Gene Symbol: palladin
Description: palladin, cytoskeletal associated protein
Alias: 2410003B16Rik, 6030492A02, palladin, 90kDa actin-associated protein palladin, palladin isoform
Species: mouse
Products:     palladin

Top Publications

  1. Jin L, Yoshida T, Ho R, Owens G, Somlyo A. The actin-associated protein Palladin is required for development of normal contractile properties of smooth muscle cells derived from embryoid bodies. J Biol Chem. 2009;284:2121-30 pubmed publisher
    b>Palladin is a widely expressed actin-associated protein localized at stress fibers, focal adhesions, and other actin-based structures, playing a significant role in cell adhesion and cell motility...
  2. Wang H, Moser M. Comparative expression analysis of the murine palladin isoforms. Dev Dyn. 2008;237:3342-51 pubmed publisher
    ..the expression of this isoform is initiated and increasing during in vitro differentiation and fusion of C2C12 myoblasts, suggesting that the 200-kDa palladin isoform may play a scaffolding role during sarcomeric organization.
  3. Mykkänen O, Grönholm M, Rönty M, Lalowski M, Salmikangas P, Suila H, et al. Characterization of human palladin, a microfilament-associated protein. Mol Biol Cell. 2001;12:3060-73 pubmed
    ..We describe here identification and characterization of human palladin, a protein expressed mainly in smooth muscle and nonmuscle and distributed along microfilaments in a periodic ..
  4. Parast M, Otey C. Characterization of palladin, a novel protein localized to stress fibers and cell adhesions. J Cell Biol. 2000;150:643-56 pubmed
    Here, we describe the identification of a novel phosphoprotein named palladin, which colocalizes with alpha-actinin in the stress fibers, focal adhesions, cell-cell junctions, and embryonic Z-lines...
  5. Endlich N, Schordan E, Cohen C, Kretzler M, Lewko B, Welsch T, et al. Palladin is a dynamic actin-associated protein in podocytes. Kidney Int. 2009;75:214-26 pubmed publisher
    b>Palladin, a cytoskeletal protein with essential functions for stress fiber formation, is found in developing and mature tissues, including the kidney...
  6. Goicoechea S, Arneman D, Disanza A, Garcia Mata R, Scita G, Otey C. Palladin binds to Eps8 and enhances the formation of dorsal ruffles and podosomes in vascular smooth muscle cells. J Cell Sci. 2006;119:3316-24 pubmed
    b>Palladin is a widely expressed phosphoprotein that plays an important role in organizing the actin cytoskeleton...
  7. Luo H, Liu X, Wang F, Huang Q, Shen S, Wang L, et al. Disruption of palladin results in neural tube closure defects in mice. Mol Cell Neurosci. 2005;29:507-15 pubmed
    b>Palladin is a newly identified actin-associated protein which was proposed to be involved in actin cytoskeleton organization and nervous system development...
  8. Boukhelifa M, Parast M, Bear J, Gertler F, Otey C. Palladin is a novel binding partner for Ena/VASP family members. Cell Motil Cytoskeleton. 2004;58:17-29 pubmed
    b>Palladin is an actin-associated protein that contains proline-rich motifs within its amino-terminal sequence that are similar to motifs found in zyxin, vinculin, and the Listeria protein ActA...
  9. Rachlin A, Otey C. Identification of palladin isoforms and characterization of an isoform-specific interaction between Lasp-1 and palladin. J Cell Sci. 2006;119:995-1004 pubmed
    Palladin is a recently described phosphoprotein with an important role in cytoskeletal organization. The major palladin isoform (90-92 kDa) binds to three actin-associated proteins (ezrin, VASP and alpha-actinin), suggesting that palladin ..

More Information


  1. Liu X, Li X, Wang Y, Shu R, Wang L, Lu S, et al. Disruption of palladin leads to defects in definitive erythropoiesis by interfering with erythroblastic island formation in mouse fetal liver. Blood. 2007;110:870-6 pubmed
    b>Palladin was originally found up-regulated with NB4 cell differentiation induced by all-trans retinoic acid. Disruption of palladin results in neural tube closure defects, liver herniation, and embryonic lethality...
  2. Boukhelifa M, Moza M, Johansson T, Rachlin A, Parast M, Huttelmaier S, et al. The proline-rich protein palladin is a binding partner for profilin. FEBS J. 2006;273:26-33 pubmed
    b>Palladin is an actin-associated protein that has been suggested to play critical roles in establishing cell morphology and maintaining cytoskeletal organization in a wide variety of cell types...
  3. Chen X, Fan X, Tan J, Shi P, Wang X, Wang J, et al. Palladin is involved in platelet activation and arterial thrombosis. Thromb Res. 2017;149:1-8 pubmed publisher
    The dynamics of actin cytoskeleton have been shown to play a critical role during platelet activation. Palladin is an actin-associated protein, serving as a cytoskeleton scaffold to bundle actin fibers and actin cross linker...
  4. Mastrototaro G, Liang X, Li X, Carullo P, Piroddi N, Tesi C, et al. Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers. Cardiovasc Res. 2015;107:216-25 pubmed publisher
    ..These results suggest that the nebulette disease causing mutations have dominant gain-of-function effects. ..
  5. Nguyen N, Wang H. Dual roles of palladin protein in in vitro myogenesis: inhibition of early induction but promotion of myotube maturation. PLoS ONE. 2015;10:e0124762 pubmed publisher
    b>Palladin is a microfilament-associated phosphoprotein whose function in skeletal muscle has rarely been studied...
  6. Nguyen N, Liang V, Wang H. Actin-associated protein palladin is required for migration behavior and differentiation potential of C2C12 myoblast cells. Biochem Biophys Res Commun. 2014;452:728-33 pubmed publisher
    The actin-associated protein palladin has been shown to be involved in differentiation processes in non-muscle tissues. However, but its function in skeletal muscle has rarely been studied...
  7. Folgueras A, Guo X, Pasolli H, Stokes N, Polak L, Zheng D, et al. Architectural niche organization by LHX2 is linked to hair follicle stem cell function. Cell Stem Cell. 2013;13:314-27 pubmed publisher
    ..These findings suggest that niche organization underlies the requirement for LHX2 in hair follicle structure and function. ..
  8. Beck M, Dixon R, Goicoechea S, Murphy G, Brungardt J, Beam M, et al. Structure and function of palladin's actin binding domain. J Mol Biol. 2013;425:3325-37 pubmed publisher
    Here, we report the NMR structure of the actin-binding domain contained in the cell adhesion protein palladin. Previously, we demonstrated that one of the immunoglobulin domains of palladin (Ig3) is both necessary and sufficient for ..
  9. Sun H, Chen X, Chen X, Liu J, Ma L, Wu H, et al. PALLD Regulates Phagocytosis by Enabling Timely Actin Polymerization and Depolymerization. J Immunol. 2017;199:1817-1826 pubmed publisher
    ..Collectively, our results show a new function for PALLD as a crucial regulator of the early phase of phagocytosis by elaborating dynamic actin polymerization and depolymerization. ..
  10. Niedenberger B, Chappell V, Otey C, Geyer C. Actin dynamics regulate subcellular localization of the F-actin-binding protein PALLD in mouse Sertoli cells. Reproduction. 2014;148:333-41 pubmed publisher
    ..b>Palladin (PALLD) is a widely expressed F-actin-binding and bundling protein recently shown to regulate these structures, ..
  11. Goicoechea S, Bednarski B, Stack C, Cowan D, Volmar K, Thorne L, et al. Isoform-specific upregulation of palladin in human and murine pancreas tumors. PLoS ONE. 2010;5:e10347 pubmed publisher
    ..The 65 kDa isoform is expressed in both normal and neoplastic ductal epithelial cells. The 85-90 kDa palladin isoform is highly overexpressed in tumor-associated fibroblasts (TAFs) in both primary and metastatic tumors compared ..
  12. Maeda M, Asano E, Ito D, Ito S, Hasegawa Y, Hamaguchi M, et al. Characterization of interaction between CLP36 and palladin. FEBS J. 2009;276:2775-85 pubmed publisher
    ..the physiological function of CLP36, we performed yeast two-hybrid screening, and found that CLP36 interacts with palladin. Palladin is an important structural element of the actin cytoskeleton that is ubiquitously expressed and ..
  13. Niedenberger B, Chappell V, Kaye E, Renegar R, Geyer C. Nuclear localization of the actin regulatory protein Palladin in sertoli cells. Mol Reprod Dev. 2013;80:403-13 pubmed publisher
    ..better understanding of actin regulation in Sertoli-germ cell interactions, we investigated the expression of the Palladin (Palld) gene, which encodes a widely expressed phosphoprotein that localizes to actin-rich cytoplasmic structures,..
  14. Shu R, Zhang F, Liu X, Li C, Wang L, Tai Y, et al. Target deletion of the cytoskeleton-associated protein palladin does not impair neurite outgrowth in mice. PLoS ONE. 2009;4:e6916 pubmed publisher
    b>Palladin is an actin cytoskeleton-associated protein which is crucial for cell morphogenesis and motility...
  15. Goicoechea S, Garcia Mata R, Staub J, Valdivia A, Sharek L, McCulloch C, et al. Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts. Oncogene. 2014;33:1265-73 pubmed publisher
    ..We showed previously that palladin, an actin-associated protein, is expressed at high levels in CAFs of pancreatic tumors and other solid tumors, ..
  16. Zou Z, Enis D, Bui H, Khandros E, Kumar V, Jakus Z, et al. The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood. 2013;121:3228-36 pubmed publisher
    ..Our findings reveal that CCBE1 plays an essential role in regulating the fetal liver erythropoietic environment and suggest that EBI formation is regulated differently in the fetal liver and bone marrow...
  17. Jin L, Gan Q, Zieba B, Goicoechea S, Owens G, Otey C, et al. The actin associated protein palladin is important for the early smooth muscle cell differentiation. PLoS ONE. 2010;5:e12823 pubmed publisher
    b>Palladin, an actin associated protein, plays a significant role in regulating cell adhesion and cell motility...
  18. Yadav R, Vattepu R, Beck M. Phosphoinositide Binding Inhibits Actin Crosslinking and Polymerization by Palladin. J Mol Biol. 2016;428:4031-4047 pubmed publisher
    ..b>Palladin is a key cytoskeletal actin binding protein whose normal function is to enable cell motility during development ..