Otud7b

Summary

Gene Symbol: Otud7b
Description: OTU domain containing 7B
Alias: 2900060B22Rik, 4930463P07Rik, AI462125, CEZANNE, Trabid2, Za20d1, OTU domain-containing protein 7B, TRAF binding domain containing 2, cellular zinc finger anti-NF-kappa-B protein, zinc finger A20 domain-containing protein 1, zinc finger protein Cezanne, zinc finger, A20 domain containing 1
Species: mouse

Top Publications

  1. ncbi A novel type of deubiquitinating enzyme
    Paul C Evans
    Molecular Immunology Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    J Biol Chem 278:23180-6. 2003
  2. pmc Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains
    Hoanh Tran
    Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, United Kingdom
    Genes Dev 22:528-42. 2008
  3. pmc OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3
    Hongbo Hu
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, Texas 77030, USA
    Nature 494:371-4. 2013
  4. doi Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination
    Le A Luong
    Department of Cardiovascular Science, University of Sheffield, Sheffield S10 2RX, UK
    Circ Res 112:1583-91. 2013
  5. pmc DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB
    R Sean McNally
    Department of Microbiology Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 286:4098-106. 2011

Scientific Experts

  • Paul C Evans
  • Hongbo Hu
  • Le A Luong
  • R Sean McNally
  • Hoanh Tran
  • Patrick H Maxwell
  • Chengming Zhu
  • Jennifer Smith
  • Mikyoung Chang
  • Jae Hoon Chang
  • Jin Jin
  • Nahum Puebla-Osorio
  • Jens Lutz
  • Joseph Boyle
  • Xuhong Cheng
  • Shao Cong Sun
  • Jonathan L E Dean
  • Maria Fragiadaki
  • Anna Zal
  • Yichuan Xiao
  • Yang Xin Fu
  • Charles Pusey
  • Sarah R Walmsley
  • George C Brittain
  • Margaret Ashcroft
  • Sarah Harten
  • Henning Walczak
  • Dorian O Haskard
  • Tomasz Zal
  • Mary Ann Accavitti-Loper
  • Beckley K Davis
  • Jenny P Y Ting
  • Casey M Clements
  • Tak W Mak
  • Thomas Schwarz-Romond
  • Mariann Bienz
  • Fumihiko Hamada

Detail Information

Publications5

  1. ncbi A novel type of deubiquitinating enzyme
    Paul C Evans
    Molecular Immunology Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    J Biol Chem 278:23180-6. 2003
    ..J. (2001) Biochem. J. 357, 617-623). One of these molecules, cellular zinc finger anti-NF-kappaB (Cezanne), a 100-kDa cytoplasmic protein, also suppressed NF-kappaB...
  2. pmc Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains
    Hoanh Tran
    Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, United Kingdom
    Genes Dev 22:528-42. 2008
    ..Our results indicate a role of K63-linked ubiquitin chains during Wnt-induced transcription...
  3. pmc OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3
    Hongbo Hu
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston, Texas 77030, USA
    Nature 494:371-4. 2013
    ..Here we have identified the deubiquitinase OTUD7B as a pivotal regulator of the non-canonical NF-κB pathway...
  4. doi Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination
    Le A Luong
    Department of Cardiovascular Science, University of Sheffield, Sheffield S10 2RX, UK
    Circ Res 112:1583-91. 2013
    ..Thus, cellular mechanisms that suppress tumor necrosis factor receptor-associated factor 6 ubiquitination are potential therapeutic targets to reduce inflammation in hypoxic tissues...
  5. pmc DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB
    R Sean McNally
    Department of Microbiology Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 286:4098-106. 2011
    ..Mass spectrometry shows that DJ-1 interacts with BBS1, CLCF1, MTREF, and Cezanne/OTUD7B/Za20d1. Among these, Cezanne is a known deubiquitination enzyme that inhibits NF-κB activity...