Pax7

Summary

Gene Symbol: Pax7
Description: paired box 7
Alias: Pax-7, paired box protein Pax-7, paired box gene 7, paired box transcription factor PAX7
Species: mouse
Products:     Pax7

Top Publications

  1. Matise M, Epstein D, Park H, Platt K, Joyner A. Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development. 1998;125:2759-70 pubmed
  2. Jeong J, McMahon A. Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development. 2005;132:143-54 pubmed
    ..Furthermore, this feedback mechanism is crucial in generating a neural tube that contains appropriate numbers of all ventral and intermediate neuronal cell types. ..
  3. Mansouri A, Stoykova A, Torres M, Gruss P. Dysgenesis of cephalic neural crest derivatives in Pax7-/- mutant mice. Development. 1996;122:831-8 pubmed
    b>Pax7 is a member of the paired box containing gene family. Its expression pattern suggests a function in cephalic neural crest derivatives, skeletal muscle and central nervous system development...
  4. Cooper A, Yu K, Brueckner M, Brailey L, Johnson L, McGrath J, et al. Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. Development. 2005;132:4407-17 pubmed
    ..The resemblance of Sufu homozygotes to Ptch1 homozygotes is consistent with mouse Sufu being a conserved negative modulator of Hh signaling. ..
  5. Burrill J, Moran L, Goulding M, Saueressig H. PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development. Development. 1997;124:4493-503 pubmed
    ..the expression domains of PAX2, EN1 and EVX1 in postmitotic neurons correlate closely with those of Pax6 and Pax7 in the ventricular zone, implicating these patterning genes in the regulation of PAX2, EN1 and EVX1...
  6. Ding Q, Motoyama J, Gasca S, Mo R, Sasaki H, Rossant J, et al. Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development. 1998;125:2533-43 pubmed
    ..Our results imply that Gli2 is required to mediate high level but not low level Shh activity and show that the development of motor neurons can occur in the absence of floor plate induction. ..
  7. Shea K, Xiang W, LaPorta V, Licht J, Keller C, Basson M, et al. Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration. Cell Stem Cell. 2010;6:117-29 pubmed publisher
    ..The transcription factor Pax7 marks satellite cells and is critical for establishing the adult satellite cell pool...
  8. White R, Ziman M. Genome-wide discovery of Pax7 target genes during development. Physiol Genomics. 2008;33:41-9 pubmed publisher
    b>Pax7 plays critical roles in development of brain, spinal cord, neural crest, and skeletal muscle...
  9. Aoto K, Nishimura T, Eto K, Motoyama J. Mouse GLI3 regulates Fgf8 expression and apoptosis in the developing neural tube, face, and limb bud. Dev Biol. 2002;251:320-32 pubmed
    ..Together, our data reveal that GLI3 limits Fgf8-expression domains in multiple tissues, through a mechanism that may include the induction or maintenance of apoptosis. ..

More Information

Publications81

  1. Ferrante M, Zullo A, Barra A, Bimonte S, Messaddeq N, Studer M, et al. Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification. Nat Genet. 2006;38:112-7 pubmed
  2. Wang C, Pan Y, Wang B. Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors. Development. 2010;137:2001-9 pubmed publisher
    ..Our study provides a new insight into the regulation of Gli2 and Gli3 stability and processing by Sufu and Spop, and reveals the unexpected Sufu-independent Gli3 repressor function...
  3. Eggenschwiler J, Anderson K. Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene. Dev Biol. 2000;227:648-60 pubmed
    ..early in neural development, the wild-type opb gene (opb(+)) is required cell autonomously for the expression of Pax7 in dorsal cells and Pax6 in lateral cells...
  4. Huang Y, Roelink H, McKnight G. Protein kinase A deficiency causes axially localized neural tube defects in mice. J Biol Chem. 2002;277:19889-96 pubmed
    ..The regional sensitivity to changes in PKA activity indicates that downstream signaling pathways differ along the anterior-posterior axis and suggests a functional role for PKA activation in neural tube development. ..
  5. Kuang S, Chargé S, Seale P, Huh M, Rudnicki M. Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis. J Cell Biol. 2006;172:103-13 pubmed
    We assessed viable Pax7(-/-) mice in 129Sv/J background and observed reduced growth and marked muscle wasting together with a complete absence of functional satellite cells...
  6. Thompson J, Lovicu F, Ziman M. Pax7 and superior collicular polarity: insights from Pax6 (Sey) mutant mice. Exp Brain Res. 2007;178:316-25 pubmed
    Pax genes are important modulators of CNS development. Pax7 and Pax6 polarise the neural tube and regionalise the brain...
  7. McKinnell I, Ishibashi J, Le Grand F, Punch V, Addicks G, Greenblatt J, et al. Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex. Nat Cell Biol. 2008;10:77-84 pubmed
    ..The paired-box transcription factor Pax7 is required for satellite cells to generate committed myogenic progenitors...
  8. Schuster Gossler K, Cordes R, Gossler A. Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants. Proc Natl Acad Sci U S A. 2007;104:537-42 pubmed
    ..Resident progenitor cells defined by Pax3/Pax7 expression are formed initially, but they are progressively lost and virtually absent at embryonic day 14.5...
  9. Eggenschwiler J, Espinoza E, Anderson K. Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway. Nature. 2001;412:194-8 pubmed
    ..The data indicate that dorsalizing signals activate transcription of Rab23 in order to silence the Shh pathway in dorsal neural cells. ..
  10. Le Grand F, Auda Boucher G, Levitsky D, Rouaud T, Fontaine Pérus J, Gardahaut M. Endothelial cells within embryonic skeletal muscles: a potential source of myogenic progenitors. Exp Cell Res. 2004;301:232-41 pubmed
    ..The marked ability of the embryonic muscle endothelial cells to activate myogenic program could be related to their somitic origin. ..
  11. Weatherbee S, Niswander L, Anderson K. A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling. Hum Mol Genet. 2009;18:4565-75 pubmed publisher
    ..Thus the disruption of Hh signaling can explain many, but not all, of the defects caused by loss of Mks1...
  12. Bjornson C, Cheung T, Liu L, Tripathi P, Steeper K, Rando T. Notch signaling is necessary to maintain quiescence in adult muscle stem cells. Stem Cells. 2012;30:232-42 pubmed publisher
  13. Lepper C, Fan C. Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells. Genesis. 2010;48:424-36 pubmed publisher
    We have generated a mouse strain carrying a Cre-ER(T2) knock-in allele at the Pax7 locus, the Pax7(CE) allele (Lepper et al., 2009, Nature 460:627-631)...
  14. Murphy M, Lawson J, Mathew S, Hutcheson D, Kardon G. Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration. Development. 2011;138:3625-37 pubmed publisher
    ..Using Tcf4, a newly identified fibroblast marker, and Pax7, a satellite cell marker, we found that after injury satellite cells and fibroblasts rapidly proliferate in close ..
  15. Persson M, Stamataki D, te Welscher P, Andersson E, Böse J, Ruther U, et al. Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev. 2002;16:2865-78 pubmed
    ..Together these data raise the possibility that Gli proteins act as common mediators integrating Shh signals, and other sources of positional information, to control patterning throughout the ventral neural tube. ..
  16. Bangs F, Antonio N, Thongnuek P, Welten M, Davey M, Briscoe J, et al. Generation of mice with functional inactivation of talpid3, a gene first identified in chicken. Development. 2011;138:3261-72 pubmed publisher
    ..This genetic mouse model will facilitate further conditional approaches, epistatic experiments and open up investigation into the function of the novel talpid3 gene using the many resources available for mice. ..
  17. Ziman M, Fletcher S, Kay P. Alternate Pax7 transcripts are expressed specifically in skeletal muscle, brain and other organs of adult mice. Int J Biochem Cell Biol. 1997;29:1029-36 pubmed
    b>Pax7 is associated with formation of skeletal muscle and the neural tube in developing embryos...
  18. Dietrich S, Abou Rebyeh F, Brohmann H, Bladt F, Sonnenberg Riethmacher E, Yamaai T, et al. The role of SF/HGF and c-Met in the development of skeletal muscle. Development. 1999;126:1621-9 pubmed
    ..They lack muscle groups that derive from migratory precursor cells, but display otherwise normal skeletal musculature. ..
  19. Borycki A, Li J, Jin F, Emerson C, Epstein J. Pax3 functions in cell survival and in pax7 regulation. Development. 1999;126:1665-74 pubmed
    ..In neural tube and somite regions where cell survival is maintained, the closely related Pax7 gene is upregulated, and its expression becomes expanded into the dorsal neural tube and somites, where Pax3 would ..
  20. Lagha M, Brunelli S, Messina G, Cumano A, Kume T, Relaix F, et al. Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitors. Dev Cell. 2009;17:892-9 pubmed publisher
    ..This provides insight into how cell fate choices are orchestrated by these lineage genes in the dermomyotome. ..
  21. Relaix F, Montarras D, Zaffran S, Gayraud Morel B, Rocancourt D, Tajbakhsh S, et al. Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells. J Cell Biol. 2006;172:91-102 pubmed
    ..and repair of skeletal muscle after birth depends on satellite cells that are characterized by the expression of Pax7. We show that Pax3, the paralogue of Pax7, is also present in both quiescent and activated satellite cells in many ..
  22. Sambasivan R, Comai G, Le Roux I, Gomès D, Konge J, Dumas G, et al. Embryonic founders of adult muscle stem cells are primed by the determination gene Mrf4. Dev Biol. 2013;381:241-55 pubmed publisher
    ..Using a Cre-lox based genetic strategy and novel highly sensitive Pax7 reporter alleles compared to the ubiquitous Rosa26-based reporters, we show that all adult satellite cells, ..
  23. Vasyutina E, Lenhard D, Wende H, Erdmann B, Epstein J, Birchmeier C. RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells. Proc Natl Acad Sci U S A. 2007;104:4443-8 pubmed
    ..In addition, satellite cells are not formed late in fetal development in conditional RBP-J mutant mice. We conclude that RBP-J is required in the developing muscle to set aside proliferating progenitors and satellite cells...
  24. Relaix F, Rocancourt D, Mansouri A, Buckingham M. A Pax3/Pax7-dependent population of skeletal muscle progenitor cells. Nature. 2005;435:948-53 pubmed
    ..We have identified a new cell population that expresses the transcription factors Pax3 and Pax7 (paired box proteins 3 and 7) but no skeletal-muscle-specific markers...
  25. Tenzen T, Allen B, Cole F, Kang J, Krauss R, McMahon A. The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell. 2006;10:647-56 pubmed
    ..Cdo and Boc bind Shh through a high-affinity interaction with a specific fibronectin repeat that is essential for activity. We propose a model where Cdo and Boc enhance Shh signaling within its target field. ..
  26. Lepper C, Partridge T, Fan C. An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration. Development. 2011;138:3639-46 pubmed publisher
    ..Cell transplantation and lineage-tracing studies have demonstrated that Pax7-expressing (Pax7(+)) satellite cells can repair damaged muscle tissue repeatedly after several bouts of acute ..
  27. Huangfu D, Anderson K. Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci U S A. 2005;102:11325-30 pubmed
  28. Van Ho A, Hayashi S, Bröhl D, Aurade F, Rattenbach R, Relaix F. Neural crest cell lineage restricts skeletal muscle progenitor cell differentiation through Neuregulin1-ErbB3 signaling. Dev Cell. 2011;21:273-87 pubmed publisher
  29. L honoré A, Coulon V, Marcil A, Lebel M, Lafrance Vanasse J, Gage P, et al. Sequential expression and redundancy of Pitx2 and Pitx3 genes during muscle development. Dev Biol. 2007;307:421-33 pubmed
    ..acting during muscle development, including bHLH muscle regulatory factors (MRFs), the paired factors Pax3 and Pax7 and the homeobox factors Six1 and Six4...
  30. LaMantia A, Bhasin N, Rhodes K, Heemskerk J. Mesenchymal/epithelial induction mediates olfactory pathway formation. Neuron. 2000;28:411-25 pubmed
    ..Thus, a cellular and molecular mechanism that facilitates musculoskeletal and vascular development elsewhere in the embryo has been adapted to guide the differentiation of the olfactory pathway in the developing forebrain. ..
  31. Mizuhara E, Nakatani T, Minaki Y, Sakamoto Y, Ono Y. Corl1, a novel neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor Lbx1. J Biol Chem. 2005;280:3645-55 pubmed
    ..Identification of a novel transcriptional corepressor with neuronal subtype-restricted expression might provide insights into the mechanisms of cell fate determination in neurons. ..
  32. Keller C, Hansen M, Coffin C, Capecchi M. Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin. Genes Dev. 2004;18:2608-13 pubmed
    ..In contrast, activation later in embryogenesis in cells that express Pax7 results in viable animals with a postnatal growth defect and a moderately decreased Pax7+ muscle satellite cell ..
  33. Seale P, Ishibashi J, Scime A, Rudnicki M. Pax7 is necessary and sufficient for the myogenic specification of CD45+:Sca1+ stem cells from injured muscle. PLoS Biol. 2004;2:E130 pubmed
    ..those isolated from regenerating muscle give rise to myoblasts expressing the paired-box transcription factor Pax7 and the bHLH factors Myf5 and MyoD...
  34. Nishijo K, Hosoyama T, Bjornson C, Schaffer B, Prajapati S, Bahadur A, et al. Biomarker system for studying muscle, stem cells, and cancer in vivo. FASEB J. 2009;23:2681-90 pubmed publisher
    ..With the use of this dual-modality bioreporter with a novel, inducible Pax7-CreER line for tracking muscle satellite cells, we demonstrate the longitudinal kinetics of muscle stem cell ..
  35. Bosnakovski D, Xu Z, Li W, Thet S, Cleaver O, Perlingeiro R, et al. Prospective isolation of skeletal muscle stem cells with a Pax7 reporter. Stem Cells. 2008;26:3194-204 pubmed publisher
    ..We used a transgenic Pax7-ZsGreen reporter mouse to prospectively isolate stem cells of skeletal muscle by flow cytometry...
  36. Forni P, Taylor Burds C, Melvin V, Williams T, Williams T, Wray S. Neural crest and ectodermal cells intermix in the nasal placode to give rise to GnRH-1 neurons, sensory neurons, and olfactory ensheathing cells. J Neurosci. 2011;31:6915-27 pubmed publisher
    ..Furthermore, the results indicate that certain conditions that impact olfaction and sexual development, such as Kallmann syndrome, may be in part neurocristopathies...
  37. Okada A, Charron F, Morin S, Shin D, Wong K, Fabre P, et al. Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature. 2006;444:369-73 pubmed
    ..Taken together, these data suggest that Boc is essential as a receptor for Shh in commissural axon guidance. ..
  38. Kassar Duchossoy L, Giacone E, Gayraud Morel B, Jory A, Gomès D, Tajbakhsh S. Pax3/Pax7 mark a novel population of primitive myogenic cells during development. Genes Dev. 2005;19:1426-31 pubmed
    ..We identify a novel population of resident Pax3+/Pax7+, muscle marker-negative cells throughout development...
  39. Grifone R, Demignon J, Houbron C, Souil E, Niro C, Seller M, et al. Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo. Development. 2005;132:2235-49 pubmed
    ..These results highlight the different roles played by Six proteins during skeletal myogenesis. ..
  40. Oustanina S, Hause G, Braun T. Pax7 directs postnatal renewal and propagation of myogenic satellite cells but not their specification. EMBO J. 2004;23:3430-9 pubmed
    The paired-box transcription factor Pax7 has been claimed to specify the muscle stem cell lineage since inactivation of Pax7 led to a failure to detect muscle satellite cells...
  41. Seale P, Sabourin L, Girgis Gabardo A, Mansouri A, Gruss P, Rudnicki M. Pax7 is required for the specification of myogenic satellite cells. Cell. 2000;102:777-86 pubmed
    The paired box transcription factor Pax7 was isolated by representational difference analysis as a gene specifically expressed in cultured satellite cell-derived myoblasts...
  42. Bai C, Joyner A. Gli1 can rescue the in vivo function of Gli2. Development. 2001;128:5161-72 pubmed
    ..We show that the defects are enhanced when Gli3 function is reduced, demonstrating that an important difference between Gli1 and Gli2 is the ability of Gli1 to antagonize Gli3 function. ..
  43. Zammit P, Relaix F, Nagata Y, Ruiz A, Collins C, Partridge T, et al. Pax7 and myogenic progression in skeletal muscle satellite cells. J Cell Sci. 2006;119:1824-32 pubmed
    ..Quiescent satellite cells express the transcription factor Pax7 and when activated, coexpress Pax7 with MyoD. Most then proliferate, downregulate Pax7 and differentiate...
  44. Jostes B, Walther C, Gruss P. The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system. Mech Dev. 1990;33:27-37 pubmed
    Eight murine paired box-containing (Pax) genes have been isolated so far. The gene described here, Pax7, contains not only a paired box, but also an octapeptide and a paired-type homeobox...
  45. Ericson J, Rashbass P, Schedl A, Brenner Morton S, Kawakami A, van Heyningen V, et al. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell. 1997;90:169-80 pubmed
    ..2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain. ..
  46. Mansouri A, Gruss P. Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord. Mech Dev. 1998;78:171-8 pubmed
    Pax3 and Pax7 are transcription factors sharing high sequence identity and overlapping patterns of expression in particular in the dorsal spinal cord...
  47. Chen M, Wilson C, Li Y, Law K, Lu C, Gacayan R, et al. Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev. 2009;23:1910-28 pubmed publisher
    ..Taken together, these studies delineate important aspects of cilium-dependent and cilium-independent Hh signal transduction and provide significant mechanistic insight into Hh signaling in diverse species. ..
  48. Lepper C, Conway S, Fan C. Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements. Nature. 2009;460:627-31 pubmed publisher
    ..potential, survival and expansion of mammalian muscle progenitors depend on the myogenic determinants Pax3 and Pax7 embryonically, and Pax7 alone perinatally...
  49. Kumar D, Shadrach J, Wagers A, Lassar A. Id3 is a direct transcriptional target of Pax7 in quiescent satellite cells. Mol Biol Cell. 2009;20:3170-7 pubmed publisher
    b>Pax7 is a key regulator of skeletal muscle stem cells and is required along with Pax3 to generate skeletal muscle precursors. We have identified a collection of genes induced by either Pax3 or Pax7 in C2C12 muscle cells...
  50. Ma Y, Erkner A, Gong R, Yao S, Taipale J, Basler K, et al. Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell. 2002;111:63-75 pubmed
    ..This activity is disrupted by alteration of residues functionally conserved in Patched and in a related family of bacterial transmembrane transporters, thus suggesting similar mechanisms of action for all of these proteins. ..
  51. Chen L, Guo Q, Li J. Transcription factor Gbx2 acts cell-nonautonomously to regulate the formation of lineage-restriction boundaries of the thalamus. Development. 2009;136:1317-26 pubmed publisher
    ..We propose that, within the developing thalamus, the dynamic and differential expression of Gbx2 may be involved in the specific segregation of thalamic neurons, leading to partition of the thalamus into different nuclei. ..
  52. Aoto K, Shikata Y, Imai H, Matsumaru D, Tokunaga T, Shioda S, et al. Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis. Dev Biol. 2009;327:106-20 pubmed publisher
    ..These findings provide new insight into the mechanism underlying HPE pathoetiology during dynamic brain and craniofacial morphogenesis. ..
  53. Yin H, Pasut A, Soleimani V, Bentzinger C, Antoun G, Thorn S, et al. MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. Cell Metab. 2013;17:210-24 pubmed publisher
    ..Therefore, microRNA-133 represents an important therapeutic target for the treatment of obesity. ..
  54. Sambasivan R, Yao R, Kissenpfennig A, Van Wittenberghe L, Paldi A, Gayraud Morel B, et al. Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration. Development. 2011;138:3647-56 pubmed publisher
    ..depletion of satellite cells by expressing a human diphtheria toxin receptor under control of the murine Pax7 locus...
  55. Chakkalakal J, Jones K, Basson M, Brack A. The aged niche disrupts muscle stem cell quiescence. Nature. 2012;490:355-60 pubmed publisher
    ..These experiments identify an age-dependent change in the stem cell niche that directly influences stem cell quiescence and function. ..
  56. Soleimani V, Punch V, Kawabe Y, Jones A, Palidwor G, Porter C, et al. Transcriptional dominance of Pax7 in adult myogenesis is due to high-affinity recognition of homeodomain motifs. Dev Cell. 2012;22:1208-20 pubmed publisher
    Pax3 and Pax7 regulate stem cell function in skeletal myogenesis. However, molecular insight into their distinct roles has remained elusive...
  57. Cheung T, Quach N, Charville G, Liu L, Park L, Edalati A, et al. Maintenance of muscle stem-cell quiescence by microRNA-489. Nature. 2012;482:524-8 pubmed publisher
    ..Our results provide evidence of the miRNA pathway in general, and of a specific miRNA, miR-489, in actively maintaining the quiescent state of an adult stem-cell population. ..
  58. von Maltzahn J, Jones A, Parks R, Rudnicki M. Pax7 is critical for the normal function of satellite cells in adult skeletal muscle. Proc Natl Acad Sci U S A. 2013;110:16474-9 pubmed publisher
    Extensive analyses of mice carrying null mutations in paired box 7 (Pax7) have confirmed the progressive loss of the satellite cell lineage in skeletal muscle, resulting in severe muscle atrophy and death...
  59. Kay P, Mitchell C, Akkari A, Papadimitriou J. Association of an unusual form of a Pax7-like gene with increased efficiency of skeletal muscle regeneration. Gene. 1995;163:171-7 pubmed
    ..To identify other candidate genes, differences were sought within the myogenic paired box/homeobox-containing gene Pax7 between SJL/J and other laboratory mouse strains...
  60. Murdoch B, DelConte C, GARCIA CASTRO M. Embryonic Pax7-expressing progenitors contribute multiple cell types to the postnatal olfactory epithelium. J Neurosci. 2010;30:9523-32 pubmed publisher
    ..Here we identify embryonic OE Pax7+ progenitors, detected at embryonic day 10.5 (E10...
  61. Keller C, Arenkiel B, Coffin C, El Bardeesy N, Depinho R, Capecchi M. Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev. 2004;18:2614-26 pubmed
  62. Bai C, Stephen D, Joyner A. All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3. Dev Cell. 2004;6:103-15 pubmed
    ..Therefore, in the spinal cord all Hh signaling is Gli dependent. Furthermore, a combination of Gli2 and Gli3 is required to regulate motor neuron development and spatial patterning of ventral spinal cord progenitors. ..
  63. Muller T, Brohmann H, Pierani A, Heppenstall P, Lewin G, Jessell T, et al. The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord. Neuron. 2002;34:551-62 pubmed
    ..We conclude that Lbx1 distinguishes two major neuronal classes in the dorsal spinal cord and is an important determinant of their distinct differentiation programs. ..
  64. Lagha M, Kormish J, Rocancourt D, Manceau M, Epstein J, Zaret K, et al. Pax3 regulation of FGF signaling affects the progression of embryonic progenitor cells into the myogenic program. Genes Dev. 2008;22:1828-37 pubmed publisher
    ..These results provide new insight into the Pax-initiated regulatory network that modulates stem cell maintenance versus tissue differentiation. ..
  65. Olguin H, Yang Z, Tapscott S, Olwin B. Reciprocal inhibition between Pax7 and muscle regulatory factors modulates myogenic cell fate determination. J Cell Biol. 2007;177:769-79 pubmed
    ..The transcription factor Pax7 is critical for satellite cell biogenesis and survival and has been also implicated in satellite cell self-renewal; ..
  66. Eggenschwiler J, Bulgakov O, Qin J, Li T, Anderson K. Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins. Dev Biol. 2006;290:1-12 pubmed
    ..Instead, Rab23 appears to regulate subcellular localization of essential components of the Hedgehog pathway that act downstream of Smoothened and upstream of Gli proteins. ..
  67. Jin J, Gu S, McKinney P, Ding J. Expression and functional analysis of Tgif during mouse midline development. Dev Dyn. 2006;235:547-53 pubmed
    ..One interpretation of these results is that the loss of TGIF function is compensated by other TGF-beta antagonists such as c-Ski and SnoN during vertebrate anterior neural development. ..
  68. Relaix F, Rocancourt D, Mansouri A, Buckingham M. Divergent functions of murine Pax3 and Pax7 in limb muscle development. Genes Dev. 2004;18:1088-105 pubmed
    Pax genes encode evolutionarily conserved transcription factors that play critical roles in development. Pax3 and Pax7 constitute one of the four Pax subfamilies...
  69. Huangfu D, Liu A, Rakeman A, Murcia N, Niswander L, Anderson K. Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature. 2003;426:83-7 pubmed
    ..Our data show that IFT machinery has an essential and vertebrate-specific role in Hedgehog signal transduction. ..
  70. Lin S, Shen H, Jin B, Gu Y, Chen Z, Cao C, et al. Brief report: Blockade of Notch signaling in muscle stem cells causes muscular dystrophic phenotype and impaired muscle regeneration. Stem Cells. 2013;31:823-8 pubmed publisher
    ..Our data thus indicate that Notch signaling controls processes that are critical to regeneration in muscular dystrophy, suggesting that Notch inhibitor therapies could have potential side effects on muscle functions. ..
  71. Wijgerde M, McMahon J, Rule M, McMahon A. A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev. 2002;16:2849-64 pubmed
    ..Thus, Hh signaling is essential for organizing ventral cell pattern, possibly through the control of differential cell affinities. ..
  72. Tajbakhsh S, Rocancourt D, Cossu G, Buckingham M. Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD. Cell. 1997;89:127-38 pubmed
    ..Therefore, Pax-3 and Myf-5 define two distinct myogenic pathways, and MyoD acts genetically downstream of these genes for myogenesis in the body. This genetic hierarchy does not appear to operate for head muscle formation. ..