Otud5

Summary

Gene Symbol: Otud5
Description: OTU domain containing 5
Alias: AA407879, AI553596, BB114028, DUBA, DXImx46e, Sfc7, OTU domain-containing protein 5, deubiquinating enzyme A, deubiquitinating enzyme A
Species: mouse
Products:     Otud5

Top Publications

  1. Brunkow M, Jeffery E, Hjerrild K, Paeper B, Clark L, Yasayko S, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet. 2001;27:68-73 pubmed
    ..In sf mice, a frameshift mutation results in a product lacking the forkhead domain. Genetic complementation demonstrates that the protein product of Foxp3, scurfin, is essential for normal immune homeostasis. ..
  2. Huang O, Ma X, Yin J, Flinders J, Maurer T, Kayagaki N, et al. Phosphorylation-dependent activity of the deubiquitinase DUBA. Nat Struct Mol Biol. 2012;19:171-5 pubmed publisher
    ..Here we show that phosphorylation of the human deubiquitinase DUBA (OTUD5) at a single residue, Ser177, is both necessary and sufficient to activate the enzyme...
  3. Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 2015;518:417-21 pubmed publisher
    ..Here we show that the deubiquitylating enzyme DUBA is a negative regulator of IL-17A production in T cells...