Gene Symbol: PHBP
Description: hyaluronic acid binding protein 2
Alias: AI035669, FSAP, HABP, HGFAL, PHBP, hyaluronan-binding protein 2, hyaduronic acid-binding protein 2, plasma hyaluronan-binding protein
Species: mouse
Products:     PHBP

Top Publications

  1. Sedding D, Daniel J, Muhl L, Hersemeyer K, Brunsch H, Kemkes Matthes B, et al. The G534E polymorphism of the gene encoding the factor VII-activating protease is associated with cardiovascular risk due to increased neointima formation. J Exp Med. 2006;203:2801-7 pubmed
    The G534E polymorphism (Marburg I [MI]) of factor VII-activating protease (FSAP) is associated with carotid stenosis and cardiovascular disease...
  2. Leiting S, Seidl S, Martínez Palacián A, Muhl L, Kanse S. Transforming Growth Factor-? (TGF-?) Inhibits the Expression of Factor VII-activating Protease (FSAP) in Hepatocytes. J Biol Chem. 2016;291:21020-21028 pubmed
    Deletion of the Habp2 gene encoding Factor VII-activating protease (FSAP) increases liver fibrosis in mice...
  3. Muggenthaler M, Chowdhury B, Hasan S, Cross H, Mark B, Harlalka G, et al. Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice. PLoS Genet. 2017;13:e1006470 pubmed publisher
  4. Azhar M, Brown K, Gard C, Chen H, Rajan S, Elliott D, et al. Transforming growth factor Beta2 is required for valve remodeling during heart development. Dev Dyn. 2011;240:2127-41 pubmed publisher
    ..Collectively, the data indicate that TGF?2 promotes valve remodeling and differentiation by inducing matrix organization and suppressing cushion mesenchyme differentiation into cartilage cell lineage during heart development. ..
  5. Borkham Kamphorst E, Zimmermann H, Gassler N, Bissels U, Bosio A, Tacke F, et al. Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men. J Hepatol. 2013;58:104-11 pubmed publisher
    Factor VII activating protease (FSAP) is a circulating serine protease produced in the liver...
  6. Hashimoto K, Tobe T, Sumiya J, Saguchi K, Sano Y, Nakano Y, et al. Cloning of the cDNA for a mouse homologue of human PHBP: a novel hyaluronan-binding protein. Biol Pharm Bull. 1997;20:1127-30 pubmed
    The cDNA which encodes the mouse counterpart of human plasma hyaluronan-binding protein (PHBP) was isolated and characterized...
  7. Mambetsariev N, Mirzapoiazova T, Mambetsariev B, Sammani S, Lennon F, Garcia J, et al. Hyaluronic Acid binding protein 2 is a novel regulator of vascular integrity. Arterioscler Thromb Vasc Biol. 2010;30:483-90 pubmed publisher
    ..HABP2 negatively regulates vascular integrity via activation of protease-activated receptor/RhoA/Rho kinase signaling and represents a potentially useful therapeutic target for syndromes of increased vascular permeability. ..
  8. Roedel E, Schwarz E, Kanse S. The factor VII-activating protease (FSAP) enhances the activity of bone morphogenetic protein-2 (BMP-2). J Biol Chem. 2013;288:7193-203 pubmed publisher
    Factor VII-activating protease (FSAP) is a circulating protease involved in the pathogenesis of atherosclerosis, calcification, and fibrotic processes...
  9. Lockhart M, Boukens B, Phelps A, Brown C, Toomer K, Burns T, et al. Alk3 mediated Bmp signaling controls the contribution of epicardially derived cells to the tissues of the atrioventricular junction. Dev Biol. 2014;396:8-18 pubmed publisher
    ..Furthermore, this study shows that EPDCs do not only play a critical role in early developmental events at the AV junction, but that they also are important in the normal maturation of the AV valves. ..

More Information


  1. Subramaniam S, Thielmann I, Morowski M, Pragst I, Sandset P, Nieswandt B, et al. Defective thrombus formation in mice lacking endogenous factor VII activating protease (FSAP). Thromb Haemost. 2015;113:870-80 pubmed publisher
    Factor VII (FVII) activating protease (FSAP) is a circulating protease with a putative function in blood coagulation and fibrinolysis. Genetic epidemiological studies have implied a role for FSAP in carotid stenosis, stroke and thrombosis...
  2. Durst R, Sauls K, Peal D, deVlaming A, Toomer K, Leyne M, et al. Mutations in DCHS1 cause mitral valve prolapse. Nature. 2015;525:109-13 pubmed publisher
    ..Understanding the role of DCHS1 in mitral valve development and MVP pathogenesis holds potential for therapeutic insights for this very common disease. ..
  3. Choi Miura N, Takahashi K, Yoda M, Saito K, Mazda T, Tomita M. Proteolytic activation and inactivation of the serine protease activity of plasma hyaluronan binding protein. Biol Pharm Bull. 2001;24:448-52 pubmed
    We prepared anti-plasma hyaluronan binding protein (PHBP) mouse monoclonal antibodies and studied the fragmentation profile of PHBP with them. PHBP is present in human plasma as a single polypeptide chain (70 kDa)...
  4. Joshi A, Orset C, Engelhardt B, Baumgart Vogt E, Gerriets T, Vivien D, et al. Deficiency of Factor VII activating protease alters the outcome of ischemic stroke in mice. Eur J Neurosci. 2015;41:965-75 pubmed publisher
    Factor VII activating protease (FSAP) is a circulating protease with a putative role in hemostasis, remodeling and inflammation...
  5. Nandadasa S, Nelson C, Apte S. ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation. Cell Rep. 2015;11:1519-28 pubmed publisher
    ..In addition, we observed disrupted Shh signaling and perturbed orientation of the mesenchymal primary cilium. Thus, ECM dynamics is a major influence on umbilical vascular SMC fate, with ADAMTS9 acting as its principal mediator. ..
  6. Daniel J, Reichel C, Schmidt Woell T, Dutzmann J, Zuchtriegel G, Krombach F, et al. Factor VII-activating protease deficiency promotes neointima formation by enhancing leukocyte accumulation. J Thromb Haemost. 2016;14:2058-2067 pubmed publisher
    Essentials Factor VII-activating protease (FSAP) is a plasma protease involved in vascular processes. Neointima formation was investigated after vascular injury in FSAP-/- mice...