Gene Symbol: Pdp1
Description: pyruvate dehyrogenase phosphatase catalytic subunit 1
Alias: Gm1024, Ppm2c, [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial, PDP 1, PDPC 1, protein phosphatase 2C, magnesium dependent, catalytic subunit, pyruvate dehydrogenase phosphatase catalytic subunit 1, pyruvate dehydrogenase phosphatase isoenzyme 2
Species: mouse
Products:     Pdp1

Top Publications

  1. Lu G, Sun H, She P, Youn J, Warburton S, Ping P, et al. Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. J Clin Invest. 2009;119:1678-87 pubmed publisher
    ..These results indicate that PP2Cm is the endogenous BCKD phosphatase required for nutrient-mediated regulation of BCKD activity and suggest that defects in PP2Cm may be responsible for a subset of human MSUD. ..
  2. Fan J, Shan C, Kang H, Elf S, Xie J, Tucker M, et al. Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex. Mol Cell. 2014;53:534-48 pubmed publisher
    ..Here, we report that lysine acetylation of PDHA1 and PDP1 is common in epidermal growth factor (EGF)-stimulated cells and diverse human cancer cells...
  3. Heo H, Kim H, Youm J, Cho S, Song I, Lee S, et al. Mitochondrial pyruvate dehydrogenase phosphatase 1 regulates the early differentiation of cardiomyocytes from mouse embryonic stem cells. Exp Mol Med. 2016;48:e254 pubmed publisher
    ..Among the differentially expressed genes, Pdp1 expression was significantly decreased (27-fold) on D8 compared to D0, which was accompanied by suppressed ..