Pgf

Summary

Gene Symbol: Pgf
Description: placental growth factor
Alias: AI854365, PIGF, Plgf, placenta growth factor
Species: mouse
Products:     Pgf

Top Publications

  1. Carmeliet P, Moons L, Luttun A, Vincenti V, Compernolle V, De Mol M, et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med. 2001;7:575-83 pubmed
    ..The role of its homolog, placental growth factor (PlGF), remains unknown...
  2. Fischer C, Jonckx B, Mazzone M, Zacchigna S, Loges S, Pattarini L, et al. Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. Cell. 2007;131:463-75 pubmed
    ..We explored the therapeutic potential and mechanisms of alphaPlGF, an antibody against placental growth factor (PlGF), a VEGF homolog, which regulates the angiogenic switch in disease, but not in health...
  3. Maes C, Coenegrachts L, Stockmans I, Daci E, Luttun A, Petryk A, et al. Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair. J Clin Invest. 2006;116:1230-42 pubmed
    ..Previous studies indicated that the VEGF homolog placental growth factor (PlGF) has a more significant role in disease than in health...
  4. Yonekura H, Sakurai S, Liu X, Migita H, Wang H, Yamagishi S, et al. Placenta growth factor and vascular endothelial growth factor B and C expression in microvascular endothelial cells and pericytes. Implication in autocrine and paracrine regulation of angiogenesis. J Biol Chem. 1999;274:35172-8 pubmed
    ..In this study, we examined the expression of the recently isolated VEGF gene family members (placenta growth factor (PlGF), VEGF-B, and VEGF-C) in human dermal microvascular endothelial cells and bovine retinal pericytes ..
  5. Bais C, Wu X, Yao J, Yang S, Crawford Y, McCutcheon K, et al. PlGF blockade does not inhibit angiogenesis during primary tumor growth. Cell. 2010;141:166-77 pubmed publisher
    It has been recently reported that treatment with an anti-placenta growth factor (PlGF) antibody inhibits metastasis and primary tumor growth...
  6. Luttun A, Tjwa M, Moons L, Wu Y, Angelillo Scherrer A, Liao F, et al. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med. 2002;8:831-40 pubmed
    The therapeutic potential of placental growth factor (PlGF) and its receptor Flt1 in angiogenesis is poorly understood...
  7. Gigante B, Morlino G, Gentile M, Persico M, De Falco S. Plgf-/-eNos-/- mice show defective angiogenesis associated with increased oxidative stress in response to tissue ischemia. FASEB J. 2006;20:970-2 pubmed
    ..We have generated a congenic line of knockout mice carrying null mutations of both placental growth factor (PlGF) and endothelial nitric oxide synthase (eNOS), two genes that play a pivotal role in the regulation of pathological ..
  8. Adini A, Kornaga T, Firoozbakht F, Benjamin L. Placental growth factor is a survival factor for tumor endothelial cells and macrophages. Cancer Res. 2002;62:2749-52 pubmed
    The vascular endothelial growth factor (VEGF)-related factor, placental growth factor (PlGF),has been shown recently to play an important role in pathological VEGF-driven angiogenesis...
  9. Odorisio T, Schietroma C, Zaccaria M, Cianfarani F, Tiveron C, Tatangelo L, et al. Mice overexpressing placenta growth factor exhibit increased vascularization and vessel permeability. J Cell Sci. 2002;115:2559-67 pubmed
    b>Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family, comprising at least five cytokines specifically involved in the regulation of vascular and/or lymphatic endothelium differentiation...

More Information

Publications77

  1. Hedlund E, Yang X, Zhang Y, Yang Y, Shibuya M, Zhong W, et al. Tumor cell-derived placental growth factor sensitizes antiangiogenic and antitumor effects of anti-VEGF drugs. Proc Natl Acad Sci U S A. 2013;110:654-9 pubmed publisher
    The role of placental growth factor (PlGF) in modulation of tumor angiogenesis and tumor growth remains an enigma. Furthermore, anti-PlGF therapy in tumor angiogenesis and tumor growth remains controversial in preclinical tumor models...
  2. Luttun A, Brusselmans K, Fukao H, Tjwa M, Ueshima S, Herbert J, et al. Loss of placental growth factor protects mice against vascular permeability in pathological conditions. Biochem Biophys Res Commun. 2002;295:428-34 pubmed
    ..Previous studies demonstrated that exogenous administration of placental growth factor (PlGF), a homologue of VEGF, stimulates vascular permeability but the role of endogenous PlGF in plasma extravasation ..
  3. Oura H, Bertoncini J, Velasco P, Brown L, Carmeliet P, Detmar M. A critical role of placental growth factor in the induction of inflammation and edema formation. Blood. 2003;101:560-7 pubmed
    ..Up-regulation of placental growth factor (PlGF), a member of the vascular endothelial growth factor (VEGF) family, has been found in several conditions associated ..
  4. Van de Veire S, Stalmans I, Heindryckx F, Oura H, Tijeras Raballand A, Schmidt T, et al. Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease. Cell. 2010;141:178-90 pubmed publisher
    Our findings that PlGF is a cancer target and anti-PlGF is useful for anticancer treatment have been challenged by Bais et al...
  5. DiPalma T, Tucci M, Russo G, Maglione D, Lago C, Romano A, et al. The placenta growth factor gene of the mouse. Mamm Genome. 1996;7:6-12 pubmed
    b>Placenta growth factor (PlGF) and vascular endothelial growth factor (VEGF) are angiogenic factors containing the 8-cysteine motif of platelet-derived growth factor (PDGF)...
  6. Jaffe I, Newfell B, Aronovitz M, Mohammad N, McGraw A, Perreault R, et al. Placental growth factor mediates aldosterone-dependent vascular injury in mice. J Clin Invest. 2010;120:3891-900 pubmed publisher
    ..Using gene expression profiling, we identify the pro-proliferative VEGF family member placental growth factor (PGF) as an aldosterone-regulated vascular MR target gene in mice and humans...
  7. Cheng S, Wang H, Yu C, Tsao P, Carmeliet P, Cheng S, et al. Prevention of elastase-induced emphysema in placenta growth factor knock-out mice. Respir Res. 2009;10:115 pubmed publisher
    Although both animal and human studies suggested the association between placenta growth factor (PlGF) and chronic obstructive pulmonary disease (COPD), especially lung emphysema, the role of PlGF in the pathogenesis of emphysema remains ..
  8. Khurana R, Moons L, Shafi S, Luttun A, Collen D, Martin J, et al. Placental growth factor promotes atherosclerotic intimal thickening and macrophage accumulation. Circulation. 2005;111:2828-36 pubmed
    Placental growth factor (PlGF) has been implicated in the pathophysiological angiogenesis and monocyte recruitment that underlie chronic inflammatory disease, but its role in atherosclerosis has not been examined...
  9. Molinas C, Campo R, Dewerchin M, Eriksson U, Carmeliet P, Koninckx P. Role of vascular endothelial growth factor and placental growth factor in basal adhesion formation and in carbon dioxide pneumoperitoneum-enhanced adhesion formation after laparoscopic surgery in transgenic mice. Fertil Steril. 2003;80 Suppl 2:803-11 pubmed
    To evaluate the role of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) in adhesion formation after laparoscopic surgery. Prospective, randomized study. Academic research center...
  10. Accornero F, van Berlo J, Benard M, Lorenz J, Carmeliet P, Molkentin J. Placental growth factor regulates cardiac adaptation and hypertrophy through a paracrine mechanism. Circ Res. 2011;109:272-80 pubmed publisher
    ..To examine the role that placental growth factor (PGF) plays in the heart as a paracrine regulator of cardiac adaptation to stress stimulation...
  11. Iwasaki H, Kawamoto A, Tjwa M, Horii M, Hayashi S, Oyamada A, et al. PlGF repairs myocardial ischemia through mechanisms of angiogenesis, cardioprotection and recruitment of myo-angiogenic competent marrow progenitors. PLoS ONE. 2011;6:e24872 pubmed publisher
    ..We explored the therapeutic potential of myocardial gene therapy of placental growth factor (PlGF), a VEGF-related angiogenic growth factor, with progenitor-mobilizing activity...
  12. Rashdan N, Lloyd P. Fluid shear stress upregulates placental growth factor in the vessel wall via NADPH oxidase 4. Am J Physiol Heart Circ Physiol. 2015;309:H1655-66 pubmed publisher
    Placental growth factor (PLGF), a potent stimulator of arteriogenesis, is upregulated during outward arterial remodeling. Increased fluid shear stress (FSS) is a key physiological stimulus for arteriogenesis...
  13. Bobic S, Seys S, De Vooght V, Callebaut I, Hox V, Dooms C, et al. Placental growth factor contributes to bronchial neutrophilic inflammation and edema in allergic asthma. Am J Respir Cell Mol Biol. 2012;46:781-9 pubmed publisher
    Placental growth factor (PlGF) and its receptor vascular endothelial growth factor receptor 1 (VEGFR1) play an important role in pathological conditions related to angiogenesis, vascular leakage, and inflammation...
  14. Chaballe L, Close P, Sempels M, Delstanche S, Fanielle J, Moons L, et al. Involvement of placental growth factor in Wallerian degeneration. Glia. 2011;59:379-96 pubmed publisher
    ..Within this network, the role of placental growth factor (PlGF) remains totally unknown...
  15. Tudisco L, Orlandi A, Tarallo V, De Falco S. Hypoxia activates placental growth factor expression in lymphatic endothelial cells. Oncotarget. 2017;8:32873-32883 pubmed publisher
    Placental growth factor (PlGF), a proangiogenic member of vascular endothelial growth family, is active during pathological conditions like cancer, metastasis formation and hind limb ischemia and in wound healing...
  16. Hou H, Cheng S, Liu H, Yang F, Wang H, Yu C. Elastase induced lung epithelial cell apoptosis and emphysema through placenta growth factor. Cell Death Dis. 2013;4:e793 pubmed publisher
    ..In our previous studies, COPD patients were noted to have higher levels of placenta growth factor (PlGF) in serum and bronchoalveolar lavage fluid than controls...
  17. Korpisalo P, Rissanen T, Bengtsson T, Liimatainen T, Laidinen S, Karvinen H, et al. Therapeutic angiogenesis with placental growth factor improves exercise tolerance of ischaemic rabbit hindlimbs. Cardiovasc Res. 2008;80:263-70 pubmed publisher
    ..This study shows that proangiogenic gene therapy can significantly improve performance of ischaemic limbs and supports the concept of therapeutic angiogenesis for the treatment of patients with ischaemia. ..
  18. Van Steenkiste C, Geerts A, Vanheule E, Van Vlierberghe H, de Vos F, Olievier K, et al. Role of placental growth factor in mesenteric neoangiogenesis in a mouse model of portal hypertension. Gastroenterology. 2009;137:2112-24.e1-6 pubmed publisher
    ..We investigated the role of placental growth factor (PlGF) and tested the effects of monoclonal antibodies against PlGF (alphaPlGF) in a mouse model of portal hypertension...
  19. Oladipupo S, Smith C, Santeford A, Park C, Sene A, Wiley L, et al. Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis. Proc Natl Acad Sci U S A. 2014;111:13379-84 pubmed publisher
  20. Kay V, Tayade C, Carmeliet P, Croy B. Influences of placental growth factor on mouse retinal vascular development. Dev Dyn. 2017;246:700-712 pubmed publisher
    Placental growth factor (PGF) is important for wound-healing and vascular collaterogenesis. PGF deficiency is associated with preeclampsia, a hypertensive disease of human pregnancy...
  21. Hick A, Delmarcelle A, Bouquet M, Klotz S, Copetti T, Forez C, et al. Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation. Dev Biol. 2013;381:227-40 pubmed publisher
    ..In turn, endothelial cells control epithelial reorganization in follicles and C-cells differentiation. ..
  22. Carnevale D, Lembo G. PlGF, immune system and hypertension. Oncotarget. 2015;6:18246-7 pubmed
  23. Zhang L, Yuan L, Zhao S, Shan Y, Wu H, Xue X. The role of placenta growth factor in the hyperoxia-induced acute lung injury in an animal model. Cell Biochem Funct. 2015;33:44-9 pubmed publisher
    ..Here, we aimed to investigate the role of placental growth factor (PLGF) in hyperoxia-induced lung injury...
  24. Ho L, van Dijk M, Chye S, Messerschmidt D, Chng S, Ong S, et al. ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. Science. 2017;357:707-713 pubmed publisher
    ..The ELA-APLNR signaling axis may offer a new paradigm for the treatment of common pregnancy-related complications, including PE. ..
  25. Patel N, Sundaram N, Yang M, Madigan C, Kalra V, Malik P. Placenta growth factor (PlGF), a novel inducer of plasminogen activator inhibitor-1 (PAI-1) in sickle cell disease (SCD). J Biol Chem. 2010;285:16713-22 pubmed publisher
    ..b>Placenta growth factor (PlGF), released at high levels by sickle erythroblasts, induced PAI-1 expression in primary human ..
  26. Bainbridge S, Minhas A, Whiteley K, Qu D, Sled J, Kingdom J, et al. Effects of reduced Gcm1 expression on trophoblast morphology, fetoplacental vascularity, and pregnancy outcomes in mice. Hypertension. 2012;59:732-9 pubmed publisher
    ..45; P<0.05). These results support a role for reduced placental Gcm1 expression as a causative factor in defective syncytiotrophoblast differentiation and maternal and placental phenotypes in preeclampsia in humans. ..
  27. Huang H, He J, Johnson D, Wei Y, Liu Y, Wang S, et al. Deletion of placental growth factor prevents diabetic retinopathy and is associated with Akt activation and HIF1α-VEGF pathway inhibition. Diabetes. 2015;64:200-12 pubmed publisher
    A new diabetic mouse strain, the Akita.PlGF knockout ((-/-)), was generated to study the role of placental growth factor (PlGF) in the pathogenesis of diabetic retinopathy (DR)...
  28. Li J, Ying H, Cai G, Guo Q, Chen L. Pre-Eclampsia-Associated Reduction in Placental Growth Factor Impaired Beta Cell Proliferation Through PI3k Signalling. Cell Physiol Biochem. 2015;36:34-43 pubmed publisher
    Reduction in serum placental growth factor (PLGF) frequently co-occurs with preeclampsia (PE) and gestational diabetes mellitus (GDM)...
  29. Kumasawa K, Ikawa M, Kidoya H, Hasuwa H, Saito Fujita T, Morioka Y, et al. Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model. Proc Natl Acad Sci U S A. 2011;108:1451-5 pubmed publisher
    ..We further showed that pravastatin induced the VEGF-like angiogenic factor placental growth factor (PGF) and ameliorated the symptoms...
  30. Maes C, Carmeliet P, Moermans K, Stockmans I, Smets N, Collen D, et al. Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Mech Dev. 2002;111:61-73 pubmed
  31. Cao R, Xue Y, Hedlund E, Zhong Z, Tritsaris K, Tondelli B, et al. VEGFR1-mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathy. Proc Natl Acad Sci U S A. 2010;107:856-61 pubmed publisher
    ..Here, we show that systemic delivery of VEGF and placental growth factor (PlGF) by protein implantation, tumors, and adenoviral vectors ablates pericytes from the mature retinal vasculature ..
  32. Viita H, Markkanen J, Eriksson E, Nurminen M, Kinnunen K, Babu M, et al. 15-lipoxygenase-1 prevents vascular endothelial growth factor A- and placental growth factor-induced angiogenic effects in rabbit skeletal muscles via reduction in growth factor mRNA levels, NO bioactivity, and downregulation of VEGF receptor 2 expre. Circ Res. 2008;102:177-84 pubmed
    ..to study the effects of 15-LO-1 on vascular endothelial growth factor (VEGF)-A165- and placental growth factor (PlGF)-induced angiogenesis in rabbit skeletal muscles...
  33. Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, et al. Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med. 2002;8:702-10 pubmed
    ..The pneumotrophic effect of VEGF may have therapeutic potential for lung maturation in preterm infants. ..
  34. Aasa K, Zavan B, Luna R, Wong P, Ventura N, Tse M, et al. Placental growth factor influences maternal cardiovascular adaptation to pregnancy in mice. Biol Reprod. 2015;92:44 pubmed publisher
    In healthy human pregnancies, placental growth factor (PGF) concentrations rise in maternal plasma during early gestation, peak over Weeks 26-30, then decline...
  35. Ohlmann A, Scholz M, Goldwich A, Chauhan B, Hudl K, Ohlmann A, et al. Ectopic norrin induces growth of ocular capillaries and restores normal retinal angiogenesis in Norrie disease mutant mice. J Neurosci. 2005;25:1701-10 pubmed
  36. Suenaga K, Kitahara S, Suzuki Y, Kobayashi M, Horie S, Sugawara J, et al. Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation. PLoS ONE. 2014;9:e104728 pubmed publisher
    ..Moreover, our study shows for the first time that VASH2 expressed in trophoblasts is involved in the regulation of cell fusion for syncytiotrophoblast formation. ..
  37. Yang X, Zhang Y, Yang Y, Lim S, Cao Z, Rak J, et al. Vascular endothelial growth factor-dependent spatiotemporal dual roles of placental growth factor in modulation of angiogenesis and tumor growth. Proc Natl Acad Sci U S A. 2013;110:13932-7 pubmed publisher
    Placental growth factor (PlGF) remodels tumor vasculatures toward a normalized phenotype, which affects tumor growth, invasion and drug responses...
  38. Richter G, Fasan A, Hauer K, Grunewald T, Berns C, Rössler S, et al. G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1. J Pathol. 2013;230:70-81 pubmed publisher
    ..Moreover, a GPR64-mediated induction of placental growth factor (PGF) in ES was observed...
  39. Luna R, Kay V, Rätsep M, Khalaj K, Bidarimath M, Peterson N, et al. Placental growth factor deficiency is associated with impaired cerebral vascular development in mice. Mol Hum Reprod. 2016;22:130-42 pubmed publisher
    Placental growth factor (PGF) is expressed in the developing mouse brain and contributes to vascularization and vessel patterning...
  40. Carnevale D, Cifelli G, Mascio G, Madonna M, Sbroggiò M, Perrino C, et al. Placental growth factor regulates cardiac inflammation through the tissue inhibitor of metalloproteinases-3/tumor necrosis factor-?-converting enzyme axis: crucial role for adaptive cardiac remodeling during cardiac pressure overload. Circulation. 2011;124:1337-50 pubmed publisher
  41. Langford Smith A, Malinowska M, Langford Smith K, Wegrzyn G, Jones S, Wynn R, et al. Hyperactive behaviour in the mouse model of mucopolysaccharidosis IIIB in the open field and home cage environments. Genes Brain Behav. 2011;10:673-82 pubmed publisher
    ..The open field test effectively identifies hyperactive behaviour in MPS IIIB mice and is a significant tool for evaluating effects of therapy on neurodegeneration. ..
  42. Fujii T, Yonemitsu Y, Onimaru M, Inoue M, Hasegawa M, Kuwano H, et al. VEGF function for upregulation of endogenous PlGF expression during FGF-2-mediated therapeutic angiogenesis. Atherosclerosis. 2008;200:51-7 pubmed publisher
    ..Recently, placental growth factor (PlGF) has been shown to play an important role in angiogenesis...
  43. Kawakami T, Yoshimi M, Kadota Y, Inoue M, Sato M, Suzuki S. Prolonged endoplasmic reticulum stress alters placental morphology and causes low birth weight. Toxicol Appl Pharmacol. 2014;275:134-44 pubmed publisher
    ..These results suggest that excessive and exogenous ER stress may induce functional abnormalities in the placenta, at least in part, with altered GLUT and vascular-related gene expression, resulting in low infant birth weight. ..
  44. Zhang H, Palmer R, Gao X, Kreidberg J, Gerald W, Hsiao L, et al. Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1. Curr Biol. 2003;13:1625-9 pubmed
    ..cells with inducible expression of BF-2, combined with microarray analysis, to identify Placental Growth Factor (PlGF), a Vascular Endothelial Growth Factor (VEGF) family member previously implicated in angiogenesis, as a downstream ..
  45. Zhou X, Qi Y. Larynx carcinoma regulates tumor-associated macrophages through PLGF signaling. Sci Rep. 2015;5:10071 pubmed publisher
    ..Recently, we reported that placental growth factor (PLGF) regulates expression of matrix metalloproteinase 3 (MMP3) through ERK/MAPK signaling pathway in LC...
  46. Lecuyer M, Laquerrière A, Bekri S, Lesueur C, Ramdani Y, Jégou S, et al. PLGF, a placental marker of fetal brain defects after in utero alcohol exposure. Acta Neuropathol Commun. 2017;5:44 pubmed publisher
    ..In mouse, using in vivo repression and overexpression of PLGF, we investigated the contribution of placenta on fetal brain angiogenesis...
  47. Carnevale D, Pallante F, Fardella V, Fardella S, Iacobucci R, Federici M, et al. The angiogenic factor PlGF mediates a neuroimmune interaction in the spleen to allow the onset of hypertension. Immunity. 2014;41:737-52 pubmed publisher
    ..Here we showed a splenic role for placental growth factor (PlGF), which accounts for the onset of hypertension, through immune system modulation...
  48. Wu M, Zhou J, Cheng M, Boriboun C, Biyashev D, Wang H, et al. E2F1 suppresses cardiac neovascularization by down-regulating VEGF and PlGF expression. Cardiovasc Res. 2014;104:412-22 pubmed publisher
    ..cell (EC) proliferation were greater, apoptotic ECs were fewer, levels of VEGF and placental growth factor (PlGF) were higher, and p53 level was lower in E2F1(-/-) than in WT mice...
  49. Kang M, Park S, Kim H, Lee J, Yu D, Bae K, et al. Gestational loss and growth restriction by angiogenic defects in placental growth factor transgenic mice. Arterioscler Thromb Vasc Biol. 2014;34:2276-82 pubmed publisher
    ..Placental growth factor (PlGF) is a member of vascular endothelial growth factor that is critical for angiogenesis and vasculogenesis...
  50. Vandewynckel Y, Laukens D, Devisscher L, Bogaerts E, Paridaens A, Van den Bussche A, et al. Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma. BMC Cancer. 2016;16:9 pubmed publisher
    ..We previously showed that the inhibition of placental growth factor (PlGF) exerts antitumour effects and induces vessel normalisation, possibly reducing hypoxia...
  51. Rätsep M, Carmeliet P, Adams M, Croy B. Impact of placental growth factor deficiency on early mouse implant site angiogenesis. Placenta. 2014;35:772-5 pubmed publisher
    Effects of placental growth factor (PGF), an angiokine product of fetal trophoblasts and maternal decidual cells, on early decidual angiogenesis are undefined...
  52. Ambati B, Nozaki M, Singh N, Takeda A, Jani P, Suthar T, et al. Corneal avascularity is due to soluble VEGF receptor-1. Nature. 2006;443:993-7 pubmed
  53. Larcher F, Franco M, Bolontrade M, Rodriguez Puebla M, Casanova L, Navarro M, et al. Modulation of the angiogenesis response through Ha-ras control, placenta growth factor, and angiopoietin expression in mouse skin carcinogenesis. Mol Carcinog. 2003;37:83-90 pubmed
    ..In the present study, we show that another VEGF family member, placenta growth factor (PlGF), was highly upregulated at all tumor stages in a ras-dependent manner...
  54. Lijnen H, Christiaens V, Scroyen I, Voros G, Tjwa M, Carmeliet P, et al. Impaired adipose tissue development in mice with inactivation of placental growth factor function. Diabetes. 2006;55:2698-704 pubmed
    Placental growth factor (PlGF)-deficient (PlGF-/-) and wild-type mice were kept on a standard-fat or high-fat diet for 15 weeks...
  55. Yano K, Okada Y, Beldi G, Shih S, Bodyak N, Okada H, et al. Elevated levels of placental growth factor represent an adaptive host response in sepsis. J Exp Med. 2008;205:2623-31 pubmed publisher
    ..we demonstrated that circulating levels of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) are increased in sepsis (Yano, K., P.C. Liaw, J.M. Mullington, S.C. Shih, H. Okada, N. Bodyak, P.M. Kang, L...
  56. Copeland J, Feng Y, Neradugomma N, Fields P, Vivian J. Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac. BMC Dev Biol. 2011;11:12 pubmed publisher
    ..We propose a role for Notch signaling in elaborating the microenvironment of the nascent arteriole, suggesting novel regulatory connections between Notch signaling and other signaling pathways during endothelial differentiation. ..
  57. Tarallo V, Bogdanovich S, Hirano Y, Tudisco L, Zentilin L, Giacca M, et al. Inhibition of choroidal and corneal pathologic neovascularization by Plgf1-de gene transfer. Invest Ophthalmol Vis Sci. 2012;53:7989-96 pubmed publisher
    ..However, besides VEGF-A, other proteins of the same family, including VEGF-B and placental growth factor (PlGF, all together VEGFs), have a crucial role in the angiogenesis process...
  58. Martino M, Briquez P, Güç E, Tortelli F, Kilarski W, Metzger S, et al. Growth factors engineered for super-affinity to the extracellular matrix enhance tissue healing. Science. 2014;343:885-8 pubmed publisher
    ..We discovered that a domain in placenta growth factor-2 (PlGF-2(123-144)) binds exceptionally strongly and promiscuously to ECM proteins...
  59. Marcellini M, De Luca N, Riccioni T, Ciucci A, Orecchia A, Lacal P, et al. Increased melanoma growth and metastasis spreading in mice overexpressing placenta growth factor. Am J Pathol. 2006;169:643-54 pubmed
    b>Placenta growth factor (PlGF), a member of the vascular endothelial growth factor family, plays an important role in adult pathological angiogenesis...
  60. Coenegrachts L, Maes C, Torrekens S, Van Looveren R, Mazzone M, Guise T, et al. Anti-placental growth factor reduces bone metastasis by blocking tumor cell engraftment and osteoclast differentiation. Cancer Res. 2010;70:6537-47 pubmed publisher
    ..We explored whether bone-derived placental growth factor (PlGF), a homologue of vascular endothelial growth factor-A, regulates osteolytic metastasis...
  61. McGraw A, Bagley J, Chen W, Galayda C, Nickerson H, Armani A, et al. Aldosterone increases early atherosclerosis and promotes plaque inflammation through a placental growth factor-dependent mechanism. J Am Heart Assoc. 2013;2:e000018 pubmed publisher
    ..Further studies focused on the proinflammatory placental growth factor (PlGF), which was released from aldosterone-treated ApoE-/- vessels...
  62. Hemmeryckx B, van Bree R, Van Hoef B, Vercruysse L, Lijnen H, Verhaeghe J. Adverse adipose phenotype and hyperinsulinemia in gravid mice deficient in placental growth factor. Endocrinology. 2008;149:2176-83 pubmed publisher
    ..Pregnancy-induced metabolic changes are regulated by signals from an expanded adipose organ. Placental growth factor (PlGF), acting through vascular endothelial growth factor receptor-1, may be among those signals...
  63. Torry R, Tomanek R, Zheng W, Miller S, Labarrere C, Torry D. Hypoxia increases placenta growth factor expression in human myocardium and cultured neonatal rat cardiomyocytes. J Heart Lung Transplant. 2009;28:183-90 pubmed publisher
    b>Placenta growth factor (PlGF) plays an important role in pathologic angiogenesis and is believed to be an independent biomarker in patients with coronary artery disease...
  64. Achen M, Gad J, Stacker S, Wilks A. Placenta growth factor and vascular endothelial growth factor are co-expressed during early embryonic development. Growth Factors. 1997;15:69-80 pubmed
    ..One amplified product encoded mouse Placenta Growth Factor (PIGF). The pattern of PIGF gene expression in mouse embryos was studied by in situ hybridization...
  65. Saint Geniez M, Ghelfi E, Liang X, Yu C, Spencer C, Abend S, et al. Fatty acid binding protein 4 deficiency protects against oxygen-induced retinopathy in mice. PLoS ONE. 2014;9:e96253 pubmed publisher
    ..Collectively, our findings suggest FABP4 as a potential target of pathologic retinal angiogenesis in proliferative retinopathies. ..
  66. Freitas Andrade M, Carmeliet P, Stanimirovic D, Moreno M. VEGFR-2-mediated increased proliferation and survival in response to oxygen and glucose deprivation in PlGF knockout astrocytes. J Neurochem. 2008;107:756-67 pubmed publisher
    ..However, the role of placental growth factor (PlGF), a VEGF homolog, in these processes is unclear...
  67. Kröger C, Vijayaraj P, Reuter U, Windoffer R, Simmons D, Heukamp L, et al. Placental vasculogenesis is regulated by keratin-mediated hyperoxia in murine decidual tissues. Am J Pathol. 2011;178:1578-90 pubmed publisher
    ..that keratin-positive trophoblast secretion of prolactin-like protein a (Prlpa) and placental growth factor (PlGF) during decidualization are altered in the absence of keratins, leading to increased infiltration of uterine ..
  68. Ding Y, Huang Y, Song N, Gao X, Yuan S, Wang X, et al. NFAT1 mediates placental growth factor-induced myelomonocytic cell recruitment via the induction of TNF-alpha. J Immunol. 2010;184:2593-601 pubmed publisher
    ..Placental growth factor (PlGF) is a potent cytokine that can attract myelomonocytic cells to the tumor...