Gene Symbol: Pcsk7
Description: proprotein convertase subtilisin/kexin type 7
Alias: AA959856, PC7, SPC7, proprotein convertase subtilisin/kexin type 7, prohormone convertase 7, prohormone convertase PC7, proprotein convertase 7, proprotein convertase PC7, subtilisin-like proprotein convertase 7, subtilisin/kexin-like protease PC7
Species: mouse
Products:     Pcsk7

Top Publications

  1. Seidah N, Hamelin J, Mamarbachi M, Dong W, Tardos H, Mbikay M, et al. cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases. Proc Natl Acad Sci U S A. 1996;93:3388-93 pubmed
    ..The gene for PC7 (Pcsk7) was mapped to mouse chromosome 9 by linkage analysis of an interspecific backcross DNA panel.
  2. Constam D, Calfon M, Robertson E. SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis. J Cell Biol. 1996;134:181-91 pubmed
    ..We isolated a novel protease, SPC7, as well as several known SPCs. SPC7, like SPC1, is expressed ubiquitously throughout development...
  3. Constam D, Robertson E. Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases. J Cell Biol. 1999;144:139-49 pubmed
    ..Collectively, these data show that the half-life of mature BMPs is greatly influenced by the identity of their pro regions. ..
  4. St Germain C, Croissandeau G, Mayne J, Baltz J, Chretien M, Mbikay M. Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development. Mol Reprod Dev. 2005;72:483-93 pubmed
    ..Furin, PACE4, PC1, and PC7 transcripts remained present at subsequent stages of preimplantation embryonic development, whereas the levels of ..
  5. Yamazaki K, Mizui Y, Sagane K, Tanaka I. Assignment of a disintegrin and metalloproteinase domain 10 (Adam10) gene to mouse chromosome 9. Genomics. 1997;46:528-9 pubmed
  6. Wickham L, Benjannet S, Marcinkiewicz E, Chretien M, Seidah N. Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin. J Neurochem. 2005;92:93-102 pubmed
    ..Furthermore, pulse and pulse-chase analyses revealed that the pro-protein convertases furin, and to a lesser extent PC7 and PC5A, process BRI3 into a C-terminal secreted approximately 4-kDa product...
  7. McColl B, Paavonen K, Karnezis T, Harris N, Davydova N, Rothacker J, et al. Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2. FASEB J. 2007;21:1088-98 pubmed
    ..The PCs furin and PC5 promote cleavage of both propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only...
  8. Scamuffa N, Basak A, Lalou C, Wargnier A, Marcinkiewicz J, Siegfried G, et al. Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7. Gut. 2008;57:1573-82 pubmed publisher
    ..cell line LoVo was restored by the expression of Furin, paired basic amino acid cleaving enzyme 4 (PACE4), PC5 or PC7. This finding is consistent with the in vitro digestions of a synthetic peptide mimicking the cleavage site of ..
  9. Mesnard D, Constam D. Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst. J Cell Biol. 2010;191:129-39 pubmed publisher
    ..The unprecedented sensitivity and spatial resolution of CLIP opens exciting new possibilities to elucidate PC functions in vivo. ..

More Information


  1. Rousselet E, Benjannet S, Marcinkiewicz E, Asselin M, Lazure C, Seidah N. Proprotein convertase PC7 enhances the activation of the EGF receptor pathway through processing of the EGF precursor. J Biol Chem. 2011;286:9185-95 pubmed publisher
    ..Among the proprotein convertases (PCs), only the membrane-bound PC7, the most ancient and conserved basic amino acid-specific PC family member, induces the processing of pro-EGF into ..
  2. Kato S, Zhang R, Roberts J. Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport. Am J Physiol Lung Cell Mol Physiol. 2013;305:L130-40 pubmed publisher
    ..We observed that overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner in human embryonic kidney (HEK) ..
  3. Wetsel W, Rodriguiz R, Guillemot J, Rousselet E, Essalmani R, Kim I, et al. Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. Proc Natl Acad Sci U S A. 2013;110:17362-7 pubmed publisher
    b>PC7 belongs to the proprotein convertase family, whose members are implicated in the cleavage of secretory precursors. The in vivo function of PC7 is unknown...
  4. Villeneuve P, Feliciangeli S, Croissandeau G, Seidah N, Mbikay M, Kitabgi P, et al. Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study. J Neurochem. 2002;82:783-93 pubmed
    ..To gain insight into the role of prohormone convertases PC1, PC2, and PC7 in this process, we investigated the maturation of pro-NT/NN in the brain of PC7 (PC7-/-), PC2 (PC2-/-), and/or PC1 ..
  5. Refaie S, Gagnon S, Gagnon H, Desjardins R, D Anjou F, D Orléans Juste P, et al. Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion. J Biol Chem. 2012;287:14703-17 pubmed publisher
    ..PC1/3 KO mice are more susceptible to septic shock than wild-type controls or other PC KO mice, such as PC2 and PC7 null mice...
  6. Bessonnard S, Mesnard D, Constam D. PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation. J Cell Biol. 2015;210:1185-97 pubmed publisher
    ..We show that morula compaction and ICM formation depend on PC7 and the related proprotein convertases (PCs) Furin and Pace4 and that these proteases jointly regulate cell-cell ..
  7. Anyetei Anum E, Blum A, Seidah N, Beinfeld M. Prohormone convertase 7 is necessary for the normal processing of cholecystokinin in mouse brain. Biochem Biophys Res Commun. 2017;482:1190-1193 pubmed publisher
    ..This study finds that PC7 is also critical for normal production of CCK in specific areas of the brain...