Pink1

Summary

Gene Symbol: Pink1
Description: PTEN induced putative kinase 1
Alias: 1190006F07Rik, AU042772, AW557854, BRPK, mFLJ00387, serine/threonine-protein kinase PINK1, mitochondrial, PTEN-induced putative kinase protein 1
Species: mouse
Products:     Pink1

Top Publications

  1. Haque M, Thomas K, D Souza C, Callaghan S, Kitada T, Slack R, et al. Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP. Proc Natl Acad Sci U S A. 2008;105:1716-21 pubmed publisher
    PTEN-induced putative kinase 1 (Pink1) is a recently identified gene linked to a recessive form of familial Parkinson's disease (PD)...
  2. Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier C, et al. PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol. 2010;189:211-21 pubmed publisher
    ..Recent identification of genes linked to familial forms of PD such as Parkin and PINK1 (PTEN-induced putative kinase 1) has revealed that ubiquitylation and mitochondrial integrity are key factors in ..
  3. Amo T, Sato S, Saiki S, Wolf A, Toyomizu M, Gautier C, et al. Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects. Neurobiol Dis. 2011;41:111-8 pubmed publisher
    Mutations in PTEN-induced putative kinase 1 (PINK1) cause a recessive form of Parkinson's disease (PD)...
  4. Iguchi M, Kujuro Y, Okatsu K, Koyano F, Kosako H, Kimura M, et al. Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation. J Biol Chem. 2013;288:22019-32 pubmed publisher
    b>PINK1 and PARKIN are causal genes for autosomal recessive familial Parkinsonism. PINK1 is a mitochondrial Ser/Thr kinase, whereas Parkin functions as an E3 ubiquitin ligase...
  5. Kawajiri S, Saiki S, Sato S, Sato F, Hatano T, Eguchi H, et al. PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy. FEBS Lett. 2010;584:1073-9 pubmed publisher
    Mutations in PTEN-induced putative kinase 1 (PINK1) cause recessive form of Parkinson's disease (PD). PINK1 acts upstream of parkin, regulating mitochondrial integrity and functions...
  6. Koyano F, Okatsu K, Kosako H, Tamura Y, Go E, Kimura M, et al. Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature. 2014;510:162-6 pubmed publisher
    b>PINK1 (PTEN induced putative kinase 1) and PARKIN (also known as PARK2) have been identified as the causal genes responsible for hereditary recessive early-onset Parkinsonism...
  7. Joselin A, Hewitt S, Callaghan S, Kim R, Chung Y, Mak T, et al. ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons. Hum Mol Genet. 2012;21:4888-903 pubmed publisher
    Mutations in several genes, including Parkin, PTEN-induced kinase 1 (Pink1) and DJ-1, are associated with rare inherited forms of Parkinson's disease (PD)...
  8. Bishop M, Chakraborty S, Matthews G, Dougalis A, Wood N, Festenstein R, et al. Hyperexcitable substantia nigra dopamine neurons in PINK1- and HtrA2/Omi-deficient mice. J Neurophysiol. 2010;104:3009-20 pubmed publisher
    ..Here we show that deletion of PD-associated genes, PINK1 or HtrA2/Omi, leads to a functional reduction in the activity of small-conductance Ca(2+)-activated potassium ..
  9. Um J, Stichel Gunkel C, Lübbert H, Lee G, Chung K. Molecular interaction between parkin and PINK1 in mammalian neuronal cells. Mol Cell Neurosci. 2009;40:421-32 pubmed publisher
    ..Mutations in PTEN-induced putative kinase 1 (PINK1) and parkin are linked to early-onset autosomal recessive forms of familial PD...

More Information

Publications79

  1. Yao Z, Gandhi S, Burchell V, Plun Favreau H, Wood N, Abramov A. Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease. J Cell Sci. 2011;124:4194-202 pubmed publisher
    ..of Parkinson's disease (PD), particularly in autosomal recessive forms of the disease caused by mutations encoding PINK1. Although mitochondrial pathology can be demonstrated in many cell types, it is neurons that bear the brunt of ..
  2. Zhou H, Falkenburger B, Schulz J, Tieu K, Xu Z, Xia X. Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice. Int J Biol Sci. 2007;3:242-50 pubmed
    ..Tested in transgenic mice, a Cre-loxP inducible U6 promoter drove the broad expression of an shRNA against the Pink1 gene whose loss-of-functional mutations cause one form of familial Parkinson's disease...
  3. Akundi R, Huang Z, Eason J, Pandya J, Zhi L, Cass W, et al. Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice. PLoS ONE. 2011;6:e16038 pubmed publisher
    PTEN-induced kinase 1 (PINK1) is linked to recessive Parkinsonism (EOPD). Pink1 deletion results in impaired dopamine (DA) release and decreased mitochondrial respiration in the striatum of mice...
  4. Taymans J, Van den Haute C, Baekelandt V. Distribution of PINK1 and LRRK2 in rat and mouse brain. J Neurochem. 2006;98:951-61 pubmed
    Mutations in two kinases, PTEN induced kinase 1 (PINK1) and leucine-rich repeat kinase 2 (LRRK2), have been shown to segregate with familial forms of Parkinson's disease...
  5. Martella G, Platania P, Vita D, Sciamanna G, Cuomo D, Tassone A, et al. Enhanced sensitivity to group II mGlu receptor activation at corticostriatal synapses in mice lacking the familial parkinsonism-linked genes PINK1 or Parkin. Exp Neurol. 2009;215:388-96 pubmed publisher
    ..glutamate (mGlu) receptor activation in two different mouse models of inherited PD, linked to mutations in PINK1 or Parkin genes...
  6. Mei Y, Zhang Y, Yamamoto K, Xie W, Mak T, You H. FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation. Proc Natl Acad Sci U S A. 2009;106:5153-8 pubmed publisher
    Loss-of-function mutations of phosphatase/tensin homolog deleted on chromosome 10 (PTEN)-induced putative kinase 1 (Pink1) (also known as Park6) identified in familial forms of Parkinson's disease (PD) are associated with compromised ..
  7. Billia F, Hauck L, Konecny F, Rao V, Shen J, Mak T. PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function. Proc Natl Acad Sci U S A. 2011;108:9572-7 pubmed publisher
    ..Mutations in PTEN-inducible kinase 1 (PINK1) link mitochondrial dysfunction, increased sensitivity to ROS, and apoptosis in Parkinson's disease...
  8. Wood Kaczmar A, Gandhi S, Yao Z, Abramov A, Abramov A, Miljan E, et al. PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS ONE. 2008;3:e2455 pubmed publisher
    ..Although the pathogenesis of sporadic PD is unknown, the identification of the mendelian genetic factor PINK1 has provided new mechanistic insights...
  9. Zhou C, Huang Y, Shao Y, May J, Prou D, Perier C, et al. The kinase domain of mitochondrial PINK1 faces the cytoplasm. Proc Natl Acad Sci U S A. 2008;105:12022-7 pubmed publisher
    Mutations in PTEN-induced putative kinase 1 (PINK1) are a cause of autosomal recessive familial Parkinson's disease (PD)...
  10. Gautier C, Kitada T, Shen J. Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc Natl Acad Sci U S A. 2008;105:11364-9 pubmed publisher
    ..Loss of function mutations in the putative mitochondrial protein PINK1 (PTEN-induced kinase 1) have been linked to familial forms of PD, but the relation of PINK1 to mammalian ..
  11. Lutz A, Exner N, Fett M, Schlehe J, Kloos K, Lämmermann K, et al. Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem. 2009;284:22938-51 pubmed publisher
    Loss-of-function mutations in the parkin gene (PARK2) and PINK1 gene (PARK6) are associated with autosomal recessive parkinsonism...
  12. Unoki M, Nakamura Y. Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. Oncogene. 2001;20:4457-65 pubmed
    ..of eight genes, EGR2/Krox-20, BPOZ, APS, HCLS1/HS1, DUSP1/MKP1, NDRG1/Drg1/RTP, NFIL3/E4BP4, and a novel gene (PINK1, PTEN-induced putative kinase)...
  13. Tanaka A, Cleland M, Xu S, Narendra D, Suen D, Karbowski M, et al. Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. J Cell Biol. 2010;191:1367-80 pubmed publisher
    ..Inhibition of Drp1-mediated mitochondrial fission, the proteasome, or p97 prevents Parkin-induced mitophagy. ..
  14. Wang H, Chou A, Wu A, Chen S, Weng Y, Kao Y, et al. PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons. Biochim Biophys Acta. 2011;1812:674-84 pubmed publisher
    Mutations in PTEN-induced kinase 1 (PINK1) gene cause recessive familial type 6 of Parkinson's disease (PARK6)...
  15. Heeman B, Van den Haute C, Aelvoet S, Valsecchi F, Rodenburg R, Reumers V, et al. Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance. J Cell Sci. 2011;124:1115-25 pubmed publisher
    Loss-of-function mutations in the gene encoding the mitochondrial PTEN-induced putative kinase 1 (PINK1) are a major cause of early-onset familial Parkinson's disease (PD)...
  16. Morais V, Verstreken P, Roethig A, Smet J, Snellinx A, Vanbrabant M, et al. Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med. 2009;1:99-111 pubmed publisher
    Mutations of the mitochondrial PTEN (phosphatase and tensin homologue)-induced kinase1 (PINK1) are important causes of recessive Parkinson disease (PD)...
  17. Shiba Fukushima K, Imai Y, Yoshida S, Ishihama Y, Kanao T, Sato S, et al. PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy. Sci Rep. 2012;2:1002 pubmed publisher
    Parkinson's disease genes PINK1 and parkin encode kinase and ubiquitin ligase, respectively. The gene products PINK1 and Parkin are implicated in mitochondrial autophagy, or mitophagy...
  18. Gandhi S, Wood Kaczmar A, Yao Z, Plun Favreau H, Deas E, Klupsch K, et al. PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Mol Cell. 2009;33:627-38 pubmed publisher
    Mutations in PINK1 cause autosomal recessive Parkinson's disease. PINK1 is a mitochondrial kinase of unknown function. We investigated calcium homeostasis and mitochondrial function in PINK1-deficient mammalian neurons...
  19. Xiong H, Wang D, Chen L, Choo Y, Ma H, Tang C, et al. Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest. 2009;119:650-60 pubmed publisher
    Mutations in PARKIN, pten-induced putative kinase 1 (PINK1), and DJ-1 are individually linked to autosomal recessive early-onset familial forms of Parkinson disease (PD)...
  20. Glasl L, Kloos K, Giesert F, Roethig A, Di Benedetto B, Kühn R, et al. Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb. Exp Neurol. 2012;235:214-27 pubmed publisher
    ..Autosomal-recessive mutations in the mitochondrial protein kinase PINK1 (PTEN-induced kinase 1) account for 1-2% of the hereditary early-onset cases...
  21. Kitada T, Pisani A, Porter D, Yamaguchi H, Tscherter A, Martella G, et al. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci U S A. 2007;104:11441-6 pubmed
    ..Recently, loss-of-function mutations in the PTEN-induced kinase 1 (PINK1) gene have been linked to early-onset PD...
  22. Chen Y, Dorn G. PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science. 2013;340:471-5 pubmed publisher
    ..mitophagic elimination through mechanisms requiring two Parkinson's disease factors, the mitochondrial kinase PINK1 (PTEN-induced putative kinase protein 1; PTEN is phosphatase and tensin homolog) and the cytosolic ubiquitin ..
  23. Shim J, Yoon S, Kim K, Han J, Ha J, Hyun D, et al. The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cells. Mitochondrion. 2011;11:707-15 pubmed publisher
    ..We characterized the pathophenotypes of dopaminergic neuronal cells that were deficient in PINK1 or DJ-1, genes with mutations linked to familial PD...
  24. Nakajima A, Kataoka K, Hong M, Sakaguchi M, Huh N. BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential. Cancer Lett. 2003;201:195-201 pubmed
    A novel protein kinase named BRPK was isolated and partially characterized. BRPK was expressed at a higher level in three carcinoma cell lines with higher metastatic potential...
  25. Gispert S, Ricciardi F, Kurz A, Azizov M, Hoepken H, Becker D, et al. Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration. PLoS ONE. 2009;4:e5777 pubmed publisher
    ..We have previously shown that loss-of-function mutations of the mitochondrial protein kinase PINK1 (PTEN induced putative kinase 1) cause the recessive PARK6 variant of PD...
  26. Pearlstein E, Michel F, Save L, Ferrari D, Hammond C. Abnormal Development of Glutamatergic Synapses Afferent to Dopaminergic Neurons of the Pink1(-/-) Mouse Model of Parkinson's Disease. Front Cell Neurosci. 2016;10:168 pubmed publisher
    In a preceding study, we showed that in adult pink1(-/-) mice, a monogenic animal model of Parkinson's disease (PD), striatal neurons display aberrant electrical activities that precede the onset of overt clinical manifestations...
  27. Choo Y, Tang C, Zhang Z. Critical role of PINK1 in regulating Parkin protein levels in vivo. Arch Neurol. 2011;68:684-5 pubmed publisher
  28. Madeo G, Martella G, Schirinzi T, Ponterio G, Shen J, Bonsi P, et al. Aberrant striatal synaptic plasticity in monogenic parkinsonisms. Neuroscience. 2012;211:126-35 pubmed publisher
  29. Rojas Charry L, Cookson M, Niño A, Arboleda H, Arboleda G. Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells. Neurotoxicology. 2014;44:140-8 pubmed publisher
    ..Loss of Pink1 (PTEN-induced putative kinase 1) function is associated with early onset recessive Parkinson's disease and it has ..
  30. Gao F, Chen D, Si J, Hu Q, Qin Z, Fang M, et al. The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway. Hum Mol Genet. 2015;24:2528-38 pubmed publisher
    ..Here, we found that the mitochondrial protein BNIP3L acts downstream of the PINK1/PARK2 pathway to induce mitophagy. BNIP3L is a substrate of PARK2 to drive PARK2-mediated mitophagy...
  31. Song S, Jang S, Park J, Bang S, Choi S, Kwon K, et al. Characterization of PINK1 (PTEN-induced putative kinase 1) mutations associated with Parkinson disease in mammalian cells and Drosophila. J Biol Chem. 2013;288:5660-72 pubmed publisher
    Mutations in PINK1 (PTEN-induced putative kinase 1) are tightly linked to autosomal recessive Parkinson disease (PD)...
  32. Shiba Fukushima K, Inoshita T, Hattori N, Imai Y. Lysine 63-linked polyubiquitination is dispensable for Parkin-mediated mitophagy. J Biol Chem. 2014;289:33131-6 pubmed publisher
    b>PINK1/Parkin-mediated mitophagy is thought to ensure mitochondrial quality control in neurons as well as other cells...
  33. Matsui H, Gavinio R, Asano T, Uemura N, Ito H, Taniguchi Y, et al. PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates. Hum Mol Genet. 2013;22:2423-34 pubmed publisher
    ..familial PD genes PARK2 and PARK6 have been attributed to mutations in the Parkin and PTEN-induced kinase 1 (PINK1) genes, respectively...
  34. Cui C, Chen S, Qiao J, Qing L, Wang L, He T, et al. PINK1-Parkin alleviates metabolic stress induced by obesity in adipose tissue and in 3T3-L1 preadipocytes. Biochem Biophys Res Commun. 2018;498:445-452 pubmed publisher
    ..Recently, several studies have shown that mitophagy mediated by PTEN-induced putative kinase 1 (PINK1) and Parkin may play a critical role in clearing the damaged mitochondria and maintaining the overall balance of ..
  35. Chiba M, Kiyosawa H, Hiraiwa N, Ohkohchi N, Yasue H. Existence of Pink1 antisense RNAs in mouse and their localization. Cytogenet Genome Res. 2009;126:259-70 pubmed publisher
    PTEN-induced kinase 1 (PINK1), which is identified as the gene transactivated by the tumor suppressor PTEN, has been found to be one of the causative genes in Parkinson's disease (PD)...
  36. Kim K, Son J. PINK1 gene knockdown leads to increased binding of parkin with actin filament. Neurosci Lett. 2010;468:272-6 pubmed publisher
    Mutations in the PINK1 gene are known to cause early onset familial Parkinson's disease (PD)...
  37. Sanchez G, Varaschin R, Bueler H, Marcogliese P, Park D, Trudeau L. Unaltered striatal dopamine release levels in young Parkin knockout, Pink1 knockout, DJ-1 knockout and LRRK2 R1441G transgenic mice. PLoS ONE. 2014;9:e94826 pubmed publisher
    ..Surprisingly, most of the various mouse lines generated such as Parkin KO, Pink1 KO, DJ-1 KO and LRRK2 transgenic have been reported to lack degeneration of nigral DA neuron, one of the hallmarks ..
  38. Madeo G, Schirinzi T, Maltese M, Martella G, Rapino C, Fezza F, et al. Dopamine-dependent CB1 receptor dysfunction at corticostriatal synapses in homozygous PINK1 knockout mice. Neuropharmacology. 2016;101:460-70 pubmed publisher
    Recessive mutations in the PTEN-induced putative kinase 1 (PINK1) gene cause early-onset Parkinson's disease (PD)...
  39. Triplett J, Zhang Z, Sultana R, Cai J, Klein J, Büeler H, et al. Quantitative expression proteomics and phosphoproteomics profile of brain from PINK1 knockout mice: insights into mechanisms of familial Parkinson's disease. J Neurochem. 2015;133:750-65 pubmed publisher
    ..Mutations in the mitochondrial Ser/Thr kinase PTEN-induced kinase 1 (PINK1) are associated with an autosomal recessive familial form of early-onset PD...
  40. Du F, Yu Q, Yan S, Hu G, Lue L, Walker D, et al. PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer's disease. Brain. 2017;140:3233-3251 pubmed publisher
    ..Here, we demonstrate for the first time that decreased PTEN-induced putative kinase 1 (PINK1) expression is associated with Alzheimer's disease pathology...
  41. Kubli D, Cortez M, Moyzis A, Najor R, Lee Y, Gustafsson Ã. PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes. PLoS ONE. 2015;10:e0130707 pubmed publisher
    Myocyte function and survival relies on the maintenance of a healthy population of mitochondria. The PINK1/Parkin pathway plays an important role in clearing defective mitochondria via autophagy in cells...
  42. Knippenberg S, Sipos J, Thau Habermann N, Körner S, Rath K, Dengler R, et al. Altered expression of DJ-1 and PINK1 in sporadic ALS and in the SOD1(G93A) ALS mouse model. J Neuropathol Exp Neurol. 2013;72:1052-61 pubmed publisher
    ..DJ-1 and PTEN-induced putative kinase 1 (PINK1) are important proteins for the maintenance of mitochondrial function and protection against cell death...
  43. Mannam P, Shinn A, Srivastava A, Neamu R, Walker W, Bohanon M, et al. MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2014;306:L604-19 pubmed publisher
    ..appeared to simultaneously increase mitochondrial biogenesis and mitophagy through the actions of Sirt1, Pink1, and Parkin. This led to a more robust mitochondrial network, which we propose provides protection against sepsis...
  44. Lenzi P, Marongiu R, Falleni A, Gelmetti V, Busceti C, Michiorri S, et al. A subcellular analysis of genetic modulation of PINK1 on mitochondrial alterations, autophagy and cell death. Arch Ital Biol. 2012;150:194-217 pubmed publisher
    Mutations in the PTEN-induced putative kinase1 (PINK1) represent the second most frequent cause of autosomal recessive Parkinson's disease...
  45. Gispert S, Brehm N, Weil J, Seidel K, Rüb U, Kern B, et al. Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression. Hum Mol Genet. 2015;24:1061-76 pubmed publisher
    ..dosage of vesicle-associated alpha-synuclein (SNCA) or recessive causes like deficiency of mitophagy factor PINK1. Interactions between these triggers and their convergence onto shared pathways are crucial, but currently ..
  46. Dagda R, Pien I, Wang R, Zhu J, Wang K, Callio J, et al. Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase A. J Neurochem. 2014;128:864-77 pubmed publisher
    ..The PTEN-induced kinase 1 (PINK1), which is linked to Parkinson's disease, is a neuroprotective kinase localized to cytosolic and mitochondrial ..
  47. Gautier C, Giaime E, Caballero E, Núñez L, Song Z, Chan D, et al. Regulation of mitochondrial permeability transition pore by PINK1. Mol Neurodegener. 2012;7:22 pubmed publisher
    Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) have been linked to familial Parkinson's disease, but the underlying pathogenic mechanism remains unclear...
  48. Martella G, Madeo G, Schirinzi T, Tassone A, Sciamanna G, Spadoni F, et al. Altered profile and D2-dopamine receptor modulation of high voltage-activated calcium current in striatal medium spiny neurons from animal models of Parkinson's disease. Neuroscience. 2011;177:240-51 pubmed publisher
    ..MSNs were recorded from reserpine-treated and 6-hydroxydopamine (6-OHDA)-lesioned rats, and from DJ-1 and PINK1 (PTEN induced kinase 1) knockout (-/-) mice. Our analysis showed no significant changes in total HVA Ca2+ current...
  49. Huang Y, Chen H, Zhu J, Zhao F, Qu Y, Mu D. [Effects of PINK1 gene on cell apoptosis and cell autophagy in neonatal mice with hypoxic-ischemic brain damage]. Zhongguo Dang Dai Er Ke Za Zhi. 2016;18:263-9 pubmed
    To study the effect of PINK1 (phosphatase and tensin homolog deleted on chromosome ten induced putative kinase 1) gene on cell apoptosis and cell autophagy in neonatal mice with hypoxic-ischemic brain damage (HIBD)...
  50. Wu W, Xu H, Wang Z, Mao Y, Yuan L, Luo W, et al. PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury. PLoS ONE. 2015;10:e0132499 pubmed publisher
    ..b>PINK1 (phosphatase and tensin homolog (PTEN)-induced putative kinase 1) and Parkin signaling is a key pathway in ..
  51. Rojansky R, Cha M, Chan D. Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1. elife. 2016;5: pubmed publisher
    ..and additionally requires the mitochondrial outer membrane protein FIS1, the autophagy adaptor P62, and PINK1 kinase...
  52. Yan W, Chen Z, Chen J, Chen H. LncRNA NEAT1 promotes autophagy in MPTP-induced Parkinson's disease through stabilizing PINK1 protein. Biochem Biophys Res Commun. 2018;496:1019-1024 pubmed publisher
    ..The numbers of TH + neurons, NEAT1 expression and the level of PINK1, LC3-II, LC3-I protein were assessed in PD mice. SH-SY5Y cells were treated with MPP+ as PD cell model...
  53. Li L, He F, Litofsky N, Recht L, Ross A. Profiling of genes expressed by PTEN haploinsufficient neural precursor cells. Mol Cell Neurosci. 2003;24:1051-61 pubmed
    ..These observations indicate that even a small decrease in PTEN levels results in substantial changes in gene expression and precursor cell function. ..
  54. Deas E, Piipari K, Machhada A, Li A, Gutierrez Del Arroyo A, Withers D, et al. PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice. Open Biol. 2014;4:140051 pubmed publisher
    The Parkinson's disease (PD) gene, PARK6, encodes the PTEN-induced putative kinase 1 (PINK1) mitochondrial kinase, which provides protection against oxidative stress-induced apoptosis...
  55. Choi J, Batchu V, Schubert M, Castellani R, Russell J. A novel PGC-1? isoform in brain localizes to mitochondria and associates with PINK1 and VDAC. Biochem Biophys Res Commun. 2013;435:671-7 pubmed publisher
    Peroxisome proliferator-activated receptor-gamma co-activator 1? (PGC-1?) and PTEN-induced putative kinase 1 (PINK1) are powerful regulators of mitochondrial function...
  56. Choi H, Choi Y, Kang H, Lim E, Park S, Lee H, et al. PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death. Hum Mol Genet. 2015;24:1127-41 pubmed publisher
    ..Here we show that PTEN-induced putative kinase 1 (PINK1), which is linked to autosomal recessive early-onset familial Parkinson's disease, phosphorylates HDAC3 at Ser-424 ..
  57. Thomas K, McCoy M, Blackinton J, Beilina A, Van Der Brug M, Sandebring A, et al. DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy. Hum Mol Genet. 2011;20:40-50 pubmed publisher
    Mutations in DJ-1, PINK1 (PTEN-induced putative kinase 1) and parkin all cause recessive parkinsonism in humans, but the relationships between these genes are not clearly defined...
  58. Wang X, Guo J, Fei E, Mu Y, He S, Che X, et al. BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. PLoS ONE. 2014;9:e86276 pubmed publisher
    Mutations in PTEN-induced kinase 1 (PINK1) gene cause PARK6 familial Parkinsonism, and loss of the stability of PINK1 may also contribute to sporadic Parkinson's disease (PD)...
  59. Blackinton J, Anvret A, Beilina A, Olson L, Cookson M, Galter D. Expression of PINK1 mRNA in human and rodent brain and in Parkinson's disease. Brain Res. 2007;1184:10-6 pubmed
    Mutations in PINK1 (PTEN-induced putative kinase 1) are causal for early onset recessive parkinsonism in humans, characterized by damage to the nigrostriatal system...
  60. Kueh S, Dempster J, Head S, Morley J. Reduced postsynaptic GABAA receptor number and enhanced gaboxadol induced change in holding currents in Purkinje cells of the dystrophin-deficient mdx mouse. Neurobiol Dis. 2011;43:558-64 pubmed publisher
    ..If similar changes occur in the CNS in boys with DMD, it will impact on the function of neural networks and may contribute to some of the motor, behavioral and cognitive impairment apparent in many boys with DMD. ..
  61. Ashrafi G, Schlehe J, LaVoie M, Schwarz T. Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin. J Cell Biol. 2014;206:655-70 pubmed publisher
    ..In this paper, we report that PINK1 and Parkin, two Parkinson's disease-associated proteins, mediate local mitophagy of dysfunctional mitochondria in ..
  62. Akundi R, Zhi L, Bueler H. PINK1 enhances insulin-like growth factor-1-dependent Akt signaling and protection against apoptosis. Neurobiol Dis. 2012;45:469-78 pubmed publisher
    Mutations in the PARK6 gene coding for PTEN-induced kinase 1 (PINK1) cause recessive early-onset Parkinsonism...
  63. Qi Z, Yang W, Liu Y, Cui T, Gao H, Duan C, et al. Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model. Neurochem Int. 2011;59:572-81 pubmed publisher
    ..Parkinson's disease (PD) is the most common neurodegenerative movement disorder. Mutations in PTEN-induced kinase 1 (PINK1) are a frequent cause of recessive PD...
  64. Choi I, Kim J, Jeong H, Kim B, Jou I, Park S, et al. PINK1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced AKT and increased p38 MAPK activation, and downregulation of EGFR. Glia. 2013;61:800-12 pubmed publisher
    b>PINK1 (PTEN induced putative kinase 1), a familial Parkinson's disease (PD)-related gene, is expressed in astrocytes, but little is known about its role in this cell type...
  65. Dagda R, Gusdon A, Pien I, Strack S, Green S, Li C, et al. Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease. Cell Death Differ. 2011;18:1914-23 pubmed publisher
    Mutations in PTEN-induced kinase 1 (PINK1) are associated with a familial syndrome related to Parkinson's disease (PD)...
  66. Ellis G, Zhi L, Akundi R, Bueler H, Marti F. Mitochondrial and cytosolic roles of PINK1 shape induced regulatory T-cell development and function. Eur J Immunol. 2013;43:3355-60 pubmed publisher
    Mutations in PTEN-induced kinase 1 (PINK1), a serine/threonine kinase linked to familial early-onset Parkinsonism, compromise mitochondrial integrity and metabolism and impair AKT signaling...
  67. Cherra S, Dagda R, Tandon A, Chu C. Mitochondrial autophagy as a compensatory response to PINK1 deficiency. Autophagy. 2009;5:1213-4 pubmed
    ..We recently reported that silencing the recessive familial Parkinson disease gene encoding PTEN-induced kinase 1 (PINK1) leads to neuronal cell death accompanied by mitochondrial dysfunction and Drp1-dependent fragmentation...
  68. Requejo Aguilar R, Lopez Fabuel I, Fernandez E, Martins L, Almeida A, Bolanos J. PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1. Nat Commun. 2014;5:4514 pubmed publisher
    PTEN-induced kinase-1 (PINK1) is a Ser/Thr kinase implicated in familial early-onset Parkinson's disease, and was first reported as a growth suppressor...
  69. Madeo G, Schirinzi T, Martella G, Latagliata E, Puglisi F, Shen J, et al. PINK1 heterozygous mutations induce subtle alterations in dopamine-dependent synaptic plasticity. Mov Disord. 2014;29:41-53 pubmed publisher
    Homozygous or compound heterozygous mutations in the phosphatase and tensin homolog-induced putative kinase 1 (PINK1) gene are causative of autosomal recessive, early onset Parkinson's disease...
  70. Chen L, Xie Z, Turkson S, Zhuang X. A53T human α-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration. J Neurosci. 2015;35:890-905 pubmed publisher
    ..Genetic deletion of either parkin or PINK1 in these transgenic mice significantly worsened mitochondrial pathologies, including drastically enlarged ..