Phb2

Summary

Gene Symbol: Phb2
Description: prohibitin 2
Alias: AU044498, BAP, Bap37, Bcap37, REA, B-cell receptor-associated protein 37, B-cell receptor-associated protein BAP37, prohibitin-2, repressor of estrogen receptor activity
Species: mouse

Top Publications

  1. ncbi The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein
    M Terashima
    Max Planck Institut für Immunobiologie, Freiburg, Germany
    EMBO J 13:3782-92. 1994
  2. ncbi CaMK IV phosphorylates prohibitin 2 and regulates prohibitin 2-mediated repression of MEF2 transcription
    Luguo Sun
    Institute of Genetics and Cytology, Northeast Normal University, Changchun, China
    Cell Signal 23:1686-90. 2011
  3. ncbi Regulation of the epithelial Mg2+ channel TRPM6 by estrogen and the associated repressor protein of estrogen receptor activity (REA)
    Gang Cao
    Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Institute for Genetic and Metabolic Disease, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Biol Chem 284:14788-95. 2009
  4. ncbi Nuclear receptor co-regulator Krüppel-like factor 9 and prohibitin 2 expression in estrogen-induced epithelial cell proliferation in the mouse uterus
    J M P Pabona
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences and Arkansas Children s Nutrition Center, Little Rock, Arkansas 72202, USA
    J Endocrinol 200:63-73. 2009
  5. ncbi Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria
    Carsten Merkwirth
    Institute for Genetics, Centre for Molecular Medicine, University of Cologne, 50674 Cologne, Germany
    Genes Dev 22:476-88. 2008
  6. ncbi A repressive role for prohibitin in estrogen signaling
    Bin He
    Department of Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Endocrinol 22:344-60. 2008
  7. ncbi Skp2B stimulates mammary gland development by inhibiting REA, the repressor of the estrogen receptor
    Karina Umanskaya
    Department of Medicine, Division of Hematology Oncology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1178, New York, NY 10029, USA
    Mol Cell Biol 27:7615-22. 2007
  8. ncbi Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland
    Paola Mussi
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:16716-21. 2006
  9. ncbi Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo
    Seong Eun Park
    University of Illinois, Department of Molecular and Integrative Physiology, 524 Burrill Hall, 407 South Goodwin Ave, Urbana, IL 61801 3704, USA
    Mol Cell Biol 25:1989-99. 2005
  10. ncbi Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases
    Vladislav Kurtev
    Institute of Medical Biochemistry, Max F Perutz Laboratories, Medical University of Vienna, Vienna Biocenter, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
    J Biol Chem 279:24834-43. 2004

Scientific Experts

  • P J Coates
  • Benita S Katzenellenbogen
  • BERT W O'MALLEY
  • Lan Liao
  • Jianming Xu
  • Seong Eun Park
  • Luguo Sun
  • Sunghee Park
  • J M P Pabona
  • Gang Cao
  • Carsten Merkwirth
  • Bin He
  • Karina Umanskaya
  • Paola Mussi
  • Seong-Eun Park
  • Vladislav Kurtev
  • Vicky Y Lin
  • Liyan Sui
  • Honglan Huang
  • Yuechao Zhao
  • Kewei Ma
  • Xu Wang
  • Weimin Yin
  • Sangyeon Yoon
  • Franco DeMayo
  • John Lydon
  • Xia Cao
  • Bin Liu
  • AnneMiete van der Kemp
  • F A Simmen
  • Jenny van der Wijst
  • Femke van Zeeland
  • Z Zeng
  • M C Velarde
  • Joost G Hoenderop
  • R C M Simmen
  • René J Bindels
  • John P Lydon
  • Benedikt Westermann
  • Sascha Dargazanli
  • David M Lonard
  • F Thomas Wunderlich
  • Qin Feng
  • Takashi Tatsuta
  • Atish Mukherjee
  • Ari Waisman
  • Jürgen Christoph von Kleist-Retzow
  • Beatrix Löwer
  • Thomas Langer
  • Stefan Geimer
  • Francesco J DeMayo
  • Susanne Radke
  • Zhen Qiang Pan
  • Rosie Monardo
  • Harish Chander
  • Zhen-Qiang Pan
  • Matthew J O'Connell
  • Xinsong Xu
  • Doris Germain
  • M A Ansari-Lari
  • Paolo Ciana
  • Adriana Maggi
  • Antonina Frolova
  • Karin Kroboth
  • Egon Ogris
  • Christian Seiser
  • Raphael Margueron
  • Vincent Cavailles
  • Margaret A Shupnik
  • Eileen M Resnick
  • R A Gibbs
  • W Miller
  • Z Zhang
  • J W Belmont
  • A C Chinault
  • S Schwartz
  • M Terashima
  • J Lu
  • J C Oeltjen
  • D M Muzny
  • J H Gorrell
  • P J Nielsen
  • M C Lamers
  • K M Kim
  • M Reth
  • T Adachi
  • G Kohler

Detail Information

Publications14

  1. ncbi The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein
    M Terashima
    Max Planck Institut für Immunobiologie, Freiburg, Germany
    EMBO J 13:3782-92. 1994
    ..p37 is highly homologous to p32. Since prohibitin was identified as an inhibitor of cell proliferation, its association with mIgM, but not mIgD, could explain the different biological events elicited after engagement of each receptor...
  2. ncbi CaMK IV phosphorylates prohibitin 2 and regulates prohibitin 2-mediated repression of MEF2 transcription
    Luguo Sun
    Institute of Genetics and Cytology, Northeast Normal University, Changchun, China
    Cell Signal 23:1686-90. 2011
    b>Prohibitin 2 (PHB2) is an evolutionarily conserved and ubiquitously expressed multifunctional protein which is present in various cellular compartments including the nucleus...
  3. ncbi Regulation of the epithelial Mg2+ channel TRPM6 by estrogen and the associated repressor protein of estrogen receptor activity (REA)
    Gang Cao
    Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Institute for Genetic and Metabolic Disease, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Biol Chem 284:14788-95. 2009
    ..Here, we identified the repressor of estrogen receptor activity (REA) as an interacting protein of TRPM6 that binds to the 6(th), 7(th), and 8(th) beta-sheets in ..
  4. ncbi Nuclear receptor co-regulator Krüppel-like factor 9 and prohibitin 2 expression in estrogen-induced epithelial cell proliferation in the mouse uterus
    J M P Pabona
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences and Arkansas Children s Nutrition Center, Little Rock, Arkansas 72202, USA
    J Endocrinol 200:63-73. 2009
    ..pregnancy uteri of WT mice, the temporal pattern of Klf9 transcript levels was inversely associated with that of Phb2. Deletion of Klf9 up-regulated uterine Phb2 expression and increased PHB2 nuclear localization in endometrial ST ..
  5. ncbi Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria
    Carsten Merkwirth
    Institute for Genetics, Centre for Molecular Medicine, University of Cologne, 50674 Cologne, Germany
    Genes Dev 22:476-88. 2008
    ..Large assemblies of PHB1 and PHB2 subunits are localized in the inner membrane of mitochondria, but various roles in other cellular compartments have ..
  6. ncbi A repressive role for prohibitin in estrogen signaling
    Bin He
    Department of Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Endocrinol 22:344-60. 2008
    ..We demonstrate that PHB interacts with the repressor of estrogen receptor activity (REA), a protein related to PHB, to form heteromers and enhance the protein stability of both ..
  7. ncbi Skp2B stimulates mammary gland development by inhibiting REA, the repressor of the estrogen receptor
    Karina Umanskaya
    Department of Medicine, Division of Hematology Oncology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1178, New York, NY 10029, USA
    Mol Cell Biol 27:7615-22. 2007
    ..We found that Skp2B interacts with the repressor of estrogen receptor activity (REA) and that overexpression of Skp2B leads to a reduction in REA levels...
  8. ncbi Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland
    Paola Mussi
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:16716-21. 2006
    ..The repressor of ER activity (REA) is an ER-interactive protein that counterbalances estrogen-induced ER transcriptional activity...
  9. ncbi Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo
    Seong Eun Park
    University of Illinois, Department of Molecular and Integrative Physiology, 524 Burrill Hall, 407 South Goodwin Ave, Urbana, IL 61801 3704, USA
    Mol Cell Biol 25:1989-99. 2005
    We previously identified a coregulator, repressor of estrogen receptor activity (REA), that directly interacts with estrogen receptor (ER) and represses ER transcriptional activity...
  10. ncbi Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases
    Vladislav Kurtev
    Institute of Medical Biochemistry, Max F Perutz Laboratories, Medical University of Vienna, Vienna Biocenter, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
    J Biol Chem 279:24834-43. 2004
    ..Using the yeast two-hybrid system, we isolated the repressor of estrogen receptor activity (REA) as a novel HDAC1-associated protein...
  11. ncbi Truncated estrogen receptor product-1 stimulates estrogen receptor alpha transcriptional activity by titration of repressor proteins
    Vicky Y Lin
    Department of Pharmacology, Division of Endocrinology and Metabolism, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 278:38125-31. 2003
    ..We found that repressor of estrogen receptor activity (REA), originally isolated from human breast cancer cells, is present in mouse pituitary ..
  12. ncbi Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence
    P J Coates
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Exp Cell Res 265:262-73. 2001
    The two prohibitin proteins, Phb1p and Phb2p(BAP37), have been ascribed various functions, including cell cycle regulation, apoptosis, assembly of mitochondrial respiratory chain enzymes, and aging...
  13. ncbi Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6
    M A Ansari-Lari
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genome Res 8:29-40. 1998
    ....
  14. ncbi Repressor of estrogen receptor activity (REA) is essential for mammary gland morphogenesis and functional activities: studies in conditional knockout mice
    Sunghee Park
    Department of Molecular and Integrative Physiology, University of Illinois, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801 3704, USA
    Endocrinology 152:4336-49. 2011
    ..we have investigated the consequences of reduction or loss of function of the coregulator repressor of ER activity (REA) by conditionally deleting one allele or both alleles of the REA gene at different stages of mammary gland ..