Pard6b

Summary

Gene Symbol: Pard6b
Description: par-6 family cell polarity regulator beta
Alias: AV025615, Par6b, partitioning defective 6 homolog beta, PAR-6 beta, PAR-6B, par-6 (partitioning defective 6) homolog beta, partitioning-defective protein 6, beta
Species: mouse
Products:     Pard6b

Top Publications

  1. Imai F, Hirai S, Akimoto K, Koyama H, Miyata T, Ogawa M, et al. Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex. Development. 2006;133:1735-44 pubmed
    ..Therefore, we concluded that, at least in the later stages of neurogenesis, regulation of cell cycle exit is independent of adherens junctions. ..
  2. Alarcon V. Cell polarity regulator PARD6B is essential for trophectoderm formation in the preimplantation mouse embryo. Biol Reprod. 2010;83:347-58 pubmed publisher
    ..Here, the role of mouse Pard6b, a homolog of par-6 gene and a component of the PAR-atypical protein kinase C (aPKC) complex, was investigated...
  3. Hirose T, Karasawa M, Sugitani Y, Fujisawa M, Akimoto K, Ohno S, et al. PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development. 2006;133:1389-98 pubmed
    ..These results also provide a clear example of the proper organization of epithelial tissues through the regulation of individual cell polarity. ..
  4. Gao L, Joberty G, Macara I. Assembly of epithelial tight junctions is negatively regulated by Par6. Curr Biol. 2002;12:221-5 pubmed
    ..These results suggest that Cdc42 and Par6 negatively regulate TJ assembly in mammalian epithelial cells. ..
  5. Hartleben B, Schweizer H, Lübben P, Bartram M, Möller C, Herr R, et al. Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. J Biol Chem. 2008;283:23033-8 pubmed publisher
  6. Vinot S, Le T, Maro B, Louvet Vallee S. Two PAR6 proteins become asymmetrically localized during establishment of polarity in mouse oocytes. Curr Biol. 2004;14:520-5 pubmed
    ..mPARD6b is the first identified protein to localize to the animal pole of the mouse oocyte and likely contributes to the polarization of the cortex. ..
  7. Cui X, Li X, Shen X, Bae Y, Kang J, Kim N. Transcription profile in mouse four-cell, morula, and blastocyst: Genes implicated in compaction and blastocoel formation. Mol Reprod Dev. 2007;74:133-43 pubmed
    ..The identification of the genes being expressed in here will provide insight into the complex gene regulatory networks effecting compaction and blastocoel formation...
  8. Gao L, Yang Z, Hiremath C, Zimmerman S, Long B, BRAKEMAN P, et al. Afadin orients cell division to position the tubule lumen in developing renal tubules. Development. 2017;144:3511-3520 pubmed publisher
    ..Together, these results support a model whereby afadin determines lumen placement by directing apical-basal spindle orientation, resulting in a continuous lumen and normal tubule morphogenesis. ..
  9. Joberty G, Petersen C, Gao L, Macara I. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol. 2000;2:531-9 pubmed
    ..This assembly is implicated in the formation of normal tight junctions at epithelial cell-cell contacts. Thus, Par6 is a key adaptor that links Cdc42 and atypical PKCs to Par3. ..

More Information

Publications24

  1. Yamanaka T, Tosaki A, Kurosawa M, Akimoto K, Hirose T, Ohno S, et al. Loss of aPKC? in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brains. PLoS ONE. 2013;8:e84036 pubmed publisher
    ..Thus, despite the polarity complex disruption, neuronal deletion of aPKC? does not induce obvious cell loss or disorientation in mouse brains after cell differentiation. ..
  2. Ezan J, Lasvaux L, Gezer A, Novakovic A, May Simera H, Belotti E, et al. Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton. Nat Cell Biol. 2013;15:1107-15 pubmed publisher
    ..Thus G-protein-dependent signalling controls the migration of the cilium cell autonomously, whereas core PCP signalling controls long-range tissue PCP. ..
  3. Tao H, Inoue K, Kiyonari H, Bassuk A, Axelrod J, Sasaki H, et al. Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis. Dev Biol. 2012;364:138-48 pubmed publisher
    ..The cell polarity phenotype was efficiently rescued by nuclear but not cytoplasmic Pk2, demonstrating the nuclear localization of Pk2 is critical for its function. ..
  4. Manabe N, Hirai S, Imai F, Nakanishi H, Takai Y, Ohno S. Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells. Dev Dyn. 2002;225:61-9 pubmed
  5. Yang Z, Zimmerman S, Tsunezumi J, Braitsch C, Trent C, Bryant D, et al. Role of CD34 family members in lumen formation in the developing kidney. Dev Biol. 2016;418:66-74 pubmed publisher
  6. Plant P, Fawcett J, Lin D, Holdorf A, Binns K, Kulkarni S, et al. A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl. Nat Cell Biol. 2003;5:301-8 pubmed
  7. Hurd T, Gao L, Roh M, Macara I, Margolis B. Direct interaction of two polarity complexes implicated in epithelial tight junction assembly. Nat Cell Biol. 2003;5:137-42 pubmed
    ..Our data highlight a previously unrecognized link between protein complexes that are essential for epithelial polarity and formation of tight junctions. ..
  8. Vinot S, Le T, Ohno S, Pawson T, Maro B, Louvet Vallee S. Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction. Dev Biol. 2005;282:307-19 pubmed
    ..During the first embryonic cleavages, before compaction, PARD6b and EMK1 are observed on the spindle...
  9. Jin D, Durgan J, Hall A. Functional cross-talk between Cdc42 and two downstream targets, Par6B and PAK4. Biochem J. 2015;467:293-302 pubmed publisher
    ..We show in the present paper that PAK4 phosphorylates Par6B at Ser143 blocking its interaction with Cdc42...
  10. Korotkevich E, Niwayama R, Courtois A, Friese S, Berger N, Buchholz F, et al. The Apical Domain Is Required and Sufficient for the First Lineage Segregation in the Mouse Embryo. Dev Cell. 2017;40:235-247.e7 pubmed publisher
    ..Thus, we provide mechanistic understanding that reconciles previous models for symmetry breaking in mouse development. ..
  11. Challen G, Gardiner B, Caruana G, Kostoulias X, Martinez G, Crowe M, et al. Temporal and spatial transcriptional programs in murine kidney development. Physiol Genomics. 2005;23:159-71 pubmed
  12. Wang Q, Hurd T, Margolis B. Tight junction protein Par6 interacts with an evolutionarily conserved region in the amino terminus of PALS1/stardust. J Biol Chem. 2004;279:30715-21 pubmed
    ..Par6 interferes with PATJ in binding PALS1, and these two interactions do not appear to function synergistically. Taken together, these results define the molecular mechanisms linking two conserved polarity complexes. ..
  13. Garrard S, Capaldo C, Gao L, Rosen M, Macara I, Tomchick D. Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6. EMBO J. 2003;22:1125-33 pubmed
    ..Nuclear magnetic resonance studies indicate that the semi-CRIB motif of Par6 is at least partially structured by the PDZ domain. The structure highlights a novel role for a PDZ domain as a structural scaffold. ..
  14. Lelli A, Michel V, Boutet de Monvel J, Cortese M, Bosch Grau M, Aghaie A, et al. Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth. J Cell Biol. 2016;212:231-44 pubmed publisher
  15. Lin D, Edwards A, Fawcett J, Mbamalu G, Scott J, Pawson T. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol. 2000;2:540-7 pubmed
    ..In vitro, mPAR-3 acts as a substrate and an inhibitor of aPKC. We conclude that mPAR-3 and mPAR-6 have a scaffolding function, coordinating the activities of several signalling proteins that are implicated in mammalian cell polarity. ..