Gene Symbol: Osr2
Description: odd-skipped related 2
Alias: 5430409I15Rik, Osr2A, Osr2B, protein odd-skipped-related 2
Species: mouse
Products:     Osr2

Top Publications

  1. Lan Y, Kingsley P, Cho E, Jiang R. Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits dynamic expression patterns during craniofacial, limb, and kidney development. Mech Dev. 2001;107:175-9 pubmed
    We have isolated a new mouse gene, odd-skipped related 2 (Osr2), that encodes a zinc finger containing protein related to Drosophila Odd-skipped...
  2. Zhou J, Gao Y, Lan Y, Jia S, Jiang R. Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis. Development. 2013;140:4709-18 pubmed publisher
    ..Whereas gene knockout studies in mice have shown that both the Osr2 and Pax9 transcription factors are essential regulators of palatogenesis, little is known about the molecular ..
  3. He F, Popkie A, Xiong W, Li L, Wang Y, Phiel C, et al. Gsk3? is required in the epithelium for palatal elevation in mice. Dev Dyn. 2010;239:3235-46 pubmed publisher
    ..Our results indicate that Gsk3? is an intrinsic regulator required in the epithelium for palate elevation, and could act through a pathway independent of Wnt/?-catenin signaling to regulate palate development...
  4. Lan Y, Ovitt C, Cho E, Maltby K, Wang Q, Jiang R. Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development. 2004;131:3207-16 pubmed
    ..identify new transcription factors regulating palate development, we previously isolated the odd-skipped related 2 (Osr2) gene, encoding a zinc-finger protein homologous to the Drosophila odd-skipped gene product, and showed that Osr2 ..
  5. Song Z, Liu C, Iwata J, Gu S, Suzuki A, Sun C, et al. Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development. J Biol Chem. 2013;288:10440-50 pubmed publisher
    ..Tak1 thus functions to regulate tongue development by controlling Fgf10 expression and could represent a candidate gene for mutation in human PRS clefting...
  6. Jeong J, Cesario J, Zhao Y, Burns L, Westphal H, Rubenstein J. Cleft palate defect of Dlx1/2-/- mutant mice is caused by lack of vertical outgrowth in the posterior palate. Dev Dyn. 2012;241:1757-69 pubmed publisher
    ..Therefore, we analyzed the morphological, cellular, and molecular changes caused by inactivation of Dlx1 and Dlx2 as related to palate development...
  7. Jin J, Li Q, Higashi Y, Darling D, Ding J. Analysis of Zfhx1a mutant mice reveals palatal shelf contact-independent medial edge epithelial differentiation during palate fusion. Cell Tissue Res. 2008;333:29-38 pubmed publisher
    ..5 in a contact-independent manner, suggesting that differentiation of the medial edge epithelium was largely programmed through an intrinsic mechanism within the palate shelf. ..
  8. Kawai S, Kato T, Inaba H, Okahashi N, Amano A. Odd-skipped related 2 splicing variants show opposite transcriptional activity. Biochem Biophys Res Commun. 2005;328:306-11 pubmed
    ..In this study, we report that alternative splicing of exon 4 resulted in two transcripts, Osr2A and Osr2B...
  9. Fu X, Xu J, Chaturvedi P, Liu H, Jiang R, Lan Y. Identification of Osr2 Transcriptional Target Genes in Palate Development. J Dent Res. 2017;96:1451-1458 pubmed publisher
    Previous studies have identified the odd-skipped related 2 (Osr2) transcription factor as a key intrinsic regulator of palatal shelf growth and morphogenesis...

More Information


  1. Tian H, Feng J, Li J, Ho T, Yuan Y, Liu Y, et al. Intraflagellar transport 88 (IFT88) is crucial for craniofacial development in mice and is a candidate gene for human cleft lip and palate. Hum Mol Genet. 2017;26:860-872 pubmed publisher
  2. Massa F, Garbay S, Bouvier R, Sugitani Y, Noda T, Gubler M, et al. Hepatocyte nuclear factor 1? controls nephron tubular development. Development. 2013;140:886-96 pubmed publisher
    ..The expression of several genes, including Irx1, Osr2 and Pou3f3, was downregulated in the S-shaped bodies...
  3. Zhang Z, Lan Y, Chai Y, Jiang R. Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row. Science. 2009;323:1232-4 pubmed publisher
    ..We found that mice lacking the transcription factor odd-skipped related-2 (Osr2) develop supernumerary teeth lingual to their molars because of expansion of the odontogenic field...
  4. Gao Y, Lan Y, Ovitt C, Jiang R. Functional equivalence of the zinc finger transcription factors Osr1 and Osr2 in mouse development. Dev Biol. 2009;328:200-9 pubmed publisher
    ..patterns, we generated mice in which the endogenous Osr2 coding region was replaced by either Osr1 cDNA or Osr2A cDNA encoding the five-finger isoform...
  5. Naillat F, Yan W, Karjalainen R, Liakhovitskaia A, Samoylenko A, Xu Q, et al. Identification of the genes regulated by Wnt-4, a critical signal for commitment of the ovary. Exp Cell Res. 2015;332:163-78 pubmed publisher
    ..genes, and found that the Notum, Phlda2, Runx-1 and Msx1 genes are typical of the wild-type ovary and the Osr2, Dach2, Pitx2 and Tacr3 genes of the testis...
  6. Kawai S, Amano A. Negative regulation of Odd-skipped related 2 by TGF-beta achieves the induction of cellular migration and the arrest of cell cycle. Biochem Biophys Res Commun. 2012;421:696-700 pubmed publisher
    The transcription factor Odd-skipped related 2 (Osr2) functions in craniofacial and limb developments in mammals...
  7. Lan Y, Wang Q, Ovitt C, Jiang R. A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney development. Genesis. 2007;45:618-24 pubmed
    ..We inserted an IresCre bicistronic expression cassette into the 3' untranslated region of the mouse Osr2 gene through gene targeting...
  8. Sherwood R, Maehr R, Mazzoni E, Melton D. Wnt signaling specifies and patterns intestinal endoderm. Mech Dev. 2011;128:387-400 pubmed publisher
    ..These findings shed light on the mechanism of embryonic intestinal induction and provide a method to manipulate intestinal development from embryonic stem cells. ..
  9. He F, Hu X, Xiong W, Li L, Lin L, Shen B, et al. Directed Bmp4 expression in neural crest cells generates a genetic model for the rare human bony syngnathia birth defect. Dev Biol. 2014;391:170-81 pubmed publisher
  10. Gao Y, Lan Y, Liu H, Jiang R. The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation. Dev Biol. 2011;352:83-91 pubmed publisher
    ..Here we report that Osr1 and Osr2, the mammalian homologs of the odd-skipped family of zinc finger transcription factors that are required for leg ..
  11. Xiong W, He F, Morikawa Y, Yu X, Zhang Z, Lan Y, et al. Hand2 is required in the epithelium for palatogenesis in mice. Dev Biol. 2009;330:131-41 pubmed publisher
    ..We further demonstrate that BMP activities are essential for the expression of Hand2 in the palate. We conclude that Hand2 is an intrinsic regulator in the epithelium and is required for palate development. ..
  12. Yokoyama S, Furukawa S, Kitada S, Mori M, Saito T, Kawakami K, et al. Analysis of transcription factors expressed at the anterior mouse limb bud. PLoS ONE. 2017;12:e0175673 pubmed publisher
    ..Our results demonstrate that gene expression analysis based on EMBRYS could contribute to the identification of genes that play a role in patterning of the limb mesenchyme. ..
  13. Parada C, Han D, Grimaldi A, Sarrión P, Park S, Pelikan R, et al. Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development. 2015;142:3734-45 pubmed publisher
    ..neural crest populating the craniofacial region, we studied two mouse models: Wnt1-Cre;Erk2(fl/fl) and Osr2-Cre;Erk2(fl/fl)...
  14. Kawai S, Michikami I, Kitagaki J, Hashino E, Amano A. Expression pattern of zinc-finger transcription factor Odd-skipped related 2 in murine development and neonatal stage. Gene Expr Patterns. 2013;13:372-6 pubmed publisher
    ..The mammalian homolog, Odd-skipped related 2 (Osr2), regulates limb, tooth, and kidney development in mouse embryos...
  15. Stricker S, Brieske N, Haupt J, Mundlos S. Comparative expression pattern of Odd-skipped related genes Osr1 and Osr2 in chick embryonic development. Gene Expr Patterns. 2006;6:826-34 pubmed
    ..In mammals two paralogs exist, Osr1 and Osr2, with functions described in heart and urogenital, and in secondary palate development, respectively...
  16. Drews C, Senkel S, Ryffel G. The nephrogenic potential of the transcription factors osr1, osr2, hnf1b, lhx1 and pax8 assessed in Xenopus animal caps. BMC Dev Biol. 2011;11:5 pubmed publisher
    ..mesoderm and the first expressed genes localized in the pronephros anlage are the transcription factors osr1, osr2, hnf1b, lhx1 and pax8, here referred to as the early nephrogenic transcription factors...
  17. Zhou J, Gao Y, Zhang Z, Zhang Y, Maltby K, Liu Z, et al. Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field. Dev Biol. 2011;353:344-53 pubmed publisher
    ..We recently reported that the zinc finger transcription factor Osr2 was expressed in a lingual-to-buccal gradient pattern surrounding the developing mouse molar tooth germs and mice ..
  18. Huang H, Yang X, Bao M, Cao H, Miao X, Zhang X, et al. Ablation of the Sox11 Gene Results in Clefting of the Secondary Palate Resembling the Pierre Robin Sequence. J Biol Chem. 2016;291:7107-18 pubmed publisher
    ..Taken together, the palate defects presented in the Sox11 loss mutant mimic the clefting in the Pierre Robin sequence in humans. ..
  19. Thomason H, Dixon M, Dixon J. Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling. Dev Biol. 2008;321:273-82 pubmed publisher
    ..Our results are consistent with a role for Tp63 in the regulation of Bmp signaling controlling the growth, modelling and fusion events underlying facial development and shed new light on the complex abnormality of facial clefting. ..
  20. Chen J, Lan Y, Baek J, Gao Y, Jiang R. Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development. Dev Biol. 2009;334:174-85 pubmed publisher
    ..Together, these results indicate that activation of the mesenchymal odontogenic program during early tooth development requires concerted actions of Bmp, Fgf and Wnt signaling from the presumptive dental epithelium to the mesenchyme...
  21. Almaidhan A, Cesario J, Landin Malt A, Zhao Y, Sharma N, Choi V, et al. Neural crest-specific deletion of Ldb1 leads to cleft secondary palate with impaired palatal shelf elevation. BMC Dev Biol. 2014;14:3 pubmed publisher
    ..Ldb1 mutant palatal shelves, cell proliferation was abnormal in the anterior, and the expression of Wnt5a, Pax9 and Osr2, which regulate palatal shelf elevation, was also altered...
  22. Gomes L, Dikic I. Autophagy in antimicrobial immunity. Mol Cell. 2014;54:224-33 pubmed publisher
    ..We also address other functions of autophagy proteins in restricting pathogen invasion, independent of the formation of a canonical double-membrane autophagosome. ..
  23. Kawai S, Yamauchi M, Wakisaka S, Ooshima T, Amano A. Zinc-finger transcription factor odd-skipped related 2 is one of the regulators in osteoblast proliferation and bone formation. J Bone Miner Res. 2007;22:1362-72 pubmed
    We report that Osr2 is one of the regulators of osteoblast function, because dominant-negative Osr2 transgenic mice exhibited decreased osteoblast activity and delayed mineralization in calvarial and tibial bone tissues...
  24. Han L, Xu J, Grigg E, Slack M, Chaturvedi P, Jiang R, et al. Osr1 functions downstream of Hedgehog pathway to regulate foregut development. Dev Biol. 2017;427:72-83 pubmed publisher
    ..We conclude that Osr1 is a novel downstream target of HH pathway, required for lung specification, branching morphogenesis and foregut mesenchymal differentiation. ..
  25. Xu J, Liu H, Lan Y, Aronow B, Kalinichenko V, Jiang R. A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development. PLoS Genet. 2016;12:e1005769 pubmed publisher
  26. Kwon H, Park E, Jia S, Liu H, Lan Y, Jiang R. Deletion of Osr2 Partially Rescues Tooth Development in Runx2 Mutant Mice. J Dent Res. 2015;94:1113-9 pubmed publisher
    ..Recent studies identified Osr2 as a repressor of tooth development and showed that inactivation of Osr2 rescued molar tooth morphogenesis in the ..
  27. Jia S, Zhou J, Gao Y, Baek J, Martin J, Lan Y, et al. Roles of Bmp4 during tooth morphogenesis and sequential tooth formation. Development. 2013;140:423-32 pubmed publisher
    ..We found that expression of Osr2, which encodes a zinc finger protein that antagonizes Msx1-mediated activation of odontogenic mesenchyme, was ..
  28. Baek J, Lan Y, Liu H, Maltby K, Mishina Y, Jiang R. Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Dev Biol. 2011;350:520-31 pubmed publisher
    ..Our data indicate that Bmp signaling plays critical roles in the regulation of palatal mesenchyme condensation and osteoblast differentiation during palatal bone formation. ..
  29. Kawai S, Kato T, Sato M, Amano A. Odd-skipped related 2 gene transcription is regulated by CCAAT enhancer-binding protein delta in mesenchymal C3H10T1/2 cells. Genes Cells. 2006;11:163-75 pubmed
    Odd-skipped related 2 (Osr2) gene is mouse homolog of Drosophila Odd-skipped gene involved with the pair-rule segmentation phenotype in Drosophila mutant embryos...
  30. Kawai S, Abiko Y, Amano A. Odd-skipped related 2 regulates genes related to proliferation and development. Biochem Biophys Res Commun. 2010;398:184-90 pubmed publisher
    ..Our previous findings suggested that Odd-skipped related 2 (Osr2) plays an important role in cellular quiescence and proliferation under epigenetic regulation...
  31. Parada C, Li J, Iwata J, Suzuki A, Chai Y. CTGF mediates Smad-dependent transforming growth factor ? signaling to regulate mesenchymal cell proliferation during palate development. Mol Cell Biol. 2013;33:3482-93 pubmed publisher
    ..We found that Ctgf expression is downregulated in both Wnt1-Cre; Tgfbr2(fl/fl) and Osr2-Cre; Smad4(fl/fl) palates...
  32. Liu W, Lan Y, Pauws E, Meester Smoor M, Stanier P, Zwarthoff E, et al. The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice. Development. 2008;135:3959-68 pubmed publisher
    ..Overexpression of Mn1 in NIH3T3 cells also increased endogenous Tbx22 mRNA expression in a dose-dependent manner. These data indicate that Mn1 and Tbx22 function in a novel molecular pathway regulating mammalian palate development. ..
  33. Liu W, Sun X, Braut A, Mishina Y, Behringer R, Mina M, et al. Distinct functions for Bmp signaling in lip and palate fusion in mice. Development. 2005;132:1453-61 pubmed
    ..Our data uncover a Bmp4-Bmpr1a genetic pathway that functions in lip fusion, and reveal that Bmp signaling has distinct roles in lip and palate fusion...
  34. Kwon H, Jia S, Lan Y, Liu H, Jiang R. Activin and Bmp4 Signaling Converge on Wnt Activation during Odontogenesis. J Dent Res. 2017;96:1145-1152 pubmed publisher
    ..Moreover, genetic inactivation of Osr2, a negative regulator of the odontogenic function of the Bmp4-Msx1 signaling pathway, rescues mandibular molar ..
  35. Shi F, Ding S, Zhao S, Han M, Zhuang Y, Xu T, et al. A piggyBac insertion disrupts Foxl2 expression that mimics BPES syndrome in mice. Hum Mol Genet. 2014;23:3792-800 pubmed publisher
    ..Therefore, this mutant presents an excellent animal model for mechanistic study of BPES and regulation of Foxl2. ..
  36. Liu H, Lan Y, Xu J, Chang C, Brugmann S, Jiang R. Odd-skipped related-1 controls neural crest chondrogenesis during tongue development. Proc Natl Acad Sci U S A. 2013;110:18555-60 pubmed publisher
  37. Wang X, Wang J, Liu Y, Yuan B, Ruest L, Feng J, et al. The specific role of FAM20C in dentinogenesis. J Dent Res. 2015;94:330-6 pubmed publisher
    ..mice were associated with the enamel defects and hypophosphatemia, we crossed Fam20C(fl/fl) mice with Wnt1-Cre and Osr2-Cre transgenic mice to inactivate Fam20C in the craniofacial mesenchymal cells that form dentin and alveolar bone...
  38. Curtain M, Heffner C, Maddox D, Gudis P, Donahue L, Murray S. A novel allele of Alx4 results in reduced Fgf10 expression and failure of eyelid fusion in mice. Mamm Genome. 2015;26:173-80 pubmed publisher
    ..Together, these data demonstrate that eyelid fusion in mice requires the expression of Alx4, accompanied by the loss of normal expression of essential components of the eyelid fusion pathway. ..
  39. Li J, Huang X, Xu X, Mayo J, Bringas P, Jiang R, et al. SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis. Development. 2011;138:1977-89 pubmed publisher
    ..Moreover, ectopic bone-like structures replaced normal dentin in the teeth of Osr2-IresCre;Smad4(fl/fl) mice...
  40. Jia S, Kwon H, Lan Y, Zhou J, Liu H, Jiang R. Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists. Dev Biol. 2016;420:110-119 pubmed publisher
    ..We recently demonstrated that deletion of Osr2, which encodes a zinc finger transcription factor expressed in a lingual-to-buccal gradient in the developing tooth ..
  41. Lan Y, Jiang R. Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development. 2009;136:1387-96 pubmed publisher
    ..we show that Shh-Smo signaling specifically regulates the expression of the transcription factors Foxf1a, Foxf2 and Osr2 in the developing palatal mesenchyme...