Gene Symbol: Papss1
Description: 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Alias: AI325286, Asapk, SK1, bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1, PAPS synthase 1, PAPSS 1, SK 1, sulfurylase kinase 1
Li H, Deyrup A, Mensch J, Domowicz M, Konstantinidis A, Schwartz N. The isolation and characterization of cDNA encoding the mouse bifunctional ATP sulfurylase-adenosine 5'-phosphosulfate kinase. J Biol Chem. 1995;270:29453-9 pubmed
..Finally, recombinant enzyme expressed in COS-1 cells exhibited both ATP sulfurylase and APS kinase activity. ..
Deyrup A, Krishnan S, Cockburn B, Schwartz N. Deletion and site-directed mutagenesis of the ATP-binding motif (P-loop) in the bifunctional murine ATP-sulfurylase/adenosine 5'-phosphosulfate kinase enzyme. J Biol Chem. 1998;273:9450-6 pubmed
..A series of highly conserved flanking cysteines (Cys-53, Cys-77, and Cys-83) were mutated to alanine, but none of these mutations showed any effect on either enzyme activity. ..
Kurima K, Warman M, Krishnan S, Domowicz M, Krueger R, Deyrup A, et al
. A member of a family of sulfate-activating enzymes causes murine brachymorphism. Proc Natl Acad Sci U S A. 1998;95:8681-5 pubmed
..We conclude that a family of SK genes are responsible for sulfate activation in mammals, that a mutation in SK2 causes murine brachymorphism, and that members of this gene family have nonredundant, tissue-specific roles. ..
Xu Z, Otterness D, Freimuth R, Carlini E, Wood T, Mitchell S, et al
. Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization. Biochem Biophys Res Commun. 2000;268:437-44 pubmed
..PAPS is synthesized from ATP and inorganic sulfate by PAPS synthetase (PAPSS). Two separate PAPSS cDNAs, PAPSS1 and PAPSS2, have been identified in human tissues...
Singh B, Schwartz N. Identification and functional characterization of the novel BM-motif in the murine phosphoadenosine phosphosulfate (PAPS) synthetase. J Biol Chem. 2003;278:71-5 pubmed
..The complexity of the bifunctional SK in catalyzing the kinase reaction and channeling APS is illustrated by the strict requirements of this novel structural motif in the kinase active site. ..
Stelzer C, Brimmer A, Hermanns P, Zabel B, Dietz U. Expression profile of Papss2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) during cartilage formation and skeletal development in the mouse embryo. Dev Dyn. 2007;236:1313-8 pubmed
..Two major isoenzymes, PAPS synthase 1 (PAPSS1) and PAPS synthase 2 (PAPSS2) were identified in higher organisms for the synthesis of PAPS...
Capellini T, Dunn M, Passamaneck Y, Selleri L, Di Gregorio A. Conservation of notochord gene expression across chordates: insights from the Leprecan gene family. Genesis. 2008;46:683-96 pubmed publisher
..These results have interesting implications for the evolution and development of chordates...
Beccari T, Bibi L, Stinchi S, Stirling J, Orlacchio A. Mouse beta-mannosidase: cDNA cloning, expression, and chromosomal localization. Biosci Rep. 2001;21:315-23 pubmed
..The mouse beta-mannosidase gene (Bmn) was mapped to the distal end of Chromosome (Chr) 3, in a region that is homologous with a segment of human Chr 4 containing the orthologous human gene. ..