Gene Symbol: Panx3
Description: pannexin 3
Alias: 3230401P04, 4833413G11Rik, pannexin-3
Species: mouse
Products:     Panx3

Top Publications

  1. Penuela S, Bhalla R, Gong X, Cowan K, Celetti S, Cowan B, et al. Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins. J Cell Sci. 2007;120:3772-83 pubmed
    ..Localization of exogenously expressed pannexin 1 (Panx1) and pannexin 3 (Panx3), together with pharmacological studies, revealed a cell surface distribution profile and life cycle ..
  2. Wang X, Streeter M, Liu Y, Zhao H. Identification and characterization of pannexin expression in the mammalian cochlea. J Comp Neurol. 2009;512:336-46 pubmed publisher
    ..However, no overlapping labeling for Panx1 and Panx2 was observed. Finally, Panx3 labeling was exclusively observed in the cochlear bone...
  3. Iwamoto T, Nakamura T, Doyle A, Ishikawa M, de Vega S, Fukumoto S, et al. Pannexin 3 regulates intracellular ATP/cAMP levels and promotes chondrocyte differentiation. J Biol Chem. 2010;285:18948-58 pubmed publisher
    b>Pannexin 3 (Panx3) is a new member of the gap junction pannexin family, but its expression profiles and physiological function are not yet clear...
  4. Penuela S, Celetti S, Bhalla R, Shao Q, Laird D. Diverse subcellular distribution profiles of pannexin 1 and pannexin 3. Cell Commun Adhes. 2008;15:133-42 pubmed publisher
    ..Localization of untagged Panx1 and Panx3 exogenously expressed in five cultured cell lines revealed a cell surface distribution profile with limited ..
  5. Baranova A, Ivanov D, Petrash N, Pestova A, Skoblov M, Kelmanson I, et al. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. Genomics. 2004;83:706-16 pubmed
    We have cloned the genes PANX1, PANX2 and PANX3, encoding putative gap junction proteins homologous to invertebrate innexins, which constitute a new family of mammalian proteins called pannexins...
  6. Celetti S, Cowan K, Penuela S, Shao Q, Churko J, Laird D. Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation. J Cell Sci. 2010;123:1363-72 pubmed publisher
    Pannexin (Panx) 1 and Panx3 are integral membrane proteins that share some sequence homology with the innexin family of invertebrate gap junctions. They are expressed in mammalian skin...
  7. Penuela S, Bhalla R, Nag K, Laird D. Glycosylation regulates pannexin intermixing and cellular localization. Mol Biol Cell. 2009;20:4313-23 pubmed publisher
    The pannexin family of mammalian proteins, composed of Panx1, Panx2, and Panx3, has been postulated to be a new class of single-membrane channels with functional similarities to connexin gap junction proteins...
  8. Ishikawa M, Iwamoto T, Nakamura T, Doyle A, Fukumoto S, Yamada Y. Pannexin 3 functions as an ER Ca(2+) channel, hemichannel, and gap junction to promote osteoblast differentiation. J Cell Biol. 2011;193:1257-74 pubmed publisher
    ..However, the cellular functions of pannexins remain largely unknown. Here, we demonstrate that pannexin 3 (Panx3) promotes differentiation of osteoblasts and ex vivo growth of metatarsals...
  9. Ishikawa M, Williams G, Ikeuchi T, Sakai K, Fukumoto S, Yamada Y. Pannexin 3 and connexin 43 modulate skeletal development through their distinct functions and expression patterns. J Cell Sci. 2016;129:1018-30 pubmed publisher
    b>Pannexin 3 (Panx3) and connexin 43 (Cx43; also known as GJA1) are two major gap junction proteins expressed in osteoblasts...

More Information


  1. Iwamoto T, Nakamura T, Ishikawa M, Yoshizaki K, Sugimoto A, Ida Yonemochi H, et al. Pannexin 3 regulates proliferation and differentiation of odontoblasts via its hemichannel activities. PLoS ONE. 2017;12:e0177557 pubmed publisher
    ..Recently, we identified pannexin 3 (Panx3) as a member of the pannexin gap junction protein family from tooth germs...
  2. Moon P, Penuela S, Barr K, Khan S, Pin C, Welch I, et al. Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis. J Mol Med (Berl). 2015;93:845-56 pubmed publisher
    ..Cartilage degeneration hallmarks OA pathogenesis, and pannexin 3 (Panx3), a member of a novel family of channel proteins, is upregulated during this process...
  3. Bond S, Lau A, Penuela S, Sampaio A, Underhill T, Laird D, et al. Pannexin 3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes. J Bone Miner Res. 2011;26:2911-22 pubmed publisher
    ..The pannexin family consists of three members, Panx1, Panx2, and Panx3, and the role each of these proteins plays in cellular processes is still under investigation...
  4. Oh S, Shin J, Baek J, Lee J, Bae J, Ankamerddy H, et al. Pannexin 3 is required for normal progression of skeletal development in vertebrates. FASEB J. 2015;29:4473-84 pubmed publisher
    ..In this study, we generated and analyzed Panx3 knockout mice and examined the skeletal phenotypes of panx3 morphant zebrafish...
  5. Caskenette D, Penuela S, Lee V, Barr K, Beier F, Laird D, et al. Global deletion of Panx3 produces multiple phenotypic effects in mouse humeri and femora. J Anat. 2016;228:746-56 pubmed publisher
    ..Of the three pannexin family members, Pannexin3 (Panx3) is the least studied but is highly expressed in skeletal tissues and is thought to play a role in the regulation ..
  6. Abitbol J, Kelly J, Barr K, Schormans A, Laird D, Allman B. Differential effects of pannexins on noise-induced hearing loss. Biochem J. 2016;473:4665-4680 pubmed
    ..The pannexin (Panx) channel proteins, Panx1 and Panx3, are regionally expressed in many cell types along the auditory pathway, and mice lacking Panx1 in specific cells ..
  7. Ishikawa M, Iwamoto T, Fukumoto S, Yamada Y. Pannexin 3 inhibits proliferation of osteoprogenitor cells by regulating Wnt and p21 signaling. J Biol Chem. 2014;289:2839-51 pubmed publisher
    ..Here, we show that Panx3 (pannexin 3) plays a key role in this transition by inhibiting the proliferation and promoting the cell cycle exit...
  8. Halliwill K, Quigley D, Kang H, Del Rosario R, Ginzinger D, Balmain A. Panx3 links body mass index and tumorigenesis in a genetically heterogeneous mouse model of carcinogen-induced cancer. Genome Med. 2016;8:83 pubmed publisher
    ..Exploring these loci in greater detail revealed a novel relationship between the Pannexin 3 gene (Panx3) and both BMI and tumorigenesis...
  9. Bhalla Gehi R, Penuela S, Churko J, Shao Q, Laird D. Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions. J Biol Chem. 2010;285:9147-60 pubmed publisher
    ..In this study, we utilized Cx43-positive BICR-M1R(k) cells to stably express Panx1, Panx3, or Panx1-green fluorescent protein (GFP) to assess their trafficking, cell surface dynamics, and interplay with ..