Pgam2

Summary

Gene Symbol: Pgam2
Description: phosphoglycerate mutase 2
Alias: phosphoglycerate mutase 2, BPG-dependent PGAM 2, PGAM-M, muscle-specific phosphoglycerate mutase, phosphoglycerate mutase isozyme M, phosphoglycerate mutase muscle-specific subunit
Species: mouse
Products:     Pgam2

Top Publications

  1. Zhang J, Yu L, Fu Q, Gao J, Xie Y, Chen J, et al. Mouse phosphoglycerate mutase M and B isozymes: cDNA cloning, enzyme activity assay and mapping. Gene. 2001;264:273-9 pubmed
    ..cDNAs encoding the non-muscle-specific or brain isoform (type B, Pgam1) and the muscle-specific isoform (type M, Pgam2) of phosphoglycerate mutase (PGAM) were isolated and characterized...
  2. Kondoh H, Lleonart M, Gil J, Wang J, Degan P, Peters G, et al. Glycolytic enzymes can modulate cellular life span. Cancer Res. 2005;65:177-85 pubmed
    ..Because wild-type p53 down-regulates PGM, mutation of p53 can facilitate immortalization via effects on PGM levels and glycolysis. ..
  3. Masino A, Gallardo T, Wilcox C, Olson E, Williams R, Garry D. Transcriptional regulation of cardiac progenitor cell populations. Circ Res. 2004;95:389-97 pubmed
    ..These results define the transcriptional profile of mammalian cardiac progenitor cells and provide insight into the molecular regulation of the earliest periods of heart development. ..
  4. Fouillade C, Baron Menguy C, Domenga Denier V, Thibault C, Takamiya K, Huganir R, et al. Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Arterioscler Thromb Vasc Biol. 2013;33:76-86 pubmed publisher
    ..Notch3-regulated transcriptome provides potential for modulating myogenic response in the cerebrovasculature. ..
  5. Mikawa T, Maruyama T, Okamoto K, Nakagama H, Lleonart M, Tsusaka T, et al. Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2. J Cell Biol. 2014;204:729-45 pubmed publisher
    ..We propose that Mdm2, a downstream effector of p53, attenuates the Warburg effect via ubiquitination and degradation of PGAM. ..
  6. Tsusaka T, Guo T, Yagura T, Inoue T, Yokode M, Inagaki N, et al. Deacetylation of phosphoglycerate mutase in its distinct central region by SIRT2 down-regulates its enzymatic activity. Genes Cells. 2014;19:766-77 pubmed publisher
    ..As prior evidence suggests that SIRT2 functions as a tumor suppressor, our results would provide support for the mechanistic basis of this activity. ..
  7. Fundele R, Winking H, Illmensee K, J├Ągerbauer E. Developmental activation of phosphoglycerate mutase-2 in the testis of the mouse. Dev Biol. 1987;124:562-6 pubmed
    ..The muscle-specific PGAM isozyme was also found in testes of bull, cat, and rat, as well as in human sperm. PGAM-B might thus be useful as a marker for germ cell differentiation, along with other germ cell-specific proteins. ..
  8. Danik S, Liu F, Zhang J, Suk H, Morley G, Fishman G, et al. Modulation of cardiac gap junction expression and arrhythmic susceptibility. Circ Res. 2004;95:1035-41 pubmed
    ..Thus, moderately severe reductions in Cx43 abundance are associated with slowing of impulse propagation and a dramatic increase in the susceptibility to inducible ventricular arrhythmias. ..
  9. Olson L, Zhang J, Taylor H, Rose D, Rosenfeld M. Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling. Proc Natl Acad Sci U S A. 2005;102:3708-13 pubmed
    ..Together, our data suggest that the hair-remodeling defect of Barx2 mutant mice could be explained, in part, by failure to repress one or more critical target genes. ..

More Information

Publications11

  1. Nakamura N, Dai Q, Williams J, Goulding E, Willis W, Brown P, et al. Disruption of a spermatogenic cell-specific mouse enolase 4 (eno4) gene causes sperm structural defects and male infertility. Biol Reprod. 2013;88:90 pubmed publisher
    ..We conclude that ENO4 is required for normal assembly of the FS and provides most of the enolase activity in sperm and that Eno1 and/or Gm5506 may encode a minor portion of the enolase activity in sperm. ..
  2. Okuda J, Niizuma S, Shioi T, Kato T, Inuzuka Y, Kawashima T, et al. Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice. PLoS ONE. 2013;8:e72173 pubmed publisher
    ..We examined the effects of persistent overexpression of phosphoglycerate mutase 2 (Pgam2), a glycolytic enzyme, on cardiac energy metabolism and function...