Gene Symbol: Pak7
Description: p21 (RAC1) activated kinase 7
Alias: 2900083L08Rik, PAK-5, PAK-7, Pak5, serine/threonine-protein kinase PAK 5, serine/threonine-protein kinase PAK 7, p21 protein (Cdc42/Rac)-activated kinase 7, p21-activated kinase 5, p21-activated kinase 7
Cotteret S, Jaffer Z, Beeser A, Chernoff J. p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol Cell Biol. 2003;23:5526-39 pubmed
b>Pak5 is the most recently identified and least understood member of the p21-activated kinase (Pak) family...
Strochlic T, Concilio S, Viaud J, Eberwine R, Wong L, Minden A, et al
. Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking. Proc Natl Acad Sci U S A. 2012;109:4116-21 pubmed publisher
..b>Pak5 (p21-activated kinase 5) is a brain-specific isoform of the group II Pak kinases whose substrates and roles within ..
Li X, Minden A. Targeted disruption of the gene for the PAK5 kinase in mice. Mol Cell Biol. 2003;23:7134-42 pubmed
b>PAK5 is a member of the group B family of PAK serine/threonine kinases and is an effector for the Rho GTPase Cdc42. PAK5 is highly expressed in the brain and is expressed at lower levels in several other tissues...
Nekrasova T, Jobes M, Ting J, Wagner G, Minden A. Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion. Dev Biol. 2008;322:95-108 pubmed publisher
..The group B PAKs, including PAK4, PAK5, and PAK6, were first identified as effector proteins for the Rho GTPase Cdc42...
Coste O, Möser C, Sisignano M, Kynast K, Minden A, Geisslinger G, et al
. The p21-activated kinase PAK 5 is involved in formalin-induced nociception through regulation of MAP-kinase signaling and formalin-specific receptors. Behav Brain Res. 2012;234:121-8 pubmed publisher
..b>PAK 5 knock-out mice showed normal acute nociception and did not differ from wild type mice in their neuropathic pain ..
Niehof M, Borlak J. RSK4 and PAK5 are novel candidate genes in diabetic rat kidney and brain. Mol Pharmacol. 2005;67:604-11 pubmed
..In multiple ChIP assays, ribosomal S6 kinase 4 (RSK4) and p21-activated kinase 5 (PAK5) were confirmed, and in vitro binding of HNF4alpha was evidenced by electrophoretic mobility shift assays (EMSA) ..
Furnari M, Jobes M, Nekrasova T, Minden A, Wagner G. Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice. PLoS ONE. 2013;8:e61321 pubmed publisher
The p21-activated kinases are effector proteins for Rho-family GTPases. PAK4, PAK5, and PAK6 are the group II PAKs associated with neurite outgrowth, filopodia formation, and cell survival...
Morris D, Pearson R, Cormican P, Kenny E, O Dushlaine C, Perreault L, et al
. An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis. Hum Mol Genet. 2014;23:3316-26 pubmed publisher
..and sequencing, we identified a tandem ~149 kb duplication overlapping the gene p21 Protein-Activated Kinase 7 (PAK7, also called PAK5) which was in linkage disequilibrium with local haplotypes (P = 2...
Sapir T, Sapoznik S, Levy T, Finkelshtein D, Shmueli A, Timm T, et al
. Accurate balance of the polarity kinase MARK2/Par-1 is required for proper cortical neuronal migration. J Neurosci. 2008;28:5710-20 pubmed publisher
..Furthermore, the exact requirements for MARK2 and its kinase activity vary during the course of neuronal migration. Collectively, our results stress the requirements for the different roles of MARK2 during neuronal migration. ..