PARP 3

Summary

Gene Symbol: PARP 3
Description: poly (ADP-ribose) polymerase family, member 3
Alias: A930002C11Rik, AW990611, Adprt3, Adprtl3, PARP-3, pADPRT-3, poly [ADP-ribose] polymerase 3, A DP-ribosyltransferase (NAD+; poly (ADP-ribose polymerase)-like 3, ADP-ribosyltransferase (NAD+, poly (ADP-ribose polymerase)-like 3, NAD+ ADP-ribosyltransferase 3, Poly[ADP-ribose] synthetase-3
Species: mouse
Products:     PARP 3

Top Publications

  1. Rulten S, Fisher A, Robert I, Zuma M, Rouleau M, Ju L, et al. PARP-3 and APLF function together to accelerate nonhomologous end-joining. Mol Cell. 2011;41:33-45 pubmed publisher
    ..These data identify molecular roles for PARP-3 and APLF in chromosomal DNA double-strand break repair reactions. ..
  2. Robert I, Gaudot L, Rogier M, Heyer V, Noll A, Dantzer F, et al. Parp3 negatively regulates immunoglobulin class switch recombination. PLoS Genet. 2015;11:e1005240 pubmed publisher
    ..We propose that Parp3 plays a CSR-specific role by controlling AID levels at switch regions during CSR. ..
  3. Urbanek P, Paces J, Kralova J, Dvorak M, Paces V. Cloning and expression of PARP-3 (Adprt3) and U3-55k, two genes closely linked on mouse chromosome 9. Folia Biol (Praha). 2002;48:182-91 pubmed
    ..We cloned and sequenced the cDNAs of the mouse PARP-3 (Adprt3) gene encoding poly(ADP-ribose) polymerase 3 and of the closely linked U3-55k gene coding for the U3 small ..
  4. Boehler C, Gauthier L, Mortusewicz O, Biard D, Saliou J, Bresson A, et al. Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression. Proc Natl Acad Sci U S A. 2011;108:2783-8 pubmed publisher
    ..Both functions open stimulating prospects for specifically targeting PARP3 in cancer therapy. ..