Gene Symbol: Pacsin1
Description: protein kinase C and casein kinase substrate in neurons 1
Alias: A830061D09Rik, H74, mKIAA1379, syndapin, protein kinase C and casein kinase substrate in neurons protein 1, Syndapin I, syndapin-1
Species: mouse
Products:     Pacsin1

Top Publications

  1. Braun A, Pinyol R, Dahlhaus R, Koch D, Fonarev P, Grant B, et al. EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling. Mol Biol Cell. 2005;16:3642-58 pubmed
    ..Heterologous and endogenous coimmunoprecipitations as well as reconstitutions of syndapin/EHD protein complexes at intracellular membranes of living cells demonstrate the in vivo relevance of the ..
  2. Koch D, Spiwoks Becker I, Sabanov V, Sinning A, Dugladze T, Stellmacher A, et al. Proper synaptic vesicle formation and neuronal network activity critically rely on syndapin I. EMBO J. 2011;30:4955-69 pubmed publisher
    ..We demonstrate that the F-BAR protein syndapin I is crucial for proper brain function...
  3. Schael S, Nüchel J, Muller S, Petermann P, Kormann J, Pérez Otaño I, et al. Casein kinase 2 phosphorylation of protein kinase C and casein kinase 2 substrate in neurons (PACSIN) 1 protein regulates neuronal spine formation. J Biol Chem. 2013;288:9303-12 pubmed publisher
    ..These findings suggest that upon BDNF signaling PACSIN 1 is phosphorylated by CK2 which is essential for spine formation. ..
  4. Sumoy L, Pluvinet R, Andreu N, Estivill X, Escarceller M. PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family. Gene. 2001;262:199-205 pubmed
    ..Two murine Pacsin genes have been reported to date: Pacsin 1 (equivalent to rat Syndapin I), and Pacsin 2 (like rat Syndapin II and chicken focal adhesion protein FAP52)...
  5. Senju Y, Itoh Y, Takano K, Hamada S, Suetsugu S. Essential role of PACSIN2/syndapin-II in caveolae membrane sculpting. J Cell Sci. 2011;124:2032-40 pubmed publisher
    ..These results indicate that PACSIN2 mediates membrane sculpting by caveolin-1 in caveola morphology and recruits dynamin-2 for caveola fission. ..
  6. Widagdo J, Fang H, Jang S, Anggono V. PACSIN1 regulates the dynamics of AMPA receptor trafficking. Sci Rep. 2016;6:31070 pubmed publisher
    ..pHluorin, tagged to the extracellular domain of the GluA2 subunit of AMPARs, we demonstrate dual roles for PACSIN1 in controlling the internalization and recycling of GluA2 after NMDAR activation...
  7. Modregger J, Ritter B, Witter B, Paulsson M, Plomann M. All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis. J Cell Sci. 2000;113 Pt 24:4511-21 pubmed
    ..These characteristics of the PACSIN protein family suggest a general function in recruitment of the interacting proteins to sites of endocytosis. ..
  8. Quan A, Robinson P. Syndapin--a membrane remodelling and endocytic F-BAR protein. FEBS J. 2013;280:5198-212 pubmed publisher
    b>Syndapin [also called PACSIN (protein kinase C and casein kinase II interacting protein)] is an Fes-CIP4 homology Bin-amphiphysin-Rvs161/167 (F-BAR) and Src-homology 3 domain-containing protein...
  9. Quan A, Xue J, Wielens J, Smillie K, Anggono V, Parker M, et al. Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation. Proc Natl Acad Sci U S A. 2012;109:3760-5 pubmed publisher
    b>Syndapin I (PACSIN 1) is a synaptically enriched membrane tubulating protein that plays important roles in activity-dependent bulk endocytosis and neuronal morphogenesis...

Scientific Experts

More Information


  1. del Pino I, Koch D, Schemm R, Qualmann B, Betz H, Paarmann I. Proteomic analysis of glycine receptor ? subunit (GlyR?)-interacting proteins: evidence for syndapin I regulating synaptic glycine receptors. J Biol Chem. 2014;289:11396-409 pubmed publisher
    ..This identified syndapin I (SdpI) as a novel interaction partner of GlyR? that coimmunoprecipitates with native GlyRs from brainstem ..
  2. Liu Y, Lv K, Li Z, Yu A, Chen J, Teng J. PACSIN1, a Tau-interacting protein, regulates axonal elongation and branching by facilitating microtubule instability. J Biol Chem. 2012;287:39911-24 pubmed publisher
    ..This study reports that PACSIN1 interacts with Tau in axon...
  3. Esashi E, Bao M, Wang Y, Cao W, Liu Y. PACSIN1 regulates the TLR7/9-mediated type I interferon response in plasmacytoid dendritic cells. Eur J Immunol. 2012;42:573-9 pubmed publisher
    ..Knockdown of PACSIN1 by short hairpin RNA (shRNA) in a human pDC cell line significantly inhibited the type I IFN response of the pDCs ..
  4. Strochlic T, Concilio S, Viaud J, Eberwine R, Wong L, Minden A, et al. Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking. Proc Natl Acad Sci U S A. 2012;109:4116-21 pubmed publisher
    ..Using this approach, we identified two novel Pak5 substrates, Pacsin1 and Synaptojanin1, proteins that directly interact with one another to regulate synaptic vesicle endocytosis and ..
  5. Plomann M, Lange R, Vopper G, Cremer H, Heinlein U, Scheff S, et al. PACSIN, a brain protein that is upregulated upon differentiation into neuronal cells. Eur J Biochem. 1998;256:201-11 pubmed
    ..One of these clones, H74, detected a 4.4-kb mRNA predominantly expressed in brain and dorsal root ganglia neurons...
  6. Grimm Günter E, Milbrandt M, Merkl B, Paulsson M, Plomann M. PACSIN proteins bind tubulin and promote microtubule assembly. Exp Cell Res. 2008;314:1991-2003 pubmed publisher
    ..These findings suggest a novel function for PACSIN proteins in dynamic microtubuli nucleation. ..
  7. Rao Y, Ma Q, Vahedi Faridi A, Sundborger A, Pechstein A, Puchkov D, et al. Molecular basis for SH3 domain regulation of F-BAR-mediated membrane deformation. Proc Natl Acad Sci U S A. 2010;107:8213-8 pubmed publisher
    ..Here we present the crystal structures of full-length syndapin 1 and its F-BAR domain...
  8. Anggono V, Koc Schmitz Y, Widagdo J, Kormann J, Quan A, Chen C, et al. PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression. Proc Natl Acad Sci U S A. 2013;110:13976-81 pubmed publisher
    ..Our results reveal that knockdown of the neuronal-specific protein, PACSIN1, leads to a significant reduction in AMPAR internalization following the activation of NMDA receptors in ..
  9. Schneider K, Seemann E, Liebmann L, Ahuja R, Koch D, Westermann M, et al. ProSAP1 and membrane nanodomain-associated syndapin I promote postsynapse formation and function. J Cell Biol. 2014;205:197-215 pubmed publisher
    ..Gene knockout and RNAi in individual neurons reveal that the F-BAR protein syndapin I is a crucial postsynaptic coordinator in formation of excitatory synapses...
  10. Ritter B, Modregger J, Paulsson M, Plomann M. PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins. FEBS Lett. 1999;454:356-62 pubmed