenous regulator of TRPM8. Nat Commun. 2013;4:2179 pubmed publisher
    b>Pirt is a membrane protein that is specifically expressed in the peripheral nervous system, where it has been shown to increase the sensitivity of the transient receptor potential vanilloid 1 channel and modulate its role in heat pain...
  3. Rakhilin N, Barth B, Choi J, Muñoz N, Kulkarni S, Jones J, et al. Simultaneous optical and electrical in vivo analysis of the enteric nervous system. Nat Commun. 2016;7:11800 pubmed publisher
    ..The implanted device captures ENS responses to neurotransmitters, drugs and optogenetic manipulation in real time. ..
  4. Kim S, Barry D, Liu X, Yin S, Munanairi A, Meng Q, et al. Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations. Sci Signal. 2016;9:ra71 pubmed publisher
    ..TRP facilitation through the formation of heteromeric complexes could be a prevalent mechanism by which the vast array of somatosensory information is encoded in sensory neurons. ..
  5. Kim Y, Chu Y, Han L, Li M, Li Z, LaVinka P, et al. Central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain. Neuron. 2014;81:873-887 pubmed publisher
    ..Our results reveal central mechanisms facilitating central terminal sensitization underlying chronic pain. ..
  6. Dvoryanchikov G, Hernández D, Roebber J, Hill D, Roper S, Chaudhari N. Transcriptomes and neurotransmitter profiles of classes of gustatory and somatosensory neurons in the geniculate ganglion. Nat Commun. 2017;8:760 pubmed publisher
  7. Weng Y, Wang X, An R, Cassin J, Vissers C, Liu Y, et al. Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System. Neuron. 2018;97:313-325.e6 pubmed publisher
    ..Our study reveals a critical epitranscriptomic mechanism in promoting injury-induced protein synthesis and axon regeneration in the adult mammalian nervous system. ..
  8. Kim Y, Anderson M, Park K, Zheng Q, Agarwal A, Gong C, et al. Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain. Neuron. 2016;91:1085-1096 pubmed publisher
    ..Therefore, neuronal coupling represents a new form of neuronal plasticity in the DRG and contributes to pain hypersensitivity by "hijacking" neighboring neurons through gap junctions. ..