| P2Y15Gene Symbol: P2Y15 Description: oxoglutarate (alpha-ketoglutarate) receptor 1 Alias: Cysltr3, Gm299, Gpr80, Gpr99, P2Y15, 2-oxoglutarate receptor 1, G protein-coupled receptor 80, G protein-coupled receptor 99, alpha-ketoglutarate receptor 1 Species: mouse Kanaoka Y, Maekawa A, Austen K. Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. J Biol Chem. 2013;288:10967-72 pubmed publisher ..b>GPR99, previously described as an oxoglutarate receptor (Oxgr1), showed both a functional and a binding response to LTE4 .. He W, Miao F, Lin D, Schwandner R, Wang Z, Gao J, et al. Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors. Nature. 2004;429:188-93 pubmed ..We also report that GPR99 (ref... Cummings H, Liu T, Feng C, Laidlaw T, Conley P, Kanaoka Y, et al. Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor. J Immunol. 2013;191:5807-10 pubmed publisher ..They signal through three specific receptors (type 1 cys-LT receptor [CysLT1R], CysLT2R, and GPR99) with overlapping ligand preferences... Inbe H, Watanabe S, Miyawaki M, Tanabe E, Encinas J. Identification and characterization of a cell-surface receptor, P2Y15, for AMP and adenosine. J Biol Chem. 2004;279:19790-9 pubmed ..Based on its ability to functionally bind the nucleotide AMP, we have named it P2Y15. Upon stimulation, P2Y15 induces both Ca2+ mobilization and cyclic AMP generation, suggesting coupling to at least .. Tokonami N, Morla L, Centeno G, Mordasini D, Ramakrishnan S, Nikolaeva S, et al. ?-Ketoglutarate regulates acid-base balance through an intrarenal paracrine mechanism. J Clin Invest. 2013;123:3166-71 pubmed publisher Omede A, Zi M, Prehar S, Maqsood A, Stafford N, Mamas M, et al. The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice. Biochem Biophys Res Commun. 2016;479:708-714 pubmed publisher ..Identification of molecules that can specifically activate or inhibit this receptor may be very useful in the development of novel therapeutic approach for pathological cardiac hypertrophy. ..
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