Pdpn

Summary

Gene Symbol: Pdpn
Description: podoplanin
Alias: E11, Gp38, OTS-8, RANDAM-2, T1-alpha, T1a, T1alpha, podoplanin, PA2.26 antigen, aggrus, glycoprotein 38, transmembrane glycoprotein E11
Species: mouse
Products:     Pdpn

Top Publications

  1. Durchdewald M, Guinea Viniegra J, Haag D, Riehl A, Lichter P, Hahn M, et al. Podoplanin is a novel fos target gene in skin carcinogenesis. Cancer Res. 2008;68:6877-83 pubmed publisher
    ..One of the most differentially expressed genes encodes the small mucin-like glycoprotein Podoplanin (Pdpn), whose expression correlates with malignant progression in mouse tumor model systems and human cancer...
  2. Ramirez M, Millien G, Hinds A, Cao Y, Seldin D, Williams M. T1alpha, a lung type I cell differentiation gene, is required for normal lung cell proliferation and alveolus formation at birth. Dev Biol. 2003;256:61-72 pubmed
    b>T1alpha, a differentiation gene of lung alveolar epithelial type I cells, is developmentally regulated and encodes an apical membrane protein of unknown function...
  3. Wilkinson G, Schittny J, Reinhardt D, Klein R. Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity. Dev Dyn. 2008;237:2220-34 pubmed publisher
    ..Postnatal day 1 mutant lungs show extracellular matrix alterations without differences in proportions of major distal cell populations. We conclude that lung alveolar formation relies on endothelial ephrinB2 function. ..
  4. Francois M, Caprini A, Hosking B, Orsenigo F, Wilhelm D, Browne C, et al. Sox18 induces development of the lymphatic vasculature in mice. Nature. 2008;456:643-7 pubmed publisher
    ..Our findings demonstrate a critical role for Sox18 in developmental lymphangiogenesis, and suggest new avenues to investigate for therapeutic management of human lymphangiopathies. ..
  5. O Brien K, Alberich Jorda M, Yadav N, Kocher O, Diruscio A, Ebralidze A, et al. CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development. 2010;137:2147-56 pubmed publisher
    ..These results demonstrate for the first time that CARM1 inhibits pulmonary cell proliferation and is required for proper differentiation of alveolar cells. ..
  6. Makinen T, Adams R, Bailey J, Lu Q, Ziemiecki A, Alitalo K, et al. PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev. 2005;19:397-410 pubmed
    ..Our studies define ephrinB2 as an essential regulator of lymphatic development and indicate that interactions with PDZ domain effectors are required to mediate its functions. ..
  7. Rishi A, Joyce Brady M, Fisher J, Dobbs L, Floros J, vanderSpek J, et al. Cloning, characterization, and development expression of a rat lung alveolar type I cell gene in embryonic endodermal and neural derivatives. Dev Biol. 1995;167:294-306 pubmed
    We report here the identification and characterization of a novel gene, T1 alpha, expressed in high abundance in adult rat lung, fetal lung, and early fetal brain...
  8. Arora R, Metzger R, Papaioannou V. Multiple roles and interactions of Tbx4 and Tbx5 in development of the respiratory system. PLoS Genet. 2012;8:e1002866 pubmed publisher
    ..Finally, we show that Tbx4 and Tbx5 interact with Fgf10 during the process of lung growth and branching but not during tracheal/bronchial cartilage development. ..
  9. Martín Villar E, Scholl F, Gamallo C, Yurrita M, Muñoz Guerra M, Cruces J, et al. Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas. Int J Cancer. 2005;113:899-910 pubmed
    We report the full cDNA sequence encoding the human homologue of murine PA2.26 (T1alpha-2, podoplanin), a small mucin-type transmembrane glycoprotein originally identified as a cell-surface antigen induced in keratinocytes during mouse ..

More Information

Publications62

  1. Uhrin P, Zaujec J, Breuss J, Olcaydu D, Chrenek P, Stockinger H, et al. Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. Blood. 2010;115:3997-4005 pubmed publisher
    ..establishment and maintenance of distinct blood and lymphatic systems, primarily by mediating proper function of podoplanin. Here, we show that this separation process critically involves platelet activation by podoplanin...
  2. Shu W, Lu M, Zhang Y, Tucker P, Zhou D, Morrisey E. Foxp2 and Foxp1 cooperatively regulate lung and esophagus development. Development. 2007;134:1991-2000 pubmed
    ..Using in vitro and in vivo assays, we show that T1alpha, a lung alveolar epithelial type 1 cell-restricted gene crucial for lung development and function, is a direct ..
  3. Wicki A, Christofori G. The potential role of podoplanin in tumour invasion. Br J Cancer. 2007;96:1-5 pubmed
    b>Podoplanin is a small mucin-like transmembrane protein, widely expressed in various specialised cell types throughout the body. Here, we revisit the mechanism of podoplanin-mediated tumour invasion...
  4. Dellinger M, Hunter R, Bernas M, Gale N, Yancopoulos G, Erickson R, et al. Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice. Dev Biol. 2008;319:309-20 pubmed publisher
    ..Taken together, this work pinpoints a specific lymphatic defect of Ang2(-/-) mice and further defines the sequential steps in lymphatic vessel remodeling. ..
  5. Hirashima M, Sano K, Morisada T, Murakami K, Rossant J, Suda T. Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos. Dev Biol. 2008;316:149-59 pubmed publisher
    ..Here we report novel lymphatic vascular phenotypes in Aspp1(-/-) mice; subcutaneous edema detected only during embryogenesis, delayed lymphatic vessel formation, and mispatterned collecting lymphatic vessels. ..
  6. Jin N, Cho S, Raso M, Wistuba I, Smith Y, Yang Y, et al. Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis. Development. 2009;136:3347-56 pubmed publisher
    ..These results demonstrate that Mig-6 is required for prenatal and perinatal lung development, in part through the regulation of EGF signaling, as well as for maintaining proper pulmonary vascularization. ..
  7. Volckaert T, Campbell A, Dill E, Li C, Minoo P, De Langhe S. Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors. Development. 2013;140:3731-42 pubmed publisher
    ..Interestingly, our data presented here show that once epithelial cells are committed to the Sox2-positive airway epithelial cell fate, Fgf10 prevents ciliated cell differentiation and promotes basal cell differentiation. ..
  8. Schacht V, Ramirez M, Hong Y, Hirakawa S, Feng D, Harvey N, et al. T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J. 2003;22:3546-56 pubmed
    Within the vascular system, the mucin-type transmembrane glycoprotein T1alpha/podoplanin is predominantly expressed by lymphatic endothelium, and recent studies have shown that it is regulated by the lymphatic-specific homeobox gene Prox1...
  9. Rawlins E, Clark C, Xue Y, Hogan B. The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells. Development. 2009;136:3741-5 pubmed publisher
    ..Taken together, this evidence supports a model in which the distal tip of the developing lung contains a multipotent epithelial population, the fate of which changes during development. ..
  10. Acton S, Astarita J, Malhotra D, Lukacs Kornek V, Franz B, Hess P, et al. Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity. 2012;37:276-89 pubmed publisher
    ..from parenchymal tissues to lymphoid organs by migrating along stromal scaffolds that display the glycoprotein podoplanin (PDPN)...
  11. Yang Y, Garcia Verdugo J, Soriano Navarro M, Srinivasan R, Scallan J, Singh M, et al. Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos. Blood. 2012;120:2340-8 pubmed publisher
    ..progenitors bud from the CV and ISVs into the surrounding mesenchyme, they begin expressing the lymphatic marker podoplanin, migrate away from the CV, and form the lymph sacs...
  12. Fu J, Gerhardt H, McDaniel J, Xia B, Liu X, Ivanciu L, et al. Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice. J Clin Invest. 2008;118:3725-37 pubmed publisher
    ..The level of O-glycoprotein podoplanin was significantly reduced in EHC T-syn(-/-) lymphatics, and podoplanin-deficient mice developed blood-filled ..
  13. Gordon E, Gale N, Harvey N. Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels. Dev Dyn. 2008;237:1901-9 pubmed publisher
    ..Our data are also the first demonstration, to our knowledge, that the mouse yolk sac is devoid of lymphatic vessels. ..
  14. Suzuki Inoue K, Kato Y, Inoue O, Kaneko M, Mishima K, Yatomi Y, et al. Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells. J Biol Chem. 2007;282:25993-6001 pubmed
    b>Podoplanin (aggrus), a transmembrane sialoglycoprotein, is involved in tumor cell-induced platelet aggregation, tumor metastasis, and lymphatic vessel formation...
  15. Larrieu Lahargue F, Welm A, Thomas K, Li D. Netrin-4 induces lymphangiogenesis in vivo. Blood. 2010;115:5418-26 pubmed publisher
    ..Together, these data provide evidence that Netrin-4 is a lymphangiogenic factor contributing to tumor dissemination and represents a potential target to inhibit metastasis formation. ..
  16. Petrova T, Karpanen T, Norrmen C, Mellor R, Tamakoshi T, Finegold D, et al. Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis. Nat Med. 2004;10:974-81 pubmed
    ..Our results indicate that an abnormal interaction between the lymphatic endothelial cells and pericytes, as well as valve defects, underlie the pathogenesis of LD. ..
  17. Yamamoto H, Yun E, Gerber H, Ferrara N, Whitsett J, Vu T. Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev Biol. 2007;308:44-53 pubmed
  18. Tiozzo C, De Langhe S, Yu M, Londhe V, Carraro G, Li M, et al. Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury. Am J Respir Crit Care Med. 2009;180:701-12 pubmed publisher
    ..Pten has a pivotal role in lung stem cell homeostasis, cell differentiation, and consequently resistance to lung injury. ..
  19. Klinger S, Turgeon B, Lévesque K, Wood G, Aagaard Tillery K, Meloche S. Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality. Proc Natl Acad Sci U S A. 2009;106:16710-5 pubmed publisher
    ..Our findings reveal a critical role for Erk3 in the establishment of fetal growth potential and pulmonary function in the mouse. ..
  20. Zou Z, Enis D, Bui H, Khandros E, Kumar V, Jakus Z, et al. The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood. 2013;121:3228-36 pubmed publisher
    ..Our findings reveal that CCBE1 plays an essential role in regulating the fetal liver erythropoietic environment and suggest that EBI formation is regulated differently in the fetal liver and bone marrow...
  21. Francois M, Short K, Secker G, Combes A, Schwarz Q, Davidson T, et al. Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice. Dev Biol. 2012;364:89-98 pubmed publisher
    ..Our data support a new model for lymphatic vascular patterning and morphogenesis, as a basis for identifying the molecular cues governing these processes...
  22. Boucherat O, Montaron S, Bérubé Simard F, Aubin J, Philippidou P, Wellik D, et al. Partial functional redundancy between Hoxa5 and Hoxb5 paralog genes during lung morphogenesis. Am J Physiol Lung Cell Mol Physiol. 2013;304:L817-30 pubmed publisher
    ..Altogether, our observations establish that the Hoxa5 and Hoxb5 paralog genes shared some functions during lung morphogenesis, Hoxa5 playing a predominant role. ..
  23. Londhe V, Nguyen H, Jeng J, Li X, Li C, Tiozzo C, et al. NF-kB induces lung maturation during mouse lung morphogenesis. Dev Dyn. 2008;237:328-38 pubmed
    ..These findings are consistent with a model whereby NF-kB may induce maturation of lung development through decreased apoptosis of epithelial cells. ..
  24. Kunita A, Kashima T, Ohazama A, Grigoriadis A, Fukayama M. Podoplanin is regulated by AP-1 and promotes platelet aggregation and cell migration in osteosarcoma. Am J Pathol. 2011;179:1041-9 pubmed publisher
    b>Podoplanin is a type-I transmembrane sialomucin-like protein, which is expressed in a wide range of cell types and is involved in platelet aggregation and tumor metastasis...
  25. Li A, Hardy R, Stoner S, Tuckermann J, Seibel M, Zhou H. Deletion of mesenchymal glucocorticoid receptor attenuates embryonic lung development and abdominal wall closure. PLoS ONE. 2013;8:e63578 pubmed publisher
    ..In addition, altered glucocorticoid signaling in the mesenchyme attenuates normal lung epithelial differentiation...
  26. Geng Y, Dong Y, Yu M, Zhang L, Yan X, Sun J, et al. Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proc Natl Acad Sci U S A. 2011;108:7058-63 pubmed publisher
    ..Therefore, we provide in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling...
  27. Desai T, Brownfield D, Krasnow M. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature. 2014;507:190-4 pubmed publisher
    ..We propose that local signals regulate AT2 stem-cell activity: a signal transduced by EGFR-KRAS controls self-renewal and is hijacked during oncogenesis, whereas another signal controls reprogramming to AT1 fate. ..
  28. Hou T, Bystrom J, Sherlock J, Qureshi O, Parnell S, Anderson G, et al. A distinct subset of podoplanin (gp38) expressing F4/80+ macrophages mediate phagocytosis and are induced following zymosan peritonitis. FEBS Lett. 2010;584:3955-61 pubmed publisher
    ..However, they are strikingly heterogeneous. During studies looking at podoplanin (gp38) expression on stromal cells in the murine spleen and peritoneal cavity we unexpectedly discovered that ..
  29. Cueni L, Hegyi I, Shin J, Albinger Hegyi A, Gruber S, Kunstfeld R, et al. Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin. Am J Pathol. 2010;177:1004-16 pubmed publisher
    The membrane glycoprotein podoplanin is expressed by several types of human cancers and might be associated with their malignant progression. Its exact biological function and molecular targets are unclear, however...
  30. Bazigou E, Xie S, Chen C, Weston A, Miura N, Sorokin L, et al. Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell. 2009;17:175-86 pubmed publisher
    ..Our findings reveal an important role for integrin-alpha9 signaling during lymphatic valve morphogenesis and implicate it as a candidate gene for primary lymphedema caused by valve defects...
  31. Bertozzi C, Schmaier A, Mericko P, Hess P, Zou Z, Chen M, et al. Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood. 2010;116:661-70 pubmed publisher
    ..b>PODOPLANIN (PDPN), a transmembrane protein expressed on the surface of lymphatic endothelial cells, is required in ..
  32. Shen Y, Chen C, Ichikawa H, Goldberg G. SRC induces podoplanin expression to promote cell migration. J Biol Chem. 2010;285:9649-56 pubmed publisher
    ..We report here that Src utilizes Cas to induce podoplanin (Pdpn) expression to promote tumor cell migration...
  33. Wicki A, Lehembre F, Wick N, Hantusch B, Kerjaschki D, Christofori G. Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell. 2006;9:261-72 pubmed
    The expression of podoplanin, a small mucin-like protein, is upregulated in the invasive front of a number of human carcinomas...
  34. Herzog B, Fu J, Wilson S, Hess P, Sen A, McDaniel J, et al. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature. 2013;502:105-9 pubmed publisher
    ..Here we report a role for the transmembrane O-glycoprotein podoplanin (PDPN, also known as gp38 and T1?) in maintaining HEV barrier function...
  35. Tsao P, Vasconcelos M, Izvolsky K, Qian J, LU J, Cardoso W. Notch signaling controls the balance of ciliated and secretory cell fates in developing airways. Development. 2009;136:2297-307 pubmed publisher
    ..It might also be relevant to mediate the metaplastic changes in the respiratory epithelium that occur in pathological conditions, such as asthma and chronic obstructive pulmonary disease. ..
  36. Hägerling R, Pollmann C, Andreas M, Schmidt C, Nurmi H, Adams R, et al. A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy. EMBO J. 2013;32:629-44 pubmed publisher
    ..Altogether, we present a significantly more detailed view and novel model of early lymphatic development. ..
  37. Finney B, Schweighoffer E, Navarro Nuñez L, Bénézech C, Barone F, Hughes C, et al. CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. Blood. 2012;119:1747-56 pubmed publisher
  38. Farr A, Berry M, Kim A, Nelson A, Welch M, Aruffo A. Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues. J Exp Med. 1992;176:1477-82 pubmed
    ..This molecule, gp38, was identified with a monoclonal antibody (mAb) (clone 8.1...
  39. Nose K, Saito H, Kuroki T. Isolation of a gene sequence induced later by tumor-promoting 12-O-tetradecanoylphorbol-13-acetate in mouse osteoblastic cells (MC3T3-E1) and expressed constitutively in ras-transformed cells. Cell Growth Differ. 1990;1:511-8 pubmed
    ..OTS-8 mRNA was induced by epidermal growth factor but not by serum. The steady-state levels of OTS-5 and OTS-8 mRNAs were significantly elevated in v-ras-transformed MC3T3 cells. ..
  40. Osada M, Inoue O, Ding G, Shirai T, Ichise H, Hirayama K, et al. Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube formation of lymphatic endothelial cells. J Biol Chem. 2012;287:22241-52 pubmed publisher
    ..An endogenous ligand for CLEC-2, podoplanin, is expressed in lymphatic endothelial cells (LECs)...
  41. Srinivasan R, Oliver G. Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves. Genes Dev. 2011;25:2187-97 pubmed publisher
    ..This is the first report describing the molecular mechanism controlling lymphovenous communication. ..
  42. Martín Villar E, Fernández Muñoz B, Parsons M, Yurrita M, Megias D, Perez Gomez E, et al. Podoplanin associates with CD44 to promote directional cell migration. Mol Biol Cell. 2010;21:4387-99 pubmed publisher
    b>Podoplanin is a transmembrane glycoprotein up-regulated in different human tumors, especially those derived from squamous stratified epithelia (SCCs)...
  43. Kulkarni R, Greenberg J, Akeson A. NFATc1 regulates lymphatic endothelial development. Mech Dev. 2009;126:350-65 pubmed publisher
    ..NFATc1 was colocalized with lymphatic markers Prox-1, VEGFR-3 and podoplanin on cardinal vein as lymphatic endothelial cells (LEC) are specified and as they segregate into lymph sacs and ..
  44. Kotani M, Tajima Y, Osanai T, Irie A, Iwatsuki K, Kanai Azuma M, et al. Complementary DNA cloning and characterization of RANDAM-2, a type I membrane molecule specifically expressed on glutamatergic neuronal cells in the mouse cerebrum. J Neurosci Res. 2003;73:603-13 pubmed
    ..These results indicate that RANDAM-2 is one of the type I membrane surface antigens constitutively expressed on undifferentiated neuronal cells and the glutamatergic neuronal cells during mouse neurogenesis. ..
  45. Scholl F, Gamallo C, Vilaro S, Quintanilla M. Identification of PA2.26 antigen as a novel cell-surface mucin-type glycoprotein that induces plasma membrane extensions and increased motility in keratinocytes. J Cell Sci. 1999;112 ( Pt 24):4601-13 pubmed
    ..These findings suggest an involvement of PA2.26 in cell migration. ..
  46. Mahtab E, Vicente Steijn R, Hahurij N, Jongbloed M, Wisse L, DeRuiter M, et al. Podoplanin deficient mice show a RhoA-related hypoplasia of the sinus venosus myocardium including the sinoatrial node. Dev Dyn. 2009;238:183-93 pubmed publisher
    We investigated the role of podoplanin in development of the sinus venosus myocardium comprising the sinoatrial node, dorsal atrial wall, and primary atrial septum as well as the myocardium of the cardinal and pulmonary veins...
  47. Morisada T, Oike Y, Yamada Y, Urano T, Akao M, Kubota Y, et al. Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. Blood. 2005;105:4649-56 pubmed
    ..On the basis of these observations, we propose that Ang signaling regulates lymphatic vessel formation through Tie2. ..
  48. Turcatel G, Rubin N, Menke D, Martin G, Shi W, Warburton D. Lung mesenchymal expression of Sox9 plays a critical role in tracheal development. BMC Biol. 2013;11:117 pubmed publisher
    ..Sox9 is expressed in both distal lung epithelium and proximal lung mesenchyme. Here, we investigated the effect of lung mesenchyme-specific inducible deletion of Sox9 during murine lung development...
  49. Flaht Zabost A, Gula G, Ciszek B, Czarnowska E, Jankowska Steifer E, Madej M, et al. Cardiac mouse lymphatics: developmental and anatomical update. Anat Rec (Hoboken). 2014;297:1115-30 pubmed publisher
    ..of cardiac lymphatic endothelial cells can be characterized as: Prox-1(+), Lyve-1(+), VEGFR3(+), Podoplanin(+), VEGFR2(+), CD144(+), Tie2(+), CD31(+), vWF(-), CD34(-), CD133(-)...
  50. Acton S, Farrugia A, Astarita J, Mourão Sá D, Jenkins R, Nye E, et al. Dendritic cells control fibroblastic reticular network tension and lymph node expansion. Nature. 2014;514:498-502 pubmed publisher
    ..Here we report that the physical elasticity of lymph nodes is maintained in part by podoplanin (PDPN) signalling in stromal fibroblastic reticular cells (FRCs) and its modulation by CLEC-2 expressed on ..
  51. Klotz L, Norman S, Vieira J, Masters M, Rohling M, Dubé K, et al. Cardiac lymphatics are heterogeneous in origin and respond to injury. Nature. 2015;522:62-7 pubmed
    ..These data prompt the re-evaluation of a century-long debate on the origin of lymphatic vessels and suggest that lymphangiogenesis may represent a therapeutic target to promote cardiac repair following injury. ..
  52. Fujimoto J, Nunomura Nakamura S, Liu Y, Lang W, McDowell T, Jakubek Y, et al. Development of Kras mutant lung adenocarcinoma in mice with knockout of the airway lineage-specific gene Gprc5a. Int J Cancer. 2017;141:1589-1599 pubmed publisher
  53. Kaneko M, Kato Y, Kunita A, Fujita N, Tsuruo T, Osawa M. Functional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha/Podoplanin) molecules expressed in Chinese hamster ovary cells. J Biol Chem. 2004;279:38838-43 pubmed
    Aggrus, also called T1alpha and podoplanin, is a novel platelet aggregation-inducing factor that is expressed in various carcinoma cells...