Pdlim2

Summary

Gene Symbol: Pdlim2
Description: PDZ and LIM domain 2
Alias: 4732462F18Rik, Slim, PDZ and LIM domain protein 2, PDZ-LIM protein mystique, STAT-interacting LIM protein, mystique
Species: mouse

Top Publications

  1. doi PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT3
    Takashi Tanaka
    Laboratory for Inflammatory Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    Sci Signal 4:ra85. 2011
  2. doi Pdlim2 is a novel actin-regulating protein of podocyte foot processes
    Laleh Sistani
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Kidney Int 80:1045-54. 2011
  3. pmc Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages
    Hongtao Guo
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 285:37787-96. 2010
  4. pmc DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target
    Zhaoxia Qu
    University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Res 70:1766-72. 2010
  5. doi PKR-mediated degradation of STAT1 regulates osteoblast differentiation
    Kaya Yoshida
    Department of Fundamental Oral Health Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto, Tokushima 770 8504, Japan
    Exp Cell Res 315:2105-14. 2009
  6. doi Sequestration of PDLIM2 in the cytoplasm of monocytic/macrophage cells is associated with adhesion and increased nuclear activity of NF-kappaB
    Nollaig C Healy
    Department of Biochemistry, Biosciences Institute, University College, Cork, Ireland
    J Leukoc Biol 85:481-90. 2009
  7. pmc Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells
    Chengjiang Gao
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Neoplasia 9:699-706. 2007
  8. ncbi PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit
    Takashi Tanaka
    Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    Nat Immunol 8:584-91. 2007
  9. ncbi Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1
    Sarah Ivins
    Molecular Medicine Unit, Institute of Child Health, London WC1N 1EH, UK
    Dev Biol 285:554-69. 2005
  10. ncbi SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling
    Takashi Tanaka
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Immunity 22:729-36. 2005

Scientific Experts

  • Kaya Yoshida
  • Takashi Tanaka
  • Michael J Grusby
  • Hongtao Guo
  • Nollaig C Healy
  • Laleh Sistani
  • Zhaoxia Qu
  • Tsuneyasu Kaisho
  • Zhiyong Mi
  • Paul C Kuo
  • Chengjiang Gao
  • Rosemary O'Connor
  • Gary Loughran
  • Sarah Ivins
  • Yu Yamamoto
  • Annika Wernerson
  • Jaakko Patrakka
  • Fredrik DunĂ©r
  • Yuichi Sekine
  • Tadashi Matsuda
  • Ryuta Muromoto
  • Osamu Ikeda
  • Mathias Uhlen
  • Karl Tryggvason
  • Kjell Hultenby
  • Christer Betsholtz
  • Sunil Udumala
  • Pengrong Yan
  • Syamal D Bhattacharya
  • Thomas E Smithgall
  • Gutian Xiao
  • Jing Fu
  • Jing Jiang
  • Dawn E Bowles
  • Paris Ataliotis
  • Merei Huigsloot
  • Chela James
  • Peter J Scambler
  • Michelle A Soriano
  • Catherine Roberts
  • Patrick A Kiely
  • Nancy L Kedersha
  • Antonio Baldini
  • Elizabeth Lindsay
  • Kelly Lammerts van Beuren

Detail Information

Publications11

  1. doi PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT3
    Takashi Tanaka
    Laboratory for Inflammatory Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    Sci Signal 4:ra85. 2011
    ..Here, we report that the PDZ-LIM domain protein PDLIM2 inhibited TH17 cell development and granulomatous responses by acting as a nuclear ubiquitin E3 ligase that ..
  2. doi Pdlim2 is a novel actin-regulating protein of podocyte foot processes
    Laleh Sistani
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Kidney Int 80:1045-54. 2011
    ..In an effort to discover novel regulatory proteins of the podocyte foot process, we identified and characterized pdlim2, a member of the actin-associated LIM protein subfamily of cytosolic proteins typified by an N-terminal PDZ domain ..
  3. pmc Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages
    Hongtao Guo
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 285:37787-96. 2010
    ..that osteopontin (OPN) increased STAT1 ubiquitination and 26 S proteasome degradation via the ubiquitin E3 ligase, PDLIM2. In this study, we further characterize OPN-dependent activation of PDLIM2 in a model of LPS-stimulated RAW264...
  4. pmc DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target
    Zhaoxia Qu
    University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Res 70:1766-72. 2010
    ..Here, we report that PDLIM2, an essential terminator of NF-kappaB activation, is repressed in various human colorectal cancer cell lines, ..
  5. doi PKR-mediated degradation of STAT1 regulates osteoblast differentiation
    Kaya Yoshida
    Department of Fundamental Oral Health Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto, Tokushima 770 8504, Japan
    Exp Cell Res 315:2105-14. 2009
    ..The expression and degradation of STAT1 protein were regulated by PKR in a SLIM-dependent pathway...
  6. doi Sequestration of PDLIM2 in the cytoplasm of monocytic/macrophage cells is associated with adhesion and increased nuclear activity of NF-kappaB
    Nollaig C Healy
    Department of Biochemistry, Biosciences Institute, University College, Cork, Ireland
    J Leukoc Biol 85:481-90. 2009
    PDLIM2 (Mystique/SLIM) is a postsynaptic density-95/discs large/zonula occludens-1-Lin-11, Isl-1, Mec-3 (PDZ-LIM) domain protein expressed in the nucleus of T lymphocytes, where it promotes degradation of the p65 subunit of NF-kappaB...
  7. pmc Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells
    Chengjiang Gao
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Neoplasia 9:699-706. 2007
    ..However, the molecular mechanisms that define the role of OPN in tumor progression and metastasis are incompletely understood...
  8. ncbi PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit
    Takashi Tanaka
    Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    Nat Immunol 8:584-91. 2007
    ..How NF-kappaB activation is terminated, however, is not fully understood. Here we report that PDLIM2 negatively regulated NF-kappaB activity, acting as a nuclear ubiquitin E3 ligase targeting the p65 subunit of NF-..
  9. ncbi Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1
    Sarah Ivins
    Molecular Medicine Unit, Institute of Child Health, London WC1N 1EH, UK
    Dev Biol 285:554-69. 2005
    ..These experiments highlight which genes and pathways potentially affected by lack of Tbx1, and whose role may be explored further by testing for epistasis using mouse mutants...
  10. ncbi SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling
    Takashi Tanaka
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Immunity 22:729-36. 2005
    ..We show that SLIM is an ubiquitin E3 ligase that acts on STAT proteins to cause their proteosome-mediated degradation and enhance ..
  11. pmc Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses Anchorage-independent growth
    Gary Loughran
    Cell Biology Laboratory, Department of Biochemistry, Biosciences Institute, National University of Ireland, Cork, Ireland
    Mol Biol Cell 16:1811-22. 2005
    ..null cell fibroblast cell line (R- cells) with cells overexpressing the IGF-IR (R+ cells), we identified the Mystique gene expressed as alternatively spliced variants. The human homologue of Mystique is located on chromosome 8p21...