Gene Symbol: Oaz1
Description: ornithine decarboxylase antizyme 1
Alias: AZ-1, AZ1, Antizyme, ODC-Az, Oaz, ornithine decarboxylase antizyme 1, antizyme 1
Species: mouse
Products:     Oaz1

Top Publications

  1. Nilsson J, Grahn B, Heby O. Antizyme inhibitor is rapidly induced in growth-stimulated mouse fibroblasts and releases ornithine decarboxylase from antizyme suppression. Biochem J. 2000;346 Pt 3:699-704 pubmed
    ..By causing ribosomal frameshifting, polyamines induce the synthesis of antizyme, a 23-kDa protein, which binds to ODC, inhibits its activity and promotes its degradation by the 26 S proteasome...
  2. Dulloo I, Gopalan G, Melino G, Sabapathy K. The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway. Proc Natl Acad Sci U S A. 2010;107:4902-7 pubmed publisher
    ..c-Jun controlled DNp73 degradation through the nonclassical, polyamine-induced antizyme (Az) pathway by regulating the latter's processing during stress response...
  3. Pietilä M, Dhungana H, Uimari A, Sironen R, Alhonen L. Systemic overexpression of antizyme 1 in mouse reduces ornithine decarboxylase activity without major changes in tissue polyamine homeostasis. Transgenic Res. 2014;23:153-63 pubmed publisher
    ..proliferative processes associated with the whole animal, we have generated transgenic mice overexpressing mouse antizyme 1 gene under its own regulatory sequences...
  4. Ivanov I, Gesteland R, Atkins J. Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit. Nucleic Acids Res. 2000;28:3185-96 pubmed
    The efficiency of programmed ribosomal frameshifting in decoding antizyme mRNA is the sensor for an autoregulatory circuit that controls cellular polyamine levels in organisms ranging from the yeast Schizosaccharomyces pombe to Drosophila ..
  5. López Contreras A, Sánchez Laorden B, Ramos Molina B, de la Morena M, Cremades A, Peñafiel R. Subcellular localization of antizyme inhibitor 2 in mammalian cells: Influence of intrinsic sequences and interaction with antizymes. J Cell Biochem. 2009;107:732-40 pubmed publisher
    Ornithine decarboxylase (ODC) and the antizyme inhibitors (AZIN1 and AZIN2), regulatory proteins of polyamine levels, are antizyme-binding proteins...
  6. Cheng L, Zhang J, Reed R. The transcription factor Zfp423/OAZ is required for cerebellar development and CNS midline patterning. Dev Biol. 2007;307:43-52 pubmed
    ..We show here that Zfp423/OAZ, a multiple zinc-finger transcription factor involved in both OE/EBF and BMP-signaling pathways, is required for ..
  7. Kankare K, Uusi Oukari M, Janne O. Structure, organization and expression of the mouse ornithine decarboxylase antizyme gene. Biochem J. 1997;324 ( Pt 3):807-13 pubmed
    Ornithine decarboxylase antizyme is a protein that participates in the regulation of cellular polyamine levels. In this study we have isolated and sequenced the mouse gene encoding antizyme protein...
  8. Feith D, Pegg A, Fong L. Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice. Carcinogenesis. 2013;34:570-6 pubmed publisher
    ..b>Antizyme (AZ) is a multifunctional negative regulator of cellular polyamine levels, and here, we evaluate the ..
  9. Murakami Y, Suzuki J, Samejima K, Oka T. Developmental alterations in expression and subcellular localization of antizyme and antizyme inhibitor and their functional importance in the murine mammary gland. Amino Acids. 2010;38:591-601 pubmed publisher
    Ornithine decarboxylase (ODC), antizyme (AZ), and antizyme inhibitor (AIn) play a key role in regulation of intracellular polyamine levels by forming a regulatory circuit through their interactions...

More Information


  1. Cohavi O, Tobi D, Schreiber G. Docking of antizyme to ornithine decarboxylase and antizyme inhibitor using experimental mutant and double-mutant cycle data. J Mol Biol. 2009;390:503-15 pubmed publisher
    b>Antizyme (Az) is a highly conserved key regulatory protein bearing a major role in regulating polyamine levels in the cell. It has the ability to bind and inhibit ornithine decarboxylase (ODC), targeting it for degradation...
  2. Lopez Garcia C, Lopez Contreras A, Cremades A, Castells M, Penafiel R. Transcriptomic analysis of polyamine-related genes and polyamine levels in placenta, yolk sac and fetus during the second half of mouse pregnancy. Placenta. 2009;30:241-9 pubmed publisher
    ..metabolism were present in the three gestational compartments analyzed, as well as those of antizymes 1 and 2 and antizyme inhibitor 1. However, no expression of antizyme 3 and antizyme inhibitor 2 was detected...
  3. Hoshino K, Momiyama E, Yoshida K, Nishimura K, Sakai S, Toida T, et al. Polyamine transport by mammalian cells and mitochondria: role of antizyme and glycosaminoglycans. J Biol Chem. 2005;280:42801-8 pubmed
    The role of antizyme (AZ) and glycosaminoglycans in polyamine uptake by mammalian cells and mitochondria was examined using NIH3T3 and FM3A cells and rat liver mitochondria. AZ is synthesized as two isoforms (29 and 24...
  4. Ivanov I, Gesteland R, Atkins J. A second mammalian antizyme: conservation of programmed ribosomal frameshifting. Genomics. 1998;52:119-29 pubmed publisher
    A second mammalian ornithine decarboxylase antizyme was discovered. The deduced protein sequence of the human antizyme2 is 54% identical and 67% similar to human antizyme1 but 99.5% identical to mouse antizyme2...
  5. Nilsson J, Koskiniemi S, Persson K, Grahn B, Holm I. Polyamines regulate both transcription and translation of the gene encoding ornithine decarboxylase antizyme in mouse. Eur J Biochem. 1997;250:223-31 pubmed
    The degradation of ornithine decarboxylase (ODC) is mediated by antizyme, a protein regulated by the end-products of ODC activity, the polyamines...
  6. Ku M, Howard S, Ni W, Lagna G, Hata A. OAZ regulates bone morphogenetic protein signaling through Smad6 activation. J Biol Chem. 2006;281:5277-87 pubmed
    ..We investigated the role of the transcriptional activator and Smad1/4 cofactor OAZ in regulating bone morphogenetic protein (BMP) signaling...
  7. Franzoni E, Booker S, Parthasarathy S, Rehfeld F, Grosser S, Srivatsa S, et al. miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6. elife. 2015;4: pubmed publisher
    ..Our results place miR-128 upstream of PHF6 in a pathway vital for cortical lamination as well as for the development of neuronal morphology and intrinsic excitability. ..
  8. Levillain O, Greco A, Diaz J, Augier R, Didier A, Kindbeiter K, et al. Influence of testosterone on regulation of ODC, antizyme, and N1-SSAT gene expression in mouse kidney. Am J Physiol Renal Physiol. 2003;285:F498-506 pubmed
    ..In this study, we document the time course effect of testosterone on 1) gene expression of ODC, antizyme 1 (AZ1), and spermidine/spermine-N1-acetyltransferase (N1-SSAT); 2) ODC activity in proximal convoluted tubules (..
  9. López Contreras A, Ramos Molina B, Cremades A, Peñafiel R. Antizyme inhibitor 2 (AZIN2/ODCp) stimulates polyamine uptake in mammalian cells. J Biol Chem. 2008;283:20761-9 pubmed publisher
    ..Transient transfected cells with mutated antizyme forms of AZ1, AZ2, and AZ3, which do not require frameshifting, showed a total blockade of polyamine uptake...
  10. Feith D, Shantz L, Pegg A. Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis. Cancer Res. 2001;61:6073-81 pubmed
    ..carcinogenesis, we used bovine keratin 5 (K5) and keratin 6 (K6) promoter elements to direct the expression of antizyme (AZ) to specific skin cell populations...
  11. Gritli Linde A, Nilsson J, Bohlooly Y M, Heby O, Linde A. Nuclear translocation of antizyme and expression of ornithine decarboxylase and antizyme are developmentally regulated. Dev Dyn. 2001;220:259-75 pubmed
    ..Inactivation of ODC is mainly exerted by antizyme (AZ), a 20--25 kDa polyamine-induced protein that binds to ODC, inactivates it, and targets it for degradation by ..
  12. Matsufuji S, Matsufuji T, Miyazaki Y, Murakami Y, Atkins J, Gesteland R, et al. Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme. Cell. 1995;80:51-60 pubmed
    Rat antizyme gene expression requires programmed, ribosomal frameshifting. A novel autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines...
  13. Ramos Molina B, Lambertos A, López Contreras A, Kasprzak J, Czerwoniec A, Bujnicki J, et al. Structural and degradative aspects of ornithine decarboxylase antizyme inhibitor 2. FEBS Open Bio. 2014;4:510-21 pubmed publisher
    ..b>Antizyme inhibitors (AZIN1 and AZIN2) are proteins homologous to ODC that bind to AZs and counteract their negative effect ..
  14. Ray R, Bavaria M, Johnson L. Interaction of polyamines and mTOR signaling in the synthesis of antizyme (AZ). Cell Signal. 2015;27:1850-9 pubmed publisher
    ..The activity of the enzyme is primarily regulated by a negative feedback mechanism involving ODC antizyme (AZ)...
  15. López Contreras A, Lopez Garcia C, Jimenez Cervantes C, Cremades A, Peñafiel R. Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity. J Biol Chem. 2006;281:30896-906 pubmed
    ..Co-transfection experiments with combinations of Odc, Az1, Az2, Az3, antizyme inhibitor (Azi), and Odcp genes showed that ODCp mimics the action of AZI, rescuing ODC from the effects of AZs ..
  16. Keren Paz A, Bercovich Z, Porat Z, Erez O, Brener O, Kahana C. Overexpression of antizyme-inhibitor in NIH3T3 fibroblasts provides growth advantage through neutralization of antizyme functions. Oncogene. 2006;25:5163-72 pubmed
    b>Antizyme inhibitor (AzI) is a homolog of ornithine decarboxylase (ODC), a key enzyme of polyamine synthesis...