Ogg1

Summary

Gene Symbol: Ogg1
Description: 8-oxoguanine DNA-glycosylase 1
Alias: Mmh, N-glycosylase/DNA lyase
Species: mouse
Products:     Ogg1

Top Publications

  1. Noren Hooten N, Kompaniez K, Barnes J, Lohani A, Evans M. Poly(ADP-ribose) polymerase 1 (PARP-1) binds to 8-oxoguanine-DNA glycosylase (OGG1). J Biol Chem. 2011;286:44679-90 pubmed publisher
    Human 8-oxoguanine-DNA glycosylase (OGG1) plays a major role in the base excision repair pathway by removing 8-oxoguanine base lesions generated by reactive oxygen species...
  2. Winter D, Phung Q, Zeng X, Seeberg E, Barnes D, Lindahl T, et al. Normal somatic hypermutation of Ig genes in the absence of 8-hydroxyguanine-DNA glycosylase. J Immunol. 2003;170:5558-62 pubmed
    ..we examined the glycosylase that removes oxidized guanine from DNA, 8-hydroxyguanine-DNA glycosylase (OGG1)...
  3. Klungland A, Rosewell I, Hollenbach S, Larsen E, Daly G, Epe B, et al. Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc Natl Acad Sci U S A. 1999;96:13300-5 pubmed
    ..Eukaryotic cells use a specific DNA glycosylase, the product of the OGG1 gene, to excise 8-oxoG from DNA...
  4. de Souza Pinto N, Eide L, Hogue B, Thybo T, Stevnsner T, Seeberg E, et al. Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice. Cancer Res. 2001;61:5378-81 pubmed
    ..main pathway for the repair of 8-oxodG is the base excision repair pathway initiated by oxoguanine DNA glycosylase (OGG1)...
  5. Takao M, Kanno S, Kobayashi K, Zhang Q, Yonei S, van der Horst G, et al. A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue. J Biol Chem. 2002;277:42205-13 pubmed
    ..These results suggest that NEIL1 is a back-up glycosylase for NTH1 with unique substrate specificity and tissue-specific expression. ..
  6. Osterod M, Hollenbach S, Hengstler J, Barnes D, Lindahl T, Epe B. Age-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient mice. Carcinogenesis. 2001;22:1459-63 pubmed
    ..We have analysed the steady-state levels and repair kinetics of oxidative DNA modifications in cells of homozygous ogg1(-/-) null mice, which are deficient in Ogg1 protein, a DNA repair glycosylase that removes the miscoding base 8-..
  7. Li G, Yuan K, Yan C, Fox J, Gaid M, Breitwieser W, et al. 8-Oxoguanine-DNA glycosylase 1 deficiency modifies allergic airway inflammation by regulating STAT6 and IL-4 in cells and in mice. Free Radic Biol Med. 2012;52:392-401 pubmed publisher
    ..OGG-1 may affect the levels of oxidative stress and proinflammatory cytokines during asthmatic conditions. OGG-1 deficiency negatively regulates allergen-induced airway inflammatory response. ..
  8. Aburatani H, Hippo Y, Ishida T, Takashima R, Matsuba C, Kodama T, et al. Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. Cancer Res. 1997;57:2151-6 pubmed
    ..MMH) has been identified in the EST database (for expressed sequence tags) through a homology search with yeast OGG1 protein...
  9. Rosenquist T, Zharkov D, Grollman A. Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. Proc Natl Acad Sci U S A. 1997;94:7429-34 pubmed
    ..We have identified and characterized mouse and human cDNAs encoding homologs of the 8-oxoguanine DNA glycosylase (ogg1) gene of Saccharomyces cerevisiae...

More Information

Publications86

  1. Kunisada M, Sakumi K, Tominaga Y, Budiyanto A, Ueda M, Ichihashi M, et al. 8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis. Cancer Res. 2005;65:6006-10 pubmed
    8-Oxoguanine is one of the oxidative DNA damages that can result in stable mutations. The Ogg1 gene encodes the repair enzyme 8-oxoguanine-DNA glycosylase, which removes the oxidized base from DNA...
  2. de Souza Pinto N, Maynard S, Hashiguchi K, Hu J, Muftuoglu M, Bohr V. The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells. Mol Cell Biol. 2009;29:4441-54 pubmed publisher
    ..These modifications are commonly repaired by the base excision repair (BER) pathway. Oxoguanine DNA glycosylase (OGG1) initiates BER of oxidized purine bases...
  3. Hu J, de Souza Pinto N, Haraguchi K, Hogue B, Jaruga P, Greenberg M, et al. Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes. J Biol Chem. 2005;280:40544-51 pubmed
    ..from wild type and knock-out mice lacking the two major DNA glycosylases for repair of oxidative DNA damage, OGG1 and NTH1. The background level of FapyG/FapyA in DNA from these mice was also determined...
  4. Xie Y, Yang H, Cunanan C, Okamoto K, Shibata D, Pan J, et al. Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors. Cancer Res. 2004;64:3096-102 pubmed
    ..in Escherichia coli, but it has remained debatable whether deficiencies in their mammalian counterparts, Myh and Ogg1, are directly involved in tumorigenesis. Here, we demonstrate that deficiencies in Myh and Ogg1 predispose 65...
  5. Larsen E, Reite K, Nesse G, Gran C, Seeberg E, Klungland A. Repair and mutagenesis at oxidized DNA lesions in the developing brain of wild-type and Ogg1-/- mice. Oncogene. 2006;25:2425-32 pubmed
    b>OGG1 (8-oxoguanine DNA glycosylase-1) is one of the main DNA glycosylases present in mammalian cells...
  6. Arai T, Kelly V, Minowa O, Noda T, Nishimura S. The study using wild-type and Ogg1 knockout mice exposed to potassium bromate shows no tumor induction despite an extensive accumulation of 8-hydroxyguanine in kidney DNA. Toxicology. 2006;221:179-86 pubmed
    ..of potassium bromate (KBrO3) on the induction of tumor formation, a 1-year carcinogenesis study was performed using Ogg1 knockout mice (Ogg1(-/-)) and wild-type mice (Ogg1(+/+))...
  7. Lu R, Nash H, Verdine G. A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer. Curr Biol. 1997;7:397-407 pubmed
    ..These 8-oxoguanine DNA glycosylases, hOgg1 (human) and mOgg1 (murine), are homologous to each other and to yeast Ogg1. They also contain an active site motif - the Helix-hairpin-Helix, Gly/Pro-rich-Asp motif - characteristic of a ..
  8. Minowa O, Arai T, Hirano M, Monden Y, Nakai S, Fukuda M, et al. Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice. Proc Natl Acad Sci U S A. 2000;97:4156-61 pubmed
    ..Products of the human MMH/OGG1 gene are known to catalyze in vitro the reactions repairing this DNA lesion...
  9. Xie Y, Yang H, Miller J, Shih D, Hicks G, Xie J, et al. Cells deficient in oxidative DNA damage repair genes Myh and Ogg1 are sensitive to oxidants with increased G2/M arrest and multinucleation. Carcinogenesis. 2008;29:722-8 pubmed publisher
    ..most frequent mutagenic base lesion 7,8-dihydro-8-oxoguanine and the resulting mismatched adenine are removed by OGG1 and MYH in mammals...
  10. Trapp C, Reite K, Klungland A, Epe B. Deficiency of the Cockayne syndrome B (CSB) gene aggravates the genomic instability caused by endogenous oxidative DNA base damage in mice. Oncogene. 2007;26:4044-8 pubmed
    ..In mammalian cells, 8-oxoG is a substrate of the repair glycosylase OGG1. Mice without this enzyme accumulate 8-oxoG in the genome and have elevated spontaneous mutation rates...
  11. Sakumi K, Tominaga Y, Furuichi M, Xu P, Tsuzuki T, Sekiguchi M, et al. Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption. Cancer Res. 2003;63:902-5 pubmed
    Using Mth1 and Ogg1 knockout mice, we evaluated the roles of these enzymes to prevent tumorigenesis and the accumulation of 8-oxoguanine (8-oxoG) in DNA...
  12. Cardozo Pelaez F, Cox D, Bolin C. Lack of the DNA repair enzyme OGG1 sensitizes dopamine neurons to manganese toxicity during development. Gene Expr. 2005;12:315-23 pubmed
    ..Wild-type and OGG1 knockout mice were exposed to manganese from conception to postnatal day 30; in both groups, exposure to manganese ..
  13. Kovtun I, Liu Y, Bjoras M, Klungland A, Wilson S, McMurray C. OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature. 2007;447:447-52 pubmed
    ..and is remarkably dependent on a single base excision repair enzyme, 7,8-dihydro-8-oxoguanine-DNA glycosylase (OGG1)...
  14. Wang H, Wang X, Chen G, Zhang X, Tang X, Park D, et al. Distinct roles of Ape1 protein, an enzyme involved in DNA repair, in high or low linear energy transfer ionizing radiation-induced cell killing. J Biol Chem. 2014;289:30635-44 pubmed publisher
    ..This discovery opens a new direction to develop approaches for either protecting astronauts from exposure to space radiation or benefiting cancer patients by sensitizing tumor cells to high LET radiotherapy. ..
  15. Kim H, Kim B, Jung J, Lee C, Lee H, Lee J, et al. Potential role of 8-oxoguanine DNA glycosylase 1 as a STAT1 coactivator in endotoxin-induced inflammatory response. Free Radic Biol Med. 2016;93:12-22 pubmed publisher
    Human 8-oxoguanine DNA glycosylase 1 (OGG1) is the major DNA repair enzyme that plays a key role in excision of oxidative damaged DNA bases such as 8-oxoguainine (8-oxoG)...
  16. Ucher A, Linehan E, Teebor G, Schrader C, Stavnezer J. The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells. PLoS ONE. 2012;7:e36061 pubmed publisher
    ..ROS can oxidize DNA bases resulting in substrates for the DNA glycosylases Ogg1 and Nth1...
  17. Karahalil B, de Souza Pinto N, Parsons J, Elder R, Bohr V. Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases. J Biol Chem. 2003;278:33701-7 pubmed
    ..We did not detect a backup glycosylase or glycosylase/AP lyase activity for thymine glycol in the mitochondrial mouse extracts. ..
  18. Jaruga P, Xiao Y, Vartanian V, Lloyd R, Dizdaroglu M. Evidence for the involvement of DNA repair enzyme NEIL1 in nucleotide excision repair of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines. Biochemistry. 2010;49:1053-5 pubmed publisher
    ..to exogenous oxidative stress, while no accumulation of these lesions was observed in liver DNA from control or ogg1(-/-) mice...
  19. Miller Pinsler L, Pinto D, Wells P. Oxidative DNA damage in the in utero initiation of postnatal neurodevelopmental deficits by normal fetal and ethanol-enhanced oxidative stress in oxoguanine glycosylase 1 knockout mice. Free Radic Biol Med. 2015;78:23-9 pubmed publisher
    ..Herein, DNA repair-deficient progeny of oxoguanine glycosylase 1 (ogg1)-knockout mice lacking repair of the oxidative DNA lesion 8-oxo-2'-deoxyguanosine (8-oxodGuo) exhibited enhanced ..
  20. Conlon K, Miller H, Rosenquist T, Zharkov D, Berrios M. The murine DNA glycosylase NEIL2 (mNEIL2) and human DNA polymerase beta bind microtubules in situ and in vitro. DNA Repair (Amst). 2005;4:419-31 pubmed
    8-oxoguanine DNA glycosylase (OGG1), a major DNA repair enzyme in mammalian cells and a component of the base excision repair (BER) pathway, was recently shown to be associated with the microtubule network and the centriole at interphase ..
  21. Goula A, Berquist B, Wilson D, Wheeler V, Trottier Y, Merienne K. Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice. PLoS Genet. 2009;5:e1000749 pubmed publisher
    ..Recent studies have suggested that DNA oxidation and OGG1, a glycosylase involved in the repair of 8-oxoguanine lesions, contribute to this process...
  22. Bigot K, Leemput J, Vacher M, Campalans A, Radicella J, Lacassagne E, et al. Expression of 8-oxoguanine DNA glycosylase (Ogg1) in mouse retina. Mol Vis. 2009;15:1139-52 pubmed
    ..8-oxoguanine DNA glycosylase (Ogg1) gene expression and messenger localization in adult mouse ocular tissues was analyzed by RT-PCR and in situ ..
  23. Wu L, Zheng Q. Active demethylation of the IL-2 Promoter in CD4+ T cells is mediated by an inducible DNA glycosylase, Myh. Mol Immunol. 2014;58:38-49 pubmed publisher
    ..These results suggest that DNA demethylation is being selectively used to orchestrate a part of the naïve CD4(+) T cell differentiation program. ..
  24. Conlon K, Zharkov D, Berrios M. Cell cycle regulation of the murine 8-oxoguanine DNA glycosylase (mOGG1): mOGG1 associates with microtubules during interphase and mitosis. DNA Repair (Amst). 2004;3:1601-15 pubmed
    8-Oxoguanine DNA glycosylase (OGG1) is a major DNA repair enzyme in mammalian cells. OGG1 participates in the repair of 8-oxoG, the most abundant known DNA lesion induced by endogenous reactive oxygen species in aerobic organisms...
  25. Wong A, McCallum G, Jeng W, Wells P. Oxoguanine glycosylase 1 protects against methamphetamine-enhanced fetal brain oxidative DNA damage and neurodevelopmental deficits. J Neurosci. 2008;28:9047-54 pubmed publisher
    ..Herein we used oxoguanine glycosylase 1 (ogg1) knock-out mice to determine the pathogenic roles of 8-oxoG and OGG1, which repairs 8-oxoG, in METH-initiated ..
  26. Bacsi A, Aguilera Aguirre L, Szczesny B, Radak Z, Hazra T, Sur S, et al. Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation. DNA Repair (Amst). 2013;12:18-26 pubmed publisher
    ..role of 8-oxoguanine (8-oxoG), a common oxidatively damaged base, and its repair by 8-oxoguanine DNA glycosylase 1 (Ogg1) in allergic airway inflammatory processes...
  27. Ohno M, Sakumi K, Fukumura R, Furuichi M, Iwasaki Y, Hokama M, et al. 8-oxoguanine causes spontaneous de novo germline mutations in mice. Sci Rep. 2014;4:4689 pubmed publisher
    ..increased frequencies of G to T mutations at a rate of 2 × 10(-7)?mutations/base/generation in offspring of Mth1/Ogg1/Mutyh triple knockout (TOY-KO) mice, which accumulate 8-oxoG in the nuclear DNA of gonadal cells...
  28. Wu M, Huang H, Zhang W, Kannan S, Weaver A, McKibben M, et al. Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epithelial cells and in mice. Infect Immun. 2011;79:75-87 pubmed publisher
    ..Pseudomonas aeruginosa significantly altered the expression and enzymatic activity of 8-oxoguanine DNA glycosylase (OGG1) in lung epithelial cells...
  29. Tsuzuki T, Nakatsu Y, Nakabeppu Y. Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis. Cancer Sci. 2007;98:465-70 pubmed
    ..We have focused on the following three enzymes: MTH1, OGG1 and MUTYH...
  30. Wang Z, Rhee D, Lu J, Bohr C, Zhou F, Vallabhaneni H, et al. Characterization of oxidative guanine damage and repair in mammalian telomeres. PLoS Genet. 2010;6:e1000951 pubmed publisher
    ..FapyG) are among the most common oxidative DNA lesions and are substrates for 8-oxoguanine DNA glycosylase (OGG1)-initiated DNA base excision repair (BER)...
  31. Hajas G, Bacsi A, Aguilera Aguirre L, Hegde M, Tapas K, Sur S, et al. 8-Oxoguanine DNA glycosylase-1 links DNA repair to cellular signaling via the activation of the small GTPase Rac1. Free Radic Biol Med. 2013;61:384-94 pubmed publisher
    ..Unexpectedly, mice that lack 8-oxoguanine DNA glycosylase-1 (OGG1) activity and accumulate 8-oxoG in their genome have a normal phenotype and longevity; in fact, they show increased ..
  32. Larsen E, Meza T, Kleppa L, Klungland A. Organ and cell specificity of base excision repair mutants in mice. Mutat Res. 2007;614:56-68 pubmed
    ..These models should comprise combined deficiencies of DNA glycosylases which initiate the BER pathway, to elaborate on the repair redundancy, as well as conditional models of the intermediate steps of BER. ..
  33. Akatsuka S, Aung T, Dutta K, Jiang L, Lee W, Liu Y, et al. Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis. Am J Pathol. 2006;169:1328-42 pubmed
    ..In the wild-type mice, low GC content areas were more likely to harbor the two modified bases. Knockout of OGG1, a repair enzyme for genomic 8-hydroxyguanine, increased the amounts of acrolein-Ade as determined by quantitative ..
  34. Osterod M, Larsen E, Le Page F, Hengstler J, van der Horst G, Boiteux S, et al. A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage. Oncogene. 2002;21:8232-9 pubmed
    ..To investigate its significance for the repair of endogenous oxidative DNA damage, homozygous csb(-/-)/ogg1(-/-) double knockout mice were generated...
  35. Freedman S, Katz M, Parker E, Laposata M, Urman M, Alvarez J. A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr(-/-) mice. Proc Natl Acad Sci U S A. 1999;96:13995-4000 pubmed
    ..These results strongly suggest that certain phenotypic manifestations of CF may result from remediable alterations in phospholipid-bound arachidonic acid and DHA levels. ..
  36. Takeda T, Hosokawa M, Takeshita S, Irino M, Higuchi K, Matsushita T, et al. A new murine model of accelerated senescence. Mech Ageing Dev. 1981;17:183-94 pubmed
    ..The P series has been named "SAM" ("Senescence Accelerated Mouse"). ..
  37. Boiteux S, Radicella J. The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis. Arch Biochem Biophys. 2000;377:1-8 pubmed
    ..These genes, fpg and mutY for E. coli and OGG1 for yeast, code for DNA glycosylases...
  38. Tani M, Shinmura K, Kohno T, Shiroishi T, Wakana S, Kim S, et al. Genomic structure and chromosomal localization of the mouse Ogg1 gene that is involved in the repair of 8-hydroxyguanine in DNA damage. Mamm Genome. 1998;9:32-7 pubmed
    ..Previously we isolated the hOGG1 gene, a human homolog of the yeast OGG1 gene, which encodes a DNA glycosylase and lyase to excise oh8Gua in DNA...
  39. Ye Y, Lin P, Zhang W, Tan S, Zhou X, Li R, et al. DNA Repair Interacts with Autophagy To Regulate Inflammatory Responses to Pulmonary Hyperoxia. J Immunol. 2017;198:2844-2853 pubmed publisher
    ..immunoprecipitation assay, we found that OGG-1 associated with the promoter of Atg7, suggesting a role for OGG1 in regulation of Atg7 activity. Knocking down OGG-1 decreased the luciferase reporter activity of Atg7...
  40. Hansen S, Olsen A, Søderlund E, Brunborg G. In vitro investigations of glycidamide-induced DNA lesions in mouse male germ cells and in mouse and human lymphocytes. Mutat Res. 2010;696:55-61 pubmed publisher
    ..The persistence of lesions was explored with cells from mice either proficient or deficient in Ogg1 (mouse 8-oxoguanine DNA glycosylase)...
  41. Kunisada M, Yogianti F, Sakumi K, Ono R, Nakabeppu Y, Nishigori C. Increased expression of versican in the inflammatory response to UVB- and reactive oxygen species-induced skin tumorigenesis. Am J Pathol. 2011;179:3056-65 pubmed publisher
    ..We have previously shown that mice lacking the repair enzyme 8-oxoguanine glycosylase (Ogg1 knockout mice) are highly susceptible to skin cancer after long-term UVB exposure...
  42. Cheresh P, Morales Nebreda L, Kim S, Yeldandi A, Williams D, Cheng Y, et al. Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice. Am J Respir Cell Mol Biol. 2015;52:25-36 pubmed publisher
    ..mediate asbestos-induced AEC intrinsic apoptosis and that mitochondrial human 8-oxoguanine-DNA glycosylase 1 (OGG1), a DNA repair enzyme, prevents oxidant-induced AEC apoptosis...
  43. Bjørge M, Hildrestrand G, Scheffler K, Suganthan R, Rolseth V, Kuśnierczyk A, et al. Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice. Cell Rep. 2015;13:2671-8 pubmed publisher
    b>Ogg1 and Mutyh DNA glycosylases cooperate to prevent mutations caused by 8-oxoG, a major premutagenic DNA lesion associated with cognitive decline. We have examined behavior and cognitive function in mice deficient of these glycosylases...
  44. Sampath H, Vartanian V, Rollins M, Sakumi K, Nakabeppu Y, Lloyd R. 8-Oxoguanine DNA glycosylase (OGG1) deficiency increases susceptibility to obesity and metabolic dysfunction. PLoS ONE. 2012;7:e51697 pubmed publisher
    ..via base excision repair, a pathway that is catalyzed by DNA glycosylases such as 8-oxoguanine DNA glycosylase (OGG1)...
  45. Smith T, De Iuliis G, Lord T, Aitken R. The senescence-accelerated mouse prone 8 as a model for oxidative stress and impaired DNA repair in the male germ line. Reproduction. 2013;146:253-62 pubmed publisher
    The discovery of a truncated base excision repair pathway in human spermatozoa mediated by OGG1 has raised questions regarding the effect of mutations in critical DNA repair genes on the integrity of the paternal genome...
  46. Habib S, Riley D, Mahimainathan L, Bhandari B, Choudhury G, Abboud H. Tuberin regulates the DNA repair enzyme OGG1. Am J Physiol Renal Physiol. 2008;294:F281-90 pubmed
    ..renal epithelial cells using siRNA resulted in a marked decrease in the abundance of the 8-oxoG-DNA glycosylase (OGG1)...
  47. Takeda T, Hosokawa M, Higuchi K. Senescence-accelerated mouse (SAM): a novel murine model of senescence. Exp Gerontol. 1997;32:105-9 pubmed
    ..The genetic background and significance of SAM development are discussed...
  48. Tumurkhuu G, Shimada K, Dagvadorj J, Crother T, Zhang W, Luthringer D, et al. Ogg1-Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis. Circ Res. 2016;119:e76-90 pubmed publisher
    ..Human atherosclerotic plaques express increased mtDNA damage. The major DNA glycosylase, 8-oxoguanine glycosylase (OGG1), is responsible for removing the most abundant form of oxidative DNA damage...
  49. Yuzefovych L, Schuler A, Chen J, Alvarez D, Eide L, LeDoux S, et al. Alteration of mitochondrial function and insulin sensitivity in primary mouse skeletal muscle cells isolated from transgenic and knockout mice: role of ogg1. Endocrinology. 2013;154:2640-9 pubmed publisher
    ..palmitate-induced mitochondrial dysfunction and IR in primary cultures of skeletal muscle derived from hind limb of ogg1(-/-) knockout mice and transgenic mice, which overexpress human (hOGG1) in mitochondria (transgenic [Tg]/MTS-hOGG1)...
  50. Ondovcik S, Tamblyn L, McPherson J, Wells P. Oxoguanine glycosylase 1 (OGG1) protects cells from DNA double-strand break damage following methylmercury (MeHg) exposure. Toxicol Sci. 2012;128:272-83 pubmed publisher
    ..stress, which can cause various oxidative DNA lesions that are primarily repaired by oxoguanine glycosylase 1 (OGG1)...
  51. Seifermann M, Ulges A, Bopp T, Melcea S, Schäfer A, Oka S, et al. Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes. DNA Repair (Amst). 2017;58:13-20 pubmed publisher
    b>OGG1 (8-oxoguanine-DNA glycosylase) is the major DNA repair glycosylase removing the premutagenic DNA base modification 8-oxo-7,8-dihydroguanine (8-oxoG) from the genome of mammalian cells...
  52. Kovtun I, Johnson K, McMurray C. Cockayne syndrome B protein antagonizes OGG1 in modulating CAG repeat length in vivo. Aging (Albany NY). 2011;3:509-14 pubmed
    b>OGG1 and MSH2/MSH3 promote CAG repeat expansion at Huntington's disease (HD) locusin vivo during removal of oxidized bases from DNA...
  53. Lee C, Goncalves L, Wells P. Resistance of CD-1 and ogg1 DNA repair-deficient mice to thalidomide and hydrolysis product embryopathies in embryo culture. Toxicol Sci. 2011;122:146-56 pubmed publisher
    ..levels of the teratogenic oxidative DNA lesion 8-oxoguanine, which is repaired by oxoguanine glycosylase 1 (OGG1)...
  54. Arai T, Kelly V, Minowa O, Noda T, Nishimura S. High accumulation of oxidative DNA damage, 8-hydroxyguanine, in Mmh/Ogg1 deficient mice by chronic oxidative stress. Carcinogenesis. 2002;23:2005-10 pubmed
    8-Hydroxyguanine (8-OH-G) is a major pre-mutagenic lesion generated from reactive oxygen species. The Mmh/Ogg1 gene product plays a major role in maintaining genetic integrity by removing 8-OH-G by way of the base excision repair pathway...
  55. Fusser M, Nesse G, Khobta A, Xia N, Li H, Klungland A, et al. Spontaneous mutagenesis in Csb(m/m)Ogg1?(/)? mice is attenuated by dietary resveratrol. Carcinogenesis. 2011;32:80-5 pubmed publisher
    ..The defect of the repair of 8-oxoG in Csb(m/m)Ogg1?(/)? mice results in elevated basal levels of these lesions and increased frequencies of spontaneous mutations, ..
  56. Pilati C, Shinde J, Alexandrov L, Assie G, Andre T, Helias Rodzewicz Z, et al. Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas. J Pathol. 2017;242:10-15 pubmed publisher
    ..Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  57. Trapp C, McCullough A, Epe B. The basal levels of 8-oxoG and other oxidative modifications in intact mitochondrial DNA are low even in repair-deficient (Ogg1(-/-)/Csb(-/-)) mice. Mutat Res. 2007;625:155-63 pubmed
    ..one of the most frequent oxidative base modifications, is removed from the mitochondrial genome by the glycosylase OGG1, the basal levels of this lesion are expected to be highly elevated in Ogg1(-/-) mice...
  58. Attia S, Ahmad S, Okash R, Bakheet S. Aroclor 1254-induced genotoxicity in male gonads through oxidatively damaged DNA and inhibition of DNA repair gene expression. Mutagenesis. 2014;29:379-84 pubmed publisher
    ..It is noteworthy that the expression of OGG1 and APEX1 was significantly decreased at 3h after the last exposure to 4 mg/kg/day Aroclor 1254...
  59. La Maestra S, Kisby G, Micale R, Johnson J, Kow Y, Bao G, et al. Cigarette smoke induces DNA damage and alters base-excision repair and tau levels in the brain of neonatal mice. Toxicol Sci. 2011;123:471-9 pubmed publisher
    ..CS also modulated the activity and distribution of the BER enzymes 8-oxoguanine-DNA-glycosylase (OGG1) and apyrimidinic/apurinic endonuclease (APE1) in several brain regions. Normal tau (i.e...
  60. Yuzefovych L, Kahn A, Schuler M, Eide L, Arora R, Wilson G, et al. Mitochondrial DNA Repair through OGG1 Activity Attenuates Breast Cancer Progression and Metastasis. Cancer Res. 2016;76:30-4 pubmed publisher
    ..role of mtDNA damage in breast cancer by genetically modulating the DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1) in the PyMT transgenic mouse model of mammary tumorigenesis...
  61. Mulder J, Turner P, Massey T. Effect of 8-oxoguanine glycosylase deficiency on aflatoxin B1 tumourigenicity in mice. Mutagenesis. 2015;30:401-9 pubmed publisher
    ..Base excision repair removes these lesions, with 8-oxoguanine glycosylase (OGG1) being the rate-limiting enzyme...
  62. Bhakat K, Mokkapati S, Boldogh I, Hazra T, Mitra S. Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo. Mol Cell Biol. 2006;26:1654-65 pubmed
    The human 8-oxoguanine-DNA glycosylase 1 (OGG1) is the major DNA glycosylase responsible for repair of 7,8-dihydro-8-oxoguanine (8-oxoG) and ring-opened fapyguanine, critical mutagenic DNA lesions that are induced by reactive oxygen ..
  63. Jensen A, Calvayrac G, Karahalil B, Bohr V, Stevnsner T. Mammalian 8-oxoguanine DNA glycosylase 1 incises 8-oxoadenine opposite cytosine in nuclei and mitochondria, while a different glycosylase incises 8-oxoadenine opposite guanine in nuclei. J Biol Chem. 2003;278:19541-8 pubmed
    ..Using liver extracts from mice knocked out for 8-oxoguanine DNA glycosylase 1 (OGG1), we demonstrated that OGG1 is the only glycosylase that incises 8-oxoA, when base-paired with cytosine in ..
  64. Tominaga Y, Ushijima Y, Tsuchimoto D, Mishima M, Shirakawa M, Hirano S, et al. MUTYH prevents OGG1 or APEX1 from inappropriately processing its substrate or reaction product with its C-terminal domain. Nucleic Acids Res. 2004;32:3198-211 pubmed
    ..duplex oligonucleotides containing A:8-oxoG pair with a lower apparent K(d) than that of the mutants, and prevented OGG1 from excising 8-oxoG opposite adenine or the generated AP site...
  65. Russo M, De Luca G, Degan P, Parlanti E, Dogliotti E, Barnes D, et al. Accumulation of the oxidative base lesion 8-hydroxyguanine in DNA of tumor-prone mice defective in both the Myh and Ogg1 DNA glycosylases. Cancer Res. 2004;64:4411-4 pubmed
    The OGG1 and MYH DNA glycosylases prevent the accumulation of DNA 8-hydroxyguanine. In Myh(-/-) mice, there was no time-dependent accumulation of DNA 8-hydroxyguanine in brain, small intestine, lung, spleen, or kidney...
  66. Osenbroch P, Auk Emblem P, Halsne R, Strand J, Forstrøm R, van der Pluijm I, et al. Accumulation of mitochondrial DNA damage and bioenergetic dysfunction in CSB defective cells. FEBS J. 2009;276:2811-21 pubmed publisher
    ..Thus, mitochondrial dysfunction may play a role in the pathology of CS. ..
  67. Mirbahai L, Kershaw R, Green R, Hayden R, Meldrum R, Hodges N. Use of a molecular beacon to track the activity of base excision repair protein OGG1 in live cells. DNA Repair (Amst). 2010;9:144-52 pubmed publisher
    ..species is 8-oxo-7,8-dihydroguanine for which the base excision repair protein 8-oxoguanine-DNA glycosylase 1 (OGG1) is a major repair enzyme...
  68. Jin M, Dewa Y, Kawai M, Nishimura J, Saegusa Y, Kemmochi S, et al. The threshold dose for liver tumor promoting effects of dicyclanil in ICR mice. J Toxicol Sci. 2010;35:69-78 pubmed
    ..5 ppm. ..
  69. Stuart J, Bourque B, de Souza Pinto N, Bohr V. No evidence of mitochondrial respiratory dysfunction in OGG1-null mice deficient in removal of 8-oxodeoxyguanine from mitochondrial DNA. Free Radic Biol Med. 2005;38:737-45 pubmed
    ..Mice null for oxoguanine DNA glycosylase (OGG1) are deficient in 8-oxodG removal and accumulate 8-oxodG in mtDNA to levels 20-fold higher than in wild-type mice (..
  70. Wang X, Liu C, Ma Q, Feng W, Yang L, Lu Y, et al. 8-oxoG DNA glycosylase-1 inhibition sensitizes Neuro-2a cells to oxidative DNA base damage induced by 900 MHz radiofrequency electromagnetic radiation. Cell Physiol Biochem. 2015;37:1075-88 pubmed publisher
    ..cells to radiofrequency electromagnetic fields (RF-EMFs) with or without silencing of 8-oxoG DNA glycosylase-1 (OGG1)...
  71. Torres Gonzalez M, Gawlowski T, KOCALIS H, Scott B, Dillmann W. Mitochondrial 8-oxoguanine glycosylase decreases mitochondrial fragmentation and improves mitochondrial function in H9C2 cells under oxidative stress conditions. Am J Physiol Cell Physiol. 2014;306:C221-9 pubmed publisher
    ..8-Oxoguanosine DNA glycosylase-1 (OGG1) recognizes and removes 8-OHdG to prevent further DNA damage...
  72. Vartanian V, Tumová J, Dobrzyn P, Dobrzyn A, Nakabeppu Y, Lloyd R, et al. 8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle. PLoS ONE. 2017;12:e0181687 pubmed publisher
    ..8-oxoguanine DNA glycosylase (OGG1) recognizes and cleaves oxidized and ring-fragmented purines, including 8-oxoguanine, the most commonly formed ..
  73. Kakehashi A, Ishii N, Okuno T, Fujioka M, Gi M, Wanibuchi H. Enhanced Susceptibility of Ogg1 Mutant Mice to Multiorgan Carcinogenesis. Int J Mol Sci. 2017;18: pubmed publisher
    The role of deficiency of oxoguanine glycosylase 1 (Ogg1) Mmh homolog, a repair enzyme of the 8-hydroxy-2'-deoxyguanosine (8-OHdG) residue in DNA, was investigated using the multiorgan carcinogenesis bioassay in mice...
  74. Trapp C, Schwarz M, Epe B. The peroxisome proliferator WY-14,643 promotes hepatocarcinogenesis caused by endogenously generated oxidative DNA base modifications in repair-deficient Csbm/m/Ogg1-/- mice. Cancer Res. 2007;67:5156-61 pubmed
    ..Both the 8-oxoG levels and the resulting spontaneous mutations are increased in the livers of Csb(m/m)/Ogg1(-/-) mice, which are deficient in the repair of 8-oxoG...
  75. Saxowsky T, Meadows K, Klungland A, Doetsch P. 8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells. Proc Natl Acad Sci U S A. 2008;105:18877-82 pubmed publisher
    ..The DNA glycosylase Ogg1 initiates base excision repair of 8OG, but its influence on TM is unknown...
  76. Zielinska A, Davies O, Meldrum R, Hodges N. Direct visualization of repair of oxidative damage by OGG1 in the nuclei of live cells. J Biochem Mol Toxicol. 2011;25:1-7 pubmed publisher
    ..ROS is 8-oxo deoxyguanine (8-oxo dG) and the major enzyme for repair of 8-oxo dG is 8-oxoguanine-DNA glycosylase 1 (OGG1)...
  77. Choi J, Kim H, Kang H, Lee D, Choi E, Chung M. Thermolabile 8-hydroxyguanine DNA glycosylase with low activity in senescence-accelerated mice due to a single-base mutation. Free Radic Biol Med. 1999;27:848-54 pubmed
    8-hydroxyguanine (8-oxoguanine; oh8Gua) DNA glycosylase (OGG1) repairs oh8Gua, a highly mutagenic oxidative DNA damage...