Pebp1

Summary

Gene Symbol: Pebp1
Description: phosphatidylethanolamine binding protein 1
Alias: HCNP, Pbp, Pbp1, Pbpr, Rkip, phosphatidylethanolamine-binding protein 1, HCNPpp, PEBP-1, Raf-1 inhibitor protein, Raf-1 kinase inhibitor protein
Species: mouse
Products:     Pebp1

Top Publications

  1. Theroux S, Pereira M, Casten K, Burwell R, Yeung K, Sedivy J, et al. Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit. Brain Res Bull. 2007;71:559-67 pubmed
    Raf kinase inhibitory protein (RKIP-1) is involved in the regulation of the MAP kinase, NF-kappaB, and GPCR signaling pathways...
  2. Dangi Garimella S, Yun J, Eves E, Newman M, Erkeland S, Hammond S, et al. Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7. EMBO J. 2009;28:347-58 pubmed publisher
    Raf kinase inhibitory protein (RKIP) negatively regulates the MAP kinase (MAPK), G protein-coupled receptor kinase-2, and NF-kappaB signalling cascades...
  3. Lin W, Ma C, Su F, Jiang Y, Lai R, Zhang T, et al. Raf kinase inhibitor protein mediates intestinal epithelial cell apoptosis and promotes IBDs in humans and mice. Gut. 2017;66:597-610 pubmed publisher
    Raf kinase inhibitor protein (RKIP) appears to control cancer cell metastasis and its expression in colonic tissue is related to colonic cancer development. We sought to identify the roles of RKIP in maintaining homeostasis of GI tract...
  4. Yamazaki T, Nakano H, Hayakari M, Tanaka M, Mayama J, Tsuchida S. Differentiation induction of human keratinocytes by phosphatidylethanolamine-binding protein. J Biol Chem. 2004;279:32191-5 pubmed
    ..These results indicate that PEBP not only inhibits cell proliferation but also induces differentiation of human keratinocytes. ..
  5. Schmid E, Neef S, Berlin C, Tomasovic A, Kahlert K, Nordbeck P, et al. Cardiac RKIP induces a beneficial β-adrenoceptor-dependent positive inotropy. Nat Med. 2015;21:1298-306 pubmed publisher
    ..Here we show that modest overexpression of the Raf kinase inhibitor protein (RKIP), encoded by Pebp1 in mice, produces a well-tolerated, persistent increase in cardiac contractility that is mediated by the β1-..
  6. Yamada K, Matsukawa N, Yuasa H, Hattori M, Nakazawa H, Borlongan C, et al. Differential expression of HCNP-related antigens in hippocampus in senescence-accelerated mice. Brain Res. 2007;1158:169-75 pubmed
    Hippocampal cholinergic neurostimulating peptide (HCNP), originally isolated from soluble fraction of young rat hippocampus and released from hippocampus by the stimulation of N-methyl-d-aspartate (NMDA) receptors, enhances the ..
  7. Park S, Ahn E, Lee S, Jung M, Park J, Yi S, et al. Proteomic analysis reveals upregulation of RKIP in S-180 implanted BALB/C mouse after treatment with ascorbic acid. J Cell Biochem. 2009;106:1136-45 pubmed publisher
    ..In particular, Raf kinase inhibitory protein (RKIP) and annexin A5 expression were quantitatively up-regulated...
  8. Sas K, Janech M, Favre E, Arthur J, Bell P. Cilia movement regulates expression of the Raf-1 kinase inhibitor protein. Am J Physiol Renal Physiol. 2011;300:F1163-70 pubmed publisher
    ..Expression of the Raf-1 kinase inhibitor protein (RKIP), an inhibitor of the MAPK pathway, was significantly elevated in rotated cilia (+) cells...
  9. Wang J, Du J, Miao C, Lian H. Raf-kinase inhibitor protein attenuates microglia inflammation in an in vitro model of intracerebral hemorrhage. Cell Mol Biol (Noisy-le-grand). 2016;62:86-91 pubmed
    ..Raf kinase inhibitor protein (RKIP), a member of the phosphatidylethanolamine-binding protein (PEBP) family, is a negative regulator of inflammatory ..

More Information

Publications39

  1. Sun M, Gomes S, Chen P, Frankenberger C, Sankarasharma D, Chung C, et al. RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2. Oncogene. 2014;33:3528-37 pubmed publisher
    ..To identify downstream targets of the metastasis suppressor Raf-1 kinase inhibitory protein (RKIP/PEBP1), we utilized an integrated approach based upon statistical analysis of tumor gene expression data combined with ..
  2. Wright K, Vella A. RKIP contributes to IFN-? synthesis by CD8+ T cells after serial TCR triggering in systemic inflammatory response syndrome. J Immunol. 2013;191:708-16 pubmed publisher
    ..Raf kinase inhibitor protein (RKIP) is a regulator of MAPK and NF-?B signaling cascades, which are both critical for production of the proinflammatory ..
  3. Zeng L, Ehrenreiter K, Menon J, Menard R, Kern F, Nakazawa Y, et al. RKIP regulates MAP kinase signaling in cells with defective B-Raf activity. Cell Signal. 2013;25:1156-65 pubmed publisher
    ..Here, we demonstrate that Raf kinase inhibitory protein (RKIP) regulates the activation of MAPK when B-Raf signaling is defective...
  4. Murga Zamalloa C, Ghosh A, Patil S, Reed N, Chan L, Davuluri S, et al. Accumulation of the Raf-1 kinase inhibitory protein (Rkip) is associated with Cep290-mediated photoreceptor degeneration in ciliopathies. J Biol Chem. 2011;286:28276-86 pubmed publisher
    ..photoreceptor degeneration is associated with aberrant accumulation of its novel interacting partner Rkip (Raf-1 kinase inhibitory protein)...
  5. Lai R, Gu M, Jiang W, Lin W, Xu P, Liu Z, et al. Raf Kinase Inhibitor Protein Preferentially Promotes TLR3-Triggered Signaling and Inflammation. J Immunol. 2017;198:4086-4095 pubmed publisher
    Raf kinase inhibitor protein (RKIP) protects against host immunological responses in nematodes and Drosophila Whether RKIP functions in innate immune responses in mammals remains unknown...
  6. Matsukawa N, Furuya Y, Ogura H, Ojika K. HCNP precursor protein transgenic mice display a depressive-like phenotype in old age. Brain Res. 2010;1349:153-61 pubmed publisher
    We have previously reported a novel peptide, hippocampal cholinergic neurostimulating peptide (HCNP), which induces acetylcholine synthesis by increasing the amount of cholineacetyltransferase (ChAT) in medial septal nuclei...
  7. Nixon B, MacIntyre D, Mitchell L, Gibbs G, O Bryan M, Aitken R. The identification of mouse sperm-surface-associated proteins and characterization of their ability to act as decapacitation factors. Biol Reprod. 2006;74:275-87 pubmed
    ..as plasma membrane fatty acid binding protein, cysteine-rich secretory protein 1 (CRISP1), phosphatidylethanolamine binding protein 1 (PBP), and an unnamed protein product that we have termed decapacitation factor 10 (DF10)...
  8. Chen Y, Ip S, Ko K, Poon T, Ng E, Lai P, et al. A proteomic approach in investigating the hepatoprotective mechanism of Schisandrin B: role of raf kinase inhibitor protein. J Proteome Res. 2011;10:299-304 pubmed publisher
    ..Among the 13 proteins, Raf kinase inhibitor protein (RKIP) was postulated to be the key regulator involved in the development of hepatotoxin-induced cellular damage...
  9. Gu M, Liu Z, Lai R, Liu S, Lin W, Ouyang C, et al. RKIP and TBK1 form a positive feedback loop to promote type I interferon production in innate immunity. EMBO J. 2016;35:2553-2565 pubmed
    ..Here we report that Raf kinase inhibitory protein (RKIP) is essential for TBK1 activation and type I interferon production triggered by viral infection...
  10. Wei J, Jiang H, Gao H, Wang G. Raf-1 Kinase Inhibitory Protein (RKIP) Promotes Retinal Ganglion Cell Survival and Axonal Regeneration Following Optic Nerve Crush. J Mol Neurosci. 2015;57:243-8 pubmed publisher
    Raf-1 kinase inhibitory protein (RKIP), a member of the phosphatidylethanolamine-binding protein (PEBP) family, plays an important role in neuronal apoptosis and cognitive deficits associated with neurodegenerative diseases...
  11. Kim S, Ives K, Wang X, Davey R, Chao C, Hellmich M. Raf-1 kinase inhibitory protein (RKIP) mediates ethanol-induced sensitization of secretagogue signaling in pancreatic acinar cells. J Biol Chem. 2012;287:33377-88 pubmed
  12. Moffit J, Boekelheide K, Sedivy J, Klysik J. Mice lacking Raf kinase inhibitor protein-1 (RKIP-1) have altered sperm capacitation and reduced reproduction rates with a normal response to testicular injury. J Androl. 2007;28:883-90 pubmed
    Raf kinase inhibitor protein-1 (RKIP-1) belongs to the phosphatidyl ethanolamine-binding family of proteins (PEBP), which are highly conserved throughout evolution and widely expressed in tissues of mammalian organisms...
  13. Matsukawa N, Tooyama I, Kimura H, Yamamoto T, Tsugu Y, Oomura Y, et al. Increased expression of hippocampal cholinergic neurostimulating peptide-related components and their messenger RNAs in the hippocampus of aged senescence-accelerated mice. Neuroscience. 1999;88:79-92 pubmed
    ..These disturbances of the septohippocampal cholinergic system might be the biochemical mechanism underlying the characteristic deterioration of senescence-accelerated-prone mice/8. ..
  14. Escara Wilke J, Keller J, Ignatoski K, Dai J, Shelley G, Mizokami A, et al. Raf kinase inhibitor protein (RKIP) deficiency decreases latency of tumorigenesis and increases metastasis in a murine genetic model of prostate cancer. Prostate. 2015;75:292-302 pubmed publisher
    Raf kinase inhibitor protein (RKIP) has been shown to act as a metastasis suppressor gene in multiple models of cancer. Loss of RKIP expression promotes invasion and metastasis in cell transplantation animal models...
  15. Xu W, Fang P, Zhu Z, Dai J, Nie D, Chen Z, et al. Cigarette smoking exposure alters pebp1 DNA methylation and protein profile involved in MAPK signaling pathway in mice testis. Biol Reprod. 2013;89:142 pubmed publisher
    ..among the 31 proteins, a spermatogenesis-associated protein, phosphatidylethanolamine-binding protein 1 (PEBP1), was especially expressed in serial sections of spermatids of spermiogenesis and interacted with ERKs...
  16. Pardo F, Altirriba J, Pradas Juni M, Garcia A, Ahlgren U, Barbera A, et al. The role of Raf-1 kinase inhibitor protein in the regulation of pancreatic beta cell proliferation in mice. Diabetologia. 2012;55:3331-40 pubmed publisher
    ..Rkip1 (also known as Pebp1) knockout (Rkip1 (-/-)) mice were characterised in terms of pancreatic and glucose homeostasis, ..
  17. Subramanian B, Anand M, Khan N, Khanna H. Loss of Raf-1 kinase inhibitory protein delays early-onset severe retinal ciliopathy in Cep290rd16 mouse. Invest Ophthalmol Vis Sci. 2014;55:5788-94 pubmed publisher
    ..16) mouse model of CEP290-LCA exhibits accumulation of CEP290-interacting protein Raf-1 kinase inhibitory protein (RKIP) prior to onset of retinal degeneration (by postnatal day P14)...
  18. Shemon A, Eves E, Clark M, Heil G, Granovsky A, Zeng L, et al. Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration. PLoS ONE. 2009;4:e6028 pubmed publisher
    Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding Protein family, negatively regulates growth factor signaling by the Raf/MAP kinase pathway...
  19. Uematsu N, Matsukawa N, Kanamori T, Arai Y, Sagisaka T, Toyoda T, et al. Overexpression of hippocampal cholinergic neurostimulating peptide in heterozygous transgenic mice increases the amount of ChAT in the medial septal nucleus. Brain Res. 2009;1305:150-7 pubmed publisher
    ..a peptide from the hippocampus of the young adult rat, named hippocampal cholinergic neurostimulating peptide (HCNP) that induces acetylcholine synthesis in vitro in the septal nucleus...
  20. Frankenberger C, Rabe D, Bainer R, Sankarasharma D, Chada K, Krausz T, et al. Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages. Cancer Res. 2015;75:4063-73 pubmed publisher
    ..TNBC is characterized by reduced expression of metastasis suppressors such as Raf kinase inhibitory protein (RKIP), which inhibits tumor invasiveness...
  21. Gibbons R, Adeoya Osiguwa S, Fraser L. A mouse sperm decapacitation factor receptor is phosphatidylethanolamine-binding protein 1. Reproduction. 2005;130:497-508 pubmed
    ..sequencing of DF-R has identified this approximately 23 kDa protein as phosphatidylethanolamine-binding protein 1 (PEBP 1)...
  22. Baritaki S, Huerta Yepez S, Sahakyan A, Karagiannides I, Bakirtzi K, Jazirehi A, et al. Mechanisms of nitric oxide-mediated inhibition of EMT in cancer: inhibition of the metastasis-inducer Snail and induction of the metastasis-suppressor RKIP. Cell Cycle. 2010;9:4931-40 pubmed
    ..transcription factor, Snail and EMT can be inhibited by the metastasis-suppressor Raf-1 kinase inhibitor protein (RKIP) and E-cadherin. Snail is transcriptionally regulated by NF-?B and in turn, Snail represses RKIP transcription...
  23. Yamamoto Y, Lee D, Kim Y, Lee B, Seo C, Kawasaki H, et al. Raf kinase inhibitory protein is required for cerebellar long-term synaptic depression by mediating PKC-dependent MAPK activation. J Neurosci. 2012;32:14254-64 pubmed publisher
    ..We here test the hypothesis that this loop is completed by the PKC substrate, Raf kinase inhibitory protein (RKIP)...
  24. Antoun G, Bouchard Cannon P, Cannon P, Cheng H. Regulation of MAPK/ERK signaling and photic entrainment of the suprachiasmatic nucleus circadian clock by Raf kinase inhibitor protein. J Neurosci. 2012;32:4867-77 pubmed publisher
    ..Here we show that Raf kinase inhibitor protein (RKIP) controls the kinetics of light-induced MAPK/ERK activity in the SCN and photic entrainment of behavioral rhythms...
  25. Hahm J, AHMED M, Kim D. RKIP phosphorylation-dependent ERK1 activation stimulates adipogenic lipid accumulation in 3T3-L1 preadipocytes overexpressing LC3. Biochem Biophys Res Commun. 2016;478:12-17 pubmed publisher
    ..Also, phosphorylation of Raf kinase inhibitory protein (RKIP) at serine 153, consequently stimulating extracellular-signal regulated kinase (ERK)1 activity, was significantly ..
  26. Al Mulla F, Bitar M, Al Maghrebi M, Behbehani A, Al Ali W, Rath O, et al. Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3?. Cancer Res. 2011;71:1334-43 pubmed publisher
    Raf kinase inhibitory protein (RKIP) is a physiologic inhibitor of c-RAF kinase and nuclear factor ?B signaling that represses tumor invasion and metastasis...
  27. Klysik J, Theroux S, Sedivy J, Moffit J, Boekelheide K. Signaling crossroads: the function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction. Cell Signal. 2008;20:1-9 pubmed
    The Raf kinase inhibitory protein 1 (RKIP-1) and its orthologs are conserved throughout evolution and widely expressed in eukaryotic organisms...
  28. Lim H, Moon I, Han K. Transcriptional cofactors exhibit differential preference toward peroxisome proliferator-activated receptors alpha and delta in uterine cells. Endocrinology. 2004;145:2886-95 pubmed
  29. Hengst U, Albrecht H, Hess D, Monard D. The phosphatidylethanolamine-binding protein is the prototype of a novel family of serine protease inhibitors. J Biol Chem. 2001;276:535-40 pubmed
    ..PEBP immunoreactivity is found on the surface of Rat-1 fibroblast cells and although its sequence contains no secretion signal, PEBP-H(6) can be purified from the conditioned medium upon recombinant expression. ..
  30. Huang Q, Bai F, Nie J, Lu S, Lu C, Zhu X, et al. Didymin ameliorates hepatic injury through inhibition of MAPK and NF-?B pathways by up-regulating RKIP expression. Int Immunopharmacol. 2017;42:130-138 pubmed publisher
    ..Interestingly, OVD notably enhanced Raf kinase inhibitor protein (RKIP) expression, and the effects of OVD on histological changes, oxidative stress and inflammation was largely ..