Pask

Summary

Gene Symbol: Pask
Description: PAS domain containing serine/threonine kinase
Alias: mKIAA0135, PAS domain-containing serine/threonine-protein kinase, PAS-kinase, paskin
Species: mouse
Products:     Pask

Top Publications

  1. Katschinski D, Marti H, Wagner K, Shibata J, Eckhardt K, Martin F, et al. Targeted disruption of the mouse PAS domain serine/threonine kinase PASKIN. Mol Cell Biol. 2003;23:6780-9 pubmed
    b>PASKIN is a novel mammalian serine/threonine kinase containing two PAS (Per-Arnt-Sim) domains. PASKIN is related to the Rhizobium oxygen sensor protein FixL and to AMP-regulated kinases...
  2. da Silva Xavier G, Farhan H, Kim H, Caxaria S, Johnson P, Hughes S, et al. Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion. Diabetologia. 2011;54:819-27 pubmed publisher
    We assessed whether per-arnt-sim (PAS) domain-containing protein kinase (PASK) is involved in the regulation of glucagon secretion...
  3. Borter E, Niessen M, Zuellig R, Spinas G, Spielmann P, Camenisch G, et al. Glucose-stimulated insulin production in mice deficient for the PAS kinase PASKIN. Diabetes. 2007;56:113-7 pubmed
    The Per-ARNT-Sim (PAS) domain serine/threonine kinase PASKIN, or PAS kinase, links energy flux and protein synthesis in yeast and regulates glycogen synthase in mammals...
  4. Hao H, Cardon C, Swiatek W, Cooksey R, Smith T, Wilde J, et al. PAS kinase is required for normal cellular energy balance. Proc Natl Acad Sci U S A. 2007;104:15466-71 pubmed
    ..We studied the role of the cellular metabolic sensor PAS kinase (PASK) in the pathogenesis of metabolic disease by using PASK(-/-) mice...
  5. Fontes G, Semache M, Hagman D, Tremblay C, Shah R, Rhodes C, et al. Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells. Diabetes. 2009;58:2048-58 pubmed publisher
    ..ascertain the role of extracellular-regulated kinases (ERKs)1/2, protein kinase B (PKB), and Per-Arnt-Sim kinase (PASK) in palmitate inhibition of insulin gene expression in pancreatic beta-cells...
  6. Semache M, Zarrouki B, Fontes G, Fogarty S, Kikani C, Chawki M, et al. Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3? in pancreatic ?-cells. J Biol Chem. 2013;288:24825-33 pubmed publisher
    ..We previously showed that the serine/threonine Per-Arnt-Sim domain-containing kinase (PASK) regulates insulin gene transcription via PDX-1. However, the mechanisms underlying this regulation are unknown...
  7. Hofer T, Spielmann P, Stengel P, Stier B, Katschinski D, Desbaillets I, et al. Mammalian PASKIN, a PAS-serine/threonine kinase related to bacterial oxygen sensors. Biochem Biophys Res Commun. 2001;288:757-64 pubmed
    ..We identified a novel mammalian PAS protein (PASKIN) containing a domain architecture resembling FixL...
  8. Soliz J, Soulage C, Borter E, van Patot M, Gassmann M. Ventilatory responses to acute and chronic hypoxia are altered in female but not male Paskin-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2008;295:R649-58 pubmed publisher
    ..b>PASKIN is the mammalian homolog of FixL, but its function is far from being understood...
  9. Schl fli P, Tr ger J, Eckhardt K, Borter E, Spielmann P, Wenger R. Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN. FEBS J. 2011;278:1757-68 pubmed publisher
    The Per-Arnt-Sim (PAS) domain serine/threonine kinase PASKIN, or PAS kinase, links energy flux and protein synthesis in yeast, regulates glycogen synthesis and protein translation in mammals, and might be involved in insulin regulation in ..

More Information

Publications15

  1. Cardon C, Rutter J. PAS kinase: integrating nutrient sensing with nutrient partitioning. Semin Cell Dev Biol. 2012;23:626-30 pubmed publisher
    Recent data suggests that PAS kinase acts as a signal integrator to adjust metabolic behavior in response to nutrient conditions...
  2. Hurtado Carneiro V, Roncero I, Blazquez E, Alvarez E, Sanz C. PAS kinase as a nutrient sensor in neuroblastoma and hypothalamic cells required for the normal expression and activity of other cellular nutrient and energy sensors. Mol Neurobiol. 2013;48:904-20 pubmed publisher
    b>PAS kinase (PASK) is a nutrient sensor that is highly conserved throughout evolution. PASK-deficient mice reveal a metabolic phenotype similar to that described in S6 kinase-1 S6K1-deficient mice that are protected against obesity...
  3. Hurtado Carneiro V, Roncero I, Egger S, Wenger R, Blazquez E, Sanz C, et al. PAS kinase is a nutrient and energy sensor in hypothalamic areas required for the normal function of AMPK and mTOR/S6K1. Mol Neurobiol. 2014;50:314-26 pubmed publisher
    ..Hypothalamic metabolic sensors play an important role in the control of feeding and energy homeostasis. PAS kinase (PASK) is a nutrient sensor proposed as a regulator of glucose metabolism and cellular energy...
  4. Semplici F, Mondragon A, Macintyre B, Madeyski Bengston K, Persson Kry A, Barr S, et al. Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production. Diabetologia. 2016;59:1938-47 pubmed publisher
    Per-Arnt-Sim kinase (PASK) is a nutrient-regulated domain-containing protein kinase previously implicated in the control of insulin gene expression and glucagon secretion...
  5. Kikani C, Wu X, Paul L, Sabic H, Shen Z, Shakya A, et al. Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis. elife. 2016;5: pubmed publisher
    PAS domain containing protein kinase (Pask) is an evolutionarily conserved protein kinase implicated in energy homeostasis and metabolic regulation across eukaryotic species...
  6. Wu X, ROMERO D, Swiatek W, Dorweiler I, Kikani C, Sabic H, et al. PAS kinase drives lipogenesis through SREBP-1 maturation. Cell Rep. 2014;8:242-55 pubmed publisher
    ..Here, we show that feeding and insulin stimulate the hepatic expression of PASK. We also demonstrate, using genetic and pharmacological approaches, that PASK is required for the proteolytic ..