Gene Symbol: Odf1
Description: outer dense fiber of sperm tails 1
Alias: outer dense fiber protein 1
Deng W, Lin H. miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis. Dev Cell. 2002;2:819-30 pubmed
..Whereas MIWI and CREM do not regulate each other's expression, MIWI complexes with mRNAs of ACT and CREM target genes. Hence, MIWI may control spermiogenesis by regulating the stability of these mRNAs. ..
Matsui M, Ichihara H, Kobayashi S, Tanaka H, Tsuchida J, Nozaki M, et al
. Mapping of six germ-cell-specific genes to mouse chromosomes. Mamm Genome. 1997;8:873-4 pubmed
Bhullar B, Zhang Y, Junco A, Oko R, van der Hoorn F. Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion. J Biol Chem. 2003;278:16159-68 pubmed
..b>ODF1, a major ODF protein, was identified as the KLC3 binding partner...
Urano A, Endoh M, Wada T, Morikawa Y, Itoh M, Kataoka Y, et al
. Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia. Mol Cell Biol. 2005;25:6834-45 pubmed
..These results may have clinical implications in the understanding of human male infertility. ..
Yang K, Grzmil P, Meinhardt A, Hoyer Fender S. Haplo-deficiency of ODF1/HSPB10 in mouse sperm causes relaxation of head-to-tail linkage. Reproduction. 2014;148:499-506 pubmed publisher
The small heat shock protein ODF1/HSPB10 is essential for male fertility in mice...
Hoyer Fender S, Burfeind P, Hameister H. Sequence of mouse Odf1 cDNA and its chromosomal localization: extension of the linkage group between human chromosome 8 and mouse chromosome 15. Cytogenet Cell Genet. 1995;70:200-4 pubmed
..The transcription starting point was verified by primer extension. The putative proteins encoded by Odf1 in mouse and by ODF1 in rat and man are very similar...
Nakamura Y, Tanaka H, Koga M, Miyagawa Y, Iguchi N, Egydio de Carvalho C, et al
. Molecular cloning and characterization of oppo 1: a haploid germ cell-specific complementary DNA encoding sperm tail protein. Biol Reprod. 2002;67:1-7 pubmed
..We named this newly isolated gene oppo 1, and we suggest that it plays an important role in sperm tail structure and/or sperm movement. ..
Yang K, Meinhardt A, Zhang B, Grzmil P, Adham I, Hoyer Fender S. The small heat shock protein ODF1/HSPB10 is essential for tight linkage of sperm head to tail and male fertility in mice. Mol Cell Biol. 2012;32:216-25 pubmed publisher
..The main protein of sperm tail outer dense fibers, ODF1/HSPB10, belongs to the family of small heat shock proteins that function as molecular chaperones...
Vourekas A, Zheng K, Fu Q, Maragkakis M, Alexiou P, Ma J, et al
. The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing. Genes Dev. 2015;29:617-29 pubmed publisher
..Our results support a model in which MOV10L1 RNA helicase activity promotes unwinding and funneling of the single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing. ..