Panx1

Summary

Gene Symbol: Panx1
Description: pannexin 1
Alias: AI847747, pannexin-1
Species: mouse
Products:     Panx1

Top Publications

  1. Zoidl G, Petrasch Parwez E, Ray A, Meier C, Bunse S, Habbes H, et al. Localization of the pannexin1 protein at postsynaptic sites in the cerebral cortex and hippocampus. Neuroscience. 2007;146:9-16 pubmed
    ..Here we demonstrate by light and electron microscopical immunohistochemistry that Panx1 reveals postsynaptic localization in rodent hippocampal and cortical principal neurons accumulating at ..
  2. Huang Y, Maruyama Y, Dvoryanchikov G, Pereira E, Chaudhari N, Roper S. The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds. Proc Natl Acad Sci U S A. 2007;104:6436-41 pubmed
    ..receptors as biosensors, we show that gustatory stimuli cause receptor cells to secrete ATP through pannexin 1 hemichannels in mouse taste buds...
  3. Penuela S, Bhalla R, Nag K, Laird D. Glycosylation regulates pannexin intermixing and cellular localization. Mol Biol Cell. 2009;20:4313-23 pubmed publisher
    The pannexin family of mammalian proteins, composed of Panx1, Panx2, and Panx3, has been postulated to be a new class of single-membrane channels with functional similarities to connexin gap junction proteins...
  4. Iglesias R, Dahl G, Qiu F, Spray D, Scemes E. Pannexin 1: the molecular substrate of astrocyte "hemichannels". J Neurosci. 2009;29:7092-7 pubmed publisher
    ..Here, we provide strong evidence that, in cultured astrocytes, pannexin1 (Panx1) but not Cx43 forms hemichannels...
  5. Sandilos J, Chiu Y, Chekeni F, Armstrong A, Walk S, Ravichandran K, et al. Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C-terminal autoinhibitory region. J Biol Chem. 2012;287:11303-11 pubmed publisher
    b>Pannexin 1 (PANX1) channels mediate release of ATP, a "find-me" signal that recruits macrophages to apoptotic cells; PANX1 activation during apoptosis requires caspase-mediated cleavage of PANX1 at its C terminus, but how the C ..
  6. Rigato C, Swinnen N, Buckinx R, Couillin I, Mangin J, Rigo J, et al. Microglia proliferation is controlled by P2X7 receptors in a Pannexin-1-independent manner during early embryonic spinal cord invasion. J Neurosci. 2012;32:11559-73 pubmed
    ..These results reveal a developmental role of P2X7R by controlling embryonic SC microglia proliferation at a critical developmental state in the SC of mouse embryos. ..
  7. Seminario Vidal L, Okada S, Sesma J, Kreda S, van Heusden C, Zhu Y, et al. Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia. J Biol Chem. 2011;286:26277-86 pubmed publisher
    ..Using knockdown and knockout approaches, we tested the hypothesis that pannexin 1 mediates ATP release from hypotonically swollen airway epithelia and investigated mechanisms regulating this ..
  8. Dvoriantchikova G, Ivanov D, Pestova A, Shestopalov V. Molecular characterization of pannexins in the lens. Mol Vis. 2006;12:1417-26 pubmed
    ..The expression of the recently characterized Panx1 and Panx2 gap junction proteins in the lens is, therefore, rather intriguing...
  9. Kanneganti T, Lamkanfi M, Kim Y, Chen G, Park J, Franchi L, et al. Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. Immunity. 2007;26:433-43 pubmed
  10. Penuela S, Bhalla R, Gong X, Cowan K, Celetti S, Cowan B, et al. Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins. J Cell Sci. 2007;120:3772-83 pubmed
    ..Localization of exogenously expressed pannexin 1 (Panx1) and pannexin 3 (Panx3), together with pharmacological studies, revealed a cell surface distribution ..

Detail Information

Publications73

  1. Zoidl G, Petrasch Parwez E, Ray A, Meier C, Bunse S, Habbes H, et al. Localization of the pannexin1 protein at postsynaptic sites in the cerebral cortex and hippocampus. Neuroscience. 2007;146:9-16 pubmed
    ..Here we demonstrate by light and electron microscopical immunohistochemistry that Panx1 reveals postsynaptic localization in rodent hippocampal and cortical principal neurons accumulating at ..
  2. Huang Y, Maruyama Y, Dvoryanchikov G, Pereira E, Chaudhari N, Roper S. The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds. Proc Natl Acad Sci U S A. 2007;104:6436-41 pubmed
    ..receptors as biosensors, we show that gustatory stimuli cause receptor cells to secrete ATP through pannexin 1 hemichannels in mouse taste buds...
  3. Penuela S, Bhalla R, Nag K, Laird D. Glycosylation regulates pannexin intermixing and cellular localization. Mol Biol Cell. 2009;20:4313-23 pubmed publisher
    The pannexin family of mammalian proteins, composed of Panx1, Panx2, and Panx3, has been postulated to be a new class of single-membrane channels with functional similarities to connexin gap junction proteins...
  4. Iglesias R, Dahl G, Qiu F, Spray D, Scemes E. Pannexin 1: the molecular substrate of astrocyte "hemichannels". J Neurosci. 2009;29:7092-7 pubmed publisher
    ..Here, we provide strong evidence that, in cultured astrocytes, pannexin1 (Panx1) but not Cx43 forms hemichannels...
  5. Sandilos J, Chiu Y, Chekeni F, Armstrong A, Walk S, Ravichandran K, et al. Pannexin 1, an ATP release channel, is activated by caspase cleavage of its pore-associated C-terminal autoinhibitory region. J Biol Chem. 2012;287:11303-11 pubmed publisher
    b>Pannexin 1 (PANX1) channels mediate release of ATP, a "find-me" signal that recruits macrophages to apoptotic cells; PANX1 activation during apoptosis requires caspase-mediated cleavage of PANX1 at its C terminus, but how the C ..
  6. Rigato C, Swinnen N, Buckinx R, Couillin I, Mangin J, Rigo J, et al. Microglia proliferation is controlled by P2X7 receptors in a Pannexin-1-independent manner during early embryonic spinal cord invasion. J Neurosci. 2012;32:11559-73 pubmed
    ..These results reveal a developmental role of P2X7R by controlling embryonic SC microglia proliferation at a critical developmental state in the SC of mouse embryos. ..
  7. Seminario Vidal L, Okada S, Sesma J, Kreda S, van Heusden C, Zhu Y, et al. Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia. J Biol Chem. 2011;286:26277-86 pubmed publisher
    ..Using knockdown and knockout approaches, we tested the hypothesis that pannexin 1 mediates ATP release from hypotonically swollen airway epithelia and investigated mechanisms regulating this ..
  8. Dvoriantchikova G, Ivanov D, Pestova A, Shestopalov V. Molecular characterization of pannexins in the lens. Mol Vis. 2006;12:1417-26 pubmed
    ..The expression of the recently characterized Panx1 and Panx2 gap junction proteins in the lens is, therefore, rather intriguing...
  9. Kanneganti T, Lamkanfi M, Kim Y, Chen G, Park J, Franchi L, et al. Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. Immunity. 2007;26:433-43 pubmed
  10. Penuela S, Bhalla R, Gong X, Cowan K, Celetti S, Cowan B, et al. Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins. J Cell Sci. 2007;120:3772-83 pubmed
    ..Localization of exogenously expressed pannexin 1 (Panx1) and pannexin 3 (Panx3), together with pharmacological studies, revealed a cell surface distribution ..
  11. Silverman W, de Rivero Vaccari J, Locovei S, Qiu F, Carlsson S, Scemes E, et al. The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem. 2009;284:18143-51 pubmed publisher
    ..In primary macrophages, potassium ion flux and the membrane channel pannexin 1 have been suggested to play roles in inflammasome activation...
  12. Anselmi F, Hernandez V, Crispino G, Seydel A, Ortolano S, Roper S, et al. ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear. Proc Natl Acad Sci U S A. 2008;105:18770-5 pubmed publisher
  13. Bruzzone R, Hormuzdi S, Barbe M, Herb A, Monyer H. Pannexins, a family of gap junction proteins expressed in brain. Proc Natl Acad Sci U S A. 2003;100:13644-9 pubmed
    ..Here, we show that two of these genes, pannexin 1 (Px1) and Px2, are abundantly expressed in the CNS...
  14. Wicki Stordeur L, Dzugalo A, Swansburg R, Suits J, Swayne L. Pannexin 1 regulates postnatal neural stem and progenitor cell proliferation. Neural Dev. 2012;7:11 pubmed publisher
    b>Pannexin 1 forms ion and metabolite permeable hexameric channels and is abundantly expressed in the brain...
  15. Bao B, Lai C, Naus C, Morgan J. Pannexin1 drives multicellular aggregate compaction via a signaling cascade that remodels the actin cytoskeleton. J Biol Chem. 2012;287:8407-16 pubmed publisher
    b>Pannexin 1 (Panx1) is a novel gap junction protein shown to have tumor-suppressive properties...
  16. Qiu F, Wang J, Spray D, Scemes E, Dahl G. Two non-vesicular ATP release pathways in the mouse erythrocyte membrane. FEBS Lett. 2011;585:3430-5 pubmed publisher
    ..Previous studies have indicated, that Pannexin1 (Panx1) provides a key ATP permeation pathway in many cell types, including human and frog erythrocytes...
  17. Karatas H, Erdener S, Gursoy Ozdemir Y, Lule S, Eren Koçak E, Sen Z, et al. Spreading depression triggers headache by activating neuronal Panx1 channels. Science. 2013;339:1092-5 pubmed publisher
    ..CSD caused neuronal Pannexin1 (Panx1) megachannel opening and caspase-1 activation followed by high-mobility group box 1 (HMGB1) release from neurons ..
  18. Qu Y, Misaghi S, Newton K, Gilmour L, Louie S, Cupp J, et al. Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation. J Immunol. 2011;186:6553-61 pubmed publisher
    ..Cell death was not delayed but, unlike their wild-type counterparts, Panx1(-/-) thymocytes failed to recruit wild-type peritoneal macrophages in a Transwell migration assay...
  19. Hanstein R, Negoro H, Patel N, Charollais A, Meda P, Spray D, et al. Promises and pitfalls of a Pannexin1 transgenic mouse line. Front Pharmacol. 2013;4:61 pubmed publisher
    ..Here, we report the use of an efficient molecular biological approach to test pannexin1 (Panx1) mRNA expression in global and conditional Panx1 KO mice derived from the KO-first mouse line, Panx1(tm1a(KOMP)..
  20. Prochnow N, Abdulazim A, Kurtenbach S, Wildförster V, Dvoriantchikova G, Hanske J, et al. Pannexin1 stabilizes synaptic plasticity and is needed for learning. PLoS ONE. 2012;7:e51767 pubmed publisher
    b>Pannexin 1 (Panx1) represents a class of vertebrate membrane channels, bearing significant sequence homology with the invertebrate gap junction proteins, the innexins and more distant similarities in the membrane topologies and ..
  21. Thompson R, Jackson M, Olah M, Rungta R, Hines D, Beazely M, et al. Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Science. 2008;322:1555-9 pubmed publisher
    ..We conclude that Px1 hemichannel opening is triggered by NMDAR stimulation and can contribute to epileptiform seizure activity. ..
  22. Romanov R, Bystrova M, Rogachevskaya O, Sadovnikov V, Shestopalov V, Kolesnikov S. The ATP permeability of pannexin 1 channels in a heterologous system and in mammalian taste cells is dispensable. J Cell Sci. 2012;125:5514-23 pubmed publisher
    ..It is widely accepted that pannexin 1 (Panx1) channels are responsible for ATP release in diverse cell types, including taste cells...
  23. Lutz S, González Fernández E, Ventura J, Perez Samartin A, Tarassishin L, Negoro H, et al. Contribution of pannexin1 to experimental autoimmune encephalomyelitis. PLoS ONE. 2013;8:e66657 pubmed publisher
    Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells...
  24. Iglesias R, Locovei S, Roque A, Alberto A, Dahl G, Spray D, et al. P2X7 receptor-Pannexin1 complex: pharmacology and signaling. Am J Physiol Cell Physiol. 2008;295:C752-60 pubmed publisher
    b>Pannexin 1 (Panx1), an ortholog to invertebrate innexin gap junctions, has recently been proposed to be the pore induced by P2X(7) receptor (P2X(7)R) activation...
  25. Bhalla Gehi R, Penuela S, Churko J, Shao Q, Laird D. Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions. J Biol Chem. 2010;285:9147-60 pubmed publisher
    ..In this study, we utilized Cx43-positive BICR-M1R(k) cells to stably express Panx1, Panx3, or Panx1-green fluorescent protein (GFP) to assess their trafficking, cell surface dynamics, and interplay ..
  26. Kranz K, Dorgau B, Pottek M, Herrling R, Schultz K, Bolte P, et al. Expression of Pannexin1 in the outer plexiform layer of the mouse retina and physiological impact of its knockout. J Comp Neurol. 2013;521:1119-35 pubmed publisher
    Pannexin1 (Panx1) belongs to a class of vertebrate proteins that exhibits sequence homology to innexins, the invertebrate gap junction proteins, and which also shares topological similarities with vertebrate gap junction proteins, the ..
  27. Billaud M, Lohman A, Straub A, Looft Wilson R, Johnstone S, Araj C, et al. Pannexin1 regulates ?1-adrenergic receptor- mediated vasoconstriction. Circ Res. 2011;109:80-5 pubmed publisher
    ..and immunogold labeling coupled to scanning and transmission electron microscopy revealed the presence of Panx1 but not Panx2 or Panx3 in thoracodorsal resistance arteries...
  28. Kim J, Kang T. The P2X7 receptor-pannexin-1 complex decreases muscarinic acetylcholine receptor-mediated seizure susceptibility in mice. J Clin Invest. 2011;121:2037-47 pubmed publisher
    Pannexin-1 (Panx1) plays a role in the release of ATP and glutamate in neurons and astrocytes. Panx1 can be opened at the resting membrane potential by extracellular ATP via the P2X7 receptor (P2X7R)...
  29. Negoro H, Lutz S, Liou L, Kanematsu A, Ogawa O, Scemes E, et al. Pannexin 1 involvement in bladder dysfunction in a multiple sclerosis model. Sci Rep. 2013;3:2152 pubmed publisher
    ..altered expression of genes associated with bladder mechanosensory, transduction and signaling systems including pannexin 1 (Panx1) and Gja1 (encoding connexin43, referred to here as Cx43)...
  30. Thi M, Islam S, Suadicani S, Spray D. Connexin43 and pannexin1 channels in osteoblasts: who is the "hemichannel"?. J Membr Biol. 2012;245:401-9 pubmed publisher
    ..and ATP-induced dye uptake is attenuated following treatment of wild-type cells with a P2X?R or Pannexin1 (Panx1) channel blocker...
  31. Hanner F, Lam L, Nguyen M, Yu A, Peti Peterdi J. Intrarenal localization of the plasma membrane ATP channel pannexin1. Am J Physiol Renal Physiol. 2012;303:F1454-9 pubmed publisher
    ..However, the mechanisms by which ATP is released into the tubular lumen are multifaceted. Pannexin1 (Panx1) is a newly identified...
  32. Riquelme M, Cea L, Vega J, Boric M, Monyer H, Bennett M, et al. The ATP required for potentiation of skeletal muscle contraction is released via pannexin hemichannels. Neuropharmacology. 2013;75:594-603 pubmed publisher
    ..We found that ATP appears to be released through pannexin1 hemichannels (Panx1 HCs)...
  33. Bunse S, Locovei S, Schmidt M, Qiu F, Zoidl G, Dahl G, et al. The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials. FEBS J. 2009;276:6258-70 pubmed publisher
    b>Pannexin 1 (Panx1), a member of the second gap junction protein family identified in vertebrates, appears to preferentially form non-junctional membrane channels...
  34. Pelegrin P, Barroso Gutierrez C, Surprenant A. P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. J Immunol. 2008;180:7147-57 pubmed
    ..by ATP resulted exclusively from activation of P2X(7)R, release of all these IL-1 cytokines involved pannexin-1 (panx1), and that there was both a panx1-dependent and -independent component to IL-1beta release...
  35. Ransford G, Fregien N, Qiu F, Dahl G, Conner G, Salathe M. Pannexin 1 contributes to ATP release in airway epithelia. Am J Respir Cell Mol Biol. 2009;41:525-34 pubmed publisher
    ..Thus, ATP release via pannexons was examined in airway epithelial cells. Quantitative RT-PCR showed Panx1 expression in normal human airway epithelial cells during redifferentiation at the air-liquid interface (ALI), at ..
  36. Wicki Stordeur L, Boyce A, Swayne L. Analysis of a pannexin 2-pannexin 1 chimeric protein supports divergent roles for pannexin C-termini in cellular localization. Cell Commun Adhes. 2013;20:73-9 pubmed publisher
    ..Recent elegant work has demonstrated that the Panx1 C-terminus plays an important role in channel trafficking...
  37. Dvoriantchikova G, Ivanov D, Barakat D, Grinberg A, Wen R, Slepak V, et al. Genetic ablation of Pannexin1 protects retinal neurons from ischemic injury. PLoS ONE. 2012;7:e31991 pubmed publisher
    Pannexin1 (Panx1) forms large nonselective membrane channel that is implicated in paracrine and inflammatory signaling. In vitro experiments suggested that Panx1 could play a key role in ischemic death of hippocampal neurons...
  38. Wang X, Streeter M, Liu Y, Zhao H. Identification and characterization of pannexin expression in the mammalian cochlea. J Comp Neurol. 2009;512:336-46 pubmed publisher
    ..To date, three pannexin isoforms (Panx1, 2, and 3) have been cloned from mouse and human genomes...
  39. Gulbransen B, Bashashati M, Hirota S, Gui X, Roberts J, MacDonald J, et al. Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis. Nat Med. 2012;18:600-4 pubmed publisher
    ..enteric neuron death by activating a neuronal signaling complex composed of P2X7 receptors (P2X7Rs), pannexin-1 (Panx1) channels, the Asc adaptor protein and caspases...
  40. Suadicani S, Iglesias R, Wang J, Dahl G, Spray D, Scemes E. ATP signaling is deficient in cultured Pannexin1-null mouse astrocytes. Glia. 2012;60:1106-16 pubmed publisher
    Pannexins (Panx1, 2, and 3) comprise a group of proteins expressed in vertebrates that share weak yet significant sequence homology with the invertebrate gap junction proteins, the innexins...
  41. Baranova A, Ivanov D, Petrash N, Pestova A, Skoblov M, Kelmanson I, et al. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. Genomics. 2004;83:706-16 pubmed
    We have cloned the genes PANX1, PANX2 and PANX3, encoding putative gap junction proteins homologous to invertebrate innexins, which constitute a new family of mammalian proteins called pannexins...
  42. Ray A, Zoidl G, Weickert S, Wahle P, Dermietzel R. Site-specific and developmental expression of pannexin1 in the mouse nervous system. Eur J Neurosci. 2005;21:3277-90 pubmed
    ..We investigated the spatio-temporal mRNA distribution of one member of this gene family, pannexin1 (Panx1), in the brain and retina of mice using quantitative real-time polymerase chain reaction and a combination of in ..
  43. Bargiotas P, Krenz A, Hormuzdi S, Ridder D, Herb A, Barakat W, et al. Pannexins in ischemia-induced neurodegeneration. Proc Natl Acad Sci U S A. 2011;108:20772-7 pubmed publisher
    b>Pannexin 1 (Px1, Panx1) and pannexin 2 (Px2, Panx2) form large-pore nonselective channels in the plasma membrane of cells and were suggested to play a role in the pathophysiology of cerebral ischemia...
  44. Santiago M, VELISKOVA J, Patel N, Lutz S, Caille D, Charollais A, et al. Targeting pannexin1 improves seizure outcome. PLoS ONE. 2011;6:e25178 pubmed publisher
    ..Pannexin1 (Panx1) is found in astrocytes and in neurons at high levels in the embryonic and young postnatal brain, declining in ..
  45. Dvoriantchikova G, Ivanov D, Panchin Y, Shestopalov V. Expression of pannexin family of proteins in the retina. FEBS Lett. 2006;580:2178-82 pubmed
    Expression of the Panx1 and Panx2 members of the pannexin family of gap junction proteins was studied in the retina by in situ hybridization and qRT-PCR...
  46. Huang Y, Grinspan J, Abrams C, Scherer S. Pannexin1 is expressed by neurons and glia but does not form functional gap junctions. Glia. 2007;55:46-56 pubmed
    ..We made antisera against mouse pannexin1 (Panx1)...
  47. Qiu F, Dahl G. A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP. Am J Physiol Cell Physiol. 2009;296:C250-5 pubmed publisher
    b>Pannexin 1 forms a large membrane channel that, based on its biophysical properties and its expression pattern, is a prime candidate to represent an ATP release channel...
  48. Panchin Y, Kelmanson I, Matz M, Lukyanov K, Usman N, Lukyanov S. A ubiquitous family of putative gap junction molecules. Curr Biol. 2000;10:R473-4 pubmed
  49. Vogt A, Hormuzdi S, Monyer H. Pannexin1 and Pannexin2 expression in the developing and mature rat brain. Brain Res Mol Brain Res. 2005;141:113-20 pubmed
    ..Furthermore, the temporal difference in the expression of the two genes indicates that the relative contribution of the two pannexins in immature and mature neuronal circuits may vary. ..
  50. Lohman A, Weaver J, Billaud M, Sandilos J, Griffiths R, Straub A, et al. S-nitrosylation inhibits pannexin 1 channel function. J Biol Chem. 2012;287:39602-12 pubmed publisher
    S-nitrosylation is a post-translational modification on cysteine(s) that can regulate protein function, and pannexin 1 (Panx1) channels are present in the vasculature, a tissue rich in nitric oxide (NO) species...
  51. Russo L, Abdeltawab N, O Brien A, Kotb M, Melton Celsa A. Mapping of genetic loci that modulate differential colonization by Escherichia coli O157:H7 TUV86-2 in advanced recombinant inbred BXD mice. BMC Genomics. 2015;16:947 pubmed publisher
    ..The identification of the QTL on chromosome 9 supports our hypothesis that individual genetic makeup affects the level of colonization after infection with STEC O157:H7. ..
  52. Hanstein R, Hanani M, Scemes E, Spray D. Glial pannexin1 contributes to tactile hypersensitivity in a mouse model of orofacial pain. Sci Rep. 2016;6:38266 pubmed publisher
    Drug studies in animal models have implicated pannexin1 (Panx1) in various types of pain, including trigeminal hypersensitivity, neuropathic pain and migraine...
  53. Wang S, Chennupati R, Kaur H, Iring A, Wettschureck N, Offermanns S. Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release. J Clin Invest. 2016;126:4527-4536 pubmed publisher
    ..Together, our data demonstrate that PIEZO1 is required for the regulation of NO formation, vascular tone, and blood pressure. ..
  54. Chen J, Zhu Y, Liang C, Chen J, Zhao H. Pannexin1 channels dominate ATP release in the cochlea ensuring endocochlear potential and auditory receptor potential generation and hearing. Sci Rep. 2015;5:10762 pubmed publisher
    Pannexin1 (Panx1) is a gap junction gene in vertebrates whose proteins mainly function as non-junctional channels on the cell surface...
  55. Yamaguchi H, Maruyama T, Urade Y, Nagata S. Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells. elife. 2014;3:e02172 pubmed publisher
    ..Intraperitoneal injection of zymosan into Adora2a- or Panx1-deficient mice produced high, sustained levels of inflammatory mediators in the peritoneal lavage...
  56. Zhan H, Moore C, Chen B, Zhou X, Ma X, Ijichi K, et al. Stomatin inhibits pannexin-1-mediated whole-cell currents by interacting with its carboxyl terminal. PLoS ONE. 2012;7:e39489 pubmed publisher
    The pannexin-1 (Panx1) channel (often referred to as the Panx1 hemichannel) is a large-conductance channel in the plasma membrane of many mammalian cells...
  57. Hanley P, Kronlage M, Kirschning C, del Rey A, Di Virgilio F, Leipziger J, et al. Transient P2X7 receptor activation triggers macrophage death independent of Toll-like receptors 2 and 4, caspase-1, and pannexin-1 proteins. J Biol Chem. 2012;287:10650-63 pubmed publisher
    ..Furthermore, pannexin-1 (Panx1) deficiency had no effect on transient ATP-induced delayed cell death or ATP-induced Yo-Pro-1 uptake (an index of ..
  58. Tordoff M, Aleman T, Ellis H, Ohmoto M, Matsumoto I, Shestopalov V, et al. Normal Taste Acceptance and Preference of PANX1 Knockout Mice. Chem Senses. 2015;40:453-9 pubmed publisher
    ..It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1)...
  59. Tang W, Ahmad S, Shestopalov V, Lin X. Pannexins are new molecular candidates for assembling gap junctions in the cochlea. Neuroreport. 2008;19:1253-7 pubmed publisher
    ..Western blot and reverse transcription-PCR detected the expression of Panx1 and Panx2. Immunolabeling localized Panx1 to the inner and outer sulcus, as well as the Claudius cells...
  60. Spagnol G, Sorgen P, Spray D. Structural order in Pannexin 1 cytoplasmic domains. Channels (Austin). 2014;8:157-66 pubmed publisher
    b>Pannexin 1 forms ion and metabolite permeable hexameric channels with abundant expression in the central nervous system and elsewhere...
  61. Cisneros Mejorado A, Gottlieb M, Cavaliere F, Magnus T, Koch Nolte F, Scemes E, et al. Blockade of P2X7 receptors or pannexin-1 channels similarly attenuates postischemic damage. J Cereb Blood Flow Metab. 2015;35:843-50 pubmed publisher
    ..reduced with P2X7 and pannexin-1 blockers as well as in organotypic cultures derived from mice lacking P2X7 and pannexin 1. Subsequently, we used transient middle cerebral artery occlusion to monitor the neuroprotective effect of those ..
  62. Dissing Olesen L, LeDue J, Rungta R, Hefendehl J, Choi H, MacVicar B. Activation of neuronal NMDA receptors triggers transient ATP-mediated microglial process outgrowth. J Neurosci. 2014;34:10511-27 pubmed publisher
    ..and genetic analyses showed that the NMDA-triggered microglia process extension was independent of Pannexin 1, the ATP releasing channels, ATP release from astrocytes via connexins, and nitric oxide generation...
  63. Billaud M, Chiu Y, Lohman A, Parpaite T, Butcher J, Mutchler S, et al. A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells. Sci Signal. 2015;8:ra17 pubmed publisher
    ..Pannexin1 (Panx1), which forms large-pore, ATP-releasing channels, is present in vascular smooth muscle cells in peripheral blood ..
  64. Vandenbeuch A, Anderson C, Kinnamon S. Mice Lacking Pannexin 1 Release ATP and Respond Normally to All Taste Qualities. Chem Senses. 2015;40:461-7 pubmed publisher
    ..Several ATP release channels are expressed in taste cells including CALHM1, Pannexin 1, Connexin 30, and Connexin 43, but whether all are involved in ATP release is not clear...
  65. Kurtenbach S, Whyte Fagundes P, Gelis L, Kurtenbach S, Brazil E, Zoidl C, et al. Investigation of olfactory function in a Panx1 knock out mouse model. Front Cell Neurosci. 2014;8:266 pubmed publisher
    b>Pannexin 1 (Panx1), the most extensively investigated member of a channel-forming protein family, is able to form pores conducting molecules up to 1.5 kDa, like ATP, upon activation...
  66. Angus J, Betrie A, Wright C. Pannexin-1 channels do not regulate α1-adrenoceptor-mediated vasoconstriction in resistance arteries. Eur J Pharmacol. 2015;750:43-51 pubmed publisher
    ..The present study demonstrates that in small resistance arteries there is no evidence that Px1 channels releasing ATP have any role in the constrictor actions of α1-adrenoceptor activation. ..
  67. Leal Denis M, Incicco J, Espelt M, Verstraeten S, Pignataro O, Lazarowski E, et al. Kinetics of extracellular ATP in mastoparan 7-activated human erythrocytes. Biochim Biophys Acta. 2013;1830:4692-707 pubmed publisher
    ..The peptide mastoparan 7 (MST7) stimulated ATP release in human erythrocytes. We explored intra- and extracellular processes governing the time-dependent accumulation of extracellular ATP (i.e., ATPe kinetics)...
  68. Harcha P, Vargas A, Yi C, Koulakoff A, Giaume C, Sáez J. Hemichannels Are Required for Amyloid β-Peptide-Induced Degranulation and Are Activated in Brain Mast Cells of APPswe/PS1dE9 Mice. J Neurosci. 2015;35:9526-38 pubmed publisher
    ..In the present work, we found a rapid degranulation of cultured MCs through a pannexin1 hemichannel (Panx1 HC)-dependent mechanism induced by Aβ25-35 peptide...
  69. Brough D, Pelegrin P, Rothwell N. Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc. Eur J Immunol. 2009;39:352-8 pubmed publisher
    ..These data provide new insights into the mechanisms of caspase-1 activation and how zinc metabolism contributes to inflammatory mechanisms. ..
  70. Dolmatova E, Spagnol G, Boassa D, Baum J, Keith K, Ambrosi C, et al. Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation. Am J Physiol Heart Circ Physiol. 2012;303:H1208-18 pubmed publisher
    ..In immune cells, ATP release from pannexin 1 (Panx1) channels acts as a paracrine signal initiating activation of innate immunity...