P2P R

Summary

Gene Symbol: P2P R
Description: retinoblastoma binding protein 6, ubiquitin ligase
Alias: 4933422O15Rik, AI316869, BB233631, C030034J04Rik, C77662, P2P-R, PACT, E3 ubiquitin-protein ligase RBBP6, RING-type E3 ubiquitin transferase RBBP6, p53-associated cellular protein of testis, proliferation potential-related protein, protein P2P-R, retinoblastoma binding protein 6
Species: mouse
Products:     P2P R

Top Publications

  1. Gao S, Witte M, Scott R. P2P-R protein localizes to the nucleolus of interphase cells and the periphery of chromosomes in mitotic cells which show maximum P2P-R immunoreactivity. J Cell Physiol. 2002;191:145-54 pubmed
    ..These include: nucleolin, B23, Ki67, and fibrillarin. ..
  2. Gao S, Scott R. Stable overexpression of specific segments of the P2P-R protein in human MCF-7 cells promotes camptothecin-induced apoptosis. J Cell Physiol. 2003;197:445-52 pubmed
    ..Therefore, P2P-R-promoted apoptosis induced by camptothecin may be influenced by such interactions. ..
  3. Simons A, Melamed Bessudo C, Wolkowicz R, Sperling J, Sperling R, Eisenbach L, et al. PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb. Oncogene. 1997;14:145-55 pubmed
    ..Recombinant forms of this protein, designated PACT, bind to wild type p53 while two different mutations abolish this interaction...
  4. Gao S, Scott R. P2P-R protein overexpression restricts mitotic progression at prometaphase and promotes mitotic apoptosis. J Cell Physiol. 2002;193:199-207 pubmed
    ..These results therefore suggest that P2P-R overexpression promotes both prometaphase arrest in mitosis and mitotic apoptosis. ..
  5. Li L, Deng B, Xing G, Teng Y, Tian C, Cheng X, et al. PACT is a negative regulator of p53 and essential for cell growth and embryonic development. Proc Natl Acad Sci U S A. 2007;104:7951-6 pubmed
    ..p53-associated cellular protein-testes derived (PACT, also known as P2P-R, RBBP6) is a 250-kDa Ring finger-containing protein that can directly bind to p53...
  6. Witte M, Scott R. The proliferation potential protein-related (P2P-R) gene with domains encoding heterogeneous nuclear ribonucleoprotein association and Rb1 binding shows repressed expression during terminal differentiation. Proc Natl Acad Sci U S A. 1997;94:1212-7 pubmed
    ..These results establish that the P2P-R cDNA encodes protein domains involved in both hnRNP association and Rb1 binding and complement recent reports that localize Rb1 to sites of RNA processing in the nucleus. ..
  7. Scott R, White Grindley E, Ruley H, Chesler E, Williams R. P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA. J Cell Physiol. 2005;204:99-105 pubmed
    ..This study represents the first description of a RNA target for mammalian Puf proteins and the first molecular confirmation of information obtained using the WebQTL database. ..
  8. Miotto B, Chibi M, Xie P, Koundrioukoff S, Moolman Smook H, Pugh D, et al. The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability. Cell Rep. 2014;7:575-87 pubmed publisher
    ..Our results uncover a pathway that ensures genome-wide DNA replication and chromosomal stability. ..

Detail Information

Publications8

  1. Gao S, Witte M, Scott R. P2P-R protein localizes to the nucleolus of interphase cells and the periphery of chromosomes in mitotic cells which show maximum P2P-R immunoreactivity. J Cell Physiol. 2002;191:145-54 pubmed
    ..These include: nucleolin, B23, Ki67, and fibrillarin. ..
  2. Gao S, Scott R. Stable overexpression of specific segments of the P2P-R protein in human MCF-7 cells promotes camptothecin-induced apoptosis. J Cell Physiol. 2003;197:445-52 pubmed
    ..Therefore, P2P-R-promoted apoptosis induced by camptothecin may be influenced by such interactions. ..
  3. Simons A, Melamed Bessudo C, Wolkowicz R, Sperling J, Sperling R, Eisenbach L, et al. PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb. Oncogene. 1997;14:145-55 pubmed
    ..Recombinant forms of this protein, designated PACT, bind to wild type p53 while two different mutations abolish this interaction...
  4. Gao S, Scott R. P2P-R protein overexpression restricts mitotic progression at prometaphase and promotes mitotic apoptosis. J Cell Physiol. 2002;193:199-207 pubmed
    ..These results therefore suggest that P2P-R overexpression promotes both prometaphase arrest in mitosis and mitotic apoptosis. ..
  5. Li L, Deng B, Xing G, Teng Y, Tian C, Cheng X, et al. PACT is a negative regulator of p53 and essential for cell growth and embryonic development. Proc Natl Acad Sci U S A. 2007;104:7951-6 pubmed
    ..p53-associated cellular protein-testes derived (PACT, also known as P2P-R, RBBP6) is a 250-kDa Ring finger-containing protein that can directly bind to p53...
  6. Witte M, Scott R. The proliferation potential protein-related (P2P-R) gene with domains encoding heterogeneous nuclear ribonucleoprotein association and Rb1 binding shows repressed expression during terminal differentiation. Proc Natl Acad Sci U S A. 1997;94:1212-7 pubmed
    ..These results establish that the P2P-R cDNA encodes protein domains involved in both hnRNP association and Rb1 binding and complement recent reports that localize Rb1 to sites of RNA processing in the nucleus. ..
  7. Scott R, White Grindley E, Ruley H, Chesler E, Williams R. P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA. J Cell Physiol. 2005;204:99-105 pubmed
    ..This study represents the first description of a RNA target for mammalian Puf proteins and the first molecular confirmation of information obtained using the WebQTL database. ..
  8. Miotto B, Chibi M, Xie P, Koundrioukoff S, Moolman Smook H, Pugh D, et al. The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability. Cell Rep. 2014;7:575-87 pubmed publisher
    ..Our results uncover a pathway that ensures genome-wide DNA replication and chromosomal stability. ..