Gene Symbol: Pak6
Description: p21 (RAC1) activated kinase 6
Alias: 4732456M09, serine/threonine-protein kinase PAK 6, PAK-6, p21 protein (Cdc42/Rac)-activated kinase 6, p21-activated kinase 6
Qu J, Li X, Novitch B, Zheng Y, Kohn M, Xie J, et al
. PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol. 2003;23:7122-33 pubmed
..PAK4-null embryos also had defects in proper folding of the caudal portion of the neural tube, suggesting an important role for PAK4 in neural tube development. ..
Li X, Minden A. Targeted disruption of the gene for the PAK5 kinase in mice. Mol Cell Biol. 2003;23:7134-42 pubmed
..The nervous system appears normal in the absence of PAK5, as do other tissues in which PAK5 is normally expressed. Our results suggest functional redundancy between PAK5 and other Rho GTPase targets. ..
Nekrasova T, Jobes M, Ting J, Wagner G, Minden A. Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion. Dev Biol. 2008;322:95-108 pubmed publisher
b>PAK6 is a member of the group B family of PAK serine/threonine kinases, and is highly expressed in the brain. The group B PAKs, including PAK4, PAK5, and PAK6, were first identified as effector proteins for the Rho GTPase Cdc42...
Furnari M, Jobes M, Nekrasova T, Minden A, Wagner G. Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice. PLoS ONE. 2013;8:e61321 pubmed publisher
The p21-activated kinases are effector proteins for Rho-family GTPases. PAK4, PAK5, and PAK6 are the group II PAKs associated with neurite outgrowth, filopodia formation, and cell survival...
Furnari M, Jobes M, Nekrasova T, Minden A, Wagner G. Differential sensitivity of Pak5, Pak6, and Pak5/Pak6 double-knockout mice to the stimulant effects of amphetamine and exercise-induced alterations in body weight. Nutr Neurosci. 2014;17:109-15 pubmed publisher
PAK5 and PAK6 are protein kinases highly expressed in the brain...
Civiero L, Cirnaru M, Beilina A, Rodella U, Russo I, Belluzzi E, et al
. Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain. J Neurochem. 2015;135:1242-56 pubmed publisher
..Here, we identified p21-activated kinase 6 (PAK6) as a novel interactor of the GTPase/ROC domain of LRRK2...