Gene Symbol: Pggt1b
Description: protein geranylgeranyltransferase type I, beta subunit
Alias: 2010207C17Rik, 2610100E13, AI451237, AI551093, BGG1, GGT1, geranylgeranyl transferase type-1 subunit beta, GGTase-I-beta, geranylgeranyl transferase type I subunit beta, type I protein geranyl-geranyltransferase subunit beta
Sjogren A, Andersson K, Khan O, Olofsson F, Karlsson C, Bergo M. Inactivating GGTase-I reduces disease phenotypes in a mouse model of K-RAS-induced myeloproliferative disease. Leukemia. 2011;25:186-9 pubmed publisher
Liu M, Sjogren A, Karlsson C, Ibrahim M, Andersson K, Olofsson F, et al
. Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer. Proc Natl Acad Sci U S A. 2010;107:6471-6 pubmed publisher
..These data shed light on the biochemical and therapeutic importance of FTase and suggest that simultaneous inhibition of FTase and GGTase-I could be useful in cancer therapeutics. ..
Khan O, Ibrahim M, Jonsson I, Karlsson C, Liu M, Sjogren A, et al
. Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice. J Clin Invest. 2011;121:628-39 pubmed publisher
..The results challenge the view that geranylgeranylation is essential for the activity and localization of RHO family proteins and suggest that reduced geranylgeranylation in macrophages can initiate erosive arthritis. ..
Khan O, Akula M, Skålén K, Karlsson C, Ståhlman M, Young S, et al
. Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice. Circulation. 2013;127:782-90 pubmed publisher
..Aortic lesions in mice lacking GGTase-I in macrophages (Pggt1b?/?) contained significantly more T lymphocytes than the lesions in controls...
Lee R, Chang S, Trinh H, Tu Y, White A, Davies B, et al
. Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes. Hum Mol Genet. 2010;19:1603-17 pubmed publisher
..importance of the protein prenyltransferases for normal tissues, we used conditional knockout alleles for Fntb and Pggt1b (which encode the beta-subunits of FTase and GGTase-I, respectively) and a keratin 14-Cre transgene to create mice ..
Yang S, Chang S, Tu Y, Lawson G, Bergo M, Fong L, et al
. Severe hepatocellular disease in mice lacking one or both CaaX prenyltransferases. J Lipid Res. 2012;53:77-86 pubmed publisher
..Our studies refute the notion that FTase is dispensable and demonstrate that GGTase-I is crucial for the vitality of hepatocytes. ..
Cheng S, Cao D, Hottman D, Yuan L, Bergo M, Li L. Farnesyltransferase haplodeficiency reduces neuropathology and rescues cognitive function in a mouse model of Alzheimer disease. J Biol Chem. 2013;288:35952-60 pubmed publisher
..These results document that farnesylation and geranylgeranylation play differential roles in AD pathogenesis and suggest that specific inhibition of protein farnesylation could be a potential strategy for effectively treating AD. ..
Afshordel S, WOOD W, Igbavboa U, Muller W, Eckert G. Impaired geranylgeranyltransferase-I regulation reduces membrane-associated Rho protein levels in aged mouse brain. J Neurochem. 2014;129:732-42 pubmed publisher
..This down-regulation could be one of the mechanisms causing age-related weakening of synaptic plasticity. ..
Yuan M, Gao S, Sun C, Chen L, Shi Q, Hu J, et al
. Inhibiting geranylgeranyltransferase I activity decreases spine density in central nervous system. Hippocampus. 2015;25:373-84 pubmed publisher
..Manipulating GGT activity may be a promising strategy for the therapies of neurodevelopmental disorders, such as autism, depression, and schizophrenia. ..