Gene Symbol: Pick1
Description: protein interacting with C kinase 1
Alias: Prkcabp, PRKCA-binding protein, protein kinase C-alpha-binding protein, protein that interacts with C kinase 1
Species: mouse
Products:     Pick1

Top Publications

  1. Atianjoh F, Yaster M, Zhao X, Takamiya K, Xia J, Gauda E, et al. Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain. Pain. 2010;151:226-34 pubmed publisher
    Protein interacting with C kinase 1 (PICK1) is a PDZ-containing protein that binds to AMPA receptor (AMPAR) GluR2 subunit and protein kinase C? (PKC?) in the central neurons...
  2. Staudinger J, Zhou J, Burgess R, Elledge S, Olson E. PICK1: a perinuclear binding protein and substrate for protein kinase C isolated by the yeast two-hybrid system. J Cell Biol. 1995;128:263-71 pubmed
    ..One of these proteins, designated PICK1, interacts specifically with the catalytic domain of PKC and is an efficient substrate for phosphorylation by PKC ..
  3. Cao M, Xu J, Shen C, Kam C, Huganir R, Xia J. PICK1-ICA69 heteromeric BAR domain complex regulates synaptic targeting and surface expression of AMPA receptors. J Neurosci. 2007;27:12945-56 pubmed
    ..b>PICK1 (protein interacts with C-kinase 1) is a peripheral membrane protein that interacts with AMPA receptors and ..
  4. Gardner S, Takamiya K, Xia J, Suh J, Johnson R, Yu S, et al. Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF. Neuron. 2005;45:903-15 pubmed
    ..We found that two GluR2-interacting proteins, the PDZ domain-containing Protein interacting with C kinase (PICK1) and N-ethylmaleimide sensitive fusion protein (NSF), are specifically required for CARP...
  5. Terashima A, Pelkey K, Rah J, Suh Y, Roche K, Collingridge G, et al. An essential role for PICK1 in NMDA receptor-dependent bidirectional synaptic plasticity. Neuron. 2008;57:872-82 pubmed publisher
    b>PICK1 is a calcium-sensing, PDZ domain-containing protein that interacts with GluR2 and GluR3 AMPA receptor (AMPAR) subunits and regulates their trafficking...
  6. Torres R, Firestein B, Dong H, Staudinger J, Olson E, Huganir R, et al. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron. 1998;21:1453-63 pubmed
    ..Thus, PDZ proteins may play critical roles in localizing vertebrate receptor tyrosine kinases and/or their ligands and may be particularly important for Eph function in guidance or patterning or at the synapse. ..
  7. Takeya R, Takeshige K, Sumimoto H. Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors. Biochem Biophys Res Commun. 2000;267:149-55 pubmed
    We have cloned the cDNA encoding human PICK1 (protein interacting with C kinase 1), a PDZ domain-containing protein of 415 amino acids, and also identified the Drosophila homologue by search of the databank...
  8. Steinberg J, Takamiya K, Shen Y, Xia J, Rubio M, Yu S, et al. Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression. Neuron. 2006;49:845-60 pubmed
    ..Phosphorylation of the AMPA receptor subunit GluR2 on serine-880 as well as interaction of GluR2 with PICK1 have been suggested to contribute to the endocytic removal of postsynaptic AMPA receptors during LTD...
  9. Volk L, Kim C, Takamiya K, Yu Y, Huganir R. Developmental regulation of protein interacting with C kinase 1 (PICK1) function in hippocampal synaptic plasticity and learning. Proc Natl Acad Sci U S A. 2010;107:21784-9 pubmed publisher
    ..Protein interacting with C kinase 1 (PICK1) is an AMPAR-binding protein shown to regulate both AMPAR trafficking and synaptic plasticity at many distinct ..

More Information


  1. Xiao N, Kam C, Shen C, Jin W, Wang J, Lee K, et al. PICK1 deficiency causes male infertility in mice by disrupting acrosome formation. J Clin Invest. 2009;119:802-12 pubmed publisher
    Protein interacting with C kinase 1 (PICK1) is a peripheral membrane protein involved in protein trafficking, a function that has been well characterized in neurons...
  2. Lin D, Huganir R. PICK1 and phosphorylation of the glutamate receptor 2 (GluR2) AMPA receptor subunit regulates GluR2 recycling after NMDA receptor-induced internalization. J Neurosci. 2007;27:13903-8 pubmed
    ..density-95/Discs large/zona occludens-1]-domain containing protein, protein interacting with protein kinase C (PICK1), have been proposed to play an important role in NMDA receptor dependent internalization of GluR2...
  3. Dev K, Nishimune A, Henley J, Nakanishi S. The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits. Neuropharmacology. 1999;38:635-44 pubmed
    Here we report an interaction between AMPA receptor subunits and a single PDZ domain-containing protein called PICK1 which is known to bind protein kinase C alpha (PKC alpha)...
  4. Holst B, Madsen K, Jansen A, Jin C, Rickhag M, Lund V, et al. PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance. PLoS Biol. 2013;11:e1001542 pubmed publisher
    ..Here, we identify the lipid binding BAR (Bin/amphiphysin/Rvs) domain protein PICK1 (protein interacting with C kinase 1) as a key component early in the biogenesis of secretory vesicles in GH-..
  5. Leonard A, Yermolaieva O, Hruska Hageman A, Askwith C, Price M, Wemmie J, et al. cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1. Proc Natl Acad Sci U S A. 2003;100:2029-34 pubmed
    ..that the extreme C-terminal residues of ASIC1 bind the PDZ domain of the protein interacting with C-kinase-1 (PICK1). We found that protein kinase A phosphorylation of Ser-479 in the ASIC1 C terminus interfered with PICK1 binding...
  6. Cao M, Mao Z, Kam C, Xiao N, Cao X, Shen C, et al. PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. PLoS Biol. 2013;11:e1001541 pubmed publisher
    ..Here we report that PICK1 and ICA69, two cytosolic lipid-binding proteins, formed heteromeric BAR-domain complexes that associated with ..
  7. Duggan A, Garcia Anoveros J, Corey D. The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons. J Biol Chem. 2002;277:5203-8 pubmed
    ..These ion channels are also expressed in the CNS. We identified the PDZ domain protein PICK1 as an interactor of BNaC1(ASIC2) in a yeast two-hybrid screen...
  8. Torres G, Yao W, Mohn A, Quan H, Kim K, Levey A, et al. Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. Neuron. 2001;30:121-34 pubmed
    ..Here, we report an interaction between the PDZ domain-containing protein PICK1 and monoamine neurotransmitter transporters in vitro and in vivo...
  9. Breiderhoff T, Christiansen G, Pallesen L, Vaegter C, Nykjaer A, Holm M, et al. Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction. PLoS ONE. 2013;8:e75006 pubmed publisher
    ..suggested by targeted proteomics approaches that identified the ability of SORCS3 to functionally interact with PICK1, an adaptor that sorts glutamate receptors at the postsynapse...
  10. He J, Xia M, Tsang W, Chow K, Xia J. ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis. J Cell Sci. 2015;128:3822-36 pubmed publisher
    Mutations in the Pick1 gene cause globozoospermia, a male infertility disorder, in both mice and humans...
  11. Zhang C, Bertaso F, Eulenburg V, Lerner Natoli M, Herin G, Bauer L, et al. Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol. J Neurosci. 2008;28:8604-14 pubmed publisher
    ..Protein interacting with C kinase 1 (PICK1), a postsynaptic density protein-95/disc-large tumor suppressor protein/zonula occludens-1 (PDZ)-domain protein, ..
  12. Höhne M, Lorscheider J, von Bardeleben A, Dufner M, Scharf M, Gödel M, et al. The BAR domain protein PICK1 regulates cell recognition and morphogenesis by interacting with Neph proteins. Mol Cell Biol. 2011;31:3241-51 pubmed publisher
    ..Here we identify the PDZ and BAR domain protein PICK1 (protein interacting with C-kinase 1) as a Neph-interacting protein...
  13. Reymond N, Garrido Urbani S, Borg J, Dubreuil P, Lopez M. PICK-1: a scaffold protein that interacts with Nectins and JAMs at cell junctions. FEBS Lett. 2005;579:2243-9 pubmed
  14. Kamano Y, Watanabe J, Iida T, Kondo T, Okawa H, Yatani H, et al. Binding of PICK1 PDZ domain with calcineurin B regulates osteoclast differentiation. Biochem Biophys Res Commun. 2018;496:83-88 pubmed publisher
    ..Here, we present evidence that PICK1 also positively regulates calcineurin B in osteoclasts to activate NFAT to promote osteoclastogenesis...
  15. Staudinger J, Lu J, Olson E. Specific interaction of the PDZ domain protein PICK1 with the COOH terminus of protein kinase C-alpha. J Biol Chem. 1997;272:32019-24 pubmed
    b>PICK1 is a protein kinase C (PKC) alpha-binding protein initially identified using the yeast two-hybrid system...
  16. Liu K, Lei R, Li Q, Wang X, Wu Q, An P, et al. Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity. Sci Rep. 2016;6:21019 pubmed publisher
    ..Thus, our study reveals that TFR functions as a novel regulator to control AMPA trafficking efficiency and synaptic plasticity. ..
  17. Razin E, Zhang Z, Nechushtan H, Frenkel S, Lee Y, Arudchandran R, et al. Suppression of microphthalmia transcriptional activity by its association with protein kinase C-interacting protein 1 in mast cells. J Biol Chem. 1999;274:34272-6 pubmed
    ..Its ability to suppres mi transcriptional activity in the transient transfected fibroblast system suggests that it can function in vivo as a negative regulator of mi-induced transcriptional activation. ..
  18. Wang Y, Zhou L, Li Y, Wang Z, Li Y, Zhang Y, et al. Protein Interacting with C-Kinase 1 Deficiency Impairs Glutathione Synthesis and Increases Oxidative Stress via Reduction of Surface Excitatory Amino Acid Carrier 1. J Neurosci. 2015;35:6429-43 pubmed publisher
    Protein interacting with C-kinase 1 (PICK1) has received considerable attention, because it interacts with a broad range of neurotransmitter receptors, transporters, and enzymes and thereby influences their localization and function in ..
  19. Li X, Mao Z, Wu M, Xia J. Rescuing infertility of Pick1 knockout mice by generating testis-specific transgenic mice via testicular infection. Sci Rep. 2013;3:2842 pubmed publisher
    b>PICK1 (protein interacting with C-kinase 1) is a peripheral membrane protein with high expression in brain, testis, pancreas and other neuroendocrine tissues...
  20. Hu Z, Huang C, Fu H, Jin Y, Wu W, Xiong Q, et al. Disruption of PICK1 attenuates the function of ASICs and PKC regulation of ASICs. Am J Physiol Cell Physiol. 2010;299:C1355-62 pubmed publisher
    ..The protein that interacts with C kinase 1 (PICK1) was cloned as one of the proteins interacting with protein kinase C (PKC) and colocalized ..
  21. Joch M, Ase A, Chen C, MacDonald P, Kontogiannea M, Corera A, et al. Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels. Mol Biol Cell. 2007;18:3105-18 pubmed
    ..Here, we identify the PSD-95/Discs-large/Zona Occludens-1 (PDZ) protein PICK1 as a novel parkin substrate...
  22. Takamiya K, Kostourou V, Adams S, Jadeja S, Chalepakis G, Scambler P, et al. A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1. Nat Genet. 2004;36:172-7 pubmed
    ..Our data indicate that GRIP1 is required for normal cell-matrix interactions during early embryonic development and that inactivation of Grip1 causes Fraser syndrome-like defects in mice. ..
  23. Chanrion B, Mannoury la Cour C, Bertaso F, Lerner Natoli M, Freissmuth M, Millan M, et al. Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proc Natl Acad Sci U S A. 2007;104:8119-24 pubmed
    ..In addition to showing that nNOS controls cell surface localization of SERT, these findings provide evidence for regulation of cellular signaling (NO production) by a substrate-carrying transporter. ..
  24. Bertaso F, Zhang C, Scheschonka A, de Bock F, Fontanaud P, Marin P, et al. PICK1 uncoupling from mGluR7a causes absence-like seizures. Nat Neurosci. 2008;11:940-8 pubmed publisher
    ..epilepsy, focusing on the mGluR7a receptor and its PDZ-interacting protein, protein interacting with C kinase 1 (PICK1), in rats and mice...
  25. Yawata S, Tsuchida H, Kengaku M, Hirano T. Membrane-proximal region of glutamate receptor delta2 subunit is critical for long-term depression and interaction with protein interacting with C kinase 1 in a cerebellar Purkinje neuron. J Neurosci. 2006;26:3626-33 pubmed
    ..We next identified protein interacting with C kinase 1 (PICK1) as a molecule interacting with the membrane-proximal C-terminal region of GluRdelta2 by yeast two-hybrid ..
  26. Hikida T, Mustafa A, Maeda K, Fujii K, Barrow R, Saleh M, et al. Modulation of D-serine levels in brains of mice lacking PICK1. Biol Psychiatry. 2008;63:997-1000 pubmed publisher
    ..Protein expression of serine racemase (SR) and its binding partner, protein interacting with C-kinase (PICK1), were examined by Western blotting in brains from wildtype and PICK1 knockout mice...
  27. Phillips R, Ernst R, Brunk B, Ivanova N, Mahan M, Deanehan J, et al. The genetic program of hematopoietic stem cells. Science. 2000;288:1635-40 pubmed
    ..The complete data, available in a biological process-oriented database, represent the molecular phenotype of the hematopoietic stem cell. ..
  28. Anggono V, Koc Schmitz Y, Widagdo J, Kormann J, Quan A, Chen C, et al. PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression. Proc Natl Acad Sci U S A. 2013;110:13976-81 pubmed publisher
    ..The protein interacting with C-kinase 1 (PICK1) directly interacts with GluA2/3 subunits of the AMPARs...
  29. Mignogna M, Giannandrea M, Gurgone A, Fanelli F, Raimondi F, Mapelli L, et al. The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition. Nat Commun. 2015;6:6504 pubmed publisher
    ..Here we show that protein interacting with C-kinase 1 (PICK1) is a downstream effector of GTP-bound RAB39B and that RAB39B-PICK1 controls trafficking from the endoplasmic ..
  30. Chenaux G, Matt L, Hill T, Kaur I, Liu X, Kirk L, et al. Loss of SynDIG1 Reduces Excitatory Synapse Maturation But Not Formation In Vivo. Eneuro. 2016;3: pubmed
    ..Together, these data are consistent with a model in which SynDIG1 regulates the maturation of excitatory synapse structure and function in the mouse hippocampus in vivo. ..
  31. Selak S, Paternain A, Aller M, Aller I, Picó E, Rivera R, et al. A role for SNAP25 in internalization of kainate receptors and synaptic plasticity. Neuron. 2009;63:357-71 pubmed publisher
    ..e., KA2) subunits. SNAP25 coimmunoprecipitates with protein complexes containing PICK1, GRIP1, and GluK5 and colocalizes with GluK5 in both hippocampal neurons and transfected HEK293 cells...
  32. Gonzalez Bosc L, Plomaritas D, Herbert L, Giermakowska W, Browning C, Jernigan N. ASIC1-mediated calcium entry stimulates NFATc3 nuclear translocation via PICK1 coupling in pulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2016;311:L48-58 pubmed publisher
    ..calcineurin have been shown to interact with the scaffolding protein known as protein interacting with C kinase-1 (PICK1)...
  33. Cheng J, Chen Y, Xing H, Jiang H, Ye X. Down-regulation of ASICs current and the calcium transients by disrupting PICK1 protects primary cultured mouse cortical neurons from OGD-Rep insults. Int J Clin Exp Pathol. 2015;8:10272-82 pubmed
    ..activation involving in glutamate receptor-independent ischemic brain injury has been generally accepted, and PICK1 is recently shown to be one of partner proteins interacting with ASICs through its PDZ domain...
  34. Nomura J, Jaaro Peled H, Lewis E, Nuñez Abades P, Huppé Gourgues F, Cash Padgett T, et al. Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice. Mol Psychiatry. 2016;21:386-93 pubmed publisher
    ..Here we report behavioral and electrophysiological deficits associated with the frontal cortex in Pick1 knockout mice, which show D-serine deficits in a neonatal- and forebrain-specific manner...
  35. Clem R, Huganir R. Norepinephrine enhances a discrete form of long-term depression during fear memory storage. J Neurosci. 2013;33:11825-32 pubmed publisher
    ..These results highlight the complexity of core mechanisms in LTD and suggest that norepinephrine exposure mediates a form of synaptic metaplasticity that recalibrates fear memory processing. ..
  36. Wang W, Yeh S, Chang Y, Hsiao S, Lian W, Lin C, et al. PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cells. J Biol Chem. 2003;278:37705-12 pubmed
    b>PICK1 binds to protein kinase Calpha (PKCalpha) through the carboxylate-binding loop in its PDZ (PSD95/Disc-large/ZO-1) domain and the C terminus of PKCalpha...
  37. Xie J, Wu X, Zhou Q, Yang Y, Tian Y, Huang C, et al. PICK1 confers anti-inflammatory effects in acute liver injury via suppressing M1 macrophage polarization. Biochimie. 2016;127:121-32 pubmed publisher
    Protein interacting with C kinase 1 (PICK1) is a scaffolding protein mainly implicated in neurological diseases, however, the function of PICK1 in acute liver injury (ALI) remains unknown...
  38. Wang W, Yeh S, Huang E, Lu Y, Wang C, Huang C, et al. Mitochondrial anchoring of PKCalpha by PICK1 confers resistance to etoposide-induced apoptosis. Apoptosis. 2007;12:1857-71 pubmed
    ..We have previously demonstrated that PKCalpha is selectively anchored to mitochondria by PICK1 in fibroblasts NIH 3T3...
  39. Makinen T, Adams R, Bailey J, Lu Q, Ziemiecki A, Alitalo K, et al. PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev. 2005;19:397-410 pubmed
    ..Our studies define ephrinB2 as an essential regulator of lymphatic development and indicate that interactions with PDZ domain effectors are required to mediate its functions. ..
  40. Pinheiro P, Jansen A, de Wit H, Tawfik B, Madsen K, Verhage M, et al. The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells. J Neurosci. 2014;34:10688-700 pubmed publisher
    Protein Interacting with C Kinase 1 (PICK1) is a Bin/Amphiphysin/Rvs (BAR) domain protein involved in AMPA receptor trafficking...
  41. Shiroshima T, Oka C, Kawaichi M. Identification of LRP1B-interacting proteins and inhibition of protein kinase Calpha-phosphorylation of LRP1B by association with PICK1. FEBS Lett. 2009;583:43-8 pubmed publisher
    ..One of the partners, PICK1 recognizes the C-terminus of LRP1B and LRP1...
  42. Wang W, Petralia R, Takamiya K, Xia J, Li Y, Huganir R, et al. Preserved acute pain and impaired neuropathic pain in mice lacking protein interacting with C Kinase 1. Mol Pain. 2011;7:11 pubmed publisher
    Protein interacting with C Kinase 1 (PICK1), a PDZ domain-containing scaffolding protein, interacts with multiple different proteins in the mammalian nervous system and is believed to play important roles in diverse physiological and ..
  43. Jaulin Bastard F, Saito H, Le Bivic A, Ollendorff V, Marchetto S, Birnbaum D, et al. The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins. J Biol Chem. 2001;276:15256-63 pubmed
    ..We have identified ERBIN and PICK1 as new binding partners for ERBB2/HER2 that associate with its carboxyl-terminal sequence through a PDZ (PSD-95/..
  44. Karataeva A, Klaassen R, Ströder J, Ruiperez Alonso M, Hjorth J, Van Nierop P, et al. C-terminal interactors of the AMPA receptor auxiliary subunit Shisa9. PLoS ONE. 2014;9:e87360 pubmed publisher
    ..Taken together, our data identifies novel interaction partners of Shisa9, and shows that the C-terminal interactions of Shisa9 through its PDZ domain interaction motif are important for AMPA receptor synaptic and network functions. ..
  45. Li Y, Zhang N, Wang Y, Shen Y, Wang Y. Multiple faces of protein interacting with C kinase 1 (PICK1): Structure, function, and diseases. Neurochem Int. 2016;98:115-21 pubmed publisher
    Protein interacting with C-kinase 1 (PICK1) has received considerable attention because it is the only protein that contains both PSD-95/DlgA/ZO-1 (PDZ) domain and Bin-Amphiphysin-Rvs (BAR) domain...
  46. Anggono V, Clem R, Huganir R. PICK1 loss of function occludes homeostatic synaptic scaling. J Neurosci. 2011;31:2188-96 pubmed publisher
    ..Here, we show that chronic activity blockade reduces PICK1 protein level on a time scale that coincides with the accumulation of surface AMPARs...
  47. Bartoe J, McKenna W, Quan T, Stafford B, Moore J, Xia J, et al. Protein interacting with C-kinase 1/protein kinase Calpha-mediated endocytosis converts netrin-1-mediated repulsion to attraction. J Neurosci. 2006;26:3192-205 pubmed
    ..We show that protein interacting with C-kinase 1 (PICK1) recruits activated protein kinase Calpha (PKCalpha) to MycUNC5A at the plasma membrane, stimulating its ..
  48. Araki S, Izumiya Y, Rokutanda T, Ianni A, Hanatani S, Kimura Y, et al. Sirt7 Contributes to Myocardial Tissue Repair by Maintaining Transforming Growth Factor-β Signaling Pathway. Circulation. 2015;132:1081-93 pubmed publisher
    ..Sirt7 maintains transforming growth factor receptor I by modulating autophagy and is involved in the tissue repair process. ..
  49. Lin W, Chang Y, Wang W, Huang C. Mitogen-stimulated TIS21 protein interacts with a protein-kinase-Calpha-binding protein rPICK1. Biochem J. 2001;354:635-43 pubmed
    ..Biol. Chem 271, 15034-15044]. The amino acid sequence deduced from clone 5A shows 96.9% identity with the murine PICK1, a protein kinase Calpha (PKCalpha)-binding protein postulated to act as an intracellular receptor for PKC...
  50. Tomioka N, Yasuda H, Miyamoto H, Hatayama M, Morimura N, Matsumoto Y, et al. Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures. Nat Commun. 2014;5:4501 pubmed publisher
    ..These results reveal a novel mechanism for interneuron subtype-specific neural circuit establishment and define a common basis bridging neurological disorders. ..
  51. Schonewille M, Gao Z, Boele H, Veloz M, Amerika W, Simek A, et al. Reevaluating the role of LTD in cerebellar motor learning. Neuron. 2011;70:43-50 pubmed publisher
    ..These findings demonstrate that PF-PC LTD is not essential for cerebellar motor learning. ..
  52. Perroy J, El Far O, Bertaso F, Pin J, Betz H, Bockaert J, et al. PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7. EMBO J. 2002;21:2990-9 pubmed
    ..subtype, mGlu7a, with the postsynaptic density-95 disc-large zona occludens 1 (PDZ) domain-containing protein, PICK1, is required for specific inhibition of P/Q-type Ca(2+) channels, in cultured cerebellar granule neurons...
  53. Deval E, Salinas M, Baron A, Lingueglia E, Lazdunski M. ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1. J Biol Chem. 2004;279:19531-9 pubmed
    ..This regulation by PKC requires PICK-1 (protein interacting with C kinase), a PDZ domain-containing protein, which interacts with the ASIC2b C terminus. ..
  54. Hanley J, Khatri L, Hanson P, Ziff E. NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex. Neuron. 2002;34:53-67 pubmed
    ..NSF and PICK1 bind the AMPAR GluR2 subunit and are involved in trafficking of AMPARs...
  55. Thomas G, Hayashi T, Huganir R, Linden D. DHHC8-dependent PICK1 palmitoylation is required for induction of cerebellar long-term synaptic depression. J Neurosci. 2013;33:15401-7 pubmed publisher
    ..Here we report that DHHC8 binds and palmitoylates the PDZ domain-containing protein PICK1 at a cysteine residue that is essential for long-term synaptic depression (LTD) in cultured mouse cerebellar ..
  56. Wang Z, Wang Y, Sun C, Yang D, Su L, Xie Y, et al. C-terminal domain of ICA69 interacts with PICK1 and acts on trafficking of PICK1-PKC? complex and cerebellar plasticity. PLoS ONE. 2013;8:e83862 pubmed publisher
    b>PICK1 (protein interacting with C-kinase 1) is a PKC (protein kinase C)-binding protein, which is essential for synaptic plasticity...
  57. Baron A, Deval E, Salinas M, Lingueglia E, Voilley N, Lazdunski M. Protein kinase C stimulates the acid-sensing ion channel ASIC2a via the PDZ domain-containing protein PICK1. J Biol Chem. 2002;277:50463-8 pubmed
    ..Recently, the PDZ domain-containing protein PICK1 (protein interacting with C-kinase) has been shown to interact with ASIC1a and ASIC2a, raising the possibility ..
  58. Zhu J, Wang Z, Zhang N, Ma J, Xu S, Wang Y, et al. Protein Interacting C-Kinase 1 Modulates Surface Expression of P2Y6 Purinoreceptor, Actin Polymerization and Phagocytosis in Microglia. Neurochem Res. 2016;41:795-803 pubmed publisher
    ..However, it remains unclear how surface expression of P2Y6R is increased. PICK1 (protein interacting with C-kinase-1) interacts with various neurotransmitter receptors, transporters, and enzymes...
  59. Alfonso S, Kessels H, Banos C, Chan T, Lin E, Kumaravel G, et al. Synapto-depressive effects of amyloid beta require PICK1. Eur J Neurosci. 2014;39:1225-33 pubmed publisher
    ..Here we showed that the PDZ domain protein, protein interacting with C kinase 1 (PICK1), was required for A? to weaken synapses...