Pik3r1

Summary

Gene Symbol: Pik3r1
Description: phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
Alias: PI3K, p50alpha, p55alpha, p85alpha, PI3-kinase subunit p85-alpha, PI3K regulatory subunit alpha, phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, phosphatidylinositol 3-kinase regulatory subunit alpha
Species: mouse

Top Publications

  1. ncbi CD86 stimulation on a B cell activates the phosphatidylinositol 3-kinase/Akt and phospholipase C gamma 2/protein kinase C alpha beta signaling pathways
    Nicholas W Kin
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Immunol 176:6727-35. 2006
  2. pmc Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers
    Barbara Geering
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, United Kingdom
    Proc Natl Acad Sci U S A 104:7809-14. 2007
  3. pmc p85 Associates with unphosphorylated PTEN and the PTEN-associated complex
    Rosalia Rabinovsky
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Mol Cell Biol 29:5377-88. 2009
  4. pmc Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms
    Kohjiro Ueki
    Research Division, Joslin Diabetes Center, and Departmentof Medicine, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 24:5434-46. 2004
  5. ncbi Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells
    Subbiah Pugazhenthi
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, P O Box 6511, Mail Stop 8106, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 293:E645-55. 2007
  6. pmc Hypoxia up-regulates CD36 expression and function via hypoxia-inducible factor-1- and phosphatidylinositol 3-kinase-dependent mechanisms
    Bupe R Mwaikambo
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 284:26695-707. 2009
  7. ncbi Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase
    Y Terauchi
    Department of Internal Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Japan
    Nat Genet 21:230-5. 1999
  8. pmc The monocyte chemoattractant protein-1/CCR2 loop, inducible by TGF-beta, increases podocyte motility and albumin permeability
    Eun Young Lee
    Division of Nephrology Hypertension, Northwestern University, Chicago, Illinois 60611, USA
    Am J Physiol Renal Physiol 297:F85-94. 2009
  9. pmc The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation
    Sang Won Park
    Division of Endocrinology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:429-37. 2010
  10. ncbi PI3-kinase activity modulates apo B available for hepatic VLDL production in apobec-1-/- mice
    Doru V Chirieac
    Dept of Pathology and Laboratory Medicine, Univ of Rochester School of Medicine and Dentistry, P O Box 626, 601 Elmwood Ave, Rochester, New York 14642, USA
    Am J Physiol Gastrointest Liver Physiol 291:G382-8. 2006

Research Grants

Scientific Experts

Detail Information

Publications116 found, 100 shown here

  1. ncbi CD86 stimulation on a B cell activates the phosphatidylinositol 3-kinase/Akt and phospholipase C gamma 2/protein kinase C alpha beta signaling pathways
    Nicholas W Kin
    Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Immunol 176:6727-35. 2006
    ..In this study, we show that CD86 stimulation on an activated B cell increases the activity of PI3K and the phosphorylation of phosphoinositide-dependent kinase 1, Akt, and IkappaB kinase alphabeta...
  2. pmc Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers
    Barbara Geering
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, United Kingdom
    Proc Natl Acad Sci U S A 104:7809-14. 2007
    ..p110beta, or p110delta) bound to any of five distinct regulatory subunits (p85alpha, p85beta, p55gamma, p55alpha, and p50alpha, collectively referred to as "p85s")...
  3. pmc p85 Associates with unphosphorylated PTEN and the PTEN-associated complex
    Rosalia Rabinovsky
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Mol Cell Biol 29:5377-88. 2009
    ..D3 position of phosphoinositide-3,4,5-trisphosphate, thereby negatively regulating the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway...
  4. pmc Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms
    Kohjiro Ueki
    Research Division, Joslin Diabetes Center, and Departmentof Medicine, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 24:5434-46. 2004
    ..These data indicate that SOCS-1 and SOCS-3 act as negative regulators in insulin signaling and serve as one of the missing links between insulin resistance and cytokine signaling...
  5. ncbi Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells
    Subbiah Pugazhenthi
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, P O Box 6511, Mail Stop 8106, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 293:E645-55. 2007
    ..Our observations suggest that demethoxy curcuminoids could be used to induce a cellular defense mechanism in beta-cells under conditions of stress as seen in diabetes...
  6. pmc Hypoxia up-regulates CD36 expression and function via hypoxia-inducible factor-1- and phosphatidylinositol 3-kinase-dependent mechanisms
    Bupe R Mwaikambo
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 284:26695-707. 2009
    ..Together, our findings indicate a novel mechanism by which hypoxia induces CD36 expression via activation of HIF-1 and the phosphatidylinositol 3-kinase pathway...
  7. ncbi Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase
    Y Terauchi
    Department of Internal Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Japan
    Nat Genet 21:230-5. 1999
    ..the role of PI3K in glucose homeostasis, we generated mice with a targeted disruption of the gene encoding the p85alpha regulatory subunit of PI3K (Pik3r1; refs 3-5)...
  8. pmc The monocyte chemoattractant protein-1/CCR2 loop, inducible by TGF-beta, increases podocyte motility and albumin permeability
    Eun Young Lee
    Division of Nephrology Hypertension, Northwestern University, Chicago, Illinois 60611, USA
    Am J Physiol Renal Physiol 297:F85-94. 2009
    ..In conclusion, this is the first description that TGF-beta signaling through PI3K induces the podocyte expression of MCP-1 that can then operate via CCR2 to increase cellular migration and alter ..
  9. pmc The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation
    Sang Won Park
    Division of Endocrinology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:429-37. 2010
    ..Here, we show that the regulatory subunits of phosphotidyl inositol 3-kinase (PI3K), p85alpha (encoded by Pik3r1) and p85beta (encoded by Pik3r2) form heterodimers that are disrupted by insulin treatment...
  10. ncbi PI3-kinase activity modulates apo B available for hepatic VLDL production in apobec-1-/- mice
    Doru V Chirieac
    Dept of Pathology and Laboratory Medicine, Univ of Rochester School of Medicine and Dentistry, P O Box 626, 601 Elmwood Ave, Rochester, New York 14642, USA
    Am J Physiol Gastrointest Liver Physiol 291:G382-8. 2006
    ....
  11. pmc Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism
    Xuxiao Zhang
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Mol Cell 41:567-78. 2011
    ..This contrasts with the nSH2 where the pY-binding site itself forms the inhibitory contact. This establishes an unusual mechanism by which p85 SH2 domains contribute to RTK signaling specificities...
  12. ncbi Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha
    D A Fruman
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Science 283:393-7. 1999
    ..The mouse gene encoding the PI3K adapter subunit p85alpha and its splice variants p55alpha and p50alpha was disrupted. Most p85alpha-p55alpha-p50alpha-/- mice die within days after birth...
  13. ncbi Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death
    Enzo Calautti
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 280:32856-65. 2005
    ..We show here that the phosphoinositide 3-kinase (PI3K)/Akt pathway is activated at early stages of mouse keratinocyte differentiation both in culture and in the intact ..
  14. ncbi Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells
    A W M Lee
    Department of Pharmacology, University of Michigan Medical School, 1150W Medical Center Dr, Ann Arbor, MI 48109, USA
    Cell Death Differ 13:1900-14. 2006
    ..This study identifies robust PI3-kinase activation as essential for optimal CSF-1-mediated mitogenesis in myeloid cells, in part through regulation of HKII and support of glycolysis...
  15. pmc Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions
    Feng Chun Yang
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Invest 116:2880-91. 2006
    ..Intercrossing Nf1(+/-) mice and mice deficient in class 1(A) PI3K (p85alpha) restored elevated PI3K activity and Nf1(+/-) osteoclast functions to WT levels...
  16. pmc T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase
    Anjali J de Souza
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 180:6518-26. 2008
    ..Tim-1 becomes phosphorylated in a lck-dependent manner, whereupon it can directly recruit p85 adaptor subunits of PI3K. This results in PI3K activation, which is required for Tim-1 function...
  17. pmc p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity
    Dong Chen
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell Biol 24:320-9. 2004
    ..tissues such as fat, muscle, and liver express the splice variants of the pik3r1 gene, p50alpha and p55alpha. To define the role of these variants, we have created mice with a deletion of p50alpha and p55alpha by using ..
  18. doi A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response
    Jonathon N Winnay
    Section on Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:438-45. 2010
    ..of insulin, is composed of a catalytic (p110alpha or p110beta) and regulatory (p85alphaalpha, p85betaalpha or p55alpha) subunit...
  19. pmc Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance
    Tobias A Beyer
    Department of Biology, Institute of Cell Biology, ETH Zurich, Zurich, Switzerland
    EMBO J 27:212-23. 2008
    ..These findings may provide the basis for the development of new strategies to improve regeneration in patients with acute or chronic liver damage...
  20. ncbi Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells
    Katia Fecchi
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    FASEB J 20:705-7. 2006
    ..insulin for 10 min results in the translocation of flotillin-1/GLUT4-containing domains to the plasma membrane in a PI3K- and PKCzeta-dependent manner...
  21. pmc The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration
    Veerendra Munugalavadla
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, 2 Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Mol Cell Biol 28:7182-98. 2008
    ..subunits of class I(A) phosphatidylinositol 3-kinase (PI3-K) although the expression of the full-length form of p85alpha is most abundant...
  22. ncbi Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation
    Lazaros C Foukas
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK
    Nature 441:366-70. 2006
    ..These findings demonstrate a critical role for p110alpha in growth factor and metabolic signalling and also suggest an explanation for selective mutation or overexpression of p110alpha in a variety of cancers...
  23. ncbi A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling
    Diana L Esposito
    Department of Oncology and Neurosciences, Section of Molecular Pathology, University Gabriele D Annunzio, 66013 Chieti, Italy
    J Clin Endocrinol Metab 88:1468-75. 2003
    ..We conclude that a naturally occurring substitution of Arg for Thr(608) in IRS-1 is a rare human mutation that may contribute to insulin resistance by impairing metabolic signaling through PI 3-kinase-dependent pathways...
  24. pmc The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
    Ji Luo
    Department of Systems Biology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Cell Biol 170:455-64. 2005
    ..To further understand the role of p85, we examined IGF-1-dependent translocation of p85alpha by using a green fluorescence protein (GFP)-tagged p85alpha (EGFP-p85alpha)...
  25. ncbi Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration
    Wen Mei Yu
    Department of Hematopoiesis, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Blood 99:2351-9. 2002
    ..Taken together, these results suggest an important signaling role for Gab2 in regulating hematopoietic cell adhesion and migration...
  26. ncbi Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase
    T Yamauchi
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113, Japan
    J Biol Chem 273:15719-26. 1998
    ..Taken together, the role of IRS-1, -2, and -3 in GH and PRL signalings appears to be phosphorylated by JAK2, thereby providing docking sites for p85 PI3-kinase and activating PI3-kinase and its downstream biological effects...
  27. pmc Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells
    Mohd Minhajuddin
    Department of Pediatrics Neonatology, Lung Biology and Disease Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 284:4052-61. 2009
    ..was defective in embryonic fibroblasts from mice with targeted disruption of PKC-delta (Pkc-delta(-)(/)(-)), p85alpha and p85beta subunits of the PI3K (p85alpha(-)(/)(-)beta(-)(/)(-)), or Akt1 and Akt2 (Akt1(-)(/)(-)2(-)(/)(-))...
  28. ncbi Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5
    Xiong Su
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:27982-90. 2006
    ..of PKB/Akt activation was because of the impaired interaction between insulin receptor substrate 1 and the p85alpha subunit of phosphatidylinositol 3-kinase...
  29. pmc Activation of phosphatidylinositol-3 kinase regulates pancreatic duodenal homeobox-1 in duct cells during pancreatic regeneration
    Hiroaki Watanabe
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX 77555 0526, USA
    Pancreas 36:153-9. 2008
    The purpose of our study was to determine whether the phosphatidylinositol 3-kinase (PI3K)/Akt pathway contributes to expression of pancreatic duodenal homeobox-1 (PDX-1) in duct cells and the cell differentiation during pancreatic ..
  30. ncbi Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha
    D A Fruman
    Division of Signal Transduction, Beth Israel Deaconess Medical Center Boston, Massachusetts, USA
    Nat Genet 26:379-82. 2000
    ..The gene Pik3r1 encodes three proteins (p85 alpha, p55 alpha and p50 alpha) that serve as regulatory subunits of class IA Pi3ks (..
  31. ncbi Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling
    Kohjiro Ueki
    Research Division, Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:48453-66. 2003
    ..regulatory isoforms, p85 alpha and p85 beta, we have established brown adipose cell lines with disruption of the Pik3r1 or Pik3r2 gene...
  32. pmc Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
    Franck Mauvais-Jarvis
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 109:141-9. 2002
    ..The major regulatory subunits of PI 3-kinase, p85alpha and its splice variants, are encoded by the Pik3r1 gene...
  33. pmc Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival
    Kohjiro Ueki
    Research Division, Joslin Diabetes Center, Harvard Medical School Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Mol Cell Biol 22:965-77. 2002
    ..of a p110 catalytic subunit and a regulatory subunit, the most common family of which is derived from the p85alpha gene (Pik3r1)...
  34. ncbi Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling
    Antonio Curcio
    Dept of Medicine, Cell Biology, and Molecular Genetics, Duke Univ Medical Center, DUMC 3104, Durham, NC 27710, USA
    Am J Physiol Heart Circ Physiol 291:H1754-60. 2006
    ..studies have shown that overexpression of the phosphoinositide kinase (PIK) domain of phosphoinositide 3-kinase (PI3K), prevents beta-AR downregulation and enhances adrenergic agonist responsiveness by inhibiting the targeting of ..
  35. doi Rescuing 3T3-L1 adipocytes from insulin resistance induced by stimulation of Akt-mammalian target of rapamycin/p70 S6 kinase (S6K1) pathway and serine phosphorylation of insulin receptor substrate-1: effect of reduced expression of p85alpha subunit of pho
    Rebecca Adochio
    Department of Veterans Affairs, University of Colorado Denver, Aurora, Colorado 80045, USA
    Endocrinology 150:1165-73. 2009
    ..We then reduced expression of the PI 3-kinase regulatory subunit, p85alpha, or expression of S6K1 kinase using small interfering RNA transfections, which led to a reduction in p85alpha ..
  36. ncbi Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains
    M Masuhara
    Institute of Life Science, Kurume University, Aikawamachi 2432 3, Kurume, 839 0861, Japan
    Biochem Biophys Res Commun 268:697-703. 2000
    ..These suggest that STAP-1 functions as an adaptor molecule downstream of c-kit in hematopoietic stem cells...
  37. pmc Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex
    Yun Zhong
    1 Laboratory of Molecular Biology, Howard Hughes Medical Institute, Rockefeller University, New York, NY 10065, USA 2 These authors contributed equally to the work
    Nat Cell Biol 11:468-76. 2009
    ..We hypothesize that by forming distinct protein complexes, Beclin 1 and its binding proteins orchestrate the precise function of the class III PI(3)K in regulating autophagy at multiple steps...
  38. pmc Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase
    Ji Luo
    Division of Signal Transduction, Beth Israel Deaconess Medical Center and Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:10238-43. 2005
    ..Here, we examined the effect of deleting various regulatory subunits of PI3K (p85alpha and p85beta) on epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice...
  39. pmc Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement
    Saskia M Brachmann
    Beth Israel Hospital, NRB, Division of Signal Transduction, Department of Systems Biology, 10th Floor, 330 Brookline, MA 02215, USA
    Mol Cell Biol 25:2593-606. 2005
    ..Although embryonic development is not impaired in mice lacking all isoforms of the p85alpha gene (p85alpha-/- p55alpha-/- p50alpha-/-) or in mice lacking the p85beta gene (p85beta-/-) (D. A. Fruman, F. Mauvais-Jarvis, D. A...
  40. pmc PI3K contributed to modulation of spinal nociceptive information related to ephrinBs/EphBs
    Li na Yu
    Department of Anesthesiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, People s Republic of China
    PLoS ONE 7:e40930. 2012
    ..In the present study, we investigated whether phosphatidylinositol 3-kinase (PI3K), as the downstream effectors, participates in modulation of spinal nociceptive information related to ephrinBs/..
  41. pmc c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway
    Christine B F Thien
    School of Pathology and Laboratory Medicine, University of Western Australia, Crawley 6009, Western Australia
    J Biol Chem 285:10969-81. 2010
    ..These findings identify tyrosine-phosphorylated c-Cbl as a critical sensor of TCR signal strength that regulates the engagement of death-promoting signals...
  42. ncbi Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase
    S Hunter
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 274:2097-106. 1999
    ....
  43. ncbi The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway
    M Ojaniemi
    La Jolla Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 272:3780-7. 1997
    ..These observations suggest that Cbl serves as a docking protein and may transduce signals to downstream signaling pathways following integrin-mediated cell adhesion in macrophages...
  44. doi Cockroach allergen Per a 7 down-regulates expression of Toll-like receptor 9 and IL-12 release from P815 cells through PI3K and MAPK signaling pathways
    Haiwei Yang
    Clinical Research Centre, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
    Cell Physiol Biochem 29:561-70. 2012
    ..However, influence of specific cockroach allergen on Th1 cytokine release and expression of TLR9 in mast cells remains uninvestigated...
  45. doi miR-376a suppresses proliferation and induces apoptosis in hepatocellular carcinoma
    Yongxia Zheng
    Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China
    FEBS Lett 586:2396-403. 2012
    ..Additionally, p85α (PIK3R1) was identified as a direct and functional target of miR-376a in Huh7 cells...
  46. ncbi Requirements for pYXXM motifs in Cbl for binding to the p85 subunit of phosphatidylinositol 3-kinase and Crk, and activation of atypical protein kinase C and glucose transport during insulin action in 3T3/L1 adipocytes
    Mary L Standaert
    Research Service, James A Haley Veterans Medical Center, and Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Biochemistry 43:15494-502. 2004
    ....
  47. pmc Separation and characterization of the activated pool of colony-stimulating factor 1 receptor forming distinct multimeric complexes with signalling molecules in macrophages
    V Kanagasundaram
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Mol Cell Biol 19:4079-92. 1999
    ..Specific structural proteins associated with the separate CSF-1R multimeric complexes upon CSF-1 stimulation and the presence of the distinct pools of the CSF-1R were dependent on the integrity of the microtubular network...
  48. ncbi RANKL-induced down-regulation of CX3CR1 via PI3K/Akt signaling pathway suppresses Fractalkine/CX3CL1-induced cellular responses in RAW264.7 cells
    Yurika Saitoh
    Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Biochem Biophys Res Commun 364:417-22. 2007
    ..Inhibitors of phosphatidylinositol 3-kinase (PI3K) and Akt, but not mitogen-activated protein kinases, restored the RANKL-induced reduction of CX3CR1 mRNA...
  49. pmc Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways
    Helena Mueller
    Department of Anesthesiology and Intensive Care Medicine, University of Munster, 48149 Munster, Germany
    Blood 115:3118-27. 2010
    ..the signaling pathway downstream of Syk divides into a phospholipase C (PLC) gamma2- and phosphoinositide 3-kinase (PI3K) gamma-dependent pathway...
  50. pmc Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2
    Si Qing Zhang
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 22:4062-72. 2002
    ..that the protein tyrosine phosphatase Shp2 regulates the strength and duration of phosphatidylinositol 3'-kinase (PI3K) activation in the epidermal growth factor (EGF) receptor signaling pathway...
  51. ncbi The PI3K-Akt pathway promotes microtubule stabilization in migrating fibroblasts
    Keisuke Onishi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Genes Cells 12:535-46. 2007
    ..Here we show that the PI3K-Akt signaling pathway plays a pivotal role in growth factor regulation of microtubule stability...
  52. ncbi TIMP-3 and Phosphatidylinositol 3-kinase genes were found to be related to the progression of colon cancer in a comparison of pneumoperitoneum and laparotomy in a murine model
    Fumiaki Tanaka
    Division of Molecular and Surgical Oncology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Beppu 874 0838, Japan
    Surg Today 37:220-5. 2007
    ..However, no basic and molecular-biological examinations have yet to elucidate the mechanisms of such an improved outcome...
  53. ncbi Vav-dependent and vav-independent phosphatidylinositol 3-kinase activation in murine B cells determined by the nature of the stimulus
    Elena Vigorito
    Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, Babraham Institute, Babraham, Cambridge, United Kingdom
    J Immunol 173:3209-14. 2004
    ..The p85alpha and p110delta subunits of PI3K both participate in anti-IgM and mIg/CD19 coligation-induced Ca(2+) flux, although ..
  54. ncbi c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway
    Wook Jin
    Laboratory of Cell Regulation and Carcinogenesis, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Incheon 406 840, Korea
    J Biol Chem 283:1391-400. 2008
    ..major effector pathways, namely the Ras-MAP kinase (MAPK) mitogenic pathway and the phosphatidylinositol 3-kinase (PI3K)-AKT pathway mediating cell survival...
  55. pmc Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development
    Yinfei Tan
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Genesis 48:531-9. 2010
    ..that participates in cell signaling by interacting with various signaling molecules including Akt, PI3-kinase (PI3K), Rab5, adiponectin receptor, and TrkA...
  56. ncbi BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
    T Okada
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan
    Immunity 13:817-27. 2000
    ..Here, we report the identification of a novel B cell adaptor for phosphoinositide 3-kinase (PI3K), termed BCAP...
  57. ncbi Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes. A possible explanation for their specific effects on glucose transport
    J M Ricort
    INSERM U 145, Faculte de Medecine, Nice, France
    Eur J Biochem 239:17-22. 1996
    ....
  58. pmc Disrupted RabGAP function of the p85 subunit of phosphatidylinositol 3-kinase results in cell transformation
    M Dean Chamberlain
    Cancer Research Unit, Health Research Division, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan S7N 4H4, Canada
    J Biol Chem 283:15861-8. 2008
    ..The p85alpha subunit of phosphatidylinositol 3-kinase has GTPase-activating protein activity toward Rab5 and Rab4, an activity ..
  59. pmc TLR4/MyD88/PI3K interactions regulate TLR4 signaling
    Michelle H W Laird
    University of Maryland, Baltimore, 660 W Redwood Street, Room 324, Baltimore, MD 21201, USA
    J Leukoc Biol 85:966-77. 2009
    ..TLR4-mediated signaling also leads to rapid activation of PI3K, one of a family of kinases involved in regulation of cell growth, apoptosis, and motility...
  60. pmc Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells
    Masashi Ohtani
    Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
    Blood 112:635-43. 2008
    Phosphoinositide 3-kinase (PI3K) negatively regulates Toll-like receptor (TLR)-mediated interleukin-12 (IL-12) expression in dendritic cells (DCs)...
  61. doi Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase
    Libor Macurek
    Department of Biology of Cytoskeleton, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Biochem J 416:421-30. 2008
    ..Furthermore, in vitro kinase assays showed that p85alpha (regulatory p85alpha subunit of PI3K) serves as a Fyn substrate...
  62. pmc PI3K signaling in glioma--animal models and therapeutic challenges
    Christine K Cheng
    Department of Neurology, University of California, San Francisco, CA 94143, USA
    Brain Pathol 19:112-20. 2009
    The PI3 kinase (PI3K) family plays a complex role in cell biology and metabolism...
  63. ncbi PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction
    Harumi Suzuki
    Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Nat Immunol 4:280-6. 2003
    Phosphoinositide-3 kinase (PI3K) is thought to activate the tyrosine kinase Btk...
  64. pmc A PI3K activity-independent function of p85 regulatory subunit in control of mammalian cytokinesis
    Zaira García
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    EMBO J 25:4740-51. 2006
    ..We studied the role of p85/p110 phosphoinositide kinase (PI3K) in mammalian cytokinesis. Deletion of the p85alpha regulatory subunit induced cell accumulation in telophase and appearance of binucleated cells, whereas inhibition ..
  65. pmc Balanced interactions between Lyn, the p85alpha regulatory subunit of class I(A) phosphatidylinositol-3-kinase, and SHIP are essential for mast cell growth and maturation
    Peilin Ma
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut Street, Indianapolis, IN 46202, USA
    Mol Cell Biol 31:4052-62. 2011
    ..forms of these receptors lacking the binding sites for Src family kinases (SFKs) and phosphatidylinositol-3-kinase (PI3K) suggest a role for these signaling molecules in regulating growth and survival, how complete loss of these ..
  66. pmc Distinct roles of phosphoinositide-3 kinase and phospholipase Cgamma2 in B-cell receptor-mediated signal transduction
    Xuezhi Dai
    Blood Research Institute, 8727 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Mol Cell Biol 26:88-99. 2006
    During B-cell receptor (BCR) signaling, phosphoinositide-3 kinase (PI3K) is thought to function upstream of phospholipase Cgamma2 (PLCgamma2)...
  67. pmc Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains
    Jennifer Y Lee
    Division of Signal Transduction, Cancer Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 108:14157-62. 2011
    ..The p85 regulatory subunit of PI3K contains Src homology-2 (SH2) domains that mediate binding to tyrosine-phosphorylated receptors or adaptor proteins ..
  68. ncbi Thrombopoietin (TPO) induces c-myc expression through a PI3K- and MAPK-dependent pathway that is not mediated by Akt, PKCzeta or mTOR in TPO-dependent cell lines and primary megakaryocytes
    Supantitra Chanprasert
    Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand
    Cell Signal 18:1212-8. 2006
    ..TPO signals through the Jak-STAT, Ras-Raf-MAPK, and PI3K pathways, and promotes survival, proliferation, and polyploidization in megakaryocytes...
  69. ncbi Role of TNF receptor-associated factor 3 in the CD40 signaling by production of reactive oxygen species through association with p40phox, a cytosolic subunit of nicotinamide adenine dinucleotide phosphate oxidase
    Yun Jung Ha
    Division of Molecular Life Sciences and Center for Cell Signaling Research, College of Natural Sciences, Ewha Womans University, 11 1 Daehyun Dong, Seodaemun gu, Seoul 120 750, Korea
    J Immunol 172:231-9. 2004
    ..Collectively, these data suggest that the CD40-induced ROS production by NADPH oxidase in WEHI 231 requires the role of TRAF3, as well as activities of PI3-K and Rac1...
  70. pmc Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α
    John E Burke
    Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
    Structure 19:1127-37. 2011
    ..DXMS identified regions decreasing exposure at membranes and also regions gaining exposure, indicating loosening of interactions within the heterodimer at membranes...
  71. pmc Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms
    Kazuma Kaneko
    Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Cell Metab 12:619-32. 2010
    ..Inhibition of class IA phosphatidylinositol 3-kinase (PI3K), using a mouse model lacking the pik3r1 gene specifically in β cells and the pik3r2 gene systemically (βDKO mouse), results in glucose intolerance and ..
  72. ncbi Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor
    A R Venkitaraman
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, GB
    Eur J Immunol 24:2168-74. 1994
    ..PtdIns 3-kinase may, therefore, play a unique and important role in the biological response to IL-7...
  73. pmc Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy
    Ji Luo
    Division of Systems Biology, Harvard Medical School, Beth Israel Deaconess Medical Center, 77 Avenue Louis Pasteur, 10th Floor, Boston, MA 02115, USA
    Mol Cell Biol 25:9491-502. 2005
    ..of dominant negative and constitutively active proteins, we generated mice with muscle-specific deletion of the p85alpha regulatory subunit and germ line deletion of the p85beta regulatory subunit of class I(A) PI3K...
  74. ncbi BCR targets cyclin D2 via Btk and the p85alpha subunit of PI3-K to induce cell cycle progression in primary mouse B cells
    Janet Glassford
    Cancer Research UK Labs and Section of Cancer Cell Biology, Department of Cancer Medicine, Imperial College School of Medicine at Hammersmith Hospital, Londom, UK
    Oncogene 22:2248-59. 2003
    The p85alpha subunit of PI3-K and Btk are two crucial components of the B-cell receptor (BCR) signalling pathway...
  75. pmc Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase
    Shi Chen
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Pathol 177:3125-32. 2010
    ..as well as pharmacological agents to link the hyperactivation of the p21(Ras)-phosphatidylinositol 3-kinase (PI3K) pathway to the increased degranulation of Nf1(+/-) mast cells both in vitro and in vivo...
  76. ncbi Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85alpha
    Amber C Donahue
    Center for Immunology and Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA
    Int Immunol 16:1789-98. 2004
    ..Mice lacking p85alpha, the predominant PI3K regulatory isoform, exhibit defects in B cell development and activation that are grossly ..
  77. pmc Toll-like receptor 2- and MyD88-dependent phosphatidylinositol 3-kinase and Rac1 activation facilitates the phagocytosis of Listeria monocytogenes by murine macrophages
    Yanna Shen
    Department of Microbiology, Kyoto University Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Infect Immun 78:2857-67. 2010
    ..The efficiency of phagocytosis was suppressed by inhibitors of phosphatidylinositol 3-kinase (PI3K) and the small Rho GTPases but not by cycloheximide...
  78. ncbi Functional p85alpha gene is required for normal murine fetal erythropoiesis
    Hannah Huddleston
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut St, R4 470, Indianapolis, IN 46202, USA
    Blood 102:142-5. 2003
    ..However, when class IA PI-3 kinase-deficient mice were generated by a targeted deletion of the p85alpha regulatory subunit, fetal erythropoiesis was reportedly unaffected...
  79. pmc The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment
    Margaret I Arbuckle
    Centre for Neuroregeneration, The University of Edinburgh, Institute of Immunology and Infection, Ashworth Buildings, Kings Buildings, Edinburgh EH9 3JT, UK
    EMBO Rep 11:473-8. 2010
    ..These results show that different types of behavioural plasticity are mediated by specific domains of PSD95 and suggest novel therapeutic avenues for reducing inflammatory pain...
  80. ncbi The GTPase dynamin binds to and is activated by a subset of SH3 domains
    I Gout
    Ludwig Institute for Cancer Research, London, England
    Cell 75:25-36. 1993
    ....
  81. doi Oncogenic H-Ras and PI3K signaling can inhibit E-cadherin-dependent apoptosis and promote cell survival after photodynamic therapy in mouse keratinocytes
    Jesus Espada
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC Departamento de Bioquímica, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain
    J Cell Physiol 219:84-93. 2009
    ..situation was observed in cells showing constitutive activation of the p110 alpha catalytic subunit of class IA PI3K. This protective effect is associated with beta-catenin-dependent transcription and with activation of survival ..
  82. doi Role of the liver in glucose homeostasis in PI 3-kinase p85alpha-deficient mice
    Kazutaka Aoki
    Department of Endocrinology and Metabolism, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Am J Physiol Endocrinol Metab 296:E842-53. 2009
    ..In the livers of p85alpha-deficient mice, p50alpha played a compensatory role in insulin-stimulated PI3K activation by binding to insulin receptor substrate (IRS)-1/..
  83. doi An involvement of BDNF and PI3-K/Akt in the anti-apoptotic effect of memantine on staurosporine-evoked cell death in primary cortical neurons
    D Jantas
    Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Apoptosis 14:900-12. 2009
    ..e. ERK1/2, JNK and GSK3-beta. The obtained data suggest an NMDAR-independent action of memantine in attenuation of neuronal apoptosis and point to the engagement of BDNF and PI3-K/Akt pathway in these processes...
  84. ncbi The gene that encodes the phosphatidylinositol-3 kinase regulatory subunit (p85 alpha) maps to chromosome 13 in the mouse
    J Hoyle
    Department of Biochemistry and Molecular Genetics, St Mary s Hospital Medical School, Imperial College, London, United Kingdom
    Genomics 24:400-2. 1994
  85. doi Mesothelin inhibits paclitaxel-induced apoptosis through the PI3K pathway
    Ming Cheng Chang
    Department of Obstetrics and Gynecology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Biochem J 424:449-58. 2009
    ..Furthermore, mesothelin-treated cells revealed rapid tyrosine phosphorylation of the p85 subunit of PI3K (phosphoinositide 3-kinase) and ERK (extracellular-signal-regulated kinase) 1/2 for enhancing MAPK (mitogen-..
  86. doi Heat shock cognate protein 70 is essential for Akt signaling in endothelial function
    Masayuki Shiota
    Department of Pharmacology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Arterioscler Thromb Vasc Biol 30:491-7. 2010
    ..Herein, we investigate the role of Hsp70s, including heat shock cognate protein 70 (Hsc70), which is constitutively expressed in nonstressed cells (ie, ECs)...
  87. pmc Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase
    Y W Fridell
    Lineberger Comprehensive Cancer Center, Department of Pharmacology, University of North Carolina at Chapel Hill 27599 7295, USA
    Mol Cell Biol 16:135-45. 1996
    ..Furthermore, our data suggest that the GAS6-Axl interaction does not induce mitogenesis and that its exact role remains to be determined...
  88. ncbi Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
    D D Schlaepfer
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186
    Nature 372:786-91. 1994
    ..Phosphorylation of FAK at Tyr 925 upon fibronectin stimulation creates an SH2-binding site for GRB2 which may link integrin engagement to the activation of the Ras/MAPK signal transduction pathway...
  89. doi Fibroblast growth factor 2-induced cytoplasmic asparaginyl-tRNA synthetase promotes survival of osteoblasts by regulating anti-apoptotic PI3K/Akt signaling
    Su Jin Park
    Brain Korea 21 Project for Medical Science, College of Medicine, Yonsei University, Seoul, Republic of Korea
    Bone 45:994-1003. 2009
    ..In addition, NARS-induced protection against apoptosis was abolished by the treatment of PI3K inhibitors, wortmannin and LY294002...
  90. ncbi Phosphoinositide 3-kinase accelerates postoperative tumor growth by inhibiting apoptosis and enhancing resistance to chemotherapy-induced apoptosis. Novel role for an old enemy
    J Calvin Coffey
    Department of Surgery, Cork University Hospital, Wilton, Cork, Munster, Ireland
    J Biol Chem 280:20968-77. 2005
    ..This identified an increase and reduction in the expression of p110gamma and p85alpha class Ia phosphoinositide 3-kinase (PI3K) subunits in recurrent tumor epithelia...
  91. pmc Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase
    Jean S Oak
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Proc Natl Acad Sci U S A 103:16882-7. 2006
    ..In addition, the mouse model described here represents a tool to study the pathogenesis and treatment of SS...
  92. ncbi Phosphatidylinositol 3-kinase/Akt plays a part in tumor necrosis factor-alpha-induced interleukin-6 synthesis in osteoblasts
    S Takai
    Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu, Japan
    Horm Metab Res 38:563-9. 2006
    ..These results strongly suggest that PI3-kinase/Akt plays a role in the TNF-alpha-stimulated IL-6 synthesis mainly independent of p44/p42 MAP kinase in osteoblasts...
  93. ncbi Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice
    Hiroshi Yamashita
    Department of Pediatric, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Pediatr Res 53:411-8. 2003
    ....
  94. ncbi Enkurin is a novel calmodulin and TRPC channel binding protein in sperm
    Keith A Sutton
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Dev Biol 274:426-35. 2004
    ..We suggest that enkurin is an adaptor that functions to localize a Ca2+ sensitive signal transduction machinery in sperm to a Ca2+-permeable ion channel...
  95. pmc LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation
    Eun Mi Hur
    Div of Molecular Life Science, Ewha Woman s University, 11 1 Daehyundong, Seodaemungu, 120 750 Seoul, Korea
    J Exp Med 198:1463-73. 2003
    ..Our data collectively show that LIME is a raft-associated transmembrane adaptor protein linking TCR stimuli to downstream signaling pathways via associations with Lck...
  96. ncbi Active Ras-induced effects on skeletal myoblast differentiation and apoptosis are independent of constitutive PI3-kinase activity
    M Karasarides
    Department of Cell Biology, Learner Research Institute, Cleveland Clinic Foundation, OH 44195, USA
    Cell Biol Int 30:308-18. 2006
    ..Thus, our data suggest that a pathway distinct from those that signals through MAPK, NFkappaB or PI3-kinase is responsible for the impaired differentiation and apoptosis in 23A2 skeletal myoblasts expressing constitutively active Ras...
  97. ncbi Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess
    Linda A Barbour
    Department of Medicine, University Colorado Health Sciences Center, Denver, 80262, USA
    J Biol Chem 280:37489-94. 2005
    ..Herein, using transgenic mice bearing deletions in p85alpha, p85beta, or insulin-like growth factor-1, we provide novel evidence suggesting that overexpression of p85alpha ..
  98. ncbi Induction of cyclooxygenase-2 in macrophages by catalase: role of NF-kappaB and PI3K signaling pathways
    Byeong Churl Jang
    Chronic Disease Research Center and Institute for Medical Science, Keimyung University School of Medicine, 194 Dongsan dong, Jung Gu, Daegu 700 712, South Korea
    Biochem Biophys Res Commun 316:398-406. 2004
    ..Catalase also induced activation of NF-kappaB, PI3K, ERKs, p38s, or JNKs...
  99. ncbi The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins
    M Dean Chamberlain
    Cancer Research Unit, Health Research Division, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan S7N 4H4, Canada
    J Biol Chem 279:48607-14. 2004
    ..The p85alpha subunit of phosphatidylinositol 3'-kinase contains a BH domain with sequence homology to GTPase activating ..
  100. ncbi Frontline: The p85alpha isoform of phosphoinositide 3-kinase is essential for a subset of B cell receptor-initiated signaling responses
    Kristen L Hess
    Center for Immunology, Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA
    Eur J Immunol 34:2968-76. 2004
    ..B cell receptor (BCR)-driven proliferation is completely blocked either in cells lacking the p85alpha regulatory isoform of PI3K or in wild-type cells treated with pharmacological PI3K inhibitors...
  101. ncbi Phosphoinositide 3-kinase, Src, and Akt modulate acute ventilation-induced vascular permeability increases in mouse lungs
    Takashige Miyahara
    Department of Physiology, University of South Alabama, Mobile, Alabama 36688, USA
    Am J Physiol Lung Cell Mol Physiol 293:L11-21. 2007
    To determine the role of phosphoinositide 3-OH kinase (PI3K) pathways in the acute vascular permeability increase associated with ventilator-induced lung injury, we ventilated isolated perfused lungs and intact C57BL/6 mice with low and ..

Research Grants27

  1. Dietary supplementation with glucan enhances immune fn
    David Williams; Fiscal Year: 2002
    ..At the successful conclusion of this research e will have established what, if any, effect dietary supplementation with glucan has on modulating immunocompetence arid whether oral glucans will increase resistance to infectious diseases. ..
  2. PI3K Signaling in Single Lymphocytes Analyzed by LMS
    David Fruman; Fiscal Year: 2005
    ..Our second aim is to apply this technology to address the role of the PI3K regulatory isoform p85alpha in activation of different downstream signaling molecules.
  3. Phosphoinositide 3-Kinase Function in Lymphocytes
    David Fruman; Fiscal Year: 2006
    ..The central hypothesis guiding this application is that the PI3K regulatory isoforms p85alpha and p85beta have distinct functional roles in lymphocyte signaling...
  4. AMELIORATION OF SEPSIS BY MACROPHAGE ACTIVATION
    David Williams; Fiscal Year: 2009
    ..The phosphoinsitide 3-kinases/Akt (PI3K/Akt) is a conserved family of signal transduction enzymes which are involved in regulating cellular proliferation ..
  5. Light Activation of Retinal Insulin Receptor Signaling
    RAJU RAJALA; Fiscal Year: 2007
    ..The biological implications extend to the cause and treatment of a number of retinal degenerative diseases. ..
  6. AMELIORATION OF SEPSIS BY MACROPHAGE ACTIVATION
    David Williams; Fiscal Year: 2009
    ..The phosphoinsitide 3-kinases/Akt (PI3K/Akt) is a conserved family of signal transduction enzymes which are involved in regulating cellular proliferation ..
  7. Light Activation of Retinal Insulin Receptor Signaling
    RAJU RAJALA; Fiscal Year: 2009
    ..The biological implications extend to the cause and treatment of a number of retinal degenerative diseases. ..
  8. AMELIORATION OF SEPSIS BY MACROPHAGE ACTIVATION
    David Williams; Fiscal Year: 1999
    ..These data may ultimately lead to the development of better management strategies for patients predisposed to sepsis and septic shock. ..
  9. INSULIN RECEPTOR SIGNALING IN THE RETINA
    RAJU RAJALA; Fiscal Year: 2002
    ..Recently, we have reported that the p85 regulatory subunit of phosphatidylinositol 3-kinase (PI3K) interacts directly with the insulin receptor-beta subunit (IRb) in retinal rod outer segments (ROS), which leads ..
  10. AMELIORATION OF SEPSIS BY MACROPHAGE ACTIVATION
    David Williams; Fiscal Year: 2004
    ..The successful completion of these aims will advance our understanding of the cellular and molecular events associated with sepsis syndrome and may lead to the development of new therapeutics. ..
  11. Light Activation of Retinal Insulin Receptor Signaling
    RAJU VS RAJALA; Fiscal Year: 2010
    ..Light-activated IR is subsequently associated with phosphoinositide 3-kinase (PI3K), a cell survival factor, and thus regulates the downstream survival pathway...