Genomes and Genes
Gene Symbol: Park7
Description: Parkinson disease (autosomal recessive, early onset) 7
Alias: DJ-1, Dj1, protein DJ-1, RNA-binding protein regulatory subunit, parkinson disease protein 7 homolog, protein deglycase DJ-1
- DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with rasD Nagakubo
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
Biochem Biophys Res Commun 231:509-13. 1997..Moreover, DJ-1 translocated from cytoplasm to nuclei in the S phase of the cell cycle. DJ-1 is thus suggested to be a novel mitogen-dependent oncogene product involved in a Ras-related signal transduction pathway...
- DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2Casey M Clements
Department of Microbiology Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7295, USA
Proc Natl Acad Sci U S A 103:15091-6. 2006DJ-1/PARK7, a cancer- and Parkinson's disease (PD)-associated protein, protects cells from toxic stresses. However, the functional basis of this protection has remained elusive...
- DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenoneSteven J Mullett
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA
Neurobiol Dis 33:28-36. 2009..Our findings support the developing view that astrocytic dysfunction, in addition to neuronal dysfunction, may contribute to the progression of a variety of neurodegenerative disorders...
- Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1Jens Waak
Laboratory of Functional Neurogenetics, Dept of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Otfried Müller Str 27, 72076 Tubingen, Germany
FASEB J 23:2478-89. 2009..These findings identify DJ-1 as a regulator of proinflammatory responses and suggest that loss of DJ-1 contributes to PD pathogenesis by deregulation of astrocytic neuroinflammatory damage...
- Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1Jens Waak
Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Tubingen 72076, Germany
J Biol Chem 284:14245-57. 2009..We suggest that impairments in oxidative conformation changes of DJ-1 might contribute to PD neurodegeneration...
- DJ-1 forms complexes with mutant SOD1 and ameliorates its toxicitySatoshi Yamashita
Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto, Japan
J Neurochem 113:860-70. 2010..DJ-1 - a causative agent of familial Parkinson's disease PARK7 - is responsible for inducing antioxidative reaction...
- DJ-1 protects against dopamine toxicityNirit Lev
Department of Neurology, Felsenstein Medical Research Centre, Rabin Medical Centre, Tel Aviv University, Petah Tikva, Israel
J Neural Transm (Vienna) 116:151-60. 2009..This mechanism elucidates how mutations in DJ-1 prompt PD and imply that modulation of DJ-1 may serve as a novel neuroprotective modality...
- Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetesDeepak Jain
Institute of Metabolic Physiology, Heinrich Heine University, D 40225 Dusseldorf, Germany
J Mol Cell Biol 4:221-30. 2012..Our data suggest that DJ-1 is more generally involved in age- and lifestyle-related human diseases and show for the first time that DJ-1 plays a key role in glucose homeostasis and might serve as a novel drug target for T2DM...
- DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responsesSophie Vasseur
Institut National de la Santé et de la Recherche Médicale Unité 624, Stress Cellulaire, 163 Avenue de Luminy, Case 915, Parc Scientifique et Technologique de Luminy, 13288 Marseille Cedex 9, France
Proc Natl Acad Sci U S A 106:1111-6. 2009In cancer, DJ-1/PARK7 acts as an oncogene that drives Akt-mediated cell survival...
- DJ-1 deficiency perturbs microtubule dynamics and impairs striatal neurite outgrowthChengyu Sheng
Laboratory of Neurodegenerative Diseases, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Science and Shanghai Jiaotong University School of Medicine, Shanghai, PR China
Neurobiol Aging 34:489-98. 2013..Our results revealed a novel role of DJ-1 in the regulation of microtubule dynamics and suggested that striatal impairments may also play an important role as loss of DA neurons in the pathogenesis of PD...
- DJ-1 induces thioredoxin 1 expression through the Nrf2 pathwayJoo Young Im
Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Hum Mol Genet 21:3013-24. 2012..These findings provide a new mechanism to support the antioxidant function of DJ-1 by increasing Trx1 expression via Nrf2-mediated transcriptional induction...
- DJ-1 mRNA anatomical localization and cell type identification in the mouse brainZhiguo Xie
State Key Laboratory of Medical Genetics of China, Xiangya Hospital, Central South University, Changsha, Hunan, China
Neurosci Lett 465:214-9. 2009....
- DJ-1 binds to mitochondrial complex I and maintains its activityTakuya Hayashi
Graduate School of Agriculture, Hokkaido University, Sapporo 060 8589, Japan
Biochem Biophys Res Commun 390:667-72. 2009..DJ-1, a causative gene product of a familial form of Parkinson's disease, PARK7, plays roles in transcriptional regulation and anti-oxidative stress...
- Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTENYun chul Kim
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
Int J Oncol 35:1331-41. 2009..These results suggest that the oxidative status of DJ-1 regulates PTEN activity, leading to cell proliferation and transformation...
- DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairmentsT T Pham
Institute of Developmental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstaedter, Neuherberg, Germany
Genes Brain Behav 9:305-17. 2010Loss of function of DJ-1 (PARK7) is associated with autosomal recessive early-onset Parkinson's disease (PD), one of the major age-related neurological diseases...
- DJ-1 null dopaminergic neuronal cells exhibit defects in mitochondrial function and structure: involvement of mitochondrial complex I assemblyJun Young Heo
Department of Biochemistry, Chungnam National University School of Medicine, Daejeon, Korea
PLoS ONE 7:e32629. 2012..These mitochondrial defects induced by DJ-1mutation may be a pathological mechanism for the degeneration of dopaminergic neurons in Parkinson's disease...
- DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathwayHossein Aleyasin
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada
Proc Natl Acad Sci U S A 107:3186-91. 2010Loss-of-function DJ-1 (PARK7) mutations have been linked with a familial form of early onset Parkinson disease. Numerous studies have supported the role of DJ-1 in neuronal survival and function...
- Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1Guido Krebiehl
Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
PLoS ONE 5:e9367. 2010..Although a critical role of DJ-1 in oxidative stress response and mitochondrial function has been recognized, the effects on mitochondrial dynamics and downstream consequences remain to be determined...
- Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavageJue Chen
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322 3090, USA
Hum Mol Genet 19:2395-408. 2010..Our findings support a role for DJ-1 protease in cellular defense against oxidative stress and have important implications for understanding and treating PD...
- DJ-1 knock-down impairs astrocyte mitochondrial functionN J Larsen
Department of Neurology, Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Neuroscience 196:251-64. 2011....
- DJ-1 protects against oxidative damage by regulating the thioredoxin/ASK1 complexJoo Young Im
Center for Neurodegenerative and Neuroimmunologic Diseases, Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
Neurosci Res 67:203-8. 2010..These findings point to yet another mechanism through which DJ-1 has anti-oxidant and cytoprotective properties by regulating the Trx1/ASK1 complex and controlling the availability of ASK1 to effect apoptosis...
- DJ-1 associates with synaptic membranesYukiko Usami
Department of Neurology, Juntendo University School of Medicine, Japan
Neurobiol Dis 43:651-62. 2011..DJ-1 is a causative gene for autosomal recessive form of PARK7-linked early-onset PD...
- DJ-1 is critical for mitochondrial function and rescues PINK1 loss of functionLing Yang Hao
Department of Biology, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 107:9747-52. 2010Mutations or deletions in PARKIN/PARK2, PINK1/PARK6, and DJ-1/PARK7 lead to autosomal recessive parkinsonism. In Drosophila, deletions in parkin and pink1 result in swollen and dysfunctional mitochondria in energy-demanding tissues...
- Protection of pancreatic beta-cells from various stress conditions is mediated by DJ-1Alex Inberg
Department of Biological Chemistry, Hebrew University of Jerusalem, Jerusalem 91904, Israel
J Biol Chem 285:25686-98. 2010..DJ-1 (park7) is a multifunctional protein implicated in familial Parkinsonism and neuroprotection in response to oxidative ..
- Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamicsI Irrcher
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada
Hum Mol Genet 19:3734-46. 2010..DJ-1 (PARK7) is a recently identified recessive familial PD gene...
- Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animalsYoko Ogawa Akazawa
Health Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka, Japan
Neurosci Lett 483:201-5. 2010..These results suggest that the oxidative modification of DJ-1 in the brain and erythrocytes is involved in the pathogenesis of PD in animal models...
- DJ-1, an oncogene and causative gene for familial Parkinson's disease, is essential for SV40 transformation in mouse fibroblasts through up-regulation of c-MycYun chul Kim
Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo, Japan
FEBS Lett 584:3891-5. 2010..We also found that DJ-1 directly bound to LT and that the expression level of c-Myc in transformed cells was parallel to that of DJ-1. These findings indicate that DJ-1 is essential for SV40 transformation...
- DJ-1 mediates paraquat-induced dopaminergic neuronal cell deathHyun Joo Kwon
Department of Biochemistry, School of Medicine, Chungnam National University, Daejeon, South Korea
Toxicol Lett 202:85-92. 2011..In summary, our results suggest that DJ-1 is critical to maintain mitochondrial complex I and complex I could be a key target in interaction of paraquat toxicity and DJ-1 for giving rise to PD...
- DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagyKelly Jean Thomas
Laboratory of Neurogenetics, National Institute on Aging, Flow Cytometry Core Facility, National Institutes of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20982 3707, USA
Hum Mol Genet 20:40-50. 2011..None of the three proteins complex together using size exclusion chromatography. These data suggest that DJ-1 works in parallel to the PINK1/parkin pathway to maintain mitochondrial function in the presence of an oxidative environment...
- DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaBR Sean McNally
Department of Microbiology Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
J Biol Chem 286:4098-106. 2011Heightened DJ-1 (Park7) expression is associated with a reduction in chemotherapeutic-induced cell death and poor prognosis in several cancers, whereas the loss of DJ-1 function is found in a subgroup of Parkinson disease associated with ..
- Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1Jaime N Guzman
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Nature 468:696-700. 2010..Knocking out DJ-1 (also known as PARK7 in humans and Park7 in mice), which is a gene associated with an early-onset form of Parkinson's disease, ..
- Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivoFilio Billia
Campbell Family Cancer Research Institute, Princess Margaret Hospital, Toronto, ON, Canada M5G 2M9
Proc Natl Acad Sci U S A 110:6085-90. 2013..Our results provide compelling in vivo evidence that DJ-1 is a unique and nonredundant antioxidant that functions independent of other antioxidative pathways in the cellular defense against ROS...
- DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxinA Mitsumoto
School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan
Free Radic Res 35:885-93. 2001..8 might increase in response to endogenously produced ROS, probably due to activation of NADPH oxidase, and imply that DJ-1 may be useful as an endogenous indicator of oxidative stress status in vivo...
- DJ-1 modulates aggregation and pathogenesis in models of Huntington's diseaseMuhammad U Sajjad
Neuroscience Group, Centre for Biological Sciences, University of Southampton, Basset Crescent East, Southampton, UK
Hum Mol Genet 23:755-66. 2014..Our findings clearly establish DJ-1 as a potential therapeutic target for HD and provide the basis for further studies into the role of DJ-1 in protein misfolding diseases. ..
- Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonismVincenzo Bonifati
Genetic Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands
Science 299:256-9. 2003The DJ-1 gene encodes a ubiquitous, highly conserved protein. Here, we show that DJ-1 mutations are associated with PARK7, a monogenic form of human parkinsonism...
- DJ-1 facilitates the interaction between STAT1 and its phosphatase, SHP-1, in brain microglia and astrocytes: A novel anti-inflammatory function of DJ-1Jong Hyeon Kim
Neuroscience Graduate Program, Ajou University School of Medicine, Suwon 442 721, Republic of Korea National Research Lab of Brain Inflammation, Ajou University School of Medicine, Suwon 442 721, Republic of Korea Department of Pharmacology, Ajou University School of Medicine, Suwon 442 721, Republic of Korea Chronic Inflammatory Disease Research Center, Ajou University School of Medicine, Suwon 442 721, Republic of Korea
Neurobiol Dis 60:1-10. 2013..In this study, we demonstrate a novel mechanism by which DJ-1 (PARK7), an early onset autosomal-recessive PD gene, negatively regulates inflammatory responses of astrocytes and ..
- Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibitionTakanori Yokota
Department of Neurology and Neurological Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, 113 8519, Tokyo, Japan
Biochem Biophys Res Commun 312:1342-8. 2003..These results suggest that loss of protective activity of DJ-1 from neuro-toxicity induced by these stresses contributes to neuronal cell death in AR-EOP with mutant DJ-1...
- Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary ParkinsonismCecile Martinat
Department of Pathology, Center for Neurobiology and Behavior, and Taub Institute, Columbia University, New York, New York, USA
PLoS Biol 2:e327. 2004..These data are consistent with a protective role for DJ-1, and demonstrate the utility of genetically modified embryonic stem cell-derived neurons as cellular models of neuronal disorders...
- Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stressRaymond H Kim
Campbell Family Institute for Breast Cancer Research, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1
Proc Natl Acad Sci U S A 102:5215-20. 2005Mutations of the DJ-1 (PARK7) gene are linked to familial Parkinson's disease. We used gene targeting to generate DJ-1-deficient mice that were viable, fertile, and showed no gross anatomical or neuronal abnormalities...
- Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null miceLinan Chen
Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 280:21418-26. 2005..These data represent the in vivo evidence that loss of DJ-1 function alters nigrostriatal dopaminergic function and produces motor deficits...
- Analysis of inflammation-related nigral degeneration and locomotor function in DJ-1(-/-) miceThi A Nguyen
Department of Physiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
J Neuroinflammation 10:50. 2013....
- Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesisLi Zhang
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Hum Mol Genet 14:2063-73. 2005..Our findings of DJ-1's mitochondrial localization may have important implications for understanding the pathogenesis of PD...
- Expression profiles of genes in DJ-1-knockdown and L 166 P DJ-1 mutant cellsHiromi Nishinaga
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
Neurosci Lett 390:54-9. 2005..These findings suggest that DJ-1 regulates expressions of genes for which functions are thought to be related to cell death or neurodegeneration...
- Evidence of oxidative stress in young and aged DJ-1-deficient miceArjun V Raman
The Parkinson s Institute, Department of Basic Research, Sunnyvale, CA, USA
FEBS Lett 587:1562-70. 2013..These changes were concomitant with increased striatal dopamine levels and uptake. Thus, increased oxidants and diminished protein quality control may contribute to nigral oxidative damage with aging in the model...
- Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasisShiori Yamaguchi
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
PLoS ONE 7:e38144. 2012DJ-1 is a novel oncogene and also causative gene for familial Parkinson's disease park7. DJ-1 has multiple functions that include transcriptional regulation, anti-oxidative reaction and chaperone and mitochondrial regulation...
- Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1Karin Görner
Laboratory of Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Ludwig Maximilians University of Munich, 80336 Munich, Germany
J Biol Chem 282:13680-91. 2007Mutations in the PARK7 gene encoding DJ-1 cause autosomal recessive Parkinson disease...
- Increased vulnerability of nigrostriatal terminals in DJ-1-deficient mice is mediated by the dopamine transporterAmy B Manning-Bog
Department of Basic Research, The Parkinson s Institute, 1170 Morse Avenue, Sunnyvale, CA 94089, USA
Neurobiol Dis 27:141-50. 2007..control striatum. Thus, under null DJ-1 conditions, DAT changes likely contribute to altered DA neurotransmission and enhanced sensitivity to toxins that utilize DAT for nigrostriatal entry...
- Oxidized DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent mannerIzumi Kato
Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita ku, Sapporo, Japan
Mol Cell Biol 33:340-59. 2013..These results indicate that DJ-1 inhibits the expression of p53 target genes and depend on p53 DNA-binding affinity and oxidation of DJ-1 C106...
- DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidaseEva Andres-Mateos
Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 North Broadway, Suite 731, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 104:14807-12. 2007..Taken together these data indicate that the DJ-1 KO mice have a deficit in scavenging mitochondrial H(2)O(2) due to the physiological function of DJ-1 as an atypical peroxiredoxin-like peroxidase...
- Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient miceWonsuk Yang
Department of Neurology, The University of Chicago, IL 60637, USA
Hum Mol Genet 16:2900-10. 2007..In conclusion, this study raises the possibility that environmental and genetic factors might cooperatively involve the mechanisms underlying proteasome impairment in PD brains...
- DJ-1 expression modulates astrocyte-mediated protection against neuronal oxidative stressSteven J Mullett
Department of Neurology and Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Mol Neurosci 49:507-11. 2013DJ-1 deficiency is a cause of genetic Parkinson's disease (PARK7 PD). In sporadic Parkinson's disease (PD), however, DJ-1 is abundantly expressed in reactive astrocytes. This may represent a compensatory protective response...
- The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damageHossein Aleyasin
Ottawa Health Research Institute, Neuroscience Group, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada K1H 8M5
Proc Natl Acad Sci U S A 104:18748-53. 2007..DJ-1 (PARK7) has been identified as the gene linked to early-onset familial Parkinson's disease...
- Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal functionJayanth S Chandran
Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A116, MSC 3707, 35 Convent Drive, Bethesda, MD 20892, USA
Neurobiol Dis 29:505-14. 2008..Taken together, our findings suggest that loss of DJ-1 leads to progressive behavioral changes without significant alterations in nigrostriatal dopaminergic and spinal motor systems...
- Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson diseaseMaxime W C Rousseaux
Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada
Proc Natl Acad Sci U S A 109:15918-23. 2012DJ-1 mutations cause autosomal recessive early-onset Parkinson disease (PD). We report a model of PD pathology: the DJ1-C57 mouse...
- RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathwaysMarcel P van der Brug
Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, 35 Convent Drive, Bethesda, MD 20892 3707, USA
Proc Natl Acad Sci U S A 105:10244-9. 2008..These data implicate a single mechanism for the pleiotropic effects of DJ-1 in different model systems, namely that the protein binds multiple RNA targets in an oxidation-dependent manner...
- Loss of DJ-1 does not affect mitochondrial respiration but increases ROS production and mitochondrial permeability transition pore openingEmilie Giaime
Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 7:e40501. 2012..Although it has been reported that DJ-1 serves as scavenger for reactive oxidative species (ROS) by oxidation on its cysteine residues, how loss of DJ-1 affects mitochondrial function is less clear...
- Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1Matthew S Goldberg
Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
Neuron 45:489-96. 2005..Furthermore, DJ-1(-/-) mice displayed hypoactivity in the open field. Collectively, our findings suggest an essential role for DJ-1 in dopaminergic physiology and D2 receptor-mediated functions...
- Loss of DJ-1 protein stability and cytoprotective function by Parkinson's disease-associated proline-158 deletionEmmy H Rannikko
Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, Faculty of Medicine, University of Tubingen, Germany
J Neurochem 125:314-27. 2013DJ-1 is a ubiquitous protein regulating cellular viability. Recessive mutations in the PARK7/DJ-1 gene are linked to Parkinson's disease (PD)...
- The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS productionG Robert
INSERM U1065, Team 2 Morts Cellulaires, Differentiation et Cancer, Nice, France
Cell Death Differ 19:1769-78. 2012..Taken together, our findings identify an original pathway by which generation of a nuclear fragment of DJ-1 through caspase 6-mediated cleavage induces ROS-dependent amplification of apoptosis...
- Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthaseJavier Sanchez-Padilla
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Nat Neurosci 17:832-40. 2014..Oxidant stress was also increased in an animal model of PD. Thus, our results point to activity-dependent Ca(2+) entry and a resulting mitochondrial oxidant stress as factors contributing to the vulnerability of LC neurons. ..
- Effects of prednisolone on the dystrophin-associated proteins in the blood-brain barrier and skeletal muscle of dystrophic mdx miceRoberto Tamma
Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
Lab Invest 93:592-610. 2013..Our results suggest a novel mechanism for PDN action on cerebral and muscular function, restoring the link between DAPs and the extracellular matrix, most likely through protein kinase inactivation...
- Mutations in DMRT3 affect locomotion in horses and spinal circuit function in miceLisa S Andersson
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, SE 75124 Uppsala, Sweden
Nature 488:642-6. 2012..The DMRT3 mutation has had a major effect on the diversification of the domestic horse, as the altered gait characteristics of a number of breeds apparently require this mutation...
- Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson's diseaseJoshua A Goldberg
Department of Physiology, Feinberg School of Medicine, Northwestern University Chicago, Illinois, USA
Nat Neurosci 15:1414-21. 2012..Knocking out DJ-1 (also known as PARK7), a gene associated with early-onset Parkinson's disease, exacerbated this stress...
- DJ-1 regulates mast cell activation and IgE-mediated allergic responsesDo Kyun Kim
Department of Immunology and Physiology, Functional Genomics Institute, College of Medicine, Konkuk University, Chungju, Korea
J Allergy Clin Immunol 131:1653-62. 2013..DJ-1 is an antioxidant protein known to reduce levels of reactive oxygen species (ROS), but its presence or function in mast cells and allergic diseases is unknown...
- Human DJ-1 and its homologs are novel glyoxalasesJu Young Lee
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yuseong Gu, Daejeon 305 701, Republic of Korea
Hum Mol Genet 21:3215-25. 2012..elegans lacking cDJR-1.2, another DJ-1 homolog expressed primarily in the head region, including neurons. Our findings that DJ-1 serves as scavengers for reactive carbonyl species may provide a new insight into the causation of PD...
- Transduced Tat-DJ-1 protein protects against oxidative stress-induced SH-SY5Y cell death and Parkinson disease in a mouse modelHoon Jae Jeong
Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chunchon 200 702, Korea
Mol Cells 33:471-8. 2012..These results suggest that Tat-DJ-1 protein provides a potential therapeutic strategy for against ROS related human diseases including PD...
- DJ-1 promotes the proteasomal degradation of Fis1: implications of DJ-1 in neuronal protectionQiang Zhang
State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
Biochem J 447:261-9. 2012Mutations in DJ-1/PARK7 (Parkinson protein 7) have been identified as a cause of autosomal-recessive PD (Parkinson's disease) and the antioxidant property of DJ-1 has been shown to be involved in the regulation of mitochondrial function ..
- The antioxidant Trolox helps recovery from the familial Parkinson's disease-specific mitochondrial deficits caused by PINK1- and DJ-1-deficiency in dopaminergic neuronal cellsJung Hee Shim
Department of Brain and Cognitive Sciences, College of Pharmacy, Brain Disease Research Institute, Ewha Womans University, Seoul, South Korea
Mitochondrion 11:707-15. 2011..These data suggest that mitochondrial deficits are severe in dopaminergic neurons in familial PD and antioxidant-mediated functional recovery is feasible...
- Monomer DJ-1 and its N-terminal sequence are necessary for mitochondrial localization of DJ-1 mutantsChinatsu Maita
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
PLoS ONE 8:e54087. 2013DJ-1 is a novel oncogene and also a causative gene for familial Parkinson's disease (park7). DJ-1 has multiple functions that include transcriptional regulation, anti-oxidative reaction and chaperone and mitochondrial regulation...
- Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient miceHiroo Yamaguchi
Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA, 02115, USA
Mol Neurodegener 2:10. 2007..Together, these results indicate that loss of DJ-1 function alone is insufficient to cause nigral degeneration and oxidative damage in the life span of mice...
- DJ-1 is essential for long-term depression at hippocampal CA1 synapsesYue Wang
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
Neuromolecular Med 10:40-5. 2008..The dopamine receptor D2/3 agonist quinpirole rescued LTD in DJ-1-/- mice, suggesting a role for impaired dopaminergic signaling in the hippocampal LTD deficit...
- Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6James A Olzmann
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
J Cell Biol 178:1025-38. 2007....
- DJ-1 and UCH-L1 gene activity patterns in the brains of controls, Parkinson and schizophrenia patients and in rodentsDagmar Galter
Karolinska Institutet, Department of Neuroscience, Retzius väg 8 B2 4, S 171 77 Stockholm, Sweden
Physiol Behav 92:46-53. 2007DJ-1 (PARK7) has been implicated in early onset and familial cases of Parkinson's disease (PD). We therefore mapped cellular activity patterns of the DJ-1 gene in human and rodent brain tissue with radioactive in-situ hybridization...
- DJ-1 changes in G93A-SOD1 transgenic mice: implications for oxidative stress in ALSNirit Lev
Laboratory of Neurosciences, Felsenstein Medical Research Center and Department of Neurology, Rabin Medical Center Beilinson Campus, The Sackler School of Medicine, Tel Aviv University, Petah Tikva, 49100, Israel
J Mol Neurosci 38:94-102. 2009..This is the first report of possible involvement of DJ-1 in ALS. Since DJ-1 has a protective role against oxidative stress, it may suggest a possible therapeutic target in ALS...
- Experimental encephalomyelitis induces changes in DJ-1: implications for oxidative stress in multiple sclerosisNirit Lev
Laboratory of Neuroscience and Department of Neurology, FMRC, Rabin Medical Center, Tel Aviv University, Petah Tikva, Israel
Antioxid Redox Signal 8:1987-95. 2006..In view of the accumulating evidence on the central role of oxidative stress in MS, and the importance of DJ-1 in oxidative stress management by the CNS, we believe that DJ-1 will be found to have a central role in MS...
- Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPaseA Pisani
Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Roma, Italy
Neurobiol Dis 23:54-60. 2006..These findings suggest that DJ-1 loss-of-function enhances vulnerability to energy metabolism alterations, and that nigral neurons are particularly sensitive to Na+/K+ ATPase impairment...
- Expression of DJ-1 in the adult mouse CNSVerian Bader
Department of Animal Physiology, Ruhr University of Bochum, D 44780 Bochum, Germany
Brain Res 1041:102-11. 2005..The high expression of DJ-1 in neuronal and glial cells, that is not confined to a single functional system or any anatomical area, supports the view of a basic physiological role in cell biology...
- Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson's diseaseChristopher M Morris
MRC Building, Institute for the Health of the Elderly, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
Neurosci Lett 352:151-3. 2003..The DJ-1 gene does not appear to be a significant risk factor for late onset Lewy body disease in this population...
- DJ-1, a target protein for an endocrine disrupter, participates in the fertilization in miceMasahiko Okada
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
Biol Pharm Bull 25:853-6. 2002....
- Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoterT Taira
Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
Gene 263:285-92. 2001....
- SOBP is mutated in syndromic and nonsyndromic intellectual disability and is highly expressed in the brain limbic systemEfrat Birk
Tel Aviv University, Israel
Am J Hum Genet 87:694-700. 2010..5-fold differences in expression, including two interacting proteins, dynamin and pacsin1. This study shows mutated SOBP involvement in syndromic and nonsyndromic ID with psychosis in humans...
- Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytesAmanda K Ashley
Cell and Molecular Biology Graduate Program, Colorado State University, Fort Collins, CO 80523, United States
Toxicol Lett 184:186-91. 2009..Our DJ-1 knockout mouse provides an exciting tool for exploring the molecular and physiological roles of DJ-1 to further explicate its functions in neurodegeneration...
- Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradationHui Xiong
Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
J Clin Invest 119:650-60. 2009....
- Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6E Giaime
Institut de Neuromédecine Moléculaire IN2M and Institut de Pharmacologie Moléculaire et Cellulaire, UMR6097 CNRS UNSA, Equipe labellisée Fondation pour la Recherche Médicale, 06560, Sophia Antipolis, Valbonne, France
Cell Death Differ 17:158-69. 2010..Therefore, we show here that DJ-1 loss of function could be due to impaired caspase-6 proteolysis and we document the fact that various DJ-1 mutations could lead to PD pathology through distinct molecular mechanisms...
- Altered Ca2+ homeostasis in the skeletal muscle of DJ-1 null miceAlexander Shtifman
Department of Neurology, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, 736 Cambridge St, CBR 406, Boston, MA 02135, USA
Neurobiol Aging 32:125-32. 2011..These results provide evidence of DJ-1's association with Ca(2+) regulatory pathways in mouse skeletal muscle, and suggest the potential benefit of resveratrol to functionally compensate for the loss of DJ-1...
- DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicityChenere P Ramsey
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6084, USA
Hum Mol Genet 19:1425-37. 2010..Mutations in the gene, PARK7, which encodes DJ-1, can cause autosomal recessive early-onset PD...
- Keap1-Nrf2 activation in the presence and absence of DJ-1Li Gan
School of Pharmacy, 6125 Rennebohm Hall, University of Wisconsin Madison, Madison, WI 53705 2222, USA
Eur J Neurosci 31:967-77. 2010..Deletion and mutations of DJ-1 (PARK7) have been reported to cause autosomal recessive familial Parkinson's disease...
- Choice of biological source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90Christiane B Knobbe
Campbell Family Institute for Breast Cancer Research, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 2C1, Canada
J Proteome Res 10:4388-404. 2011....
- Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neuronsLiviu Aron
Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Martinsried, Germany
PLoS Biol 8:e1000349. 2010..A better understanding of the molecular connections between trophic signaling, cellular stress and aging could uncover new targets for drug development in PD...
- Multiple coregulatory control of tyrosine hydroxylase gene transcriptionSirigiri Divijendra Natha Reddy
Department of Biochemistry and Molecular Biology and Institute of Coregulator Biology, George Washington University Medical Center, Washington, DC 20037, USA
Proc Natl Acad Sci U S A 108:4200-5. 2011..MTA1 physically achieves these functions by interacting directly with DJ1 (Parkinson disease 7) and in turn recruits the DJ1/MTA1/RNA polymerase II complex to the bicoid binding element (..
- The familial Parkinson's disease gene DJ-1 (PARK7) is expressed in red cells and plays a role in protection against oxidative damageXiuling Xu
Department of Molecular and Experimental Medicine, The Scripps Research Institute La Jolla, California 92037, USA
Blood Cells Mol Dis 45:227-32. 2010..expression profiling of normal and SOD2 deficient erythroblasts identified the Parkinson's disease locus DJ-1 (Park7) as a differentially expressed transcript...
- Altered profile and D2-dopamine receptor modulation of high voltage-activated calcium current in striatal medium spiny neurons from animal models of Parkinson's diseaseG Martella
Department of Neuroscience, University Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Neuroscience 177:240-51. 2011..These results demonstrate that both dopamine depletion and DJ-1 deletion induce a rearrangement in the HVA Ca2+ channel profile, specifically involving those channels that are selectively modulated by D2 receptors...
- DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell deathDong Hee Choi
Neurology Neuroscience Department, Weill Medical College of Cornell University, New York, New York, USA
Antioxid Redox Signal 14:2137-50. 2011..Our data suggest that DJ-1 is fragmented by the intracellular MMP3 in response to cell stress, abolishing the protective role of DJ-1 against oxidative damage, and this contributes to the pathogenesis of PD...
- The E163K DJ-1 mutant shows specific antioxidant deficiencyChenere P Ramsey
Department of Pharmacology, University of Pennsylvania School of Medicine, 125 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
Brain Res 1239:1-11. 2008..These findings suggest that DJ-1 influences several neuroprotective pathways and that the E163K mutation impairs the mechanism that is more specific to oxidative stress...
- Intramolecular Regulation of Ryanodine ReceptorsAlexander Shtifman; Fiscal Year: 2004..This work will provide novel information needed to better understand the process of EC coupling and also may shed new light on the nature of muscle disorders such as malignant hyperthermia. ..