Gene Symbol: Pip5k1b
Description: phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
Alias: PI4P5K-I[b], PIP5K1-beta, PIP5KIbeta, Pipk5b, STM7, phosphatidylinositol 4-phosphate 5-kinase type-1 beta, phosphatidylinositol 4-phosphate 5-kinase type I beta, ptdIns(4)P-5-kinase 1 beta
Species: mouse
Products:     Pip5k1b

Top Publications

  1. Davis J, Rock C, Cheng M, Watson J, Ashmun R, Kirk H, et al. Complementation of growth factor receptor-dependent mitogenic signaling by a truncated type I phosphatidylinositol 4-phosphate 5-kinase. Mol Cell Biol. 1997;17:7398-406 pubmed
    ..These results suggest a role for PIP5K-Ibeta in receptor endocytosis and that the truncated enzyme compensated for a mitogenically defective CSF-1R by interfering with this process. ..
  2. Ishihara H, Shibasaki Y, Kizuki N, Katagiri H, Yazaki Y, Asano T, et al. Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1996;271:23611-4 pubmed
    ..Molecular identification of type I PI4P5K isoforms in insulin-secreting cells should provide insights into the role of phosphatidylinositol metabolism in regulated exocytosis of insulin-containing large dense core vesicles. ..
  3. Sasaki J, Sasaki T, Yamazaki M, Matsuoka K, Taya C, Shitara H, et al. Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J Exp Med. 2005;201:859-70 pubmed
    ..Our results indicate that the different PIPKI isoforms might be functionally specialized. ..
  4. Chang J, Field S, Rameh L, Carpenter C, Cantley L. Identification and characterization of a phosphoinositide phosphate kinase homolog. J Biol Chem. 2004;279:11672-9 pubmed
    ..These results suggest that PIPKH acts as a scaffold to localize and regulate type I PI(4)P 5-kinases and the synthesis of PI(3,4,5)P(3). ..
  5. Wang Y, Chen X, Lian L, Tang T, Stalker T, Sasaki T, et al. Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proc Natl Acad Sci U S A. 2008;105:14064-9 pubmed publisher
    ..that PIP5KI isoforms have nonoverlapping functions, we generated a murine line containing a null mutation of PIP5KIbeta and analyzed the effect on platelet signaling. PIP5KIbeta-null mice had normal platelet counts...
  6. Volpicelli Daley L, Lucast L, Gong L, Liu L, Sasaki J, Sasaki T, et al. Phosphatidylinositol-4-phosphate 5-kinases and phosphatidylinositol 4,5-bisphosphate synthesis in the brain. J Biol Chem. 2010;285:28708-14 pubmed publisher
  7. Guerriero C, Weixel K, Bruns J, Weisz O. Phosphatidylinositol 5-kinase stimulates apical biosynthetic delivery via an Arp2/3-dependent mechanism. J Biol Chem. 2006;281:15376-84 pubmed
    ..Our results suggest a previously unidentified role for actin comet-mediated propulsion in the biosynthetic delivery of a subset of apical proteins. ..
  8. Aoyagi K, Sugaya T, Umeda M, Yamamoto S, Terakawa S, Takahashi M. The activation of exocytotic sites by the formation of phosphatidylinositol 4,5-bisphosphate microdomains at syntaxin clusters. J Biol Chem. 2005;280:17346-52 pubmed
    ..These results suggest that the formation of PI(4,5)P2 microdomains at syntaxin clusters with docked LDCVs is essential for Ca2+-dependent exocytosis. ..
  9. Coppolino M, Dierckman R, Loijens J, Collins R, Pouladi M, Jongstra Bilen J, et al. Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis. J Biol Chem. 2002;277:43849-57 pubmed
    ..PIPKIalpha appears to contribute to the transient changes in PIP(2) levels that are associated with, and likely required for, the recruitment and regulation of actin-modulating proteins. ..

More Information


  1. Yamazaki M, Miyazaki H, Watanabe H, Sasaki T, Maehama T, Frohman M, et al. Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling. J Biol Chem. 2002;277:17226-30 pubmed
  2. Tolias K, Hartwig J, Ishihara H, Shibasaki Y, Cantley L, Carpenter C. Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly. Curr Biol. 2000;10:153-6 pubmed
    ..These results demonstrate that PIP 5-kinase alpha is a critical mediator of thrombin- and Rac-dependent actin assembly. ..
  3. Ishihara H, Shibasaki Y, Kizuki N, Wada T, Yazaki Y, Asano T, et al. Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. J Biol Chem. 1998;273:8741-8 pubmed
    ..Surprisingly, a kinase-deficient substitution mutant also induced an abnormal actin polymerization, suggesting a role of PIP5Ks via structural interactions with other molecules. ..
  4. Vasudevan L, Jeromin A, Volpicelli Daley L, De Camilli P, Holowka D, Baird B. The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells. J Cell Sci. 2009;122:2567-74 pubmed publisher
  5. Szalinski C, Guerriero C, Ruiz W, Docter B, Rbaibi Y, PASTOR SOLER N, et al. PIP5KI? selectively modulates apical endocytosis in polarized renal epithelial cells. PLoS ONE. 2013;8:e53790 pubmed publisher
    ..PtdIns(4,5)P(2) may be required to overcome specific structural constraints that limit the efficiency of apical endocytosis. ..
  6. Akiba Y, Suzuki R, Saito Saino S, Owada Y, Sakagami H, Watanabe M, et al. Localization of mRNAs for phosphatidylinositol phosphate kinases in the mouse brain during development. Brain Res Gene Expr Patterns. 2002;1:123-33 pubmed
    ..The distinct expression for the gene encoding PIPK IIalpha was detected in the postnatal white matter such as the cerebellar medulla, the corpus callosum, the hippocampal fimbriae, and the internal capsule. ..
  7. Yamazaki M, Yamauchi Y, Goshima Y, Kanaho Y. Phosphatidylinositol 4-phosphate 5-kinase ? regulates growth cone morphology and semaphorin 3A-triggered growth cone collapse in mouse dorsal root ganglion neurons. Neurosci Lett. 2013;547:59-64 pubmed publisher
    ..These results provide evidence that PIP5K? negatively regulates axon elongation and growth cone size and is involved in the cellular signaling pathway for Sema3A-triggered repulsion in DRG neurons. ..
  8. Halstead J, Savaskan N, van den Bout I, van Horck F, Hajdo Milasinovic A, Snell M, et al. Rac controls PIP5K localisation and PtdIns(4,5)P? synthesis, which modulates vinculin localisation and neurite dynamics. J Cell Sci. 2010;123:3535-46 pubmed publisher
    ..Our findings support a role for PtdIns(4,5)P? synthesis in the regulation of vinculin localisation at focal complexes and ultimately in the regulation of neurite dynamics. ..
  9. Ip W, Medzhitov R. Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation. Nat Commun. 2015;6:6931 pubmed publisher
    ..Our findings identify an unknown function of the inflammasome as a sensor of hyperosmotic stress, which is crucial for the induction of inflammatory Th17 response. ..
  10. Neely G, Rao S, Costigan M, Mair N, Racz I, Milinkeviciute G, et al. Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet. 2012;8:e1003071 pubmed publisher
    ..Our data provide a systems map for heat nociception and reinforces the extraordinary conservation of molecular mechanisms of nociception across different species. ..
  11. Weernink P, Meletiadis K, Hommeltenberg S, Hinz M, Ishihara H, Schmidt M, et al. Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42. J Biol Chem. 2004;279:7840-9 pubmed
  12. Hasegawa H, Noguchi J, Yamashita M, Okada R, Sugimoto R, Furuya M, et al. Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis. Biol Reprod. 2012;86:136, 1-12 pubmed publisher
    ..Three PIP5K isozymes, PIP5K1A, PIP5K1B, and PIP5K1C, have been identified in mammals so far...
  13. Wang Y, Litvinov R, Chen X, Bach T, Lian L, Petrich B, et al. Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J Clin Invest. 2008;118:812-9 pubmed publisher
    ..Notably, both PIP5KIbeta- and PIP5KIgamma(-/-) cells had impaired PIP(2) synthesis...
  14. Huang P, Yeku O, Zong H, Tsang P, Su W, Yu X, et al. Phosphatidylinositol-4-phosphate-5-kinase alpha deficiency alters dynamics of glucose-stimulated insulin release to improve glucohomeostasis and decrease obesity in mice. Diabetes. 2011;60:454-63 pubmed publisher
    ..The increased first-phase glucose-stimulated release of insulin observed on the normal diet may underlie the partial protection against the elevated serum glucose and obesity seen in type 2 diabetes-like model systems. ..
  15. Wang L, Li G, Sugita S. A central kinase domain of type I phosphatidylinositol phosphate kinases is sufficient to prime exocytosis: isoform specificity and its underlying mechanism. J Biol Chem. 2005;280:16522-7 pubmed
  16. Wong K, Isberg R. Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake. J Exp Med. 2003;198:603-14 pubmed
    ..These results indicate that both Arf6 and PIP5K are involved in integrin-dependent uptake, and that Arf6 participates in both activation of PIP5K as well as in other events associated with bacterial uptake. ..
  17. Wright B, Loo L, Street S, Ma A, Taylor Blake B, Stashko M, et al. The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron. 2014;82:836-47 pubmed publisher
    ..Our studies reveal that PIP5K1C regulates PIP2-dependent nociceptive signaling and suggest that PIP5K1C is a therapeutic target for chronic pain. ..
  18. Pehrson J, Changolkar L, Costanzi C, Leu N. Mice without macroH2A histone variants. Mol Cell Biol. 2014;34:4523-33 pubmed publisher
    ..MacroH2A-dependent gene regulation changes substantially in postnatal development and can be strongly affected by fasting. We propose that macroH2As produce adaptive changes to gene expression, which in the liver focus on metabolism. ..
  19. Halstead J, van Rheenen J, Snel M, Meeuws S, Mohammed S, D Santos C, et al. A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis. Curr Biol. 2006;16:1850-6 pubmed
    ..These observations demonstrate that certain apoptotic stimuli initiate an essential signaling pathway during cell death, and this pathway leads to caspase-independent downregulation of PIP5Kalpha and its product PtdIns(4,5)P(2). ..
  20. Legate K, Montag D, Böttcher R, Takahashi S, Fassler R. Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type I? in vivo. J Cell Sci. 2012;125:5636-46 pubmed publisher
  21. van den Bout I, Jones D, Shah Z, Halstead J, Keune W, Mohammed S, et al. Collaboration of AMPK and PKC to induce phosphorylation of Ser413 on PIP5K1B resulting in decreased kinase activity and reduced PtdIns(4,5)P2 synthesis in response to oxidative stress and energy restriction. Biochem J. 2013;455:347-58 pubmed publisher
    ..b>PIP5K1B is negatively regulated in response to oxidative stress although it remains unclear which pathways regulate its ..
  22. Anderson R, Boronenkov I, Doughman S, Kunz J, Loijens J. Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes. J Biol Chem. 1999;274:9907-10 pubmed