Pdcd4

Summary

Gene Symbol: Pdcd4
Description: programmed cell death 4
Alias: D19Ucla1, Ma3, Tis, programmed cell death protein 4, protein MA-3, topoisomerase-inhibitor suppressed protein
Species: mouse
Products:     Pdcd4

Top Publications

  1. Yang H, Jansen A, Komar A, Zheng X, Merrick W, Costes S, et al. The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Mol Cell Biol. 2003;23:26-37 pubmed
    b>Pdcd4 is a novel transformation suppressor that inhibits tumor promoter-induced neoplastic transformation and the activation of AP-1-dependent transcription required for transformation...
  2. Schmid T, Jansen A, Baker A, Hegamyer G, Hagan J, Colburn N. Translation inhibitor Pdcd4 is targeted for degradation during tumor promotion. Cancer Res. 2008;68:1254-60 pubmed publisher
    ..The translation inhibitor programmed cell death 4 (Pdcd4) suppresses tumorigenesis and invasion...
  3. Laronde Leblanc N, Santhanam A, Baker A, Wlodawer A, Colburn N. Structural basis for inhibition of translation by the tumor suppressor Pdcd4. Mol Cell Biol. 2007;27:147-56 pubmed
    The tumor suppressor function of Programmed Cell Death 4 (Pdcd4) is achieved through interactions between Pdcd4 and components of the translation initiation complex, namely, the RNA helicase eIF4A and the scaffolding protein eIF4G...
  4. Palamarchuk A, Efanov A, Maximov V, Aqeilan R, Croce C, Pekarsky Y. Akt phosphorylates and regulates Pdcd4 tumor suppressor protein. Cancer Res. 2005;65:11282-6 pubmed
    Programmed cell death 4 (Pdcd4) is a tumor suppressor protein that interacts with eukaryotic initiation factor 4A and inhibits protein synthesis...
  5. Jansen A, Camalier C, Colburn N. Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis. Cancer Res. 2005;65:6034-41 pubmed
    Programmed cell death 4 (Pdcd4) is a novel repressor of in vitro transformation. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A, a component of the translation initiation complex...
  6. Bitomsky N, Böhm M, Klempnauer K. Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun. Oncogene. 2004;23:7484-93 pubmed
    The transformation suppressor gene Pdcd4 (programmed cell death gene 4) inhibits the tumor-promoter mediated transformation of mouse keratinocytes and has recently been implicated as a potential tumor suppressor gene in the development ..
  7. Böhm M, Sawicka K, Siebrasse J, Brehmer Fastnacht A, Peters R, Klempnauer K. The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA. Oncogene. 2003;22:4905-10 pubmed
    The Pdcd4 gene has originally been isolated in a search for genes that are activated in cells undergoing apoptosis...
  8. Ruan Q, Wang T, Kameswaran V, Wei Q, Johnson D, Matschinsky F, et al. The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death. Proc Natl Acad Sci U S A. 2011;108:12030-5 pubmed publisher
    ..we describe a unique regulatory pathway of ? cell death that comprises microRNA-21, its target tumor suppressor PDCD4, and its upstream transcriptional activator nuclear factor-?B (NF-?B)...
  9. Merline R, Moreth K, Beckmann J, Nastase M, Zeng Brouwers J, Tralhão J, et al. Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21. Sci Signal. 2011;4:ra75 pubmed publisher
    ..the soluble form of the extracellular matrix proteoglycan decorin controls inflammation and tumor growth through PDCD4 (programmed cell death 4) and miR-21 (microRNA-21) by two mechanisms...

More Information

Publications53

  1. Kroczynska B, Sharma B, Eklund E, Fish E, Platanias L. Regulatory effects of programmed cell death 4 (PDCD4) protein in interferon (IFN)-stimulated gene expression and generation of type I IFN responses. Mol Cell Biol. 2012;32:2809-22 pubmed publisher
    ..We provide evidence that IFN-? induces phosphorylation of programmed cell death 4 (PDCD4) protein on Ser67...
  2. Shibahara K, Asano M, Ishida Y, Aoki T, Koike T, Honjo T. Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death. Gene. 1995;166:297-301 pubmed
    ..The MA-3 gene was highly conserved during evolution and cross-hybridization bands were found not only in vertebrates but also in Drosophila melanogaster. ..
  3. Waters L, Strong S, Ferlemann E, Oka O, Muskett F, Veverka V, et al. Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor. J Biol Chem. 2011;286:17270-80 pubmed publisher
    ..The tumor suppressor protein Pdcd4 has been shown to inhibit cap-dependent translation by interacting tightly with the RNA helicase eIF4A via its ..
  4. Hilliard A, Hilliard B, Zheng S, Sun H, Miwa T, Song W, et al. Translational regulation of autoimmune inflammation and lymphoma genesis by programmed cell death 4. J Immunol. 2006;177:8095-102 pubmed
    ..Programmed cell death 4 (PDCD4) is a newly described inhibitor of protein translation...
  5. Sheedy F, Palsson McDermott E, Hennessy E, Martin C, O Leary J, Ruan Q, et al. Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat Immunol. 2010;11:141-7 pubmed publisher
    The tumor suppressor PDCD4 is a proinflammatory protein that promotes activation of the transcription factor NF-kappaB and suppresses interleukin 10 (IL-10)...
  6. Dennis M, Jefferson L, Kimball S. Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis. J Biol Chem. 2012;287:42890-9 pubmed publisher
    ..ribosomal protein S6 kinase 1 (p70S6K1), which subsequently phosphorylates eIF4B, and programmed cell death 4 (PDCD4), which sequesters eIF4A from the eIF4E·eIF4G complex, resulting in repressed translation of mRNAs with highly ..
  7. Loh P, Yang H, Walsh M, Wang Q, Wang X, Cheng Z, et al. Structural basis for translational inhibition by the tumour suppressor Pdcd4. EMBO J. 2009;28:274-85 pubmed publisher
    b>Pdcd4 is a tumour suppressor protein. It inhibits translation through interaction with translation initiator eIF4A, resulting in the suppression of neoplastic transformation and tumour invasion...
  8. Kolpa H, Peal D, Lynch S, Giokas A, Ghatak S, Misra S, et al. miR-21 represses Pdcd4 during cardiac valvulogenesis. Development. 2013;140:2172-80 pubmed publisher
    ..b>PDCD4 knockdown alone was sufficient to enhance endothelial cell migration...
  9. Cmarik J, Min H, Hegamyer G, Zhan S, Kulesz Martin M, Yoshinaga H, et al. Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation. Proc Natl Acad Sci U S A. 1999;96:14037-42 pubmed
    ..An A7-1 cDNA was isolated that was identical to murine Pdcd4 gene cDNAs, also known as MA-3 or TIS, and analogous to human H731 and 197/15a...
  10. Shang Y, Fang N, Wang F, Wang H, Wang Z, Tang M, et al. MicroRNA-21, induced by high glucose, modulates macrophage apoptosis via programmed cell death 4. Mol Med Rep. 2015;12:463-9 pubmed publisher
    ..In addition, inhibition of miR-21 increased mRNA and protein levels of programmed cell death 4 (PDCD4), which, by contrast, were reduced in miR-21-inhibited cells that had been treated with a high concentration of ..
  11. Ge C, Song J, Chen L, Wang L, Chen Y, Liu X, et al. Atheroprotective pulsatile flow induces ubiquitin-proteasome-mediated degradation of programmed cell death 4 in endothelial cells. PLoS ONE. 2014;9:e91564 pubmed publisher
    We recently found low level of tumor suppressor programmed cell death 4 (PDCD4) associated with reduced atherosclerotic plaque area (unpublished)...
  12. Yang H, Knies J, Stark C, Colburn N. Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation. Oncogene. 2003;22:3712-20 pubmed
    Transformation suppressor Pdcd4 is downregulated in transformed (Tx) mouse epidermal JB6 RT101 cells relative to transformation-resistant (P-) and susceptible (P+) variants...
  13. Wang T, Long S, Zhao N, Wang Y, Sun H, Zou Z, et al. Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair. Int J Mol Sci. 2015;17: pubmed publisher
    Programmed cell death 4 (PDCD4) is one multi-functional tumor suppressor inhibiting neoplastic transformation and tumor invasion...
  14. Ye J, Guo R, Shi Y, Qi F, Guo C, Yang L. miR-155 Regulated Inflammation Response by the SOCS1-STAT3-PDCD4 Axis in Atherogenesis. Mediators Inflamm. 2016;2016:8060182 pubmed
    ..However, the precise mechanism of miR-155 remains unclear in AS. Here, we also found that miR-155 and PDCD4 were elevated in the aortic tissue of atherosclerotic mice and ox-LDL treated RAW264.7 cells...
  15. Zhang L, Wei Z, Zhang X, Gao Q, Ma Y, Liu X, et al. The inhibitory action of PDCD4 in lipopolysaccharide/D-galactosamine-induced acute liver injury. Lab Invest. 2013;93:291-302 pubmed publisher
    Programmed cell death 4 (PDCD4) acts as a tumor suppressor gene, which suppresses tumor growth, infiltration and metastasis...
  16. Wang Q, Dong Z, Liu X, Song X, Song Q, Shang Q, et al. Programmed cell death-4 deficiency prevents diet-induced obesity, adipose tissue inflammation, and insulin resistance. Diabetes. 2013;62:4132-43 pubmed publisher
    Programmed cell death-4 (PDCD4), a selective protein translation inhibitor, has shown proinflammatory effect in some inflammatory diseases, but its roles in obesity remain unestablished...
  17. Onishi Y, Kizaki H. Molecular cloning of the genes suppressed in RVC lymphoma cells by topoisomerase inhibitors. Biochem Biophys Res Commun. 1996;228:7-13 pubmed
    ..These results suggest that the early down-regulation of these genes contributes to the cytotoxicity of the topoisomerase inhibitors that induce DNA cleavage...
  18. Subedi A, Kim M, Nepal S, Lee E, Kim J, Sohn D, et al. Globular adiponectin modulates expression of programmed cell death 4 and miR-21 in RAW 264.7 macrophages through the MAPK/NF-?B pathway. FEBS Lett. 2013;587:1556-61 pubmed publisher
    MicroRNA-21 and programmed cell death 4 (PDCD4), a downstream target of miR-21, mediate diverse physiological responses. Here we demonstrate that globular adiponectin (gAcrp) modulates expression of miR-21 and PDCD4 in RAW 264...
  19. Kumar S, Marriott C, Alhasawi N, Bone A, Macfarlane W. The role of tumour suppressor PDCD4 in beta cell death in hypoxia. PLoS ONE. 2017;12:e0181235 pubmed publisher
    Hypoxia is known to induce pancreatic beta cell dysfunction and apoptosis. Changes in Programmed Cell Death Gene 4 (PDCD4) expression have previously been linked with beta cell neogenesis and function...
  20. Hong S, Lee J, Jiang H, Kim J, Lee A, Kim S, et al. Dual expression of shAkt1 and Pdcd4 suppresses lung tumorigenesis in K-rasLA1 mice. Anticancer Res. 2015;35:2015-9 pubmed
    ..An shRNA targeting Akt1 (shAkt1) and cDNA of programmed cell death protein 4 (Pdcd4) were inserted into a dual expression vector (shAkt1+Pdcd4)...
  21. Zhang Z, Zha Y, Hu W, Huang Z, Gao Z, Zang Y, et al. The autoregulatory feedback loop of microRNA-21/programmed cell death protein 4/activation protein-1 (MiR-21/PDCD4/AP-1) as a driving force for hepatic fibrosis development. J Biol Chem. 2013;288:37082-93 pubmed publisher
    ..We further found that miR-21 maintained itself at constant high levels by using a microRNA-21/programmed cell death protein 4/activation protein-1 (miR-21/PDCD4/AP-1) feedback loop...
  22. Junker F, Chabloz A, Koch U, Radtke F. Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression. Blood. 2015;126:993-1004 pubmed publisher
    ..Herein, we demonstrate that miR-21 regulates T-ALL cell survival via repression of the tumor suppressor Pdcd4.
  23. Jiang Y, Gao Q, Wang L, Guo C, Zhu F, Wang B, et al. Deficiency of programmed cell death 4 results in increased IL-10 expression by macrophages and thereby attenuates atherosclerosis in hyperlipidemic mice. Cell Mol Immunol. 2016;13:524-34 pubmed publisher
    Programmed cell death 4 (Pdcd4) is a newly defined inhibitor of transcription and translation and a tumor suppressor. Recent studies have suggested that Pdcd4 may also be involved in some inflammatory diseases...
  24. Hou L, Bowman L, Meighan T, Pratheeshkumar P, Shi X, Ding M. Induction of miR-21-PDCD4 signaling by UVB in JB6 cells involves ROS-mediated MAPK pathways. Exp Toxicol Pathol. 2013;65:1145-8 pubmed publisher
    ..The present study examined the alterations of miR-21-PDCD4 signaling in a mouse epidermal cell line (JB6 P(+)) post exposure to UVB irradiation...
  25. Santos J, Montagutelli X, Acevedo A, Lopez P, Vaquero C, Fernández M, et al. A new locus for resistance to gamma-radiation-induced thymic lymphoma identified using inter-specific consomic and inter-specific recombinant congenic strains of mice. Oncogene. 2002;21:6680-3 pubmed
    ..In addition to the discovery of a new locus controlling RITL development, our study emphasizes the value of ICS and IRCS for the genetic analysis of cancer predisposition. ..
  26. Roghani A, Welch C, Xia Y, Liu Y, Peter D, Finn J, et al. Assignment of the mouse vesicular monoamine transporter genes, Slc18a1 and Slc18a2, to chromosomes 8 and 19 by linkage analysis. Mamm Genome. 1996;7:393-4 pubmed
  27. Onishi Y, Hashimoto S, Kizaki H. Cloning of the TIS gene suppressed by topoisomerase inhibitors. Gene. 1998;215:453-9 pubmed
    We recently cloned the cDNA TIS (topoisomerase inhibitor-suppressed) in RVC lymphoma cells exposed to the topoisomerase inhibitors...
  28. Jurisicova A, Latham K, Casper R, Varmuza S. Expression and regulation of genes associated with cell death during murine preimplantation embryo development. Mol Reprod Dev. 1998;51:243-53 pubmed
    ..We propose that PCD may occur by default in embryos that fail to execute essential developmental events during the first cell cycle. ..
  29. Clee S, Yandell B, Schueler K, Rabaglia M, Richards O, Raines S, et al. Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus. Nat Genet. 2006;38:688-93 pubmed
    ..Our identification of the Sorcs1 gene provides insight into the pathway underlying the pathophysiology of obesity-induced type 2 diabetes mellitus. ..
  30. Hwang S, Minai Tehrani A, Lim H, Shin J, An G, Lee K, et al. Decreased level of PDCD4 (programmed cell death 4) protein activated cell proliferation in the lung of A/J mouse. J Aerosol Med Pulm Drug Deliv. 2010;23:285-93 pubmed publisher
    Programmed cell death 4 (PDCD4), a protein that binds to eukaryotic initiation factor 4A (eIF4A), inhibits the initiation of translation...
  31. White K, Dempsie Y, Caruso P, Wallace E, McDonald R, Stevens H, et al. Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase-3 axis. Hypertension. 2014;64:185-94 pubmed publisher
    ..stimuli, human pulmonary arterial endothelial cells exhibited robust induction of a programmed cell death 4 (PDCD4)/caspase-3/apoptotic pathway that was reversible by direct PDCD4 silencing...
  32. Cho J, Kim Y, Keum Y. Sulforaphane suppresses LPS-induced or TPA-induced downregulation of PDCD4 in RAW 264.7 cells. Phytother Res. 2014;28:1606-11 pubmed publisher
    ..that lipopolysaccharide (LPS) or 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment reduces cellular levels of PDCD4, and this event is mediated by affecting both transcription and proteolysis in RAW 264.7?cells...
  33. Hu H, Jiang W, Xi X, Zou C, Ye Z. MicroRNA-21 attenuates renal ischemia reperfusion injury via targeting caspase signaling in mice. Am J Nephrol. 2014;40:215-23 pubmed publisher
    ..urea nitrogen (BUN) and creatinine, lower histopathological scores and a decrease in programmed cell death 4 (PDCD4) mRNA and active caspase-3, caspase-8 proteins expressions...
  34. Lu Z, Liu M, Stribinskis V, Klinge C, Ramos K, Colburn N, et al. MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene. 2008;27:4373-9 pubmed publisher
    ..using a reporter assay and identified a potential miR-21 target in the 3'-UTR of the programmed cell death 4 (PDCD4) gene...
  35. He J, Yue Y, Dong C, Xiong S. MiR-21 confers resistance against CVB3-induced myocarditis by inhibiting PDCD4-mediated apoptosis. Clin Invest Med. 2013;36:E103-11 pubmed
    ..that miR-21 could protect myocardial apoptosis by specifically inhibiting its target programmed cell death 4 (PDCD4) expression...
  36. Cohen T, Prince A. Bacterial pathogens activate a common inflammatory pathway through IFN? regulation of PDCD4. PLoS Pathog. 2013;9:e1003682 pubmed publisher
    ..In human epithelial cells IFN? inhibited miR-21 via STAT3 resulting in upregulation of PDCD4, a protein known to promote inflammatory signaling...
  37. Wang L, Zhao M, Guo C, Wang G, Zhu F, Wang J, et al. PDCD4 Deficiency Aggravated Colitis and Colitis-associated Colorectal Cancer Via Promoting IL-6/STAT3 Pathway in Mice. Inflamm Bowel Dis. 2016;22:1107-18 pubmed publisher
    Although programmed cell death (PDCD) 4 is generally considered to be a new tumor suppressor, the consequence of Pdcd4 deficiency in tumorigenesis is not well established...
  38. Liang X, Xu Z, Yuan M, Zhang Y, Zhao B, Wang J, et al. MicroRNA-16 suppresses the activation of inflammatory macrophages in atherosclerosis by targeting PDCD4. Int J Mol Med. 2016;37:967-75 pubmed publisher
    Programmed cell death 4 (PDCD4) is involved in a number of bioprocesses, such as apoptosis and inflammation. However, its regulatory mechanisms in atherosclerosis remain unclear...
  39. Bai Y, Shang Q, Zhao H, Pan Z, Guo C, Zhang L, et al. Pdcd4 restrains the self-renewal and white-to-beige transdifferentiation of adipose-derived stem cells. Cell Death Dis. 2016;7:e2169 pubmed publisher
    ..Programmed cell death 4 (Pdcd4) has been demonstrated to be involved in the development of obesity, but its possible roles in ADSC function and ..
  40. Bai Y, Dong Z, Shang Q, Zhao H, Wang L, Guo C, et al. Pdcd4 Is Involved in the Formation of Stress Granule in Response to Oxidized Low-Density Lipoprotein or High-Fat Diet. PLoS ONE. 2016;11:e0159568 pubmed publisher
    ..We previously reported the implication of programmed cell death 4 (Pdcd4) in obesity-induced stress responses, but the possible link between Pdcd4 and SGs remains lacking...
  41. Welch C, Xia Y, Edwards P, Lusis A, Ericsson J. Assignment of Gpam to distal mouse chromosome 19 by linkage analysis. Mamm Genome. 1998;9:93 pubmed
  42. Wang Q, Zhu J, Wang Y, Dai Y, Wang Y, Wang C, et al. Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma. Oncogene. 2017;36:6225-6234 pubmed publisher
    Programmed cell death 4 (Pdcd4), a tumor invasion suppressor, is frequently downregulated in colorectal cancer and other cancers...
  43. Wang D, Guo S, Han S, Xu N, Guo J, Sun Q. Distinct roles of different fragments of PDCD4 in regulating the metastatic behavior of B16 melanoma cells. Int J Oncol. 2013;42:1725-33 pubmed publisher
    ..In this study, we demonstrated that the levels of the programmed cell death 4 (PDCD4) protein and mRNA were lower in tumor tissues compared with normal tissues...
  44. Yasuda M, Nishizawa T, Ohigashi H, Tanaka T, Hou D, Colburn N, et al. Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction. Carcinogenesis. 2009;30:1209-16 pubmed publisher
    ..40 muM and 1600 nmol in JB6 cells and mouse skin, respectively) induced expression of programmed cell death 4 (Pdcd4), a novel tumor suppressor protein...