Gene Symbol: Pafah1b3
Description: platelet-activating factor acetylhydrolase, isoform 1b, subunit 3
Alias: Pafahg, mus[g], platelet-activating factor acetylhydrolase IB subunit gamma, PAF acetylhydrolase 29 kDa subunit, PAF-AH 29 kDa subunit, PAF-AH gamma, PAF-AH subunit gamma, PAFAH subunit gamma, platelet-activating factor acetylhydrolase, isoform 1b, alpha1 subunit
Species: mouse
Products:     Pafah1b3

Top Publications

  1. Albrecht U, Abu Issa R, Ratz B, Hattori M, Aoki J, Arai H, et al. Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor. Dev Biol. 1996;180:579-93 pubmed
    ..Mechanisms by which PAF could affect neuronal migration are discussed. ..
  2. Koizumi H, Yamaguchi N, Hattori M, Ishikawa T, Aoki J, Taketo M, et al. Targeted disruption of intracellular type I platelet activating factor-acetylhydrolase catalytic subunits causes severe impairment in spermatogenesis. J Biol Chem. 2003;278:12489-94 pubmed
  3. Yan W, Assadi A, Wynshaw Boris A, Eichele G, Matzuk M, Clark G. Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis. Proc Natl Acad Sci U S A. 2003;100:7189-94 pubmed
    ..Here, we report disruptions of the alpha2 (Pafah1b2) and alpha1 (Pafah1b3) genes in mice...
  4. Liu J, Chen R, Marathe G, Febbraio M, Zou W, McIntyre T. Circulating platelet-activating factor is primarily cleared by transport, not intravascular hydrolysis by lipoprotein-associated phospholipase A2/ PAF acetylhydrolase. Circ Res. 2011;108:469-77 pubmed publisher
    ..Intravascular PAF has access to intracellular compartments. Inflammatory and proapoptotic phospholipids may accumulate in the circulation as transport is overwhelmed by substrates in hyperlipidemia. ..
  5. Zhang G, Assadi A, Roceri M, Clark G, D ARCANGELO G. Differential interaction of the Pafah1b alpha subunits with the Reelin transducer Dab1. Brain Res. 2009;1267:1-8 pubmed publisher
    ..Our data suggest that the Alpha2 subunit may play a modulatory role in the formation of protein complexes that affect brain development and hydrocephalus. ..
  6. Sweeney K, Prokscha A, Eichele G. NudE-L, a novel Lis1-interacting protein, belongs to a family of vertebrate coiled-coil proteins. Mech Dev. 2001;101:21-33 pubmed
  7. Saito Y, Doi K, Yamagishi N, Ishihara K, Hatayama T. Screening of Hsp105alpha-binding proteins using yeast and bacterial two-hybrid systems. Biochem Biophys Res Commun. 2004;314:396-402 pubmed
    ..The interaction was validated by the results of a pull-down assay and indirect immunofluorescence analysis. The significance of Hsp105alpha and Hsp105alpha-binding proteins in cells was discussed. ..
  8. Fowles L, Bennetts J, Berkman J, Williams E, Koopman P, Teasdale R, et al. Genomic screen for genes involved in mammalian craniofacial development. Genesis. 2003;35:73-87 pubmed
  9. Escámez T, Bahamonde O, Tabares Seisdedos R, Vieta E, Martinez S, Echevarria D. Developmental dynamics of PAFAH1B subunits during mouse brain development. J Comp Neurol. 2012;520:3877-94 pubmed publisher
    ..enzyme that deacetylates the PAF (PAFAH1B) is composed of a tetramer of two catalytic subunits, ALPHA1 (PAFAH1B3) and ALPHA2 (PAFAH1B2), and a regulatory dimer of LIS1 (PAFAH1B1)...

More Information


  1. Gardner A, Reichert E, Topham M, Stafforini D. Identification of a domain that mediates association of platelet-activating factor acetylhydrolase with high density lipoprotein. J Biol Chem. 2008;283:17099-106 pubmed publisher
    ..These findings contribute to our understanding of the mechanisms responsible for association of human PAF-AH with HDL and may facilitate future studies aimed at precisely determining the function of PAF-AH in each lipoprotein particle. ..
  2. Park I, Qian D, Kiel M, Becker M, Pihalja M, Weissman I, et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 2003;423:302-5 pubmed
    ..Expression of p16Ink4a and p19Arf in normal HSCs resulted in proliferative arrest and p53-dependent cell death, respectively. Our results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs. ..
  3. Forte T, Oda M, Knoff L, Frei B, Suh J, Harmony J, et al. Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration. J Lipid Res. 1999;40:1276-83 pubmed
    ..2 nm particles. We conclude that the concomitant reduction in HDL and apoA-I concentrations and PON and PAF-AH activities is best explained by rapid clearance of the small HDL particles found in LCAT deficiency. ..
  4. Yamaguchi N, Takanezawa Y, Koizumi H, Umezu Goto M, Aoki J, Arai H. Expression of NUDEL in manchette and its implication in spermatogenesis. FEBS Lett. 2004;566:71-6 pubmed
    ..These results suggest that NUDEL plays an important role in germ cell formation, including nucleoplasmic transport and nucleus shaping by manchette microtubules. ..
  5. Zhang G, Assadi A, McNeil R, Beffert U, Wynshaw Boris A, Herz J, et al. The Pafah1b complex interacts with the reelin receptor VLDLR. PLoS ONE. 2007;2:e252 pubmed
    ..signaling and cortical layer formation and found that catalytic subunits of the Pafah1b complex, Pafah1b2 and Pafah1b3, specifically bind to the NPxYL sequence of VLDLR, but not to ApoER2...
  6. Stojanov T, O NEILL C. In vitro fertilization causes epigenetic modifications to the onset of gene expression from the zygotic genome in mice. Biol Reprod. 2001;64:696-705 pubmed
    ..Thus, IVF causes epigenetic modification in the normal pattern of expression of some but not all genes involved in normal embryo growth and survival. ..
  7. Eggert D, Dash P, Serradji N, Dong C, Clayette P, Heymans F, et al. Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders. J Neuroimmunol. 2009;213:47-59 pubmed publisher
    ..These observations support the further development of PMS-601 as an adjunctive therapy for HIV-1 associated neurocognitive disorders. ..
  8. Ware J, Russell S, Ruggeri Z. Cloning of the murine platelet glycoprotein Ibalpha gene highlighting species-specific platelet adhesion. Blood Cells Mol Dis. 1997;23:292-301 pubmed
    ..The results further define the structural elements necessary for the interaction of human vWF and platelets. ..