Gene Symbol: Pin1
Description: protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
Alias: 0610025L01Rik, D9Bwg1161e, peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, PPIase Pin1, peptidyl-prolyl cis-trans isomerase Pin1, rotamase Pin1
Species: mouse
Products:     Pin1

Top Publications

  1. Fujimori F, Takahashi K, Uchida C, Uchida T. Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest. Biochem Biophys Res Commun. 1999;265:658-63 pubmed
    The peptidyl prolil cis/trans isomerase Ess1/Pin1 is essential for mitosis progression in yeast cells and is hypothesized to perform the same role in mammalian cells...
  2. Liou Y, Sun A, Ryo A, Zhou X, Yu Z, Huang H, et al. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature. 2003;424:556-61 pubmed
    ..motifs exist in two distinct conformations, whose conversion in some proteins is catalysed by the Pin1 prolyl isomerase...
  3. Ryo A, Suizu F, Yoshida Y, Perrem K, Liou Y, Wulf G, et al. Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol Cell. 2003;12:1413-26 pubmed
    ..Here we demonstrate that NF-kappaB function is regulated by Pin1-mediated prolyl isomerization and ubiquitin-mediated proteolysis of its p65/RelA subunit...
  4. Saitoh T, Tun Kyi A, Ryo A, Yamamoto M, Finn G, Fujita T, et al. Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1. Nat Immunol. 2006;7:598-605 pubmed
    ..Here we report that activation of IRF3 is negatively regulated by the peptidyl-prolyl isomerase Pin1. After stimulation by double-stranded RNA, induced phosphorylation of the Ser339-Pro340 motif of IRF3 led to its ..
  5. Kim S, Lee M, Lim S, Hien T, Kim J, Ahn S, et al. Role of Pin1 in neointima formation: down-regulation of Nrf2-dependent heme oxygenase-1 expression by Pin1. Free Radic Biol Med. 2010;48:1644-53 pubmed publisher
    ..b>Pin1, a peptidyl prolyl isomerase recognizing phosphorylated Ser/Thr-Pro, isomerizes the peptide bond...
  6. Balastik M, Lim J, Pastorino L, Lu K. Pin1 in Alzheimer's disease: multiple substrates, one regulatory mechanism?. Biochim Biophys Acta. 2007;1772:422-9 pubmed
    ..Recently, the peptidyl-prolyl cis/trans isomerase Pin1 has been identified to regulate the function of certain proteins after phosphorylation and to play an important ..
  7. Shen Z, Esnault S, Rosenthal L, Szakaly R, Sorkness R, Westmark P, et al. Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis. J Clin Invest. 2008;118:479-90 pubmed publisher
    ..We investigated the regulation of TGF-beta1 and show here that the peptidyl-prolyl isomerase (PPIase) Pin1 promoted the stability of TGF-beta1 mRNA in human Eos...
  8. Girardini J, Napoli M, Piazza S, Rustighi A, Marotta C, Radaelli E, et al. A Pin1/mutant p53 axis promotes aggressiveness in breast cancer. Cancer Cell. 2011;20:79-91 pubmed publisher
    ..Here we demonstrate the fundamental role of the prolyl isomerase Pin1 in mutant p53 oncogenic functions...
  9. Ryo A, Nakamura M, Wulf G, Liou Y, Lu K. Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat Cell Biol. 2001;3:793-801 pubmed
    ..and the conformation of certain phosphorylated Ser/Thr-Pro bonds is regulated specifically by the prolyl isomerase Pin1. Whereas the inhibition of Pin1 induces apoptosis, Pin1 is strikingly overexpressed in a subset of human tumours...

More Information


  1. Zita M, Marchionni I, Bottos E, Righi M, Del Sal G, Cherubini E, et al. Post-phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function. EMBO J. 2007;26:1761-71 pubmed
    ..undergoes proline-directed phosphorylation, which is followed by the recruitment of the peptidyl-prolyl isomerase Pin1. The interaction between gephyrin and Pin1 is strictly dependent on gephyrin phosphorylation and requires serine-..
  2. Liao Y, Wei Y, Zhou X, Yang J, Dai C, Chen Y, et al. Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation. Oncogene. 2009;28:2436-45 pubmed publisher
    ..we showed a strong correlation between the expression levels of an oncogenic peptidyl-prolyl cis/trans isomerase Pin1 and levels of Akt phosphorylation at S473 in multiple cancer types (P<0.0001)...
  3. Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, et al. Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis. J Biol Chem. 2011;286:20812-22 pubmed publisher
    Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) is a unique enzyme that associates with the pSer/Thr-Pro motif and catalyzes cis-trans isomerization...
  4. Lee T, Chen C, Suizu F, Huang P, Schiene Fischer C, Daum S, et al. Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function. Mol Cell. 2011;42:147-59 pubmed publisher
    b>Pin1 is a phospho-specific prolyl isomerase that regulates numerous key signaling molecules and whose deregulation contributes to disease notably cancer...
  5. Tun Kyi A, Finn G, Greenwood A, Nowak M, Lee T, Asara J, et al. Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity. Nat Immunol. 2011;12:733-41 pubmed publisher
    ..We found here that TLR7 and TLR9 activated the isomerase Pin1, which then bound to IRAK1; this resulted in activation of IRAK1 and facilitated its release from the receptor ..
  6. Akiyama H, Shin R, Uchida C, Kitamoto T, Uchida T. Pin1 promotes production of Alzheimer's amyloid beta from beta-cleaved amyloid precursor protein. Biochem Biophys Res Commun. 2005;336:521-9 pubmed
    Here we show that prolyl isomerase Pin1 is involved in the Abeta production central to the pathogenesis of Alzheimer's disease...
  7. Zheng H, You H, Zhou X, Murray S, Uchida T, Wulf G, et al. The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature. 2002;419:849-53 pubmed
    ..DNA damage specifically induces p53 phosphorylation on Ser/Thr-Pro motifs, which facilitates its interaction with Pin1, a member of peptidyl-prolyl isomerase...
  8. Liou Y, Ryo A, Huang H, Lu P, Bronson R, Fujimori F, et al. Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proc Natl Acad Sci U S A. 2002;99:1335-40 pubmed
    ..The conformation and function of a subset of these phosphorylated proteins is regulated by the prolyl isomerase Pin1 through isomerization of phosphorylated Ser/Thr-Pro bonds...
  9. Grison A, Mantovani F, Comel A, Agostoni E, Gustincich S, Persichetti F, et al. Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin. Proc Natl Acad Sci U S A. 2011;108:17979-84 pubmed publisher
    ..phosphorylation of p53 on Ser46, leading to its interaction with phosphorylation-dependent prolyl isomerase Pin1 and consequent dissociation from the apoptosis inhibitor iASPP, thereby inducing the expression of apoptotic target ..
  10. Sorrentino G, Mioni M, Giorgi C, Ruggeri N, Pinton P, Moll U, et al. The prolyl-isomerase Pin1 activates the mitochondrial death program of p53. Cell Death Differ. 2013;20:198-208 pubmed publisher
    ..Here we have explored the role had in this pathway by the prolyl-isomerase Pin1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1), a crucial transducer of p53's phosphorylation into ..
  11. Akiyama H, Misawa T, Ono M, Uchida C, Uchida T. Prolyl isomerase pin1 protects mice from endotoxin shock. PLoS ONE. 2011;6:e14656 pubmed publisher
    Prolyl isomerase Pin1 may be involved in innate immunity against microbial infection, but the mechanism how Pin1 controls the innate immunity is poorly understood...
  12. Steger M, Murina O, Huhn D, Ferretti L, Walser R, Hänggi K, et al. Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection. Mol Cell. 2013;50:333-43 pubmed publisher
    ..Here, we show that PIN1, a phosphorylation-specific prolyl isomerase, interacts with key DSB repair factors and affects the relative ..
  13. Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, et al. Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity. J Biol Chem. 2010;285:33018-27 pubmed publisher
    b>Pin1 is a unique regulator, which catalyzes the conversion of a specific phospho-Ser/Thr-Pro-containing motif in target proteins...
  14. Wulf G, Garg P, Liou Y, Iglehart D, Lu K. Modeling breast cancer in vivo and ex vivo reveals an essential role of Pin1 in tumorigenesis. EMBO J. 2004;23:3397-407 pubmed
    ..The conformation and function of phosphorylated Ser/Thr-Pro motifs are further regulated by the prolyl isomerase Pin1. Pin1 is prevalently overexpressed in human cancers and implicated in oncogenesis...
  15. Pastorino L, Sun A, Lu P, Zhou X, Balastik M, Finn G, et al. The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. Nature. 2006;440:528-34 pubmed
    ..Ser/Thr-Pro motifs in peptides can exist in cis or trans conformations, the conversion of which is catalysed by the Pin1 prolyl isomerase...
  16. Shen Z, Esnault S, Schinzel A, Borner C, Malter J. The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation. Nat Immunol. 2009;10:257-65 pubmed publisher
    ..Erk1/2, which phosphorylated Thr167 of Bax; this facilitated new interaction of Bax with the prolyl isomerase Pin1. Blockade of Pin1 led to cleavage and mitochondrial translocation of Bax and caspase activation, regardless of the ..
  17. Zheng Y, Xia Y, Hawke D, Halle M, Tremblay M, Gao X, et al. FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell. 2009;35:11-25 pubmed publisher
    ..ERK phosphorylates FAK S910 and recruits PIN1 and PTP-PEST, which colocalize with FAK at the lamellipodia of migrating cells...
  18. Esnault S, Braun R, Shen Z, Xiang Z, Heninger E, Love R, et al. Pin1 modulates the type 1 immune response. PLoS ONE. 2007;2:e226 pubmed
    ..We now show that Pin1, a third member of the PPIase family mediates the post-transcriptional regulation of Th1 cytokines by activated T ..
  19. Tatara Y, Terakawa T, Uchida T. Identification of Pin1-binding phosphorylated proteins in the mouse brain. Biosci Biotechnol Biochem. 2010;74:2480-3 pubmed
    To determine the role of Pin1 in the neurotransmission pathway, Pin1-binding proteins in mouse brain extract were identified...
  20. Lee T, Tun Kyi A, Shi R, Lim J, Soohoo C, Finn G, et al. Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance. Nat Cell Biol. 2009;11:97-105 pubmed publisher
    ..regulator in telomere maintenance is the telomeric protein TRF1, which was also identified as Pin2 in a screen for Pin1. Pin1 is a unique prolyl isomerase that regulates protein conformation and function after phosphorylation...
  21. Yeh E, Lew B, Means A. The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability. J Biol Chem. 2006;281:241-51 pubmed
    ..Since the prolyl isomerase Pin1 binds the c-Myc phosphodegron and participates in regulation of c-Myc turnover, we hypothesized that Pin1 would ..
  22. Min S, Lau A, Lee T, Inuzuka H, Wei S, Huang P, et al. Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase. Mol Cell. 2012;46:771-83 pubmed publisher that Fbw7 protein destruction and tumor suppressor function are negatively regulated by the prolyl isomerase Pin1. Pin1 interacts with Fbw7 in a phoshorylation-dependent manner and promotes Fbw7 self-ubiquitination and protein ..
  23. Zacchi P, Gostissa M, Uchida T, Salvagno C, Avolio F, Volinia S, et al. The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature. 2002;419:853-7 pubmed
    ..Here we report that, on DNA damage, p53 interacts with Pin1, a peptidyl-prolyl isomerase, which regulates the function of many proteins involved in cell cycle control and ..
  24. Atchison F, Capel B, Means A. Pin1 regulates the timing of mammalian primordial germ cell proliferation. Development. 2003;130:3579-86 pubmed
    ..5 to 13.5 days post coitum (dpc). We show that a peptidyl-prolyl isomerase, Pin1, is involved in the regulation of mammalian PGC proliferation...
  25. Nakamura K, Kosugi I, Lee D, Hafner A, Sinclair D, Ryo A, et al. Prolyl isomerase Pin1 regulates neuronal differentiation via ?-catenin. Mol Cell Biol. 2012;32:2966-78 pubmed publisher
    ..b>Pin1 is a prolyl isomerase that regulates cell signaling uniquely by controlling protein conformation after ..
  26. Han C, Hien T, Lim S, Kang K. Role of Pin1 in UVA-induced cell proliferation and malignant transformation in epidermal cells. Biochem Biophys Res Commun. 2011;410:68-74 pubmed publisher
    Ultraviolet A (UVA) radiation (? = 320-400 nm) is considered a major cause of human skin cancer. Pin1, a peptidyl prolyl isomerase, is overexpressed in most types of cancer tissues and plays an important role in cell proliferation and ..
  27. Soares Dos Reis R, Pessoa A, Dias A, Falcão M, Matos M, Vitorino R, et al. A role for prolyl isomerase PIN1 in the phosphorylation-dependent modulation of PRRXL1 function. Biochem J. 2017;474:683-697 pubmed publisher
    ..Four are phospho-S/T-P sites, which suggest a role for the prolyl isomerase PIN1 in regulating PRRXL1...
  28. Chen C, Li W, Sultana R, You M, Kondo A, Shahpasand K, et al. Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease. Neurobiol Dis. 2015;76:13-23 pubmed publisher
    The unique proline isomerase Pin1 is pivotal for protecting against age-dependent neurodegeneration in Alzheimer's disease (AD), with its inhibition providing a molecular link between tangle and plaque pathologies...
  29. Luo M, Gong C, Chen C, Lee D, Hu H, Huang P, et al. Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer. Cancer Res. 2014;74:3603-16 pubmed publisher
    ..Here we identify a fundamental role for the prolyl isomerase Pin1 in driving BCSC expansion, invasiveness, and tumorigenicity, defining it as a key target of miR200c, which is known ..
  30. Johnson N, Condello C, Guan S, Oehler A, Becker J, Gavidia M, et al. Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice. Proc Natl Acad Sci U S A. 2017;114:E11029-E11036 pubmed publisher
  31. Pinton P, Rimessi A, Marchi S, Orsini F, Migliaccio E, Giorgio M, et al. Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc. Science. 2007;315:659-63 pubmed
    ..of p66Shc and triggers mitochondrial accumulation of the protein after it is recognized by the prolyl isomerase Pin1. Once imported, p66Shc causes alterations of mitochondrial Ca2+ responses and three-dimensional structure, thus ..
  32. Sosa L, Malter J, Hu J, Bustos Plonka F, Oksdath M, Nieto Guil A, et al. Protein interacting with NIMA (never in mitosis A)-1 regulates axonal growth cone adhesion and spreading through myristoylated alanine-rich C kinase substrate isomerization. J Neurochem. 2016;137:744-55 pubmed publisher
    ..b>Pin1, a peptidyl-prolyl cis/trans isomerase (PPIase) that recognizes and binds to phosphorylated serine/threonine ..
  33. Toko H, Hariharan N, Konstandin M, Ormachea L, McGregor M, Gude N, et al. Differential regulation of cellular senescence and differentiation by prolyl isomerase Pin1 in cardiac progenitor cells. J Biol Chem. 2014;289:5348-56 pubmed publisher
    ..The prolyl isomerase Pin1 regulates multiple signaling cascades by modulating protein folding and thereby activity and stability of ..
  34. Namgoong G, Khanal P, Cho H, Lim S, Oh Y, Kang B, et al. The prolyl isomerase Pin1 induces LC-3 expression and mediates tamoxifen resistance in breast cancer. J Biol Chem. 2010;285:23829-41 pubmed publisher
    ..Here, we demonstrate that peptidyl-prolyl isomerase Pin1 is an important determinant of resistance to tamoxifen and show that Pin1 increases E2F-4- and Egr-1-driven ..
  35. Li X, Hyink D, Radbill B, Sudol M, Zhang H, Zheleznova N, et al. Protein kinase-X interacts with Pin-1 and Polycystin-1 during mouse kidney development. Kidney Int. 2009;76:54-62 pubmed publisher
    ..These studies suggest that Polycystin-1 and Pin-1 may mediate the function of PRKX in kidney development. ..
  36. Risal P, Park B, Cho B, Kim J, Jeong Y. Overexpression of peptidyl-prolyl isomerase Pin1 attenuates hepatocytes apoptosis and secondary necrosis following carbon tetrachloride-induced acute liver injury in mice. Pathol Int. 2012;62:8-15 pubmed publisher
    b>Pin1, a member of the parvulin family of PPIase enzymes, plays a crucial role in the post phosphorylation regulation that governs important roles in the cell signaling mechanism and regulates a variety of cellular events...
  37. Xu T, Zhang H, Park S, Venneti S, Kuick R, Ha K, et al. Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis. Neoplasia. 2017;19:216-225 pubmed publisher
    ..discovered a novel interaction between GLI1, a key transcription factor for the mediation of Hedgehog signals, and PIN1, a peptidylprolyl cis/trans isomerase that regulates the postphosphorylation fate of its targets...
  38. Lee S, Jeong H, Han Y, Cheong H, Kang B, Lee K. Prolyl isomerase Pin1 regulates the osteogenic activity of Osterix. Mol Cell Endocrinol. 2015;400:32-40 pubmed publisher
    ..Peptidyl-prolyl isomerase 1 (Pin1) catalyzes the isomerization of pSer/Thr-Pro bonds and induces a conformational change in its substrates, ..
  39. Jeong H, Pokharel Y, Lim S, Hwang Y, Han E, Yoon J, et al. Novel role of Pin1 induction in type II collagen-mediated rheumatoid arthritis. J Immunol. 2009;183:6689-97 pubmed publisher
    ..Inflammatory mediators such as PGs and proinflammatory cytokines contribute to RA progress. Pin1, a peptidyl prolyl isomerase, plays important pathophysiological roles in several diseases, including cancer and ..
  40. Cancino G, Miller F, Kaplan D. p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease. Neurobiol Aging. 2013;34:387-99 pubmed publisher
    ..with 2 mouse models of neurodegeneration, TgCRND8+/Ø mice that express human mutant amyloid precursor protein, and Pin1-/- mice...
  41. Wei S, Yoshida N, Finn G, Kozono S, Nechama M, Kyttaris V, et al. Pin1-Targeted Therapy for Systemic Lupus Erythematosus. Arthritis Rheumatol. 2016;68:2503-13 pubmed publisher
    ..Notably, the prolyl isomerase Pin1 is an essential regulator of IRAK-1 in TLR-7/TLR-9 signaling, but its role in SLE is unknown...
  42. Takahashi K, Akiyama H, Shimazaki K, Uchida C, Akiyama Okunuki H, Tomita M, et al. Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch1. Oncogene. 2007;26:3835-45 pubmed
    ..DNA damage leads to phosphorylation on the Ser/Thr-Pro motifs of p53, which facilitates interaction with Pin1, a pSer/pThr-Pro-specific peptidyl prolyl isomerase...
  43. Stanya K, Liu Y, Means A, Kao H. Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT. J Cell Biol. 2008;183:49-61 pubmed publisher
    ..However, regulation of SMRT stability remains largely unexplored. We show that the peptidyl-prolyl isomerase Pin1 interacts with SMRT both in vitro and in mammalian cells...
  44. Bitomsky N, Conrad E, Moritz C, Polonio Vallon T, Sombroek D, Schultheiss K, et al. Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death. Proc Natl Acad Sci U S A. 2013;110:E4203-12 pubmed publisher
    ..Mechanistically, autophosphorylation creates a binding signal for the phospho-specific isomerase Pin1. Pin1 links HIPK2 activation to its stabilization by inhibiting HIPK2 polyubiquitination and modulating Siah-1-..
  45. Shen Z, Hu J, Ali A, Pastor J, Shiizaki K, Blank R, et al. Pin1 null mice exhibit low bone mass and attenuation of BMP signaling. PLoS ONE. 2013;8:e63565 pubmed publisher
    ..Here we show, for the first time, that the peptidyl-prolyl isomerase PIN1 controls the osteogenic activity of osteoblasts...
  46. Park J, Lee J, Park S, Lee D, Kim S, Kim H, et al. A critical step for JNK activation: isomerization by the prolyl isomerase Pin1. Cell Death Differ. 2012;19:153-61 pubmed publisher
    ..However, the precise molecular mechanisms for activation after phosphorylation remain elusive. Here we show that Pin1, a peptidyl-prolyl isomerase, has a key role in the JNK1 activation process by modulating a phospho-Thr-Pro motif ..
  47. Huang G, Qiu J, Li B, Wu J, Lu Y, Liu X, et al. Prolyl isomerase Pin1 regulated signaling pathway revealed by Pin1 +/+ and Pin1 -/- mouse embryonic fibroblast cells. Pathol Oncol Res. 2013;19:667-75 pubmed publisher
    b>Pin1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1) plays a key role in a number of diseases including cancer and Alzheimer disease. Previous studies have identified a wide range of phosphoproteins as Pin1 substrates...
  48. Min S, Cho J, Oh J, Shim S, Hwang D, Lee S, et al. Tau and GSK3beta dephosphorylations are required for regulating Pin1 phosphorylation. Neurochem Res. 2005;30:955-61 pubmed
    b>Pin1 binds mitotically phosphorylated Thr231-Pro232 and Thr212-Pro213 sites on tau, and a Pin1 deficiency in mice leads to tau hyperphosphorylation...
  49. Li Q, Tep C, Yune T, Zhou X, Uchida T, Lu K, et al. Opposite regulation of oligodendrocyte apoptosis by JNK3 and Pin1 after spinal cord injury. J Neurosci. 2007;27:8395-404 pubmed c-Jun N-terminal kinase 3 (JNK3) and protein interacting with the mitotic kinase, never in mitosis A I (Pin1), the actions of which converge on myeloid cell leukemia sequence-1 (Mcl-1)...
  50. Lim J, Balastik M, Lee T, Nakamura K, Liou Y, Sun A, et al. Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. J Clin Invest. 2008;118:1877-89 pubmed publisher
    ..The prolyl isomerase Pin1 binds and isomerizes tau and has been implicated in protecting against neurodegeneration, but whether such Pin1 ..
  51. Nakatsu Y, Mori K, Matsunaga Y, Yamamotoya T, Ueda K, Inoue Y, et al. The prolyl isomerase Pin1 increases ?-cell proliferation and enhances insulin secretion. J Biol Chem. 2017;292:11886-11895 pubmed publisher
    The prolyl isomerase Pin1 binds to the phosphorylated Ser/Thr-Pro motif of target proteins and enhances their cis-trans conversion...
  52. Antonelli R, De Filippo R, Middei S, Stancheva S, Pastore B, Ammassari Teule M, et al. Pin1 Modulates the Synaptic Content of NMDA Receptors via Prolyl-Isomerization of PSD-95. J Neurosci. 2016;36:5437-47 pubmed publisher
    ..targets through postphosphorylation conformational changes catalyzed by the peptidyl-prolyl cis-/trans isomerase Pin1. By flipping the substrate between two different functional conformations, this enzyme exerts a fine-tuning of ..
  53. Lee Y, Que J, Chen Y, Lin J, Liou Y, Liao P, et al. Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex. J Cell Sci. 2013;126:4862-72 pubmed publisher
    b>Pin1 was the first prolyl isomerase identified that is involved in cell division. The mechanism by which Pin1 acts as a negative regulator of mitotic activity in G2 phase remains unclear...