Pcbp4

Summary

Gene Symbol: Pcbp4
Description: poly(rC) binding protein 4
Alias: 1200003L19Rik, AlphaCP-4, poly(rC)-binding protein 4, alpha-CP4
Species: mouse
Products:     Pcbp4

Top Publications

  1. Makeyev A, Liebhaber S. Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins. Genomics. 2000;67:301-16 pubmed
    ..These data establish a new subfamily of genes predicted to encode closely related KH-containing RNA-binding proteins with potential functions in posttranscriptional controls. ..
  2. Scoumanne A, Cho S, Zhang J, Chen X. The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability. Nucleic Acids Res. 2011;39:213-24 pubmed publisher
    ..b>PCBP4, also called MCG10, is an RBP belonging to the poly(C)-binding protein family and a target of p53 tumor suppressor...
  3. Zheng S, Damoiseaux R, Chen L, Black D. A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing. Genome Res. 2013;23:998-1007 pubmed publisher
    ..These results identify multiple new regulators of Dlg4 splicing, and validate an approach to isolating splicing regulators for almost any cassette exon from libraries of cDNAs, shRNAs, or small molecules. ..
  4. Yan W, Scoumanne A, Jung Y, Xu E, Zhang J, Zhang Y, et al. Mice deficient in poly(C)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation. Genes Dev. 2016;30:522-34 pubmed publisher
    Poly(C)-binding protein 4 (PCBP4), also called MCG10 and a target of p53, plays a role in the cell cycle and is implicated in lung tumor suppression...