Gene Symbol: Phf1
Description: PHD finger protein 1
Alias: AW557215, D17Ertd455e, Pcl1, Phf2, Tctex3, PHD finger protein 1, polycomb-like protein 1, t-complex testis-expressed 3
Species: mouse
Products:     Phf1

Top Publications

  1. Ha H, Howard C, Yeom Y, Abe K, Uehara H, Artzt K, et al. Several testis-expressed genes in the mouse t-complex have expression differences between wild-type and t-mutant mice. Dev Genet. 1991;12:318-32 pubmed
    ..Interestingly, four Tctex genes show differences in the amount of transcript between wild-type and t-mutant testes. The chromosomal location and expression pattern imply that Tctex genes might be candidate genes for sterility or TRD. ..
  2. Jacquemin P, Chen Z, Martial J, Davidson I. Genomic structure and chromosomal mapping of the mouse transcription factor TEF-5 (Tead3) gene. Mamm Genome. 1999;10:632-4 pubmed
  3. Stauffer D, Howard T, Nyun T, Hollenberg S. CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression. J Cell Sci. 2001;114:2383-93 pubmed
    ..In combination, these observations suggest that CHMP1 plays a role in stable gene silencing within the nucleus. ..
  4. Li G, Margueron R, Ku M, Chambon P, Bernstein B, Reinberg D. Jarid2 and PRC2, partners in regulating gene expression. Genes Dev. 2010;24:368-80 pubmed publisher
    ..In addition to the well-documented defects in embryonic viability upon down-regulation of Jarid2, ES cell differentiation is impaired, as is Oct4 silencing. ..
  5. Yeom Y, Abe K, Bennett D, Artzt K. Testis-/embryo-expressed genes are clustered in the mouse H-2K region. Proc Natl Acad Sci U S A. 1992;89:773-7 pubmed
    ..Surprisingly, virtually all of these genes are expressed in testis and/or embryos. The genomic organization of this region is contrasted with the 150 kb of the homologous area where only three genes and an endogenous retrovirus reside. ..
  6. Kawakami S, Mitsunaga K, Kikuti Y, Ando A, Inoko H, Yamamura K, et al. Tctex3, related to Drosophila polycomblike, is expressed in male germ cells and mapped to the mouse t-complex. Mamm Genome. 1998;9:874-80 pubmed
    b>Tctex3 showing restricted expression in male germ cells has been isolated during the process of chromosome walking in the mouse t-complex region...
  7. Yoshitake Y, Howard T, Christian J, Hollenberg S. Misexpression of Polycomb-group proteins in Xenopus alters anterior neural development and represses neural target genes. Dev Biol. 1999;215:375-87 pubmed
    ..Misexpression of Pcl1 by RNA injection into embryos produces defects in the anterior central nervous system...
  8. Kitaguchi T, Nakata K, Nagai T, Aruga J, Mikoshiba K. Xenopus Polycomblike 2 (XPcl2) controls anterior to posterior patterning of the neural tissue. Dev Genes Evol. 2001;211:309-14 pubmed
    ..shows greater amino acid sequence homology to human and mouse M96 (hPcl2, mPcl2) than Xenopus Pcl1 (XPcl1), mouse Tctex3 (mPcl1) and human PHF1 (hPcl1), indicating that at least two types of Polycomblike genes are conserved between ..
  9. Ballaré C, Lange M, Lapinaite A, Martin G, Morey L, Pascual G, et al. Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Nat Struct Mol Biol. 2012;19:1257-65 pubmed publisher
    ..These findings show that the interaction of Phf19 with H3K36me2 and H3K36me3 is essential for PRC2 complex activity and for proper regulation of gene repression in embryonic stem cells. ..

More Information


  1. Cao R, Wang H, He J, Erdjument Bromage H, Tempst P, Zhang Y. Role of hPHF1 in H3K27 methylation and Hox gene silencing. Mol Cell Biol. 2008;28:1862-72 pubmed
    ..Therefore, our results reveal hPHF1 as a component of a novel EED-EZH2 complex and demonstrate its important role in H3K27 methylation and Hox gene silencing. ..