P2ry2

Summary

Gene Symbol: P2ry2
Description: purinergic receptor P2Y, G-protein coupled 2
Alias: P2U1, P2Y2, P2Y purinoceptor 2, ATP receptor, P2U purinoceptor 1
Species: mouse
Products:     P2ry2

Top Publications

  1. Vanderstocken G, Bondue B, Horckmans M, Di Pietrantonio L, Robaye B, Boeynaems J, et al. P2Y2 receptor regulates VCAM-1 membrane and soluble forms and eosinophil accumulation during lung inflammation. J Immunol. 2010;185:3702-7 pubmed publisher
    ..Our data define P2Y(2) as a regulator of membrane and soluble forms of VCAM-1 and eosinophil accumulation during lung inflammation. ..
  2. Vanderstocken G, Van de Paar E, Robaye B, Di Pietrantonio L, Bondue B, Boeynaems J, et al. Protective role of P2Y2 receptor against lung infection induced by pneumonia virus of mice. PLoS ONE. 2012;7:e50385 pubmed publisher
    ..In conclusion, P2Y(2) receptor, previously described as a target in cystic fibrosis therapy and as a mediator of Th2 response in asthma, may also regulate Th1 response protecting mice against lung viral infection...
  3. Lustig K, Shiau A, Brake A, Julius D. Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc Natl Acad Sci U S A. 1993;90:5113-7 pubmed
    ..mRNA encoding the P2U purinergic receptor is found in neural and nonneural tissues. ..
  4. Yu N, Erb L, Shivaji R, Weisman G, Seye C. Binding of the P2Y2 nucleotide receptor to filamin A regulates migration of vascular smooth muscle cells. Circ Res. 2008;102:581-8 pubmed publisher
    ..Thus, this study demonstrates that P2Y(2)R/FLNa interaction selectively regulates spreading and migration of vascular SMCs. ..
  5. Pochynyuk O, Bugaj V, Rieg T, Insel P, Mironova E, Vallon V, et al. Paracrine regulation of the epithelial Na+ channel in the mammalian collecting duct by purinergic P2Y2 receptor tone. J Biol Chem. 2008;283:36599-607 pubmed publisher
    ..ATP and other nucleotides, including UTP, decrease ENaC activity via apical P2Y2 receptors. ENaC in collecting ducts isolated from mice lacking this receptor have blunted responses to ATP...
  6. Elliott M, Chekeni F, Trampont P, Lazarowski E, Kadl A, Walk S, et al. Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance. Nature. 2009;461:282-6 pubmed publisher
    ..was abolished by depletion of nucleotides and was significantly decreased in P2Y(2)(-/-) (also known as P2ry2(-/-)) mice...
  7. Chen X, Molliver D, Gebhart G. The P2Y2 receptor sensitizes mouse bladder sensory neurons and facilitates purinergic currents. J Neurosci. 2010;30:2365-72 pubmed publisher
    ..These results support involvement of P2Y(2) receptors in bladder sensation, suggesting an important contribution to bladder neuron excitability and hypersensitivity. ..
  8. Chen Y, Corriden R, Inoue Y, Yip L, Hashiguchi N, Zinkernagel A, et al. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science. 2006;314:1792-5 pubmed
    ..the leading edge of the cell surface to amplify chemotactic signals and direct cell orientation by feedback through P2Y2 nucleotide receptors...
  9. Stockand J, Mironova E, Bugaj V, Rieg T, Insel P, Vallon V, et al. Purinergic inhibition of ENaC produces aldosterone escape. J Am Soc Nephrol. 2010;21:1903-11 pubmed publisher
    ..These data suggest that control of ENaC by purinergic signaling is necessary for aldosterone escape. ..

More Information

Publications62

  1. Geary C, Akinbi H, Korfhagen T, Fabre J, Boucher R, Rice W. Increased susceptibility of purinergic receptor-deficient mice to lung infection with Pseudomonas aeruginosa. Am J Physiol Lung Cell Mol Physiol. 2005;289:L890-5 pubmed
    ..the role of purinergic receptors in innate host defense of the lung in vivo by infecting mice deficient in P2Y1, P2Y2, or both receptors with intratracheal instillation of Pseudomonas aeruginosa. After P...
  2. Xing Y, Gu Y, Gomes R, You J. P2Y(2) receptors and GRK2 are involved in oscillatory fluid flow induced ERK1/2 responses in chondrocytes. J Orthop Res. 2011;29:828-33 pubmed publisher
  3. You J, Jacobs C, Steinberg T, Donahue H. P2Y purinoceptors are responsible for oscillatory fluid flow-induced intracellular calcium mobilization in osteoblastic cells. J Biol Chem. 2002;277:48724-9 pubmed
    ..Thus, by the process of elimination, our data suggest that P2Y purinoceptors (P2Y2 or P2Y4) are involved in the Ca(2+)(i) response to fluid flow...
  4. Muller T, Robaye B, Vieira R, Ferrari D, Grimm M, Jakob T, et al. The purinergic receptor P2Y2 receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation. Allergy. 2010;65:1545-53 pubmed publisher
    ..Together our data suggest that targeting P2Y(2) R might be a therapeutic option for the treatment of asthma. ..
  5. Zhang Y, Sands J, Kohan D, Nelson R, Martin C, Carlson N, et al. Potential role of purinergic signaling in urinary concentration in inner medulla: insights from P2Y2 receptor gene knockout mice. Am J Physiol Renal Physiol. 2008;295:F1715-24 pubmed publisher
    ..Vasopressin (AVP) increases expression of both AQP2 and UT-A isoforms. Activation of the P2Y2 receptor (P2Y2-R) in the medullary collecting duct inhibits AVP-induced water flow...
  6. Zambon A, Hughes R, Meszaros J, Wu J, Torres B, Brunton L, et al. P2Y(2) receptor of MDCK cells: cloning, expression, and cell-specific signaling. Am J Physiol Renal Physiol. 2000;279:F1045-52 pubmed
  7. Beldi G, Wu Y, Sun X, Imai M, Enjyoji K, Csizmadia E, et al. Regulated catalysis of extracellular nucleotides by vascular CD39/ENTPD1 is required for liver regeneration. Gastroenterology. 2008;135:1751-60 pubmed publisher
    ..were assessed following partial hepatectomy in mice that do not express CD39, that do not express ATP/UTP receptor P2Y2, and in controls...
  8. Vallon V, Rieg T. Regulation of renal NaCl and water transport by the ATP/UTP/P2Y2 receptor system. Am J Physiol Renal Physiol. 2011;301:F463-75 pubmed publisher
  9. Xing Y, Gu Y, Bresnahan J, Paul E, Donahue H, You J. The roles of P2Y2 purinergic receptors in osteoblasts and mechanotransduction. PLoS ONE. 2014;9:e108417 pubmed publisher
    We previously demonstrated, using osteoblastic MC3T3-E1 cells, that P2Y2 purinergic receptors are involved in osteoblast mechanotransduction...
  10. Klämbt V, Wohlfeil S, Schwab L, Hülsdünker J, Ayata K, Apostolova P, et al. A Novel Function for P2Y2 in Myeloid Recipient-Derived Cells during Graft-versus-Host Disease. J Immunol. 2015;195:5795-804 pubmed publisher
    ..A second ATP-activated purinergic receptor involved in inflammatory diseases is P2Y2. In this study, we used P2y2(-/-) mice to test the role of this receptor in GvHD...
  11. Stachon P, Geis S, Peikert A, Heidenreich A, Michel N, Unal F, et al. Extracellular ATP Induces Vascular Inflammation and Atherosclerosis via Purinergic Receptor Y2 in Mice. Arterioscler Thromb Vasc Biol. 2016;36:1577-86 pubmed publisher
    ..Thus, we hypothesize contribution of extracellular ATP and its receptor P2Y2 in vascular inflammation and atherosclerosis...
  12. Erb L, Garrad R, Wang Y, Quinn T, Turner J, Weisman G. Site-directed mutagenesis of P2U purinoceptors. Positively charged amino acids in transmembrane helices 6 and 7 affect agonist potency and specificity. J Biol Chem. 1995;270:4185-8 pubmed
    ..A three-dimensional model of the P2UR indicates the feasibility of His262, Arg265, and Arg292 interactions with the phosphate groups of nucleotides. ..
  13. Ehre C, Zhu Y, Abdullah L, Olsen J, Nakayama K, Nakayama K, et al. nPKCepsilon, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells. Am J Physiol Cell Physiol. 2007;293:C1445-54 pubmed
    ..The translocation of nPKCdelta observed in activated cells is likely not related to mucin secretion but to some other aspect of goblet cell biology...
  14. Coutinho Silva R, Ojcius D, Górecki D, Persechini P, Bisaggio R, Mendes A, et al. Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages. Biochem Pharmacol. 2005;69:641-55 pubmed
    ..These techniques also demonstrated the presence of mRNA for P2Y(1), P2Y(2), P2Y(4) and P2Y(6) receptors along with protein expression for the three subtypes we investigated, namely, P2Y(1), P2Y(2) and P2Y(4). ..
  15. del Rey A, Renigunta V, Dalpke A, Leipziger J, Matos J, Robaye B, et al. Knock-out mice reveal the contributions of P2Y and P2X receptors to nucleotide-induced Ca2+ signaling in macrophages. J Biol Chem. 2006;281:35147-55 pubmed
    ..stimulatory effect of UTP (or ATP) on endoplasmic reticulum (ER) Ca2+ release was abolished in cells isolated from P2Y2/P2Y4 double knock-out mice. Moreover, P2Y4(0/-), but not P2Y2-/-, macrophages responded to UTP...
  16. Malin S, Davis B, Koerber H, Reynolds I, Albers K, Molliver D. Thermal nociception and TRPV1 function are attenuated in mice lacking the nucleotide receptor P2Y2. Pain. 2008;138:484-96 pubmed publisher
    ..These results indicate that nucleotide signaling through P2Y(2) plays a key role in thermal nociception. ..
  17. Matos J, Robaye B, Boeynaems J, Beauwens R, Leipziger J. K+ secretion activated by luminal P2Y2 and P2Y4 receptors in mouse colon. J Physiol. 2005;564:269-79 pubmed
    ..To this end P2Y2 and P2Y4 knock-out mice were used to measure distal colonic ion transport in an Ussing chamber...
  18. Zhang Y, Pop I, Carlson N, Kishore B. Genetic deletion of the P2Y2 receptor offers significant resistance to development of lithium-induced polyuria accompanied by alterations in PGE2 signaling. Am J Physiol Renal Physiol. 2012;302:F70-7 pubmed publisher
  19. Müller T, Fay S, Vieira R, Karmouty Quintana H, Cicko S, Ayata K, et al. The purinergic receptor subtype P2Y2 mediates chemotaxis of neutrophils and fibroblasts in fibrotic lung disease. Oncotarget. 2017;8:35962-35972 pubmed publisher
    ..Here we investigated the role of the purinergic receptor subtype P2Y2 in the context of fibrotic lung diseases...
  20. Chen X, Qian S, Hoggatt A, Tang H, Hacker T, Obukhov A, et al. Endothelial Cell-Specific Deletion of P2Y2 Receptor Promotes Plaque Stability in Atherosclerosis-Susceptible ApoE-Null Mice. Arterioscler Thromb Vasc Biol. 2017;37:75-83 pubmed publisher
  21. Bao Y, Ledderose C, Graf A, Brix B, Birsak T, Lee A, et al. mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis. J Cell Biol. 2015;210:1153-64 pubmed publisher
    ..Adenosine triphosphate (ATP) release and autocrine purinergic signaling via P2Y2 receptors at the front and A2a receptors at the back of cells regulate chemotaxis...
  22. Wang S, Iring A, Strilic B, Albarrán Juárez J, Kaur H, Troidl K, et al. P2Y₂ and Gq/G₁₁ control blood pressure by mediating endothelial mechanotransduction. J Clin Invest. 2015;125:3077-86 pubmed publisher
    ..Here, we evaluated human and bovine endothelial cells and found that the purinergic receptor P2Y2 and the G proteins Gq/G11 mediate fluid shear stress-induced endothelial responses, including [Ca2+]i transients, ..
  23. Kunapuli S, Daniel J. P2 receptor subtypes in the cardiovascular system. Biochem J. 1998;336 ( Pt 3):513-23 pubmed
    ..However, the exact functions of these multiple receptor subtypes remain to be understood, as P2-receptor-selective agonists and antagonists are still under development. ..
  24. Schumacher D, Strilic B, Sivaraj K, Wettschureck N, Offermanns S. Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor. Cancer Cell. 2013;24:130-7 pubmed publisher
    ..We identified the endothelial P2Y2 receptor, which is activated by ATP, as the primary mediator of this effect...
  25. Degagné E, Turgeon N, Moore Gagné J, Asselin C, Gendron F. P2Y(2) receptor expression is regulated by C/EBP? during inflammation in intestinal epithelial cells. FEBS J. 2012;279:2957-65 pubmed publisher
    ..Chromatin immunoprecipitation assays revealed that both proteins simultaneously bind to the P2Y(2) promoter. Thus, we have identified C/EBP? as a novel regulator of P2Y(2) expression. ..
  26. Mamenko M, Zaika O, Jin M, O Neil R, Pochynyuk O. Purinergic activation of Ca2+-permeable TRPV4 channels is essential for mechano-sensitivity in the aldosterone-sensitive distal nephron. PLoS ONE. 2011;6:e22824 pubmed publisher
    ..ratiometric Fura-2 based monitoring of [Ca(2+)](i) in freshly isolated split-opened ASDN with targeted deletion of P2Y2 and TRPV4 in mice to probe a role for purinergic signaling in mediating mechano-sensitive responses in ASDN cells...
  27. Schrader A, Camden J, Weisman G. P2Y2 nucleotide receptor up-regulation in submandibular gland cells from the NOD.B10 mouse model of Sjögren's syndrome. Arch Oral Biol. 2005;50:533-40 pubmed
    ..e., disease progression). P2Y(2) receptor up-regulation in SMGs is associated with the SS phenotype in NOD.B10 mice, which encourages further attempts to determine the role of this pathway in the development of SS. ..
  28. Yamamoto S, Ichishima K, Ehara T. Regulation of extracellular UTP-activated Cl- current by P2Y-PLC-PKC signaling and ATP hydrolysis in mouse ventricular myocytes. J Physiol Sci. 2007;57:85-94 pubmed
    ..Our results strongly suggest that I(Cl.UTP) is due to the activation of CFTR Cl- channels through Gq/11-coupled P2Y2 receptor-PLC-PKC signaling and ATP hydrolysis in mouse heart.
  29. Dong X, Smoll E, Ko K, Lee J, Chow J, Kim H, et al. P2Y receptors mediate Ca2+ signaling in duodenocytes and contribute to duodenal mucosal bicarbonate secretion. Am J Physiol Gastrointest Liver Physiol. 2009;296:G424-32 pubmed publisher
  30. Kronlage M, Song J, Sorokin L, Isfort K, Schwerdtle T, Leipziger J, et al. Autocrine purinergic receptor signaling is essential for macrophage chemotaxis. Sci Signal. 2010;3:ra55 pubmed publisher
    ..We propose a model in which autocrine purinergic receptor signaling amplifies and translates chemotactic cues into directional motility. ..
  31. Hatanaka H, Takada S, Choi Y, Fujiwara S, Soda M, Enomoto M, et al. Transforming activity of purinergic receptor P2Y, G-protein coupled, 2 revealed by retroviral expression screening. Biochem Biophys Res Commun. 2007;356:723-6 pubmed
    ..One of such cDNAs turned out to encode purinergic receptor P2Y, G-protein coupled, 2 (P2RY2)...
  32. Zhu H, Yu Y, Zheng L, Wang L, Li C, Yu J, et al. Chronic inflammatory pain upregulates expression of P2Y2 receptor in small-diameter sensory neurons. Metab Brain Dis. 2015;30:1349-58 pubmed publisher
  33. Chen S, Smith B, Iype J, Prestipino A, Pfeifer D, Grundmann S, et al. MicroRNA-155-deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activation. Blood. 2015;126:103-12 pubmed publisher
    ..Inhibiting proinflammatory miR-155 by antagomir treatment could help reduce this complication of allo-HCT. ..
  34. Huang Y, Dando R, Roper S. Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. J Neurosci. 2009;29:13909-18 pubmed publisher
    ..These results begin to sort out how purinergic and aminergic transmitters function within the taste bud to modulate gustatory signaling in these peripheral sensory organs...
  35. De Oliveira Moreira D, Santo Neto H, Marques M. P2Y2 purinergic receptors are highly expressed in cardiac and diaphragm muscles of mdx mice, and their expression is decreased by suramin. Muscle Nerve. 2017;55:116-121 pubmed publisher
    ..P2-selective drugs with specific actions in the dystrophic heart may ameliorate cardiomyopathy in dystrophinopathies. Muscle Nerve 55: 116-121, 2017. ..
  36. DISSMORE T, Seye C, Medeiros D, Weisman G, Bradford B, Mamedova L. The P2Y2 receptor mediates uptake of matrix-retained and aggregated low density lipoprotein in primary vascular smooth muscle cells. Atherosclerosis. 2016;252:128-135 pubmed publisher
    ..is that under pathophysiological conditions, nucleotide release from blood-derived and vascular cells activates SMC P2Y2 receptors (P2Y2Rs) leading to rearrangement of the actin cytoskeleton and cell motility...
  37. Hanley P, Kronlage M, Kirschning C, del Rey A, Di Virgilio F, Leipziger J, et al. Transient P2X7 receptor activation triggers macrophage death independent of Toll-like receptors 2 and 4, caspase-1, and pannexin-1 proteins. J Biol Chem. 2012;287:10650-63 pubmed publisher
    ..Thus, "transient" P2X(7) receptor activation and Ca(2+) overload act as a death trigger for native mouse macrophages independent of Panx1 and pro-inflammatory caspase-1 and TLR signaling. ..
  38. Guns P, Van Assche T, Fransen P, Robaye B, Boeynaems J, Bult H. Endothelium-dependent relaxation evoked by ATP and UTP in the aorta of P2Y2-deficient mice. Br J Pharmacol. 2006;147:569-74 pubmed
    ..the mouse aorta, endothelium-dependent relaxation by nucleotides is mediated by P2Y1 (adenosine diphosphate (ADP)), P2Y2 (adenosine triphosphate (ATP)) and P2Y6 (uridine diphosphate (UDP)) receptors...
  39. Arthur D, Akassoglou K, Insel P. P2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation. Proc Natl Acad Sci U S A. 2005;102:19138-43 pubmed
  40. Zhang Y, Listhrop R, Ecelbarger C, Kishore B. Renal sodium transporter/channel expression and sodium excretion in P2Y2 receptor knockout mice fed a high-NaCl diet with/without aldosterone infusion. Am J Physiol Renal Physiol. 2011;300:F657-68 pubmed publisher
    The P2Y(2) receptor (P2Y2-R) antagonizes sodium reabsorption in the kidney...
  41. Rowlands D, Islam M, Das S, Huertas A, Quadri S, Horiuchi K, et al. Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity of inflammation in mouse lung microvessels. J Clin Invest. 2011;121:1986-99 pubmed publisher
    ..The proinflammatory cytokine soluble TNF-? (sTNF-?) increased mitochondrial Ca2+, and the purinergic receptor P2Y2 prolonged the response...
  42. Kouzaki H, Iijima K, Kobayashi T, O Grady S, Kita H. The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses. J Immunol. 2011;186:4375-87 pubmed publisher
    ..Pharmacological inhibitors of purinergic receptors or deficiency in the P2Y2 gene abrogate IL-33 release and Th2-type responses in the Alternaria-induced airway inflammation model in naive ..
  43. Janssens R, Communi D, Pirotton S, Samson M, Parmentier M, Boeynaems J. Cloning and tissue distribution of the human P2Y1 receptor. Biochem Biophys Res Commun. 1996;221:588-93 pubmed
    ..synthesized on the basis of the best conserved regions of the chick brain P2Y/P2Y1 and the murine neuroblastoma P2U/P2Y2 receptors were used in polymerase chain reaction experiments on human genomic DNA...
  44. Gödecke S, Decking U, Godecke A, Schrader J. Cloning of the rat P2u receptor and its potential role in coronary vasodilation. Am J Physiol. 1996;270:C570-7 pubmed
    ..Our experiments suggest that, in the rat heart, endothelial P2u receptors are involved in the ATP/UTP-mediated vasodilation of coronary blood vessels...
  45. Wildman S, Boone M, Peppiatt Wildman C, Contreras Sanz A, King B, Shirley D, et al. Nucleotides downregulate aquaporin 2 via activation of apical P2 receptors. J Am Soc Nephrol. 2009;20:1480-90 pubmed publisher
    ..In summary, these data suggest that AQP2-mediated water transport is downregulated not only by basolateral nucleotides, mediated by P2Y(2) receptors, but also by luminal nucleotides, mediated by P2X(2) and/or P2Y(4) receptors. ..
  46. Inoue Y, Chen Y, Hirsh M, Yip L, Junger W. A3 and P2Y2 receptors control the recruitment of neutrophils to the lungs in a mouse model of sepsis. Shock. 2008;30:173-7 pubmed
    We have recently shown that A3 adenosine receptors and P2Y2 purinergic receptors play an important role in neutrophil chemotaxis. Chemotaxis of neutrophils to sites of infections is critical for immune defense...
  47. Haanes K, Edvinsson L. Characterization of the contractile P2Y14 receptor in mouse coronary and cerebral arteries. FEBS Lett. 2014;588:2936-43 pubmed publisher
    ..After organ culture of the coronary artery, the EC50 value decreased and an increased staining for the P2Y14 receptor was observed, showing receptor plasticity. ..
  48. Jin H, Seo J, Eun S, Joo Y, Park S, Lee J, et al. P2Y2 R activation by nucleotides promotes skin wound-healing process. Exp Dermatol. 2014;23:480-5 pubmed publisher
    b>P2Y2 R has been shown to be upregulated in a variety of tissues in response to stress or injury and to mediate tissue regeneration through its ability to activate multiple signalling pathways...
  49. Cicko S, Lucattelli M, Müller T, Lommatzsch M, De Cunto G, Cardini S, et al. Purinergic receptor inhibition prevents the development of smoke-induced lung injury and emphysema. J Immunol. 2010;185:688-97 pubmed publisher
    ..We demonstrate, for the first time, that endogenous ATP contributes to smoke-induced lung inflammation and then development of emphysema via activation of the purinergic receptor subtypes, such as P2Y(2)R. ..
  50. Ayata C, Ganal S, Hockenjos B, Willim K, Vieira R, Grimm M, et al. Purinergic P2Y? receptors promote neutrophil infiltration and hepatocyte death in mice with acute liver injury. Gastroenterology. 2012;143:1620-1629.e4 pubmed publisher
    ..Reagents designed to target P2Y(2)R might be developed to treat inflammatory liver disease. ..
  51. Kim H, Ajit D, Peterson T, Wang Y, Camden J, Gibson Wood W, et al. Nucleotides released from A????? -treated microglial cells increase cell migration and A????? uptake through P2Y? receptor activation. J Neurochem. 2012;121:228-38 pubmed publisher
    ..Taken together, our findings suggest that P2Y(2) Rs can activate microglial cells to enhance A? clearance and highlight the P2Y(2) R as a therapeutic target in Alzheimer's disease. ..
  52. Isfort K, Ebert F, Bornhorst J, Sargin S, Kardakaris R, Pasparakis M, et al. Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to complement C5a is phosphatidylinositol 3-kinase (PI3K)- and p38 mitogen-activated protein kinase (MAPK)-independent. J Biol Chem. 2011;286:44776-87 pubmed publisher
    ..We propose that ATP signaling is strictly autocrine or paracrine and that ATP and ADP may act as short-range "touch me" (rather than long-range find me) signals to promote phagocytic clearance via cell spreading. ..
  53. Rieg T, Gerasimova M, Boyer J, Insel P, Vallon V. P2Y₂ receptor activation decreases blood pressure and increases renal Na⁺ excretion. Am J Physiol Regul Integr Comp Physiol. 2011;301:R510-8 pubmed publisher
    ..Systemic activation of P2Y(2) receptors thus lowers blood pressure and inhibits renal Na(+) reabsorption, effects suggesting the potential utility of P2Y(2) agonism in the treatment of hypertension. ..