P2rx3

Summary

Gene Symbol: P2rx3
Description: purinergic receptor P2X, ligand-gated ion channel, 3
Alias: 4930513E20Rik, P2X3, P2X purinoceptor 3, ATP receptor, purinergic receptor P2X3
Species: mouse
Products:     P2rx3

Top Publications

  1. Kunapuli S, Daniel J. P2 receptor subtypes in the cardiovascular system. Biochem J. 1998;336 ( Pt 3):513-23 pubmed
    ..However, the exact functions of these multiple receptor subtypes remain to be understood, as P2-receptor-selective agonists and antagonists are still under development. ..
  2. Koshimizu T, Ueno S, Tanoue A, Yanagihara N, Stojilkovic S, Tsujimoto G. Heteromultimerization modulates P2X receptor functions through participating extracellular and C-terminal subdomains. J Biol Chem. 2002;277:46891-9 pubmed
    ..These results indicate that heteromeric receptors formed by distinct P2XR subunits develop new functions resulting from integrative effects of the participating extracellular and C-terminal subdomains. ..
  3. Simonetti M, Giniatullin R, Fabbretti E. Mechanisms mediating the enhanced gene transcription of P2X3 receptor by calcitonin gene-related peptide in trigeminal sensory neurons. J Biol Chem. 2008;283:18743-52 pubmed publisher
    ..BDNF was an intermediate to extend the sensitizing effect of CGRP also to CGRP-insensitive neurons. This combinatorial action could serve as a powerful process to amplify and prolong pain mediated by P2X(3) receptors. ..
  4. D Arco M, Giniatullin R, Leone V, Carloni P, Birsa N, Nair A, et al. The C-terminal Src inhibitory kinase (Csk)-mediated tyrosine phosphorylation is a novel molecular mechanism to limit P2X3 receptor function in mouse sensory neurons. J Biol Chem. 2009;284:21393-401 pubmed publisher
    ..The present study provides the first demonstration of an original molecular mechanism responsible for negative control over P2X(3) receptor function and outlines a potential new target for trigeminal pain suppression. ..
  5. Shinoda M, Feng B, Gebhart G. Peripheral and central P2X receptor contributions to colon mechanosensitivity and hypersensitivity in the mouse. Gastroenterology. 2009;137:2096-104 pubmed publisher
    ..These results suggest differential roles for peripheral and central P2X(3) receptors in colon mechanosensory transduction and hypersensitivity. ..
  6. Fabbretti E, Nistri A. Regulation of P2X3 receptor structure and function. CNS Neurol Disord Drug Targets. 2012;11:687-98 pubmed
    The strong expression of ATP-gated P2X3 receptors by a subpopulation of sensory neurons indicates the important role of these membrane proteins in nociceptive signaling in health and disease, especially when the latter is accompanied by ..
  7. Simonetti M, Fabbro A, D Arco M, Zweyer M, Nistri A, Giniatullin R, et al. Comparison of P2X and TRPV1 receptors in ganglia or primary culture of trigeminal neurons and their modulation by NGF or serotonin. Mol Pain. 2006;2:11 pubmed
  8. Ishida Y, Ugawa S, Ueda T, Yamada T, Shibata Y, Hondoh A, et al. P2X(2)- and P2X(3)-positive fibers in fungiform papillae originate from the chorda tympani but not the trigeminal nerve in rats and mice. J Comp Neurol. 2009;514:131-44 pubmed publisher
    ..Taken together, these findings suggest that most P2X(2) and P2X(3) receptors in fungiform papillae are used for gustation rather than somatosensation...
  9. Luo W, Wickramasinghe S, Savitt J, Griffin J, Dawson T, Ginty D. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron. 2007;54:739-54 pubmed
    ..These findings support a model in which NGF controls maturation of nonpeptidergic DRG neurons through a combination of GFR/Ret-dependent and -independent signaling pathways. ..

More Information

Publications71

  1. Chen C, Broom D, Liu Y, de Nooij J, Li Z, Cen C, et al. Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron. 2006;49:365-77 pubmed
    ..Moreover, mice lacking Runx1 exhibit specific defects in thermal and neuropathic pain. Thus, Runx1 coordinates the phenotype of a large cohort of nociceptors, a finding with implications for pain therapy. ..
  2. Cockayne D, Dunn P, Zhong Y, Rong W, Hamilton S, Knight G, et al. P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP. J Physiol. 2005;567:621-39 pubmed
    ..signalling and sensory regulation of visceral function through ionotropic receptors variably composed of P2X2 and P2X3 subunits...
  3. Hullugundi S, Ferrari M, van den Maagdenberg A, Nistri A. The mechanism of functional up-regulation of P2X3 receptors of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine type 1 (FHM-1). PLoS ONE. 2013;8:e60677 pubmed publisher
    ..1 channels shows, at the level of the trigeminal ganglion, selective functional up-regulation of ATP -gated P2X3 receptors of sensory neurons that convey nociceptive signals to the brainstem...
  4. Huang T, Krimm R. BDNF and NT4 play interchangeable roles in gustatory development. Dev Biol. 2014;386:308-20 pubmed publisher
    ..Spatial and temporal differences in BDNF and NT4 expression can regulate differential gene expression in vivo and determine their specific roles during development. ..
  5. Nair A, Simonetti M, Birsa N, Ferrari M, van den Maagdenberg A, Giniatullin R, et al. Familial hemiplegic migraine Ca(v)2.1 channel mutation R192Q enhances ATP-gated P2X3 receptor activity of mouse sensory ganglion neurons mediating trigeminal pain. Mol Pain. 2010;6:48 pubmed publisher
    ..We investigated whether this gain-of-function mutation changed the structure and function of trigeminal neuron P2X3 receptors that are thought to be important contributors to migraine pain...
  6. Finger T, Danilova V, Barrows J, Bartel D, Vigers A, Stone L, et al. ATP signaling is crucial for communication from taste buds to gustatory nerves. Science. 2005;310:1495-9 pubmed
    ..Genetic elimination of ionotropic purinergic receptors (P2X2 and P2X3) eliminates taste responses in the taste nerves, although the nerves remain responsive to touch, temperature, and ..
  7. Ma B, Ruan H, Cockayne D, Ford A, Burnstock G, Dunn P. Identification of P2X receptors in cultured mouse and rat parasympathetic otic ganglion neurones including P2X knockout studies. Neuropharmacology. 2004;46:1039-48 pubmed
    ..In conclusion, we have shown for the first time that at least two distinct P2X receptors are present in mouse and rat otic neurones, probably homomeric P2X(2) and heteromeric P2X(2/3) receptors. ..
  8. Fei D, Krimm R. Taste neurons consist of both a large TrkB-receptor-dependent and a small TrkB-receptor-independent subpopulation. PLoS ONE. 2013;8:e83460 pubmed publisher
    ..In addition, these remaining neurons do not express the TrkB receptor, which indicates that either BDNF or NT-4 must act via additional receptors to influence tongue innervation and/or targeting. ..
  9. Ren A, Wang K, Zhang H, Liu A, Ma X, Liang Q, et al. ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons. Nat Commun. 2014;5:4984 pubmed publisher
    ..Our findings point to ZBTB20 as a critical regulator of nociception and pain sensation by modulating TRP channels expression in nociceptors. ..
  10. Vandenbeuch A, Larson E, Anderson C, Smith S, Ford A, Finger T, et al. Postsynaptic P2X3-containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice. J Physiol. 2015;593:1113-25 pubmed publisher
    Taste buds release ATP to activate ionotropic purinoceptors composed of P2X2 and P2X3 subunits, present on the taste nerves...
  11. Kestler C, Neuhuber W, Raab M. Distribution of P2X(3) receptor immunoreactivity in myenteric ganglia of the mouse esophagus. Histochem Cell Biol. 2009;131:13-27 pubmed publisher
    ..We conclude that ATP might act as a neuromodulator in IGLEs via a (P2X(2))-P2X(3) receptor-mediated pathway especially in the abdominal portion of the mouse esophagus. ..
  12. Kanaya K, Iba K, Abe Y, Dohke T, Okazaki S, Matsumura T, et al. Acid-sensing ion channel 3 or P2X2/3 is involved in the pain-like behavior under a high bone turnover state in ovariectomized mice. J Orthop Res. 2016;34:566-73 pubmed publisher
    ..These results indicated that the skeletal pain accompanying osteoporosis is possibly associated with the acidic microenvironment and increased ATP level caused by osteoclast activation under a high bone turnover state. ..
  13. Tsuda M, Shigemoto Mogami Y, Ueno S, Koizumi S, Ueda H, Iwanaga T, et al. Downregulation of P2X3 receptor-dependent sensory functions in A/J inbred mouse strain. Eur J Neurosci. 2002;15:1444-50 pubmed
    ..However, the determinant factors for the strain-specific differences remain unknown. The P2X3 sensory-specific ATP-gated channel has been implicated as a damage-sensing molecule that evokes a pain sensation by ..
  14. Shimizu I, Iida T, Guan Y, Zhao C, Raja S, Jarvis M, et al. Enhanced thermal avoidance in mice lacking the ATP receptor P2X3. Pain. 2005;116:96-108 pubmed
    b>P2X3 is an ATP-gated cation channel subtype expressed by a subpopulation of primary sensory neurons...
  15. Morikawa Y, Tamura S, Minehata K, Donovan P, Miyajima A, Senba E. Essential function of oncostatin m in nociceptive neurons of dorsal root ganglia. J Neurosci. 2004;24:1941-7 pubmed
    ..In the DRGs of the OSM-deficient mice, vanilloid receptor 1 (VR1)- and P2X3-positive small-sized neurons were significantly decreased...
  16. Kabanova N, Vassilevski A, Rogachevskaja O, Bystrova M, Korolkova Y, Pluzhnikov K, et al. Modulation of P2X3 receptors by spider toxins. Biochim Biophys Acta. 2012;1818:2868-75 pubmed publisher
    ..and shown to exert marked modulatory effects on P2X3 receptors in rat sensory neurons...
  17. Banerjee B, Medda B, Schmidt J, Zheng Y, Zhang Z, Shaker R, et al. Altered expression of P2X3 in vagal and spinal afferents following esophagitis in rats. Histochem Cell Biol. 2009;132:585-97 pubmed publisher
    ..Changes in P2X(3) expression in vagal and spinal sensory neurons may contribute to esophageal hypersensitivity following acid reflux-induced esophagitis. ..
  18. Cho T, Chaban V. Expression of P2X3 and TRPV1 receptors in primary sensory neurons from estrogen receptors-? and estrogen receptor-? knockout mice. Neuroreport. 2012;23:530-4 pubmed publisher
    ..Our previous data strongly suggest an interaction between ERs and ATP-induced purinergic (P2X3) as well as ERs and capsaicin-induced vanilloid (TRPV1) receptors at the level of dorsal root ganglion (DRG) ..
  19. Brierley S, Carter R, Jones W, Xu L, Robinson D, Hicks G, et al. Differential chemosensory function and receptor expression of splanchnic and pelvic colonic afferents in mice. J Physiol. 2005;567:267-81 pubmed
    ..thoracolumbar and lumbosacral dorsal root ganglia (DRG) were retrogradely labelled from the colon and analysed for P2X3- and TRPV1-like immunoreactivity (LI)...
  20. Eddy M, Eschle B, Barrows J, Hallock R, Finger T, Delay E. Double P2X2/P2X3 purinergic receptor knockout mice do not taste NaCl or the artificial sweetener SC45647. Chem Senses. 2009;34:789-97 pubmed publisher
    The P2X ionotropic purinergic receptors, P2X2 and P2X3, are essential for transmission of taste information from taste buds to the gustatory nerves...
  21. Dykes I, Lanier J, Eng S, Turner E. Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation. Neural Dev. 2010;5:3 pubmed publisher
    ..Together these data show that Brn3a acts upstream of the Runx factors, which then repress TrkB expression to allow establishment of the non-overlapping Trk receptor profiles and correct terminally differentiated phenotypes. ..
  22. Rong W, Gourine A, Cockayne D, Xiang Z, Ford A, Spyer K, et al. Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia. J Neurosci. 2003;23:11315-21 pubmed
    ..receptor subunit showed a markedly attenuated ventilatory response to hypoxia, whereas the response to hypoxia in P2X3-deficient mice was comparable with that seen in wild-type controls...
  23. Chen Y, Zhang X, Wang C, Li G, Gu Y, Huang L. Activation of P2X7 receptors in glial satellite cells reduces pain through downregulation of P2X3 receptors in nociceptive neurons. Proc Natl Acad Sci U S A. 2008;105:16773-8 pubmed publisher
    ..Thus, direct blocking P2X7Rs, as proposed before, may not be the best strategy for reducing pain or lessening neuronal degeneration because it also disrupts the protective function of P2X7Rs. ..
  24. Cockayne D, Hamilton S, Zhu Q, Dunn P, Zhong Y, Novakovic S, et al. Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature. 2000;407:1011-5 pubmed
    ..The ATP receptor P2X3 is selectively expressed on small diameter sensory neurons, supporting this hypothesis...
  25. Shigematsu Y, Shimoda Y, Kaneda M. Distribution of immunoreactivity for P2X3, P2X5, and P2X6-purinoceptors in mouse retina. J Mol Histol. 2007;38:369-71 pubmed
    ..In the present study, we used an immunohistochemical technique to examine whether P2X3-, P2X5, and P2X6-purinoceptors are also important for the modulation of cholinergic amacrine cells in mouse retina...
  26. Bian X, Ren J, DeVries M, Schnegelsberg B, Cockayne D, Ford A, et al. Peristalsis is impaired in the small intestine of mice lacking the P2X3 subunit. J Physiol. 2003;551:309-22 pubmed
    ..In this study, we used tissues from P2X3 wild-type (P2X3+/+) mice and mice in which the P2X3 subunit gene had been deleted (P2X3-/-) to investigate the role ..
  27. Stratford J, Finger T. Central representation of postingestive chemosensory cues in mice that lack the ability to taste. J Neurosci. 2011;31:9101-10 pubmed publisher
    The gustatory nerves of mice lacking P2X2 and P2X3 purinergic receptor subunits (P2X-dblKO) are unresponsive to taste stimulation (Finger et al., 2005)...
  28. Cui X, Li X, Shen X, Bae Y, Kang J, Kim N. Transcription profile in mouse four-cell, morula, and blastocyst: Genes implicated in compaction and blastocoel formation. Mol Reprod Dev. 2007;74:133-43 pubmed
    ..The identification of the genes being expressed in here will provide insight into the complex gene regulatory networks effecting compaction and blastocoel formation...
  29. Lou S, Pan X, Huang T, Duan B, Yang F, Yang J, et al. Incoherent feed-forward regulatory loops control segregation of C-mechanoreceptors, nociceptors, and pruriceptors. J Neurosci. 2015;35:5317-29 pubmed publisher
    ..The evolvement of these I-FFLs provides an explanation for how modality-selective sensory subtypes are formed during development and may also have intriguing implications for sensory neuron evolution and sensory coding. ..
  30. Fei D, Huang T, Krimm R. The neurotrophin receptor p75 regulates gustatory axon branching and promotes innervation of the tongue during development. Neural Dev. 2014;9:15 pubmed publisher
    ..This function is likely accomplished independently of BDNF, NT4, and TrkB. In addition, p75 does not support the remaining neurons or taste buds in TrkB-/-mice. ..
  31. Barth K, Kasper M. Membrane compartments and purinergic signalling: occurrence and function of P2X receptors in lung. FEBS J. 2009;276:341-53 pubmed publisher
  32. Vlaskovska M, Kasakov L, Rong W, Bodin P, Bardini M, Cockayne D, et al. P2X3 knock-out mice reveal a major sensory role for urothelially released ATP. J Neurosci. 2001;21:5670-7 pubmed
    ..These data strongly suggest a major sensory role for urothelially released ATP acting via P2X(3) receptors on a subpopulation of pelvic afferent fibers. ..
  33. Chen Z, Rebelo S, White F, Malmberg A, Baba H, Lima D, et al. The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron. 2001;31:59-73 pubmed
    ..Drg11 is thus required for the formation of spatio-temporally appropriate projections from nociceptive sensory neurons to their central targets in the dorsal horn of the spinal cord. ..
  34. Zhong Y, Dunn P, Bardini M, Ford A, Cockayne D, Burnstock G. Changes in P2X receptor responses of sensory neurons from P2X3-deficient mice. Eur J Neurosci. 2001;14:1784-92 pubmed
    ..In the present study, we examined the P2X receptors on DRG and nodose neurons from P2X3-deficient (P2X3-/-) mice, using whole cell voltage-clamp recording and immunohistochemistry...
  35. Ruan H, Moules E, Burnstock G. Changes in P2X3 purinoceptors in sensory ganglia of the mouse during embryonic and postnatal development. Histochem Cell Biol. 2004;122:539-51 pubmed
    ..The neurons that were positive for calbindin in embryonic dorsal, trigeminal and nodose ganglia showed colocalisation with P2X(3) receptors, but few showed colocalisation postnatally. ..
  36. Walczak J, Price T, Cervero F. Cannabinoid CB1 receptors are expressed in the mouse urinary bladder and their activation modulates afferent bladder activity. Neuroscience. 2009;159:1154-63 pubmed publisher
    ..Finally, the reduction of nerve activity induced by cannabinoid-receptor activation implicates CB(1) receptors in the peripheral modulation of bladder afferent information. ..
  37. Souslova V, Cesare P, Ding Y, Akopian A, Stanfa L, Suzuki R, et al. Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors. Nature. 2000;407:1015-7 pubmed
    ATP activates damage-sensing neurons (nociceptors) and can evoke a sensation of pain. The ATP receptor P2X3 is selectively expressed by nociceptors and is one of seven ATP-gated, cation-selective ion channels...
  38. Vilotti S, Marchenkova A, Ntamati N, Nistri A. B-type natriuretic peptide-induced delayed modulation of TRPV1 and P2X3 receptors of mouse trigeminal sensory neurons. PLoS ONE. 2013;8:e81138 pubmed publisher
    ..neurons that express transient receptor vanilloid-1 (TRPV1) channels and/or adenosine triphosphate (ATP)-gated P2X3 receptors whose activity is upregulated by endogenous neuropeptides in acute and chronic pain models...
  39. Kunori S, Matsumura S, Mabuchi T, Tatsumi S, Sugimoto Y, Minami T, et al. Involvement of prostaglandin F 2 alpha receptor in ATP-induced mechanical allodynia. Neuroscience. 2009;163:362-71 pubmed publisher
  40. Sclafani A, Ackroff K. Maltodextrin and fat preference deficits in "taste-blind" P2X2/P2X3 knockout mice. Chem Senses. 2014;39:507-14 pubmed publisher
    ..Genetic deletion of the purinergic P2X2/P2X3 receptor greatly reduces the neural and behavioral response to prototypical primary taste stimuli...
  41. Stratford J, Thompson J, Finger T. Immunocytochemical organization and sour taste activation in the rostral nucleus of the solitary tract of mice. J Comp Neurol. 2017;525:271-290 pubmed publisher
    ..J. Comp. Neurol. 525:271-290, 2017. © 2016 Wiley Periodicals, Inc. ..
  42. Koudelka J, Horn J, Vatanashevanopakorn C, Minichiello L. Genetic dissection of TrkB activated signalling pathways required for specific aspects of the taste system. Neural Dev. 2014;9:21 pubmed publisher
    ..These results advance our knowledge of the biology of the taste system, one of the fundamental sensory systems crucial for an organism to relate to the environment. ..
  43. Gao X, Feng J, Wang W, Xiang Z, Liu X, Zhu C, et al. Pirt reduces bladder overactivity by inhibiting purinergic receptor P2X3. Nat Commun. 2015;6:7650 pubmed publisher
    ..Pirt and P2X3 receptor co-localize in bladder nerve fibres and heterologous Pirt expression significantly reduces P2X3-mediated ..
  44. McIlwrath S, Davis B, Bielefeldt K. Deletion of P2X3 receptors blunts gastro-oesophageal sensation in mice. Neurogastroenterol Motil. 2009;21:890-e66 pubmed publisher
    ..We therefore hypothesized that deletion of P2X3 receptors will blunt responses to gastric distension in vagal sensory neurons...
  45. Huang Y, Stone L, Pereira E, Yang R, Kinnamon J, Dvoryanchikov G, et al. Knocking out P2X receptors reduces transmitter secretion in taste buds. J Neurosci. 2011;31:13654-61 pubmed publisher
    In response to gustatory stimulation, taste bud cells release a transmitter, ATP, that activates P2X2 and P2X3 receptors on gustatory afferent fibers...
  46. Marchenkova A, Vilotti S, Ntamati N, van den Maagdenberg A, Nistri A. Inefficient constitutive inhibition of P2X3 receptors by brain natriuretic peptide system contributes to sensitization of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine. Mol Pain. 2016;12: pubmed publisher
    On trigeminal ganglion neurons, pain-sensing P2X3 receptors are constitutively inhibited by brain natriuretic peptide via its natriuretic peptide receptor-A...
  47. Marchenkova A, Vilotti S, Fabbretti E, Nistri A. Brain natriuretic peptide constitutively downregulates P2X3 receptors by controlling their phosphorylation state and membrane localization. Mol Pain. 2015;11:71 pubmed publisher
    ATP-gated P2X3 receptors are important transducers of nociceptive stimuli and are almost exclusively expressed by sensory ganglion neurons...
  48. Wang Y, Mackes J, Chan S, Haughey N, Guo Z, Ouyang X, et al. Impaired long-term depression in P2X3 deficient mice is not associated with a spatial learning deficit. J Neurochem. 2006;99:1425-34 pubmed
    ..Here we show that mice lacking the P2X3 ATP receptor (P2X3KO mice) exhibit abnormalities in hippocampal synaptic plasticity that can be restored by pharmacological ..
  49. Marchenkova A, van den Maagdenberg A, Nistri A. Loss of inhibition by brain natriuretic peptide over P2X3 receptors contributes to enhanced spike firing of trigeminal ganglion neurons in a mouse model of familial hemiplegic migraine type-1. Neuroscience. 2016;331:197-205 pubmed publisher
    Purinergic P2X3 receptors (P2X3Rs) play an important role in pain pathologies, including migraine. In trigeminal neurons, P2X3Rs are constitutively downregulated by endogenous brain natriuretic peptide (BNP)...
  50. Coutinho Silva R, Knight G, Burnstock G. Impairment of the splenic immune system in P2X(2)/P2X(3) knockout mice. Immunobiology. 2005;209:661-8 pubmed
  51. Huang L, Ryan A, Cockayne D, Housley G. Developmentally regulated expression of the P2X3 receptor in the mouse cochlea. Histochem Cell Biol. 2006;125:681-92 pubmed
    ..These data suggest a role for P2X(3) receptor-mediated purinergic signaling in cochlear synaptic reorganization, and establishment of neurotransmission, which occurs just prior to the onset of hearing function. ..
  52. Jarvis M, Khakh B. ATP-gated P2X cation-channels. Neuropharmacology. 2009;56:208-15 pubmed publisher
    ..In this article we have tried to present as much information as possible in two tables in the hope this will be useful as a day-to-day resource, and also because an excellent and detailed review has recently been published. ..
  53. González Rodríguez S, Pevida M, Roques B, Fournie Zaluski M, Hidalgo A, Menéndez L, et al. Involvement of enkephalins in the inhibition of osteosarcoma-induced thermal hyperalgesia evoked by the blockade of peripheral P2X3 receptors. Neurosci Lett. 2009;465:285-9 pubmed publisher
    ..This synergism opens the theoretical possibility that the combination of both types of drugs could be useful to counteract some nociceptive symptoms derived from tumor development. ..
  54. Souslova V, Ravenall S, Fox M, Wells D, Wood J, Akopian A. Structure and chromosomal mapping of the mouse P2X3 gene. Gene. 1997;195:101-11 pubmed
    b>P2X3 is one of seven cloned ATP-gated non-selective cation channels. We have isolated a full-length mouse P2X3 gene from a phage lambda-129/Sv genomic library. The gene consists of 12 exons spanning a locus of approximately 40 kb...
  55. Cho T, Chaban V. Interaction between P2X3 and oestrogen receptor (ER)?/ER? in ATP-mediated calcium signalling in mice sensory neurones. J Neuroendocrinol. 2012;24:789-97 pubmed publisher
    Emerging evidence supports a role of purinergic P2X3 receptors in modulating nociceptive signalling in sensory neurones...
  56. Kiyatkin M, Feng B, Schwartz E, Gebhart G. Combined genetic and pharmacological inhibition of TRPV1 and P2X3 attenuates colorectal hypersensitivity and afferent sensitization. Am J Physiol Gastrointest Liver Physiol. 2013;305:G638-48 pubmed publisher
    The ligand-gated channels transient receptor potential vanilloid 1 (TRPV1) and P2X3 have been reported to facilitate colorectal afferent neuron sensitization, thus contributing to organ hypersensitivity and pain...
  57. Boldogkoi Z, Schütz B, Sallach J, Zimmer A. P2X(3) receptor expression at early stage of mouse embryogenesis. Mech Dev. 2002;118:255-60 pubmed
  58. Yasuda M, Shinoda M, Kiyomoto M, Honda K, Suzuki A, Tamagawa T, et al. P2X3 receptor mediates ectopic mechanical allodynia with inflamed lower lip in mice. Neurosci Lett. 2012;528:67-72 pubmed publisher
    ..This P2X(3)R overexpression may underlie ectopic mechanical allodynia in the whisker pad skin after CFA injection into the lower lip...
  59. Gnanasekaran A, Sundukova M, Hullugundi S, Birsa N, Bianchini G, Hsueh Y, et al. Calcium/calmodulin-dependent serine protein kinase (CASK) is a new intracellular modulator of P2X3 receptors. J Neurochem. 2013;126:102-12 pubmed publisher
    ATP-gated P2X3 receptors of sensory ganglion neurons are important transducers of painful stimuli and are modulated by extracellular algogenic substances, via changes in the receptor phosphorylation state...
  60. Hallock R, Tatangelo M, Barrows J, Finger T. Residual chemosensory capabilities in double P2X2/P2X3 purinergic receptor null mice: intraoral or postingestive detection?. Chem Senses. 2009;34:799-808 pubmed publisher
    Mice lacking the purinergic receptors, P2X2 and P2X3 (P2X2/P2X3(Dbl-/-)), exhibit essentially no tastant-evoked activity in the chorda tympani and glossopharyngeal nerves and substantial loss of tastant-evoked behavior as measured in long-..
  61. Wang E, Lee J, Ruiz W, Balestreire E, von Bodungen M, Barrick S, et al. ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells. J Clin Invest. 2005;115:2412-22 pubmed
    ..Moreover, knockout mice lacking expression of P2X2 and/or P2X3 receptors failed to show increases in apical surface area when exposed to hydrostatic pressure...
  62. Shinoda M, La J, Bielefeldt K, Gebhart G. Altered purinergic signaling in colorectal dorsal root ganglion neurons contributes to colorectal hypersensitivity. J Neurophysiol. 2010;104:3113-23 pubmed publisher
    ..These findings suggest that colorectal hypersensitivity produced by intracolonic zymosan increases excitability and enhances purinergic signaling in c-DRG neurons. ..