P2P R

Summary

Gene Symbol: P2P R
Description: retinoblastoma binding protein 6, ubiquitin ligase
Alias: 4933422O15Rik, AI316869, BB233631, C030034J04Rik, C77662, P2P-R, PACT, E3 ubiquitin-protein ligase RBBP6, RING-type E3 ubiquitin transferase RBBP6, p53-associated cellular protein of testis, proliferation potential-related protein, protein P2P-R, retinoblastoma binding protein 6
Species: mouse

Top Publications

  1. doi The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability
    Benoit Miotto
    Epigenetics and Cell Fate, University Paris Diderot, Sorbonne Paris Cité, UMR 7216 CNRS, 75013 Paris, France
    Cell Rep 7:575-87. 2014
  2. ncbi PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb
    A Simons
    Department of Genetics, The Hebrew University of Jerusalem, Israel
    Oncogene 14:145-55. 1997
  3. pmc The proliferation potential protein-related (P2P-R) gene with domains encoding heterogeneous nuclear ribonucleoprotein association and Rb1 binding shows repressed expression during terminal differentiation
    M M Witte
    Department of Pathology, University of Tennessee Medical Center, Memphis 38163, USA
    Proc Natl Acad Sci U S A 94:1212-7. 1997
  4. ncbi P2P-R protein localizes to the nucleolus of interphase cells and the periphery of chromosomes in mitotic cells which show maximum P2P-R immunoreactivity
    Sizhi Gao
    Department of Pathology, University of Tennessee Health Science Center, Memphis 38163, USA
    J Cell Physiol 191:145-54. 2002
  5. ncbi P2P-R protein overexpression restricts mitotic progression at prometaphase and promotes mitotic apoptosis
    Sizhi Gao
    Department of Pathology, University of Tennessee Health Science Center, Memphis TN 38163, Tennessee, USA
    J Cell Physiol 193:199-207. 2002
  6. ncbi Stable overexpression of specific segments of the P2P-R protein in human MCF-7 cells promotes camptothecin-induced apoptosis
    S Gao
    Department of Pathology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Cell Physiol 197:445-52. 2003
  7. ncbi P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA
    Robert E Scott
    Department of Pathology, University of Tennessee Health Science Center, Memphis Tennessee, USA
    J Cell Physiol 204:99-105. 2005
  8. pmc PACT is a negative regulator of p53 and essential for cell growth and embryonic development
    Li Li
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People s Republic of China
    Proc Natl Acad Sci U S A 104:7951-6. 2007
  9. pmc TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress
    Aïcha Daher
    Virus Cell Interactions Laboratory, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    Mol Cell Biol 29:254-65. 2009

Scientific Experts

  • Robert E Scott
  • Sizhi Gao
  • Benoit Miotto
  • Lingqiang Zhang
  • Fuchu He
  • Aïcha Daher
  • Li Li
  • S Gao
  • Ping Xie
  • David Pugh
  • Pierre Antoine Defossez
  • Moredreck Chibi
  • Michelle Debatisse
  • Hanlie Moolman-Smook
  • Stephane Koundrioukoff
  • Antoine H F M Peters
  • Robert E Braun
  • Ghislaine Laraki
  • Anne Gatignol
  • Madhurima Singh
  • Eliane F Meurs
  • Carlos E Melendez-Peña
  • Rekha C Patel
  • Sylvie Bannwarth
  • Xue Gao
  • Yan Teng
  • Yunping Zhu
  • Xiushan Yin
  • Xuan Cheng
  • Juntao Yang
  • Chunyan Tian
  • Xiao Yang
  • Binwei Deng
  • Guichun Xing
  • Qihong Sun
  • M M Witte
  • A Simons
  • Michael M Witte
  • R Wolkowicz
  • R Sperling
  • J Sperling
  • V Rotter
  • C Melamed-Bessudo
  • L Eisenbach

Detail Information

Publications9

  1. doi The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability
    Benoit Miotto
    Epigenetics and Cell Fate, University Paris Diderot, Sorbonne Paris Cité, UMR 7216 CNRS, 75013 Paris, France
    Cell Rep 7:575-87. 2014
    ..Our results uncover a pathway that ensures genome-wide DNA replication and chromosomal stability...
  2. ncbi PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb
    A Simons
    Department of Genetics, The Hebrew University of Jerusalem, Israel
    Oncogene 14:145-55. 1997
    ..Recombinant forms of this protein, designated PACT, bind to wild type p53 while two different mutations abolish this interaction...
  3. pmc The proliferation potential protein-related (P2P-R) gene with domains encoding heterogeneous nuclear ribonucleoprotein association and Rb1 binding shows repressed expression during terminal differentiation
    M M Witte
    Department of Pathology, University of Tennessee Medical Center, Memphis 38163, USA
    Proc Natl Acad Sci U S A 94:1212-7. 1997
    ..These results establish that the P2P-R cDNA encodes protein domains involved in both hnRNP association and Rb1 binding and complement recent reports that localize Rb1 to sites of RNA processing in the nucleus...
  4. ncbi P2P-R protein localizes to the nucleolus of interphase cells and the periphery of chromosomes in mitotic cells which show maximum P2P-R immunoreactivity
    Sizhi Gao
    Department of Pathology, University of Tennessee Health Science Center, Memphis 38163, USA
    J Cell Physiol 191:145-54. 2002
    ..These include: nucleolin, B23, Ki67, and fibrillarin...
  5. ncbi P2P-R protein overexpression restricts mitotic progression at prometaphase and promotes mitotic apoptosis
    Sizhi Gao
    Department of Pathology, University of Tennessee Health Science Center, Memphis TN 38163, Tennessee, USA
    J Cell Physiol 193:199-207. 2002
    ..These results therefore suggest that P2P-R overexpression promotes both prometaphase arrest in mitosis and mitotic apoptosis...
  6. ncbi Stable overexpression of specific segments of the P2P-R protein in human MCF-7 cells promotes camptothecin-induced apoptosis
    S Gao
    Department of Pathology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Cell Physiol 197:445-52. 2003
    ..Therefore, P2P-R-promoted apoptosis induced by camptothecin may be influenced by such interactions...
  7. ncbi P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA
    Robert E Scott
    Department of Pathology, University of Tennessee Health Science Center, Memphis Tennessee, USA
    J Cell Physiol 204:99-105. 2005
    ..This study represents the first description of a RNA target for mammalian Puf proteins and the first molecular confirmation of information obtained using the WebQTL database...
  8. pmc PACT is a negative regulator of p53 and essential for cell growth and embryonic development
    Li Li
    State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, People s Republic of China
    Proc Natl Acad Sci U S A 104:7951-6. 2007
    ..p53-associated cellular protein-testes derived (PACT, also known as P2P-R, RBBP6) is a 250-kDa Ring finger-containing protein that can directly bind to p53...
  9. pmc TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress
    Aïcha Daher
    Virus Cell Interactions Laboratory, Lady Davis Institute for Medical Research, Montreal, Quebec, Canada
    Mol Cell Biol 29:254-65. 2009
    ..Protein, TRBP, inhibits the activity of the interferon-induced protein kinase R (PKR), whereas the PKR activator, PACT, activates its function...