Gene Symbol: Onecut1
Description: one cut domain, family member 1
Alias: D9Ertd423e, HNF-6, Hfh12, Hnf6, Hnf6b, OC-1, Oc1, hepatocyte nuclear factor 6, HNF-3/forkhead homolog 12, hepatic nuclear factor 6, one cut homeobox 1
Species: mouse
Products:     Onecut1

Top Publications

  1. Zhang H, Ables E, Pope C, Washington M, Hipkens S, Means A, et al. Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation. Mech Dev. 2009;126:958-73 pubmed publisher
    Within the developing pancreas Hepatic Nuclear Factor 6 (HNF6) directly activates the pro-endocrine transcription factor, Ngn3...
  2. Emerson M, Surzenko N, Goetz J, TRIMARCHI J, Cepko C. Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors. Dev Cell. 2013;26:59-72 pubmed publisher
    ..Molecular analysis of ThrbCRM1 revealed that it is combinatorially regulated by the Otx2 and Onecut1 transcription factors. Onecut1 is sufficient to induce cells with the earliest markers of cones and HCs...
  3. Landry C, Clotman F, Hioki T, Oda H, Picard J, Lemaigre F, et al. HNF-6 is expressed in endoderm derivatives and nervous system of the mouse embryo and participates to the cross-regulatory network of liver-enriched transcription factors. Dev Biol. 1997;192:247-57 pubmed
  4. Dubois C, Shih H, Seymour P, Patel N, Behrmann J, Ngo V, et al. Sox9-haploinsufficiency causes glucose intolerance in mice. PLoS ONE. 2011;6:e23131 pubmed publisher
    ..suggested that Sox9 controls expression of a network of important developmental regulators, including Tcf2/MODY5, Hnf6, and Foxa2, in pancreatic progenitor cells...
  5. Oliver Krasinski J, Kasner M, Yang J, Crutchlow M, Rustgi A, Kaestner K, et al. The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. J Clin Invest. 2009;119:1888-98 pubmed publisher
    ..occupies an evolutionarily conserved enhancer region of Ngn3 and interacts with the transcription factor one cut homeobox 1 (Hnf6) to activate this enhancer...
  6. Antoniou A, Raynaud P, Cordi S, Zong Y, Tronche F, Stanger B, et al. Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9. Gastroenterology. 2009;136:2325-33 pubmed publisher
    ..In the embryo, hepatoblasts differentiate to cholangiocytes, which give rise to the bile ducts. Here, we investigated duct development in mouse liver and characterized the role of the SRY-related HMG box transcription factor 9 (SOX9)...
  7. Wilding Crawford L, Tweedie Ables E, Oh Y, Boone B, Levy S, Gannon M. Gene expression profiling of a mouse model of pancreatic islet dysmorphogenesis. PLoS ONE. 2008;3:e1611 pubmed publisher
    ..Previous studies have shown that transgenic over-expression of the transcription factor Hnf6 specifically in the pancreatic endocrine cell lineage resulted in disruptions in islet morphogenesis, including ..
  8. Vanhorenbeeck V, Jacquemin P, Lemaigre F, Rousseau G. OC-3, a novel mammalian member of the ONECUT class of transcription factors. Biochem Biophys Res Commun. 2002;292:848-54 pubmed
    ..Our earlier work on HNF-6 and the expression patterns of the three mammalian ONECUT genes suggest that they all participate to the control of organ development from the foregut and midgut endoderm. ..
  9. Rausa F, Samadani U, Ye H, Lim L, Fletcher C, Jenkins N, et al. The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas. Dev Biol. 1997;192:228-46 pubmed
    ..We used interspecific backcross analysis to determine that murine Hnf6 gene is located in the middle of mouse chromosome 9...

More Information


  1. Prevot P, Simion A, Grimont A, Colletti M, Khalaileh A, Van den Steen G, et al. Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia. Gut. 2012;61:1723-32 pubmed publisher
    ..In this study, the role of the ductal transcription factors hepatocyte nuclear factor 6 (HNF6, also known as Onecut1) and SRY-related HMG box factor 9 (Sox9) in ADM was investigated.
  2. Stam F, Hendricks T, Zhang J, Geiman E, Francius C, Labosky P, et al. Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program. Development. 2012;139:179-90 pubmed publisher
    ..We show that the selective activation of the Onecut transcription factors Oc1 and Oc2 during the first wave of V1 interneuron neurogenesis is a key step in the RC differentiation program...
  3. Francius C, Clotman F. Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development. Neuroscience. 2010;165:116-29 pubmed publisher
    The Onecut (OC) transcription factors, namely Hepatocyte nuclear factor 6 (HNF-6), OC-2 and OC-3, are transcriptional activators expressed in liver, pancreas and nervous system during development...
  4. Margagliotti S, Clotman F, Pierreux C, Beaudry J, Jacquemin P, Rousseau G, et al. The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration. Dev Biol. 2007;311:579-89 pubmed
    ..This network operating at the onset of liver development contains candidate genes for investigation of liver carcinogenesis. ..
  5. Plumb Rudewiez N, Clotman F, Strick Marchand H, Pierreux C, Weiss M, Rousseau G, et al. Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver. Hepatology. 2004;40:1266-74 pubmed
    ..We observed that Foxa1 expression was upregulated in the liver of Hnf6(-/-) mouse embryos and in bipotential mouse embryonic liver (BMEL) cell lines derived from embryonic Hnf6(-/-) ..
  6. Clotman F, Lannoy V, Reber M, Cereghini S, Cassiman D, Jacquemin P, et al. The onecut transcription factor HNF6 is required for normal development of the biliary tract. Development. 2002;129:1819-28 pubmed
    ..Previous work has shown that the onecut transcription factor HNF6 is expressed in hepatoblasts and in the gallbladder primordium...
  7. Gannon M, Ray M, Van Zee K, Rausa F, Costa R, Wright C. Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function. Development. 2000;127:2883-95 pubmed
    We used transgenesis to explore the requirement for downregulation of hepatocyte nuclear factor 6 (HNF6) expression in the assembly, differentiation, and function of pancreatic islets...
  8. Samadani U, Costa R. The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression. Mol Cell Biol. 1996;16:6273-84 pubmed
    ..These studies suggest that HNF-6 may regulate hepatocyte-specific genes and may play a role in epithelial cell differentiation of gut endoderm via regulation of HNF-3(beta). ..
  9. Espana A, Clotman F. Onecut factors control development of the Locus Coeruleus and of the mesencephalic trigeminal nucleus. Mol Cell Neurosci. 2012;50:93-102 pubmed publisher
    ..Hence, we propose that OC factors are required at early developmental stages for differentiation of the MTN neurons that are in turn necessary for maintenance of the LC. ..
  10. Clotman F, Jacquemin P, Plumb Rudewiez N, Pierreux C, Van Der Smissen P, Dietz H, et al. Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors. Genes Dev. 2005;19:1849-54 pubmed
    ..Thus, a gradient of activin/TGFbeta signaling modulated by Onecut factors is required to segregate the hepatocytic and the biliary lineages. ..
  11. Jacquemin P, Durviaux S, Jensen J, Godfraind C, Gradwohl G, Guillemot F, et al. Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol Cell Biol. 2000;20:4445-54 pubmed
    b>Hepatocyte nuclear factor 6 (HNF-6) is the prototype of a new class of cut homeodomain transcription factors...
  12. Wu F, Sapkota D, Li R, Mu X. Onecut 1 and Onecut 2 are potential regulators of mouse retinal development. J Comp Neurol. 2012;520:952-69 pubmed publisher
    Our current study focuses on the expression of two members of the onecut transcription factor family, Onecut1 (Oc1) and Onecut2 (Oc2), in the developing mouse retina...
  13. Wu F, Li R, Umino Y, Kaczynski T, Sapkota D, Li S, et al. Onecut1 is essential for horizontal cell genesis and retinal integrity. J Neurosci. 2013;33:13053-65, 13065a pubmed publisher
    ..Previously, we showed that Onecut 1 (Oc1), an atypical homeodomain transcription factor, is expressed in developing horizontal cells (HCs) and retinal ..
  14. Maestro M, Boj S, Luco R, Pierreux C, Cabedo J, Servitja J, et al. Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas. Hum Mol Genet. 2003;12:3307-14 pubmed
    ..We furthermore show that Hnf1beta expression is markedly reduced in early pancreatic epithelial cells of Hnf6-deficient mice, in which formation of Ngn3+ cells is defective...
  15. Thompson N, Gesina E, Scheinert P, Bucher P, Grapin Botton A. RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors. Mol Cell Biol. 2012;32:1189-99 pubmed publisher
    ..Pdx1, Nkx6.1, and Onecut1 are also direct PTF1a targets whose expression is promoted by PTF1a...
  16. Pierreux C, Vanhorenbeeck V, Jacquemin P, Lemaigre F, Rousseau G. The transcription factor hepatocyte nuclear factor-6/Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm. J Biol Chem. 2004;279:51298-304 pubmed
    ..hepatocyte nuclear factor-6 (HNF-6), which controls pancreas and liver development as shown in our previous work on Hnf6 knock-out embryos...
  17. Jacquemin P, Lemaigre F, Rousseau G. The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade. Dev Biol. 2003;258:105-16 pubmed
    ..Indeed, the pancreas of Hnf6(-/-) mice was hypoplastic...
  18. Pierreux C, Poll A, Kemp C, Clotman F, Maestro M, Cordi S, et al. The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse. Gastroenterology. 2006;130:532-41 pubmed
    ..b>Hnf6 null mice at various stages of development were studied by immunolocalization methods to assess the morphology, ..
  19. Tan Y, Yoshida Y, Hughes D, Costa R. Increased expression of hepatocyte nuclear factor 6 stimulates hepatocyte proliferation during mouse liver regeneration. Gastroenterology. 2006;130:1283-300 pubmed
    The hepatocyte nuclear factor 6 (HNF6 or ONECUT-1) protein is a cell-type specific transcription factor that regulates expression of hepatocyte-specific genes...
  20. Vanhorenbeeck V, Jenny M, Cornut J, Gradwohl G, Lemaigre F, Rousseau G, et al. Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation. Dev Biol. 2007;305:685-94 pubmed
    ..In conclusion, our data reveal partially redundant roles for HNF-6 and OC-2 in developing pancreas and identify new markers for antero-posterior patterning of the gut and for enteroendocrine differentiation. ..
  21. Espana A, Clotman F. Onecut transcription factors are required for the second phase of development of the A13 dopaminergic nucleus in the mouse. J Comp Neurol. 2012;520:1424-41 pubmed publisher
    ..Hence, Onecut factors are markers of the A13 nucleus throughout embryonic development. They are dispensable for the first phase of A13 development but are required for the second phase of development and for maintenance of this nucleus. ..
  22. Haumaitre C, Barbacci E, Jenny M, Ott M, Gradwohl G, Cereghini S. Lack of TCF2/vHNF1 in mice leads to pancreas agenesis. Proc Natl Acad Sci U S A. 2005;102:1490-5 pubmed
    ..This study provides further insights into early molecular events controlling pancreas development and may contribute to the development of cell-replacement strategies for diabetes. ..
  23. Tweedie E, Artner I, Crawford L, Poffenberger G, Thorens B, Stein R, et al. Maintenance of hepatic nuclear factor 6 in postnatal islets impairs terminal differentiation and function of beta-cells. Diabetes. 2006;55:3264-70 pubmed
    The Onecut homeodomain transcription factor hepatic nuclear factor 6 (Hnf6) is necessary for proper development of islet beta-cells...
  24. Kalinichenko V, Zhou Y, Bhattacharyya D, Kim W, Shin B, Bambal K, et al. Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder development. J Biol Chem. 2002;277:12369-74 pubmed
  25. Audouard E, Schakman O, Rene F, Huettl R, Huber A, Loeffler J, et al. The Onecut transcription factor HNF-6 regulates in motor neurons the formation of the neuromuscular junctions. PLoS ONE. 2012;7:e50509 pubmed publisher
    ..Indeed, adult Hnf6 mutant mice exhibit hindlimb muscle weakness and abnormal locomotion...
  26. Suzuki A, Nakauchi H, Taniguchi H. Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells. Proc Natl Acad Sci U S A. 2003;100:5034-9 pubmed
    ..Our findings suggest that efficient induction of insulin production in intestinal epithelial cells by GLP-1-(1-37) could represent a new therapeutic approach to diabetes mellitus. ..
  27. Houard N, Rousseau G, Lemaigre F. HNF-6-independent differentiation of mouse embryonic stem cells into insulin-producing cells. Diabetologia. 2003;46:378-85 pubmed
    ..We generated mouse Hnf6-/- embryonic stem cells and grew them as embryoid bodies...
  28. Rausa F, Tan Y, Costa R. Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding. Mol Cell Biol. 2003;23:437-49 pubmed
    ..This is the first reported example of a liver-enriched transcription factor (HNF-6) functioning as a coactivator protein to potentiate the transcriptional activity of another liver factor, FoxA2. ..
  29. Kaestner K, Katz J, Liu Y, Drucker D, Schutz G. Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo. Genes Dev. 1999;13:495-504 pubmed
    ..We also showed that HNF3alpha could bind to and transactivate the proglucagon gene promoter. These observations invoke a central role for HNF3alpha in the regulatory control of islet genes essential for glucose homeostasis in vivo. ..
  30. Kyrmizi I, Hatzis P, Katrakili N, Tronche F, Gonzalez F, Talianidis I. Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev. 2006;20:2293-305 pubmed
    ..The results illustrate the remarkable flexibility of a self-sustaining transcription factor network, built up by complex dominant and redundant regulatory motifs in developing hepatocytes. ..
  31. Kanazawa T, Konno A, Hashimoto Y, Kon Y. Hepatocyte nuclear factor 4 alpha is related to survival of the condensed mesenchyme in the developing mouse kidney. Dev Dyn. 2010;239:1145-54 pubmed publisher
    ..These results suggest the possibility that Hnf4alpha plays an important role in the regulation of the cell survival at the CM stage in nephrogenesis. ..
  32. Harmon E, Apelqvist A, Smart N, Gu X, Osborne D, Kim S. GDF11 modulates NGN3+ islet progenitor cell number and promotes beta-cell differentiation in pancreas development. Development. 2004;131:6163-74 pubmed
    ..Thus, our studies reveal mechanisms by which GDF11 regulates the production and maturation of islet progenitor cells in pancreas development. ..
  33. Simion A, Laudadio I, Prevot P, Raynaud P, Lemaigre F, Jacquemin P. MiR-495 and miR-218 regulate the expression of the Onecut transcription factors HNF-6 and OC-2. Biochem Biophys Res Commun. 2010;391:293-8 pubmed publisher
    ..These results indicate that the expression of regulators of liver and pancreas development is modulated by microRNAs. They also suggest a developmental role for miR-495 and miR-218. ..
  34. Kang H, Kim Y, Zeruth G, Beak J, Gerrish K, Kilic G, et al. Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression. Mol Cell Biol. 2009;29:6366-79 pubmed publisher
    ..In addition, we provide evidence that Glis3 regulates insulin gene expression through two Glis-binding sites in its proximal promoter, indicating that Glis3 also regulates beta-cell function. ..
  35. Lugani F, Arora R, Papeta N, Patel A, Zheng Z, Sterken R, et al. A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse. PLoS Genet. 2013;9:e1003206 pubmed publisher
    ..This striking example of an enhancer mutation resulting in profound developmental defects suggests that disruption of conserved regulatory elements may also contribute to human malformation syndromes...
  36. Laumonnerie C, Bechara A, Vilain N, Kurihara Y, Kurihara H, Rijli F. Facial whisker pattern is not sufficient to instruct a whisker-related topographic map in the mouse somatosensory brainstem. Development. 2015;142:3704-12 pubmed publisher
    ..These results provide novel insights into periphery-dependent versus periphery-independent mechanisms of trigeminal ganglion and brainstem patterning in matching whisker topography. ..
  37. Ejarque M, Cervantes S, Pujadas G, Tutusaus A, Sanchez L, Gasa R. Neurogenin3 cooperates with Foxa2 to autoactivate its own expression. J Biol Chem. 2013;288:11705-17 pubmed publisher
  38. Popova N, Teti K, Wu K, Morris R. Identification of two keratinocyte stem cell regulatory loci implicated in skin carcinogenesis. Carcinogenesis. 2003;24:417-25 pubmed
  39. Jacquemin P, Pierreux C, Fierens S, van Eyll J, Lemaigre F, Rousseau G. Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2. Gene Expr Patterns. 2003;3:639-44 pubmed
    ..The human genome contains three Onecut paralogues, Hnf6 (also called Oc1), Oc2 and Oc3...
  40. Mead T, Wang Q, Bhattaram P, Dy P, Afelik S, Jensen J, et al. A far-upstream (-70 kb) enhancer mediates Sox9 auto-regulation in somatic tissues during development and adult regeneration. Nucleic Acids Res. 2013;41:4459-69 pubmed publisher
    ..They provide thereby novel insights on molecular mechanisms controlling developmental and disease processes and suggest new strategies to improve disease treatments. ..
  41. Chakrabarty K, von Oerthel L, Hellemons A, Clotman F, Espana A, Groot Koerkamp M, et al. Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development. Biol Open. 2012;1:693-704 pubmed publisher
    ..Furthermore, we provide evidence of two divergent regulatory pathways resulting in the expression of Chrna6 and Chrnb3 respectively. ..
  42. Krupczak Hollis K, Wang X, Kalinichenko V, Gusarova G, Wang I, Dennewitz M, et al. The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis. Dev Biol. 2004;276:74-88 pubmed
  43. Faure A, Schmidt D, Watt S, Schwalie P, Wilson M, Xu H, et al. Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res. 2012;22:2163-75 pubmed publisher
    ..Finally, we observe that the presence of mirrored CTCF binding events at promoters and their nearby cohesin-bound enhancers is associated with elevated expression levels. ..
  44. Chavan R, Preitner N, Okabe T, Strittmatter L, Xu C, Ripperger J, et al. REV-ERB? regulates Fgf21 expression in the liver via hepatic nuclear factor 6. Biol Open. 2017;6:1-7 pubmed publisher
    ..At the molecular level, REV-ERB? modulates the expression of FGF21 via the liver-specific hepatic nuclear factor 6 (HNF6)...
  45. Pekala K, Ma X, Kropp P, Petersen C, Hudgens C, Chung C, et al. Loss of HNF6 expression correlates with human pancreatic cancer progression. Lab Invest. 2014;94:517-27 pubmed publisher
    ..Transcriptional regulation of this progression is poorly understood. In mouse, the hepatic nuclear factor 6 (Hnf6) transcription factor is expressed in ductal cells and at lower levels in acinar cells of the adult ..
  46. Goetz J, Martin G, Chowdhury R, Trimarchi J. Onecut1 and Onecut2 play critical roles in the development of the mouse retina. PLoS ONE. 2014;9:e110194 pubmed publisher
    ..In this study, we show that two of those factors, Onecut1 and Onecut2, are expressed during mouse retinal development...
  47. Cerdá Esteban N, Naumann H, Ruzittu S, Mah N, Pongrac I, Cozzitorto C, et al. Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2. Nat Commun. 2017;8:14127 pubmed publisher
    ..This study uncovers the reprogramming activity of TGIF2 and suggests a stepwise reprogramming paradigm, whereby a 'lineage-restricted' dedifferentiation step precedes the identity switch. ..
  48. Keng V, Yagi H, Ikawa M, Nagano T, Myint Z, Yamada K, et al. Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage. Biochem Biophys Res Commun. 2000;276:1155-61 pubmed
    ..Expression of transcription factors involved in hepatocyte differentiation, hepatocyte nuclear factor (Hnf)3beta, Hnf6, Hnf4alpha and Hnf1alpha, were restricted to the capsule and internal matrix-like structure in the mutant liver and ..
  49. Rausa F, Hughes D, Costa R. Stability of the hepatocyte nuclear factor 6 transcription factor requires acetylation by the CREB-binding protein coactivator. J Biol Chem. 2004;279:43070-6 pubmed
    We previously demonstrated that the formation of complexes between the DNA binding domains of the hepatocyte nuclear factor 6 (HNF6) and Forkhead Box a2 (Foxa2) transcription factors resulted in synergistic transcriptional activation of ..
  50. Uemura M, Hara K, Shitara H, Ishii R, Tsunekawa N, Miura Y, et al. Expression and function of mouse Sox17 gene in the specification of gallbladder/bile-duct progenitors during early foregut morphogenesis. Biochem Biophys Res Commun. 2010;391:357-63 pubmed publisher
    ..Our findings show that Sox17 functions cell-autonomously to specify gallbladder/bile-duct in the mouse embryo. ..
  51. Lannoy V, Decaux J, Pierreux C, Lemaigre F, Rousseau G. Liver glucokinase gene expression is controlled by the onecut transcription factor hepatocyte nuclear factor-6. Diabetologia. 2002;45:1136-41 pubmed
    ..of the ONECUT family of transcription factors, are present in the hepatic promoter of the glucokinase gene and hnf6 knockout mice are diabetic [corrected]...
  52. Conforto T, Steinhardt G, Waxman D. Cross Talk Between GH-Regulated Transcription Factors HNF6 and CUX2 in Adult Mouse Liver. Mol Endocrinol. 2015;29:1286-302 pubmed publisher liver sex differences by repressing many male-biased genes and inducing many female-biased genes, whereas HNF6 is expressed at similar levels in male and female liver...
  53. Poncy A, Antoniou A, Cordi S, Pierreux C, Jacquemin P, Lemaigre F. Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts. Dev Biol. 2015;404:136-48 pubmed publisher
    ..We conclude that SOX4 is a new regulator of liver development and that it exerts a pleiotropic control on bile duct development in cooperation with SOX9. ..
  54. Audouard E, Schakman O, Ginion A, Bertrand L, Gailly P, Clotman F. The Onecut transcription factor HNF-6 contributes to proper reorganization of Purkinje cells during postnatal cerebellum development. Mol Cell Neurosci. 2013;56:159-68 pubmed publisher
    ..Adult Hnf6 mutant mice exhibit locomotion defects characterized by hindlimb muscle weakness, abnormal gait and defective ..
  55. Klimova L, Antosova B, Kuzelova A, Strnad H, Kozmik Z. Onecut1 and Onecut2 transcription factors operate downstream of Pax6 to regulate horizontal cell development. Dev Biol. 2015;402:48-60 pubmed publisher
    ..In this study, we identified two transcription factors of the Onecut family, Onecut1 and Onecut2, as Pax6 downstream-acting factors...
  56. Yuan J, Lei Z, Wang X, Deng Y, Chen D. Interaction between Oc-1 and Lmx1a promotes ventral midbrain dopamine neural stem cells differentiation into dopamine neurons. Brain Res. 2015;1608:40-50 pubmed publisher
    ..Inhibiting Wnt1 signaling in vmNSCs provoked similar responses. Our data suggested that Oc-1 interacts with Lmx1a to promote vmNSCs differentiation into dopamine neuron through Wnt1-Lmx1a pathway. ..
  57. Wilding L, Gannon M. The role of pdx1 and HNF6 in proliferation and differentiation of endocrine precursors. Diabetes Metab Res Rev. 2004;20:114-23 pubmed
    ..Here, we provide speculation as to the role of pdx1 and HNF6 in these different stages of pancreatic endocrine cell development...
  58. Jochheim A, Hillemann T, Kania G, Scharf J, Attaran M, Manns M, et al. Quantitative gene expression profiling reveals a fetal hepatic phenotype of murine ES-derived hepatocytes. Int J Dev Biol. 2004;48:23-9 pubmed
    ..With sophisticated differentiation protocols, hepatic gene expression can be induced in a proportion of ES cells with gene expression patterns similar to early fetal liver. ..
  59. Nguyen D, Rohrbaugh M, Lai Z. The Drosophila homolog of Onecut homeodomain proteins is a neural-specific transcriptional activator with a potential role in regulating neural differentiation. Mech Dev. 2000;97:57-72 pubmed
    ..In support of this notion, overexpression of a putative dominant negative form of D-Onecut during eye development does not affect early cell fate specification, but severely affects photoreceptor differentiation. ..
  60. Kang H, Takeda Y, Jeon K, Jetten A. The Spatiotemporal Pattern of Glis3 Expression Indicates a Regulatory Function in Bipotent and Endocrine Progenitors during Early Pancreatic Development and in Beta, PP and Ductal Cells. PLoS ONE. 2016;11:e0157138 pubmed publisher
    ..5 in the nucleus of bipotent progenitors in the trunk domains, where it co-localized with Sox9, Hnf6, and Pdx1...
  61. Lemaire L, Goulley J, Kim Y, Carat S, Jacquemin P, Rougemont J, et al. Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis. Development. 2015;142:858-70 pubmed publisher
    ..We show that BICC1 functions downstream of ONECUT1 in the pathway controlling both NEUROG3(+) endocrine cell production and ductal morphogenesis, and suggest a new ..
  62. Briancon N, Bailly A, Clotman F, Jacquemin P, Lemaigre F, Weiss M. Expression of the alpha7 isoform of hepatocyte nuclear factor (HNF) 4 is activated by HNF6/OC-2 and HNF1 and repressed by HNF4alpha1 in the liver. J Biol Chem. 2004;279:33398-408 pubmed associated with P2 activity that is still retained in adult liver, contains functional HNF1 and HNF6 binding sites and confers full promoter activity in transient transfections...
  63. Jacquemin P, Yoshitomi H, Kashima Y, Rousseau G, Lemaigre F, Zaret K. An endothelial-mesenchymal relay pathway regulates early phases of pancreas development. Dev Biol. 2006;290:189-99 pubmed the dorsal pancreatic bud and appears genetically redundant with a role for the transcription factor gene HNF6 in promoting the induction of Pdx-1-positive dorsal endoderm...
  64. Oikawa T, Kamiya A, Kakinuma S, Zeniya M, Nishinakamura R, Tajiri H, et al. Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells. Gastroenterology. 2009;136:1000-11 pubmed publisher
    ..These results suggest that Sall4 plays a crucial role in controlling the lineage commitment of hepatoblasts not only inhibiting their differentiation into hepatocytes but also driving their differentiation toward cholangiocytes. ..
  65. Walter T, Vanderpool C, Cast A, Huppert S. Intrahepatic bile duct regeneration in mice does not require Hnf6 or Notch signaling through Rbpj. Am J Pathol. 2014;184:1479-88 pubmed publisher
    ..Notch signaling and Hnf6 have each been shown to be important for the morphogenesis of IHBDs in mice...
  66. Beaudry J, Pierreux C, Hayhurst G, Plumb Rudewiez N, Weiss M, Rousseau G, et al. Threshold levels of hepatocyte nuclear factor 6 (HNF-6) acting in synergy with HNF-4 and PGC-1alpha are required for time-specific gene expression during liver development. Mol Cell Biol. 2006;26:6037-46 pubmed
    ..In this context we investigate here the role of the LETF hepatocyte nuclear factor 6 (HNF-6; also called Onecut-1) during hepatocyte differentiation...
  67. Malin D, Kim I, Boetticher E, Kalin T, Ramakrishna S, Meliton L, et al. Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression. Mol Cell Biol. 2007;27:2486-98 pubmed
    ..Foxf1 plays an essential role in mesenchyme migration by transcriptionally regulating Itgbeta3. ..
  68. Sherwood R, Chen T, Melton D. Transcriptional dynamics of endodermal organ formation. Dev Dyn. 2009;238:29-42 pubmed publisher
    ..These results contribute to understanding the mechanism of endodermal organogenesis and should assist efforts to replicate this process using pluripotent stem cells. ..
  69. Yang Y, Magnuson M, Stein R, Wright C. The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine cell specification and postnatal β-cell maturation. Development. 2017;144:248-257 pubmed publisher
    ..Therefore, trans-regulatory integration through Area II mediates a surprisingly extensive range of progenitor and β-cell-specific Pdx1 functions. ..
  70. Spence J, Lange A, Lin S, Kaestner K, Lowy A, Kim I, et al. Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell. 2009;17:62-74 pubmed publisher
    ..Restricting SOX17+ biliary progenitor cells to the ventral region of the gut requires the notch effector Hes1. Our results highlight the role of Sox17 and Hes1 in patterning and morphogenetic segregation of ventral foregut lineages. ..